Unveiling Tim Ferriss' Supplement Stack: What He Takes

Tim Ferriss has risen in popularity over the years as a well-known entrepreneur, author, and healthy lifestyle advocate. Many may be familiar with Tim as the author of The 4-Hour Workweek, a book focused on time management techniques and building positive lifestyle habits. For the last 10 years, he has also hosted a popular podcast exploring business topics.

Throughout this time, Tim has mentioned using various techniques to optimize his own mental and physical performance. An array of supplements have been included in his routine, leading many to wonder whether these supplements may be beneficial to help optimize their own well-being.

Tim has provided his own rationale for using each of these supplements at times. Let’s take some time to explore each supplement individually, including some of the potential benefits and risks that have been uncovered in clinical research.


Who is Tim Ferriss?

Tim has described experiencing trauma and various health concerns early in life. These experiences ultimately shaped a desire to explore self-improvement methods and share them with others. After graduating from Princeton, Tim founded a successful supplement company, BrainQuicken, which was later sold to investors.

While much of Tim’s professional background has been directly associated with entrepreneurship and business, his influence has continued to include lifestyle and wellness topics due to a focus on examining the habits of top performers in various industries.

Overview of Tim Ferriss’ health philosophy

Tim Ferriss has focused on maintaining an open mind and believes in a willingness to experiment with lifestyle adjustments, technology, and supplements to promote health optimization and enhance his well-being. This approach is often referred to as ‘biohacking,’ or using technology and supplements to improve performance, efficiency, and overall longevity.

The amount of scientific evidence supporting many biohacking practices varies widely. In some instances, advice based on the available research can be very sound, such as prioritizing good sleep hygiene and staying physically active. In other cases, supporting research may be lacking.

Tim Ferriss' supplement routine

Tim has mentioned taking a wide variety of supplements, so let’s break these down one by one.


Supplements for general well-being

Operating at peak mental and physical capacity requires addressing the fundamentals. Nutrition supports all of the body’s functions, including healthy immune function, metabolism, and mental health. Nutritional supplements are often used to provide a foundation and cover any nutritional gaps. At times, products can also be used with the intent to offer an additional boost. Let’s explore some supplements Tim has considered valuable for overall well-being.

Apple cider vinegar (ACV)

Tim has mentioned taking apple cider vinegar each morning, stating it can help improve immune function. Early studies have suggested a potential for slowing the growth of potentially harmful microorganisms, but no larger formal studies have been conducted related to overall immune function.

Comparatively, more studies have examined whether apple cider vinegar may be beneficial for blood sugar and cholesterol control in individuals managing type 2 diabetes. These studies have shown some promise but are relatively small and use a variety of sources and doses of apple cider vinegar.

Because vinegar is highly acidic, side effects can include tooth enamel erosion and stomach upset. It’s also important to note that individuals already taking insulin or insulin secretagogues (e.g., glipizide or glimepiride) may be at a higher risk of developing dangerously low blood sugar levels when adding apple cider vinegar to their regimen.

Further studies would be helpful in general to help define who may be most likely to benefit and which forms and dosages maximize benefit while minimizing side effects.

AG1 (Athletic Greens)

Tim has mentioned using AG1 as a daily nutritional supplement. In general, AG1 can be considered a potential replacement for a multivitamin, helping to fill nutritional gaps. The manufacturers of AG1 claim their product helps support healthy digestion and immunity while boosting energy levels. There is at least some basis in clinical research for each of these claims.

Gut health probiotics like Lactobacillus acidophilus and Bifidobacterium bifidum have shown promise for reducing inflammation and aiding in the management of inflammatory bowel disease.


Zinc and vitamin C may help improve the immune response.

The perception of improved 'energy' can vary depending on how an individual intends to use it. More efficient use of oxygen in the tissues has been associated with improvements in physical performance and reduced mental fatigue. B vitamins like thiamine, riboflavin, pantothenic acid, and folate may offer support in these areas.

AG1 includes over 70 ingredients. These offer a variety of potential benefits, but it’s also important to note the risk of drug interactions. Particularly if you’re already taking prescribed medications, it’s critical to discuss new supplements with your healthcare providers as some interactions may become dangerous.


Initial research related to berberine has focused on its potential ability to protect against cardiovascular disease. Notably, one meta-analysis has reported that there were improvements in triglyceride and cholesterol levels among individuals taking berberine. While no direct effect on cardiovascular events has been established, improving these markers may ostensibly lower the risk of CVD.

Berberine has also been associated with improved blood glucose control. However, individuals already using medications like insulin should exercise caution, as they may be at a higher risk of developing dangerously low blood sugar levels.

Vitamin D

Sunlight helps your body produce vitamin D, but many people don’t get enough due to factors like limited sun exposure, dietary restrictions, or living in less sunny climates. Supplements can help maintain recommended vitamin D levels. Tim has mentioned using vitamin D to support bone health; research extensively supports this benefit.

Vitamin D is important for absorbing calcium and supporting bone health and the immune system. Low levels of vitamin D have also been linked to higher risks of heart disease and depression. Supplementing may be helpful for mood stabilization and stress reduction among those at risk of deficiency.

Recommended doses can vary widely depending on your individual needs. For example, people managing osteopenia, osteoporosis, or severe vitamin D deficiency may need higher doses. Your clinic can easily test your vitamin D levels to determine if you need a supplement and the appropriate dose.

Fish oil


Tim has mentioned using fish oil, among other cognitive supplements, to promote brain health. Fish oil supplements, rich in omega-3 acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may reduce inflammation and help in reducing cognitive decline.

Fish oil is also commonly used to promote heart health, but research has shown mixed results. Fish oil supplements may be beneficial for those with heart conditions like atrial fibrillation. However, in healthy individuals, there may be a higher risk of major events like stroke. Before starting fish oil supplements, consult your healthcare providers to discuss your specific health needs and risks.


Getting enough magnesium is important, as lower magnesium levels have been associated with chronic conditions like high blood pressure, heart disease, diabetes, and osteoporosis. Low magnesium can also cause muscle cramps. Magnesium is often found in vegetables and other high-fiber foods. Supplements can help, especially if your diet is low in fiber. However, high doses of magnesium can act as a laxative, so if you experience loose stools, talk with your healthcare provider about adjusting your dose.

Tim has mentioned taking magnesium specifically to promote better sleep. Research related to magnesium supplementation and sleep patterns has been mixed, and further research is needed.

Medicinal mushrooms

Tim has cited lion’s mane benefits and mentions using several varieties of mushroom extracts, including reishi and cordyceps, citing their ability to boost immune function.

Ganoderma lucidum (reishi) and Cordyceps sinensis mushrooms have some background in clinical research, notably being researched in certain types of cancer. Research is very early in all aspects, including safety, efficacy, and potential interactions, but initial research suggests a role in producing cytokines, a critical component of the immune response.

Nicotinamide riboside (NR)

Tim Ferriss states nicotinamide riboside can be helpful for anti-aging benefits. Nicotinamide riboside (NR) is a precursor of nicotinamide adenine dinucleotide (NAD+), an important cofactor for enzymes involved in metabolism. Theoretically, supplements aimed at increasing levels of NAD+ may be helpful in addressing cognitive decline and lowering the risk for cardiovascular disease.

In practice, while NR has become one of the more prominently used NAD+ precursors, research related to its benefits remains limited. Future research will help better define optimal dosing, individuals most likely to benefit, and any potential side effects.

Supplements for athletic performance

Athletic supplements are meant to provide energy for workouts, increase metabolic rate, and supply the building blocks for building and maintaining lean muscle. Tim's supplements tend to lean more heavily toward metabolism and muscle growth.

Alpha lipoic acid

Over time, alpha lipoic acid supplements have become more widely used for metabolism support and antioxidant properties. Because it may help with blood sugar management, it’s also sometimes recommended for conditions like polycystic ovary syndrome (PCOS) and diabetic neuropathy. However, it may not be suitable for everyone, especially individuals already taking insulin, metformin, or medications for blood sugar control, as the combination may cause dangerously low blood sugar levels. Always consult your healthcare provider before starting alpha lipoic acid to ensure it’s safe for your needs.


The term branched-chain amino acids (BCAAs) refers to the essential amino acids leucine, isoleucine, and valine. Essential amino acids are not produced by the body naturally and must be obtained in the diet or through supplementation. Protein-rich foods like milk, eggs, and meat products are among the most prominent sources. BCAAs are used by muscle cells for muscle protein synthesis and may be helpful for muscle recovery after exercise.

Individuals interested in combining BCAAs with workout routines for building muscle are the most likely to benefit, as not all essential amino acids are provided.


Another supplement aimed primarily at building and maintaining muscle, creatine has been widely used for many years. Over time, a number of studies have demonstrated its potential to increase muscle strength and mass when paired with resistance training. Some studies have also explored its potential for aiding in maintaining muscle mass and bone mineral density in aging adults.

It’s important to note that higher-than-recommended doses and combinations with other medications and supplements have led to some potential concerns with kidney and liver injury. Consulting your healthcare provider before starting creatine is critical for ensuring safe use.


A naturally produced compound derived from the amino acids L-methionine and L-lysine, L-carnitine has been touted for its potential to boost exercise performance and maintain metabolism and energy levels. While there may be some short-term benefits, there are potential risks associated with long-term use, such as an increased risk of cardiovascular disease. Consulting a healthcare provider can help you weigh the potential risks and benefits over time.


Tim has discussed using L-glutamine to improve muscle recovery. L-glutamine is an amino acid integral to several metabolic pathways, including the immune response and building and maintaining muscle fiber.

L-glutamine is among the most abundant amino acids in the body, and research related to supplementation has ultimately been mixed. Across numerous trials, L-glutamine has shown mixed results regarding its effects on immune response, aerobic performance, or body composition.

Protein powder

Protein powder is a standard component of any supplement stack aimed at building muscle, but it can also be beneficial for preventing dietary deficiencies. Whey protein provides all essential amino acids not produced by the body naturally, so it can be a reliable supplement for diets prone to potential deficiencies (e.g., vegan diets). Whey protein has also been associated with an increase in muscle mass in numerous clinical studies.

However, it’s critical to note that protein supplements should be used with caution in individuals with reduced kidney function.

Supplements for sleep

Adequate sleep is essential for mental and physical well-being. Tim has also prioritized sleep hygiene, consistent scheduling, turning off electronics, and limiting evening beverages and snacks. He has also mentioned using supplements for additional support, so let’s examine each.

California poppy extract

Eschscholzia californica (California poppy) has been used for several purposes, including helping with sleep, anxiety, and pain. Like many plant extracts, the final product delivers many potentially active compounds.

In initial studies, it appears California poppy may interact with GABA, serotonin, norepinephrine, and opioid receptors. Interactions with these receptors may provide a sedative, stress-reducing effect, but human safety and efficacy studies are very limited. Because of the receptors involved, exercising caution with prescription medications is critical.


Tim reports using melatonin regularly in addition to practicing good sleep hygiene (i.e., no screen time before bed). A naturally produced hormone central to establishing the body’s circadian rhythm, melatonin supplementation has become routinely recommended for insomnia. Melatonin has been well-tolerated in general, but it’s important to start with a low dose and increase slowly to minimize the risk of morning or daytime drowsiness.

Huperzine A

Huperzine A has been used in traditional Chinese medicine for centuries, and contemporary medicine is beginning to explore its potential. While Tim has mentioned using huperzine A for sleep, much of the current research has been related to its potential neuroprotective properties. Early studies have suggested it may have potential benefits for people suffering from Alzheimer’s disease and epilepsy, but further research is needed to better understand its safety and efficacy.

Research related to sleep is very limited, but it does seem to increase GABAergic activity, which reduces the excitability of neurons.

Should you follow his routine?

Many of the supplements Tim Ferriss uses have established benefits or show promise in supporting overall health. However, several important factors must be noted.

While Tim has mentioned each of these supplements, they have been mentioned at different times. He has not specifically mentioned using all of them together, and his regimen has likely changed over time. Combining a large number of supplements has the potential to be harmful.

Each individual’s health needs are unique. Supplements are best paired with a healthy lifestyle. This includes a balanced diet, adequate exercise, and healthy sleep habits. It’s best to review each supplement individually to determine whether it may be helpful for your needs. Before starting any new supplement, have a conversation with your healthcare providers. This will help you determine whether it may interact with any existing therapy. You will also be able to review your health concerns and goals while weighing the risks and benefits of adding additional supplements to your routine.

Final word

Tim Ferriss has built an excellent reputation based on transparency and building habits that promote reaching our cognitive and physical potential. Among his strategies have been numerous supplements, and many have become interested in whether taking these supplements would be beneficial for them. While some of these supplements may benefit you, it’s important to consider them individually. Consulting your doctor before starting any new supplement will help you determine whether it fits your safety needs and will be suitable for your health goals.


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