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Best Polyphenol Supplements in 2024 For Optimal Brain And Hearth Health

Polyphenol supplements consist of plant compounds known as polyphenols, naturally found in various plant-based foods like fruits, vegetables, herbs, tea, red wine, coffee, and dark chocolate. These compounds act as antioxidants, protecting the body from damage caused by harmful free radicals.

Regular consumption of polyphenols is believed to offer several health benefits, including improved digestion, brain health, and protection against conditions such as heart disease, type 2 diabetes, and certain cancers.

This article will review the best polyphenol supplement options targeting specific individual needs.

Best polyphenols supplement in 2024: shortlist

  1. Invity — best polyphenol supplement for eye and heart health
  2. Nummies — best polyphenol supplement for digestive health
  3. A Quality Life — best polyphenol supplement for boosting energy
  4. Bulletproof — best polyphenol supplement for anti-aging

How to choose the best polyphenol supplement for me?

When choosing the best polyphenol supplement, it is important to look at specific criteria that will allow you to make a proper assessment. You should consider ingredient quality, dosage and price ratio, provider reputation, customer reviews, and other factors.

Clean, science-backed ingredientsReputable providerAdequate dosage and priceCustomer feedback
Derived from natural sources, no fillersGMP-certified, third-party testedPrice vs. the amount of polyphenol
Has positive customer reviews and testimonials
  • Clean and science-backed ingredients. Ensure the supplement contains pure and high-quality ingredients, preferably derived from natural sources. Look for supplements that use standardized extracts and avoid those with unnecessary fillers or additives.
  • Reputable provider. Choose a brand with a good reputation known for producing high-quality supplements. Look for companies that follow good manufacturing practices (GMP) and have third-party testing or certifications to ensure product quality and safety.
  • Adequate dosage and price. Consider the dosage of polyphenols provided in each serving of the supplement and compare it with the price. Look for supplements that offer a good-price dosage ratio of polyphenols at a reasonable price point.
  • Positive reviews and reputation. Read reviews from other customers and check the brand's reputation. Look for brands that have overall positive reviews and testimonials, indicating customer satisfaction and trust in the product's effectiveness.

Best polyphenol supplement brands on the market in 2024: overview

While compiling this list, we evaluated brands and polyphenol supplements addressing different health needs.

It's vital to choose a product that aligns with your personal health goals to ensure that you get the most benefits out of it. Though most polyphenol supplements share common characteristics, they possess distinctive properties that set them apart. Keeping this in mind is imperative for attaining specific health objectives.

Below we present the 4 best polyphenol brands you should try in 2024.

1. Invity — best supplement for eye and heart health

Invity Ultimate Polyphenols

Invity Ultimate Polyphenols is a high-strength supplement, designed to boost daily antioxidant intake and protect the body from harmful free radicals.

According to the provider, this supplement is beneficial for both eye and heart health, containing a broad spectrum of polyphenols and carotenoids, including:

  • Lutemax 2020® (protects eyes, reduces eye fatigue symptoms, improves dry eye and macular function, and improves sleep quality)
  • Purple rice
  • Walnut polyphenol
  • Maqui berry

Ultimate Polyphenols may also support a healthy blood flow and maintain proper cholesterol levels.

According to the provider, the product is vegan, cruelty-free, and scientifically formulated and is also manufactured according to GMP and Food & Drug Administration (FDA) requirements.

Invity Ultimate Polyphenols is priced at $55.00 per bottle.

2. Nummies — best for digestive health

Nummies Supergreen Vitamin Gummies

Supergreen Vitamin Gummies by Nummies is a daily super green blend packed with prebiotics, digestive enzymes, and micronutrients (vitamins/minerals). These gummies are designed to improve digestion, boost metabolism while also strengthening the immune system.

They contain 550mg of organic functional mushrooms, including Reishi, Lion's Mane, and over 25 adaptogenic “superfoods” and greens. The supplements also include vitamins C, D2, B6, B12, and Zinc.

According to the provider, the product promotes long-lasting energy levels and is loaded with antioxidants to improve recovery, fight inflammation, and help prevent illnesses.

Based on the website information, all the ingredients in Nummies’ products are natural-based and non-GMO.

The gummies are priced at $21.99 for a one-time purchase, with a 15% discount for subscription purchases.

3. A Quality Life — best energy-boosting polyphenol supplement


Fitness Advance of Green by A Quality Life Nutrition is a natural supplement formulated with green coffee beans, green tea, raspberry ketones, and garcinia cambogia. Green tea, in particular, is known to have a vast range of antioxidant properties

The supplement is designed to enhance energy and vitality. It may also yield additional antioxidant support to your diet to complement an active lifestyle.

When incorporated into a well-balanced diet and regular physical activity, the elements of Fitness Advance of Green formula, such as green coffee beans and green tea, have the potential to assist in achieving your health objectives.

The product is GMO-free and uses only natural ingredients without harmful chemicals or additives.

Fitness Advance of Green is priced at $36.45 per bottle.

4. Bulletproof — best anti-aging polyphenol supplement

Bulletproof Polyphenol

Bulletproof is a health supplement brand focusing on a variety of products, including Polyphenomenal. It's a unique anti-aging supplement packed with polyphenols — potent antioxidants derived from a diverse blend of berries and botanicals.

According to the provider, the supplement provides a daily dose of plant-based antioxidants that combat free radicals and support healthy aging. It features a broad spectrum of polyphenols, including quercetin, from sources like pomegranate, turmeric, blueberries, and green tea.

The product is vegan-friendly, with vegetable capsules made from all-natural alpha cellulose derived from pine trees.

According to Bulletproof, the product is formulated with science-backed ingredients, ensuring effectiveness.

The product is priced at $27.96 for a one-time purchase or as part of a subscription model, with free shipping on orders over $49.00.

Comparison of the 4 top-rated polyphenol supplement brands

BrandPricePolyphenol typesCost per servingServing sizeDoseAdditional ingredientsVegan/vegetarian
Invity$55.00Lutemax 2020, purple rice, walnut polyphenol, maqui berry and other~$1.834 capsules4 capsules dailyN/AVegan
Nummies$21.99Organic spinach, organic broccoli, and organic spirulina~$0.732 gummies2 gummies a dayReishi, Lion's Mane, over 25 adaptogenic “superfoods” and greens, vitamins C, D2, B6, B12, and Zinc. N/A
A Quality Life$36.45Green tea polyphenols~$0.611 capsule1 capsule twice a dayGreen Coffee Bean, Raspberry Ketone, Garcinia Cambogia, Caffeine AnhydrousVegetarian, possibly suitable for vegans
Bulletproof$27.96A range of 9 antioxidants, including Quercetin~$0.934 capsules4 capsules dailyBamboo silica, modified cellulose (vegetable capsule), sulting agents.Vegan

What are polyphenols? Types of polyphenols

Polyphenols are a category of plant compounds found naturally in various plant-based foods, including fruits, vegetables, herbs, spices, tea, dark chocolate, and wine.

There are more than 8,000 identified types of polyphenols, which can be categorized into four main groups:

  • Flavonoids. They make up approximately 60% of all polyphenols and include compounds like quercetin, kaempferol, catechins, and anthocyanins. Foods such as apples, onions, dark chocolate, and red cabbage are rich sources of flavonoids.
  • Phenolic acids. This group accounts for around 30% of all polyphenols. Examples of phenolic acids include stilbenes and lignans, which are mostly found in fruits, vegetables, whole grains, and seeds.
  • Polyphenolic amides. This category includes capsaicinoids found in chili peppers and avenanthramides found in oats.
  • Other polyphenols. This group consists of various polyphenols, such as resveratrol in red wine, ellagic acid in berries, curcumin in turmeric, and lignans in flax seeds, sesame seeds, and whole grains.

Why you should take polyphenol supplements

Polyphenols are a multi-functional group of active plant compounds with antioxidant properties linked to numerous benefits, such as:

  • Improved cardiovascular health
  • Reduced inflammation
  • Lowered cholesterol
  • Cognitive function enhancement

These properties can protect cells from damage caused by free radicals.

Here’s a more in-depth explanation of some of the main benefits of polyphenol use:

Can help manage blood pressure

Polyphenols have been associated with managing blood pressure levels. Research suggests that polyphenols may have a relaxing effect and reduce inflammation in the blood vessels, contributing to lower blood pressure. This can be beneficial for individuals with hypertension or those looking to maintain healthy blood pressure levels.

Protects the skin

Polyphenols have been found to possess skin-protective properties. Their antioxidant and anti-inflammatory effects can help combat oxidative stress, reduce inflammation, and protect the skin from damage caused by environmental factors such as UV radiation and pollution. This can contribute to maintaining healthier and more youthful-looking skin.

Improves gut health

Polyphenols may have a positive impact on gut health by supporting the growth of beneficial gut bacteria and reducing the growth of harmful bacteria. This can help maintain a balanced gut microbiota, which is essential for optimal digestion, nutrient absorption, and overall gut health.

Additionally, polyphenols may have anti-inflammatory effects in the gut, which can contribute to reducing the risk of gastrointestinal disorders.

Supports brain health

Research studies have shown that polyphenols have the ability to reduce cognitive decline in neurodegenerative diseases.

For instance, consuming fruits rich in polyphenols can potentially reverse neuropathological changes linked to cognitive impairments in Alzheimer's disease. Furthermore, the intake of polyphenols is associated with positive improvements in cognitive performance, which can be attributed to their ability to cross the blood-brain barrier.

However, it's important to note that further research is needed to fully understand the extent of the benefits.

Do polyphenol supplements have side effects?

Polyphenol supplements generally have a good safety profile, but like any supplement, they may cause side effects in some individuals. Common side effects may include gastrointestinal issues such as stomach upset or diarrhea.

Consuming polyphenols through food sources is generally considered safe and provides additional nutrients and fiber. The side effects of supplements can differ from those of food due to differences in concentration and potential interactions with other compounds in the supplement.

It's important for pregnant/breastfeeding women and individuals with specific health conditions to consult their healthcare provider before consuming polyphenol supplements.

Additionally, polyphenols may interact with certain medications, so discussing potential side effects with a healthcare professional is also recommended.

When is the best time to take polyphenols supplements?

The best time to take polyphenol supplements can vary depending on the specific supplement and individual preferences. However, it is generally recommended to take any supplements with meals to aid in their absorption and minimize the risk of gastrointestinal discomfort. Taking them with food allows for the activation of digestive enzymes and provides a medium for better absorption.

It's important to note that individual responses and needs may vary, so consulting with a healthcare professional is always advised for personalized recommendations based on specific polyphenol supplements and health conditions.

Foods that are rich in polyphenols

A handful of foods contain polyphenols, including fruits, vegetables, beverages, nuts and seeds, and spices. The polyphenol content can vary depending on factors such as the variety, ripeness, and processing of the food. It's also worth mentioning that these values are approximate and can vary based on different sources and analysis methods.

Almonds187 mg of polyphenols per 100 g
Apples183 mg of polyphenols per 100 g
183 mg of polyphenols per 100 g
Cinnamon178 mg of polyphenols per 100 g
Flaxseed152 mg of polyphenols per 100 g
Onions120 mg of polyphenols per 100 g
Spinach119 mg of polyphenols per 100 g
Grapes101 mg of polyphenols per 100 g
Green tea89 mg of polyphenols per 100 ml
Broccoli81 mg of polyphenols per 100 g
71 mg of polyphenols per 100 g
Cloves15.188 mg of polyphenols per 100 g

The vast amount of foods containing polyphenols makes it easy enough to add them to your add diet and improve your overall health. However, using polyphenol supplements can increase your intake even more.

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