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Best Quercetin Supplement in 2025: Top Brands in the Market

Quercetin is a natural compound (flavonoid) found in plants like grapes, cranberries, capers, red onions, apple skins, and kale. It is often recognized for its potential to support immune health, reduce inflammation, and offer antioxidant benefits.

Some studies also suggest it could help with allergy relief due to its antihistamine properties.

Since it can be challenging to get consistent amounts of quercetin from food alone, supplements might provide a more concentrated source enhancing its benefits.

In this guide, I'll cover 5 top-rated quercetin supplements, analyzing their purity, bioavailability, and cost to help you choose the best one. I’ll also team up with Healthnews researchers to explore scientific evidence behind quercetin’s effects and see if these claims hold up.

Keep reading to uncover the potential benefits of this powerful natural compound.

Recent updates
In our latest update, we have reviewed and updated the quercetin supplement list, added valuable insights on the benefits of quercetin, and included the most recent research on its effects on immune support, allergy relief, and overall health.

Best quercetin supplements: shortlist

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Why do we think partiQlar’s quercetin is the best?

We believe partiQlar’s Pure Quercetin is the best choice due to its commitment to quality and transparency. Each capsule delivers a potent 500 mg dose of quercetin, aimed at potentially supporting immune health and promoting longevity.

Manufactured in the U.S. in NSF-registered facilities that adhere to GMP standards, partiQlar ensures high-quality production and rigorous third-party testing for purity and accuracy.

Best quercetin supplements and brands: product review

To help you make an informed decision, we've compiled a list of the top 5 quercetin supplements, evaluated for purity, bioavailability, and cost. Explore these options to find the best value that fits your needs.

1. partiQlar — best overall quercetin made in the U.S.

partiQlar Quercetin

We recommend partiQlar’s Pure Quercetin because it stands out as the premier choice for potentially boosting NAD+ levels with its 500 mg of pure quercetin per capsule, possibly promoting longevity and well-being.

Additionally, partiQlar is manufactured in the U.S. within NSF-registered facilities adhering to strict GMP standards and its products undergo rigorous third-party testing to ensure quality and label accuracy.

Who might benefit the most from this product?

This quercetin supplement may be particularly beneficial for individuals dealing with seasonal allergies or general inflammation. They could also support brain health, cardiovascular function, and overall aging, making them suitable for those seeking holistic wellness support.

Key ingredients

Quercetin from Sophara Japonica bud extract — 500 mg.

Our verdict

What stands out to us about partiQlar is its transparency with third-party testing and GMP certifications, which provide customers with added peace of mind. We also appreciate that the product is reasonably priced, offering both quality and affordability.

However, one downside is that, like some other products on this list, the supplement does not offer enhanced bioavailability.

2. ProHealth — best quercetin with potent antioxidants

ProHealth Quercetin / Bromelain Complex

Quercetin / Bromelain Complex by ProHealth is an excellent blend enriched with vitamin C and magnesium. Each 3-tablet serving delivers 1 gram of quercetin.

This supplement pairs quercetin with bromelain to enhance absorption and effectiveness, potentially aiding histamine balance and supporting a healthy inflammatory response, especially during pollen season.

Moreover, ProHealth ensures its products' quality through third-party lab testing and follows strict manufacturing practices certified by GMP and registered with the FDA.

Who might benefit the most from this product?

According to the brand, it might help people with allergies by potentially aiding histamine balance and supporting a healthy inflammatory response.

Key ingredients

  • Vitamin C — 600 mg
  • Magnesium — 39 mg
  • Quercetin — 1,000 mg
  • Bromelain — 300 mg

Our verdict

What we like about this product is its transparency, demonstrated through GMP certification and third-party testing. Additionally, we appreciate the fact that the supplement offers enhanced bioavailability.

While there isn't anything specific we disliked about this product, we believe the brand could improve communication with customers to provide more clarity about delivery services and potential additional fees.

3. Purovitalis — best quercetin with enhanced absorption

Hand holding a Purovitalis Quercetin product bottle in front of a grey curtain background

Liposomal Quercetin by Purovitalis stands out with its unique liposomal formulation of quercetin, which may offer enhanced absorption. By encapsulating the active ingredient in liposomes, they are shielded from early breakdown, allowing for more precise delivery to target cells or tissues, according to the brand.

The brand recommends taking one capsule daily with food. The quercetin used is derived from Sophora japonica extract, a natural source rather than a synthetic one.

Manufactured in the Netherlands with premium Swiss liposome technology, Purovitalis ensures quality and purity through ISO certification and rigorous third-party lab testing, providing Certificates of Analysis (COA) for added assurance.

Who might benefit the most from this product?

According to the brand, this supplement may be most beneficial for individuals looking to support healthy aging and address inflammation. It may also support those seeking to boost immune function, reduce allergy symptoms, and promote cardiovascular health.

Key ingredients

Quercetin — 125 mg

Our verdict

What stood out to us most about Purovitalis was its commitment to transparency, evidenced by its certifications and third-party testing, ensuring high-quality products. Additionally, its enhanced bioavailability may provide superior results compared to other brands.

One drawback is that the product is not available in major online stores and can only be purchased from the official website.

4. Thorne — best gluten-free pure quercetin capsules

Thorne Quercetin Complex

Quercetin Complex by Thorne stands out for its balanced formula of quercetin phytosome and bromelain, enhancing absorption and bioavailability.

Each capsule provides 250 mg of quercetin phytosome — designed for better absorption — and 100 mg of bromelain, a natural enzyme from pineapple, both working together to improve effectiveness.

The product is made with natural flavors and colors and is gluten-free, dairy-free, and soy-free.

Manufactured in the U.S. and third-party tested, Quercetin Complex by Thorne ensures purity and label accuracy. Each bottle contains 60 servings, with a recommended dose of one capsule taken with meals.

Who might benefit the most from this product?

According to the brand, this product may be most beneficial for individuals seeking allergy relief and enhanced immune support.

Key ingredients

  • Quercetin phytosome — 250 mg
  • Bromelain — 100 mg

Our verdict

We recommend Quercetin Complex by Thorne for its thoughtfully crafted formula, combining quercetin phytosome for improved absorption, and bromelain. Thorne's commitment to quality is clear in its gluten-, dairy-, and soy-free formulation, along with third-party testing to ensure purity and label accuracy.

While it comes at a higher price point, the premium quality makes it a worthwhile investment.

5. Double Wood Supplements — best quercetin with bromelain

Double Wood Quercetin

We have selected Quercetin Supplement by Double Wood Supplements due to its excellent formula, designed to support the immune system health. Each capsule contains 500 mg of quercetin and 100 mg of bromelain, which may enhance the absorption of quercetin, thus improving the compound’s bioavailability.

The brand recommends a daily quercetin dosage of 1,000 mg, or two capsules, preferably taken with meals to enhance absorption, as quercetin is fat-soluble.

Moreover, the product is manufactured in the U.S., is GMP-certified, and third-party tested for quality and label accuracy. It is also soy-free, gluten-free, non-GMO, and vegan.

Who might benefit the most from this product?

According to the brand, this product is ideal for individuals looking to support their overall health through natural antioxidant- and immune-boosting benefits. It may particularly benefit those who want to enhance immune function and improve zinc absorption, as quercetin acts as a zinc transporter, helping cells absorb zinc more effectively when taken together.

Key ingredients

  • Quercetin — 1,000 mg
  • Bromelain — 200 mg

Our verdict

What we liked most about this brand is its transparency, third-party testing, and GMP certification. We also noticed a lot of aspects highlighting the company's trustworthiness, reputation, quality products, and attentive customer service.

Comparing the best quercetin supplements

Find a side-by-side comparison of their prices, serving sizes, quantities, and additional features.

BrandPrice
Total servings per bottle
Serving size
Quercetin amount per serving
Enhanced bioavailability
Third-party testedBest for?
partiQlar$22.9960 1500 mgNoYesSupporting immune function
ProHealth$25.353331,000 mgYesYesSupporting a healthy inflammatory response
Purovitalis
$20.9560
1
125 mg Yes
YesSupporting healthy aging and potentially reducing inflammation
Thorne$48.00601250 mgYesYesRelieving allergies and enhancing immune support
Double Wood Supplements$24.956021,000 mgYesYes Enhancing immune function and improving zinc absorption

How we evaluated the best quercetin supplement brands

Healthnews research team and I dedicated over 40 hours to evaluating quercetin supplements, focusing on the effectiveness and benefits of quercetin for overall health. Our researchers examined over 20 peer-reviewed studies, exploring quercetin’s potential impact on immune support, allergy relief, cardiovascular health, and anti-inflammatory properties.

We selected supplements with well-researched formulations, paying close attention to bioavailability enhancers, such as bromelain, which is known to improve quercetin absorption.

Beyond scientific research, I analyzed product specifications, considering practical factors like dosage forms, ease of consumption, and allergen-free formulations.

This approach ensures our evaluation is grounded in both scientific evidence and user experience, providing readers with a well-rounded assessment of the top quercetin supplements on the market.

What is quercetin?

Quercetin is a natural pigment found in various plant-based foods, classified as a flavonoid. This group of compounds is widely known for its antioxidant properties, which help neutralize harmful free radicals in the body. Free radicals, if not neutralized, can cause oxidative stress and contribute to chronic conditions.

As one of the most abundant flavonoids in the diet, quercetin is commonly consumed through everyday foods such as onions, apples, berries, tomatoes, broccoli, and even beverages like green tea and red wine. It is also available as a supplement, often in capsule or powder form.

People use quercetin for a variety of proposed health benefits, including boosting immunity, reducing inflammation, and managing allergies. Given its widespread presence in everyday foods, quercetin plays a key role in supporting overall health and well-being.

Benefits of quercetin supplements

Currently, clinical studies are exploring several potential benefits of quercetin, including its effects on cardiovascular health, allergy relief, athletic performance, brain health, and inflammation. In the following section, we'll examine each of these areas in more detail.

Potential Benefits of quercetin supplements

Cardiovascular health

Quercetin may support cardiovascular health by reducing blood pressure and offering potent antioxidant benefits. These effects help counteract oxidative stress and inflammation, key contributors to cardiovascular disease (CVD).

Quercetin's cardioprotective properties have been observed in various studies, suggesting it can be a helpful addition to a heart-healthy lifestyle that includes dietary changes and other preventive measures.

Additionally, some studies suggest that quercetin may prevent platelet aggregation, which could help reduce the likelihood of blood clots and possibly lower the risk of cardiovascular complications. However, the evidence is not fully understood and further research is needed.

Blood sugar levels

A 2024 randomized controlled trial looked at how taking quercetin supplements affects the key factors of metabolic syndrome (MetS), which is a group of health issues like high blood sugar, high blood pressure, and excess fat around the waist. The study found that quercetin can help lower fasting blood sugar levels and systolic blood pressure.

However, it didn’t show much effect on factors like cholesterol levels, waist size, or the bottom number of blood pressure. It also suggested that taking quercetin for a longer period might lead to better results in lowering blood sugar.

General inflammation

Promising studies suggest that quercetin is a powerful anti-inflammatory that helps reduce inflammation in the body by blocking substances like cytokines and enzymes that cause it. Quercetin also has antioxidant properties that protect cells from damage caused by inflammatory processes.

A study of seven randomized controlled clinical trials showed that quercetin significantly lowered C-reactive protein (CRP), an indicator of inflammation in the body, particularly when taken in doses of 500 mg/day or more, and most noticeably in people with moderate inflammation.

Athletic performance

Quercetin has been explored for its potential to enhance athletic performance by improving endurance and reducing fatigue. It is thought to support the energy-producing capacity of cells, which might contribute to improved exercise performance.

Furthermore, its antioxidant and anti-inflammatory properties may aid recovery by minimizing muscle damage and inflammation following intense physical activity.

However, according to the NIH summary on supplements for athletic performance, quercetin shows little to no impact on endurance or maximal oxygen consumption, highlighting the need for more research to confirm its efficacy in this area.

Brain health

This study suggests that quercetin may have neuroprotective effects due to its anti-inflammatory and antioxidant properties, which could help improve brain health. While research on its impact on neuroinflammation and toxicity is still early, animal studies indicate that quercetin may reduce neuroinflammation damage and improve cognitive function.

Additionally, quercetin can reduce pro-inflammatory messengers and oxidative stress, potentially protecting cells during inflammation. However, more research is needed to confirm these benefits.

Allergy relief

Quercetin may alleviate allergy symptoms by stabilizing mast cells, which release histamine, a key chemical in allergic reactions. It also has anti-inflammatory properties that may potentially help reduce swelling and inflammation associated with allergies. These effects suggest that quercetin may help manage symptoms like sneezing, runny nose, and itching.

However, while these potential benefits are proposed based on their properties, they have not yet been evaluated in human studies, where individuals with allergies receive quercetin supplementation to assess a direct reduction in allergy symptoms. Therefore, more research is needed to confirm these effects in humans.

Possible side effects of quercetin supplements

Quercetin

supplements are generally considered safe for most individuals, with little to no side effects when taken at appropriate doses.

However, higher doses may lead to some mild side effects. These can include digestive issues like:

  • Stomach upset
  • Indigestion
  • Acid reflux
  • Diarrhea

Additionally, some people report experiencing headaches or a tingling sensation in the arms and legs. Very high doses of quercetin may also pose a risk to kidney health, potentially affecting kidney function.

It is important to be mindful of potential interactions with medications. Quercetin can interfere with certain drugs, including antibiotics and blood thinners, which may affect their effectiveness.

Disclaimer
As with any supplement, it is advisable to consult your healthcare provider before use, particularly if you have underlying health conditions or are taking prescription medications.

Foods rich in quercetin

Here are some of the primary food sources of quercetin.

Foods rich in quercetin

How to take quercetin supplements

Quercetin is a powerful flavonoid found in many plants, but its low solubility can make absorption challenging.

To improve absorption, consider taking quercetin with a meal that includes healthy fats, as it enhances bioavailability. Foods like avocados, nuts, olive oil, peanut butter, Greek yogurt, and oily fish would be a great addition when taking this supplement.

Alternatively, opt for supplements that use liposomal delivery systems or include bromelain, an enzyme derived from pineapple, which may enhance quercetin's bioavailability.

Best form of quercetin supplements

The effectiveness of quercetin supplements largely depends on their bioavailability, which is how well the body can absorb and utilize them. Since quercetin naturally has poor bioavailability, it’s important to choose formulations designed to enhance absorption.

Options include quercetin dihydrate, a modified version that improves how the body absorbs it; quercetin complex, which combines quercetin with ingredients like bromelain or vitamin C to aid uptake; and quercetin phytosome, a formulation that binds quercetin to fat molecules, further increasing its absorption potential. These forms are designed to maximize quercetin's benefits for the body.

Who should not take quercetin?

If you are pregnant or breastfeeding it's best to avoid taking quercetin supplements, as it is naturally present in many foods, and consuming too much may not be safe.

Additionally, if you are taking medications such as antibiotics, cyclosporine, warfarin, or drugs metabolized by the liver, exercise caution. Quercetin may alter how these medications work and potentially increase the risk of side effects.

How to choose the right quercetin supplement

When choosing a high-quality quercetin supplement, look for formulations that enhance bioavailability, such as those with bromelain or liposomal technology, as quercetin is not easily absorbed by the body.

Ensure the dosage aligns with typical research-backed, safe ranges of 500–1,000 mg per day and that the product is free from unnecessary additives, meeting specific dietary needs like being non-GMO or gluten-free.

Opt for supplements tested by third-party organizations, such as NSF or USP, to ensure purity and potency. Additionally, check customer reviews and brand transparency about sourcing and manufacturing.

Best quercetin supplements: conclusion

Quercetin is a promising antioxidant with potential benefits for immune support, reducing inflammation, and combating allergies. Quercetin supplements may be a valuable option for those seeking to enhance their overall health and well-being.

However, while quercetin shows promise in various areas of health, it is not a one-size-fits-all solution and should be considered carefully before incorporating it into your routine.

Additionally, it is important not to rely solely on supplements. A well-rounded approach to health, which includes a balanced diet, regular exercise, and stress management, is essential for overall wellness.

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