Spermidine has been getting a lot of attention lately for its potential health benefits. Emerging research suggests that spermidine supplements might enhance cellular function, improve cardiovascular health, and even contribute to a longer, healthier life. Found naturally in a variety of foods and plants, this biogenic polyamine has sparked a lot of interest due to its growing evidence as a therapeutic agent.
One of the reasons spermidine is catching on is its ability to trigger autophagy — the self-cleaning process of the cells. And with more people looking for natural ways to support their health and vitality, spermidine is quickly becoming a favorite.
But with so many choices out there, finding the best spermidine supplement can be quite a task. That’s why we’re here to walk you through what we think are some of the best spermidine supplements on the market today, so you won’t miss out if you’re not already on board with the latest longevity trend.
Best spermidine supplements in 2024: shortlist
- Oxford Healthspan — best bioavailable spermidine
- partiQlar — best spermidine supplement with value for money
- Purovitalis — best spermidine supplement with vitamins
- Omre — best spermidine supplement for those starting out
- GenuinePurity — best pure spermidine supplement
- spermidineLIFE — best spermidine supplement sourced naturally
Comparison of the top 6 spermidine supplements
| Brand | Cost per bottle | Serving size | Servings per bottle/package | Cost per serving | Spermidine per serving | Active ingredients |
| Oxford Healthspan | $90.00 | 3 capsules | 30 | $3.00 | 1 mg | 1 |
| partiQlar | $39.99 | 1 capsule | 60 | $0.66 | 8 mg | 1 |
| Purovitalis | $45.00 | 1 capsule | 30 | $1.50 | 5 mg | 7 |
| Omre | $44.97 | 2 capsules | 30 | $1.49 | 10 mg | 1 |
| GenuinePurity | $59.95 | 2 capsules | 30 | $1.99 | 8 mg | 1 |
| spermidineLIFE | $69.00 | 2 capsules | 30 | $2.96 | 1 mg | 3 |
Our list of the best spermidine supplements: what makes them stand out?
Spermidine supplements are not all created the same — they may differ in their formulations, how well they're absorbed, the price point, and overall quality. These factors can dictate how you choose to supplement with spermidine, with your final decision, of course, coming down to your preferences and needs. Recognizing this, as we compiled our list of the best spermidine supplements, our goal was to be as inclusive and considerate of these preferences and needs as possible.
Based on your priorities, if you're more drawn to bioavailability rather than cost and want to optimize spermidine absorption in your body, our top recommendation is Oxford Healthspan — a brand that’s all about delivering supplements in a form that maximizes absorption for the best results.
Now, when keeping costs low is a priority, look no further than partiQlar. This supplement appears to strike the best balance between price and quality compared to others we've encountered in our research.
In case you're looking for a spermidine supplement that's without any extras — just pure spermidine — GenuinePurity would be our selection. For those new to spermidine supplements, there's Omre, a product that embodies what seems to be the main features of a quality supplement, including third-party testing, a simple formulation, and affordability.
For naturally sourced supplements, turn to spermidineLIFE — a brand distinguished by its commitment to sourcing spermidine only from natural origins.
And finally, those hunting for something extra in a market full of supplements containing solely spermidine should try Purovitalis — it goes beyond spermidine by adding essential vitamins.
In the end, no matter what you seek — purity, affordability, bioavailability, added micronutrients, or natural origins — our list has each category covered.
Spermidine supplement reviews in 2024
As research continues to highlight their benefits, spermidine supplements are gaining traction in the longevity market. Their anti-inflammatory and antioxidant properties, along with their involvement in cellular renewal processes, suggest they could potentially support a longer life.
And while, of course, spermidine supplements alone won’t make your immune system invincible or guarantee a dramatically longer lifespan, recent studies indicate that spermidine may enhance cellular health and help you live longer. If you’re interested in exploring these potential benefits, you might want to consider adding some of these spermidine supplements to your routine.
1. Oxford Healthspan Primeadine
Amazon rating — 4.3 ⭐⭐⭐⭐
Trustpilot rating — 4.5 ⭐⭐⭐⭐⭐
Now, if the price point is not your main concern, but instead bioavailability is — Oxford Healthspan and its Primeadine offering have a compelling case.
Primeadine is a pure, entirely food-derived spermidine supplement. According to the manufacturer, it boasts high bioavailability and, along with prebiotic fiber, includes two additional polyamines — spermine and putrescine.
The makers state that the presence of these additional polyamines increases the bioavailability of spermidine derived from food. Putrescine acts as the precursor to spermidine and spermine, forming a virtuous recycling loop that may help enhance your body's natural production of spermidine.
The supplement is manufactured in an FDA-registered facility under strict GMP standards. Besides that, it is third-party lab tested.
What’s also noteworthy is the feedback this Oxford Healthspan product receives from its customers. While the vast majority of customers express satisfaction with the Primeadine, there is a distinct pattern in their feedback — it relates to hair growth.
What users liked about the product
- Positive reports include mentions of improved hair growth, healthier nails, and better sleep quality
- Customers were pleased with how fast results were achieved.
- Excellent and responsive customer service
What users didn’t like about the product
- A number of customers felt the product was too expensive
- A few users had to opt for an alternative product because of the gluten in this product
- Some didn’t notice the benefits they were hoping for with this supplement
While Primeadine may come at a premium price point of $90 for a 30-day supply, I believe the investment is well justified by both the product's makeup in terms of bioavailability and the resounding customer satisfaction across impartial platforms such as Trustpilot.
2. partiQlar Pure Spermidine
Trustpilot rating — 4.5 ⭐⭐⭐⭐⭐
Price is always a consideration, whether we acknowledge it or not. And those who want quality without breaking the bank should really turn their heads to partiQlar Pure Spermidine.
Right away, the main thing that grabbed my attention about this spermidine supplement is its purity level of 98%, and the fact that it's reasonably priced made all the sense in the world for nominating it as the wallet-friendly option, so to speak.
Another appealing aspect of Pure Spermidine is its formulation. The supplement is purposefully created to meet the market demand for products that are gluten-free, soy-free, and non-GMO. This commitment to inclusivity and transparency speaks volumes about the brand's efforts to distinguish itself from other options on the market.
Plus, all partiQlar products, including this one, are manufactured in FDA and NSF-registered facilities within the U.S.
And finally, the price point. Despite its quality, Pure Spermidine remains surprisingly affordable, priced at just $39.99 for a 60-capsule bottle.
What users liked about the product
- The non-synthetic and additive-free profile has been highly-regarded
- Manufactured according to high market standards with relevant certificates
- Easy-to-navigate website
What users didn’t like about the product
- Several users experienced delayed deliveries
- Delayed response from customer support
- A few noted they didn't notice immediate results
In my book, whether you're new to spermidine or seeking a budget-friendly yet high-quality option, partiQlar’s offering has a good chance of exceeding your expectations.
3. Purovitalis Liposomal Spermidine Fusion
Trustpilot rating — 4.7 ⭐⭐⭐⭐⭐
After weighing Purovitalis Liposomal Spermidine Fusion against its alternatives on the market, I'm convinced that it's the top choice for a spermidine supplement with added vitamins. Let me explain why the Fusion formula shines.
Purovitalis has blended spermidine with essential B-group vitamins, vitamin D3, and zinc, creating a powerhouse supplement that goes beyond traditional offerings. This blend may not only provide the purported benefits of spermidine but may also offer additional support for overall cellular health and vitality.
One of the key selling points of Purovitalis is the liposomal technology it employs. It is a delivery technique that uses liposomes to transport active ingredients to their desired destinations in the body. The technology works by encapsulating the active ingredients within liposomes to protect them from degradation and enhance their absorption in the gastrointestinal tract so that they could have a higher chance of being delivered to target cells.
When it comes to quality assurance, Purovitalis upholds stringent standards throughout the manufacturing process. Its products are manufactured in a GMP-certified facility and are also subjected to third-party testing.
What users liked about the product
- Independent laboratory verifying the purity of the product
- Many liked how convenient was the one-capsule serving size
- Excellent customer service
What users didn’t like about the product
- Custom taxes for U.S. orders
- It was difficult for some to make returns
- Many customer reviews point to consistent problems with the delivery process
A 30-day supply of Liposomal Spermidine Fusion is tagged at an attractive price point of $45. Considering the vitamin-infused formula and the brand's efforts toward quality assurance, this product looks to me as a compelling investment for someone who's looking for a well-rounded spermidine supplement.
4. Omre Spermidine
Amazon rating — 4.9 ⭐⭐⭐⭐⭐
Trustpilot rating — no reviews
If you’re looking to kick-start your spermidine supplementation journey with a clean product that packs a punch, Omre’s offering should be a frontrunner on your list.
This dietary supplement contains no artificial additives, and while this aspect alone makes it an ideal choice for those seeking a clean supplement, the positives don’t stop there.
Where Omre also excels is their testing protocol. See, before reaching the consumer, each batch must go through third-party testing to verify dose accuracy and ingredient purity. Additionally, the product passes tests for bacterial, fungal, and heavy metal contamination.
Manufactured in a GMP-compliant and FDA-registered facility in the U.S., Omre's commitment to quality and compliance is evident at every step of the production process.
In terms of value, Omre Spermidine offers a 30-day supply at a fair price of $44.97 when purchased directly from the official website. This represents an accessible entry point for those starting their journey towards supplementing with spermidine.
What users liked about the product
- Tangible benefits such as better skin and increased energy levels
- People are happy with the quality considering the price
- Customer service has been reflected positively
What users didn’t like about the product
- With the exception of some who didn't see immediate results, there aren't many reviews, positive or negative
In the end, with its emphasis on purity, rigorous testing standards, and affordability, Omre Spermidine is a compelling choice for those starting out.
5. GenuinePurity Spermidine
Amazon rating — 4.3 ⭐⭐⭐⭐
Trustpilot rating — hasn’t received any reviews yet
As someone who's recently been immersed in research on spermidine supplements, I can say that GenuinePurity’s Spermidine possesses all the necessary attributes to become the next consumer favorite. Let me walk you through why I believe it deserves the nomination for the best pure spermidine supplement on the market.
Firstly, let's talk about what sets GenuinePurity apart. That is its dedication to transparency and safety. Not only is the supplement manufactured in a GMP-certified facility, but it is also third-party tested. You can easily access the testing certification on their website, giving you peace of mind that you're getting exactly what you pay for.
But what really impressed me was the brand’s commitment to quality. One of the standout features is the liposomal encapsulation. This advanced delivery method is proposed to strengthen absorption so that you may get the most out of each dose. Plus, the formula is pure — free from unnecessary additives that can dilute the quality of the product.
And let's not forget about value. With free shipping on all U.S. orders, GenuinePurity offers both quality and affordability. At $59.95 for a month's supply, it's a fair investment for the potential health benefits. Plus, for those looking to stock up, there are even greater value options available for securing supplements for a longer period of time.
What users liked about the product
- Noticeable benefits like better sleep and enhanced energy levels
- Transparent testing information and detailed analysis
- Easy-to-take capsules with no odor
What users didn’t like about the product
- Quite a few customers thought the product's price was too high
- Some found the dosing instructions unclear
- Others questioned the product's bioavailability
As a final point, you can tell that there’s just something different about GenuinePurity's Spermidine. From its commitment to quality and transparency to its formulation and affordability, it ticks all the boxes for what I would look for in a spermidine supplement. So, if you're in the market for a high-quality product that delivers real results, I highly recommend giving GenuinePurity's Spermidine a try.
6. spermidineLIFE
Amazon rating — 4.3 ⭐⭐⭐⭐
Trustpilot rating — hasn’t received any reviews yet
Synthetic or natural — I believe most of us know which of the two we'd choose. And those who prefer a natural approach to supplementation should certainly consider spermidineLIFE.
spermidineLIFE is a brand driven by a shared belief within its circles in a natural approach to supplementation. Its primary source of spermidine is wheat germ extract — one of the richest natural sources of spermidine.
Another key pillar of spermidineLIFE's ethos is transparency. The company openly shares the origins of its products and provides a window into its sourcing practices and ingredient lists.
What users liked about the product
- Measurable changes in hair growth
- Mentions of noticeable effects on skin quality, sleep quality, and energy levels
- Excellent customer service
What users didn’t like about the product
- Some thought the spermidine dose was low
- Others believed the product was too expensive
- Given it contains gluten, some people found it difficult to incorporate the product into their diets
What also propelled us to place spermidineLIFE on our list is that its suggested benefits seem to align with the scientific community's consensus. So, if you're looking for a natural approach to your longevity efforts, a 60-count bottle of spermidineLIFE priced at $69 appears to be a deal worth cashing in.
Choosing the best spermidine supplements
Finding the right supplement involves some nuance, and this holds true for most dietary supplements. That’s why understanding what to look for and what to avoid is essential. Below, we describe in detail the criteria that guided our choices and explain why each one matters.
| Bioavailability | Manufacturing | Safety | Dose |
| Formulations for enhanced delivery | cGMP-certification or similar | Third-party laboratory testing | Research-supported |
- Bioavailability. Bioavailability determines how well your body can absorb and use the compound. If a supplement has low bioavailability, you might not get as much of the active ingredient delivered to the target areas to have an effect. In putting together our list, we looked closely at the bioavailability of each supplement, including whether they use methods like liposomal technology or are specially formulated to improve compound absorption.
- Manufacturing. Manufacturing in cGMP-certified facilities means strict adherence to quality control, which is crucial for upholding high standards and preventing contamination. We searched for products that have cGMP or comparable quality certifications.
- Safety. Spermidine products that are third-party laboratory tested were a top priority for us. Such testing provides insights into product quality, safety, and labeling accuracy, which in turn helps consumers understand exactly what they’re purchasing, without company bias.
- Dose. Using doses supported by research is the best approach to achieving the desired benefits from a supplement. It not only maximizes the supplement’s potential efficacy but also minimizes the risks of any unwanted side effects.
How to choose the right spermidine supplement for you
In our search for the best spermidine supplements, we learned it was crucial to consider specific factors to compile a line-up that truly reflects the absolute best selections out there. Here's what we recommend looking into:
- Research the source and quality. Prioritize supplements derived from natural sources like that of wheat germ. Also, products with third-party certifications like GMPs or certificates of analysis (COAs) can be a good indicator of quality.
- Look for scientific backing. While spermidine is a relatively new area of study, products that reference or support their health claims with scientific evidence can offer more credibility.
- Inspect the ingredient label. It's important to check the list of ingredients in the supplement. Avoid products with unnecessary fillers, additives, or allergens that might not align with your dietary preferences or restrictions. Choose supplements with minimal, clean ingredients.
- Consider the price point. While cost shouldn't be the primary factor, it's important to assess the cost-effectiveness of different options. Compare prices per serving and consider any potential discounts or subscription offers for long-term use.
What is spermidine?
Spermidine is a major member of the biogenic polyamine group, which also comprises spermine and putrescine. Whether it's found naturally in foods or taken as a standalone supplement, emerging research suggests spermidine could have a positive impact on your health.
As an ingredient in biogenic polyamine supplements, spermidine plays a role in maintaining cellular balance and is also essential for cell growth.
Keeping your spermidine levels up throughout life might help support heart health and potentially contribute to a longer life. However, as we age, our natural levels of spermidine tend to drop, and studies suggest this decline could be linked to some age-related health issues.
Spermidine's anti-aging properties are largely tied to its effects on several biological processes, one in particular being autophagy. This intricate molecular mechanism facilitates cellular waste removal and promotes optimal cell functioning. By supporting autophagy, spermidine is believed to enhance cellular function.
Spermidine effectiveness: what science tells us
Spermidine plays an essential role in various cellular processes and acts as an antioxidant. What is particularly interesting is its newfound potential as a longevity supplement, especially when formulated in a liposomal delivery system. This system has the potential to increase the cellular permeability of the formulation, thereby enhancing the bioavailability of liposomal spermidine and making it worth considering.
This biogenic polyamine has been demonstrated in some emerging studies to have an effect on age-related conditions, potentially supporting heart health and cognitive function. Scientific studies on this autophagy-inducing agent have also demonstrated its protective effects against cognitive impairment in animal models.
Intriguingly, spermidine intake with food has shown some advantageous effects on aging. This discovery opens up an appealing possibility — employing a spermidine-rich diet to increase its levels in the human body. This approach shows promise as a strategy to foster healthy aging.
We must conclude that while spermidine shows promise as a natural compound with various potential health benefits, particularly in aging-related processes, evidence of this in humans is still emerging. More clinical studies are needed to fully elucidate its effectiveness.
Benefits of spermidine supplements
Although the research on spermidine is still in its early stages, supplements containing this compound may provide a variety of benefits. These could include promoting autophagy, reducing inflammation, supporting heart health, and possibly enhancing cognitive function.
- Induces autophagy. Autophagy is the main mechanism at the molecular level through which spermidine works. As we get older, this process tends to slow down, which is why adding bioactive compounds like spermidine to our diet can be so beneficial. It may help keep the cells functioning optimally and support healthy aging.
- Supports cardiovascular health. Research suggests spermidine may positively impact cardiovascular health. Animal studies have shown it can play a role in blood pressure regulation, support cardiac function, and promote better cardiovascular health overall.
- Reduces inflammation. Research supports spermidine’s anti-inflammatory properties, showing that it can regulate immune responses and reduce the production of pro-inflammatory molecules. These findings suggest that spermidine could be useful as a therapeutic compound for managing inflammation and supporting overall health.
- Enhances cognitive function. Believed to benefit cognitive function, spermidine has been shown in animal studies to potentially support memory and learning capabilities. These effects are thought to result from spermidine’s ability to trigger autophagy in the brain. This process is thought to facilitate the removal of protein aggregates and, in this way, promote better cognitive function.
Possible side effects of spermidine supplements
While available studies have not reported any side effects from short-term spermidine supplementation so far, it’s good to remember that, like with any supplement, they’re not completely free of potential risks. That said, when taken responsibly, spermidine is generally considered safe.
We still need more research to fully understand any possible side effects and the long-term safety of spermidine supplements. Despite the current status, ongoing clinical trials exploring supplementation of spermidine-rich plant extracts are reporting encouraging findings about their safety and tolerability.
Is it safe to take spermidine?
Yes, taking spermidine is considered safe. Spermidine is generally well-tolerated, whether consumed in supplement form or through dietary sources.
Now, if you are on specific medication, adding spermidine to your routine requires consideration. It's best to consult with a healthcare professional beforehand — they can ensure the new supplement aligns with your current health status and medication use.
Recommended dosage of spermidine supplements
As of now, a universal standard dosage for spermidine supplements hasn’t been established. However, evidence suggests that taking up to 15 mg daily is generally well-tolerated with no reported side effects.
While ongoing research is still needed to pinpoint the ideal dosage and fully understand spermidine’s effects, sticking to the recommended amount on the supplement packaging is the recommended approach. Also, remember that eating a balanced diet with spermidine-rich foods like wheat germ, soybeans, and certain fruits can help you get this compound naturally.
How do I know if spermidine supplements work?
Figuring out whether spermidine supplements are effective can be subjective, but there are still several signs to watch for. Start by keeping track of specific health goals you had when you began taking the supplements.
If you notice improvements like more energy, better memory, or fewer signs of aging, that could be a good sign that the supplements are having a positive effect. It’s also useful to monitor certain biomarkers, such as blood pressure, cholesterol, and inflammation levels, since spermidine is linked to regulating these.
Remember, everyone’s response to supplements can be different. It is advisable to consult with a healthcare professional who can guide you through the process and, if necessary, conduct relevant tests. They can also help you interpret any changes you notice and decide if spermidine is right for your needs.
Spermidine rich foods
Present in all tissues of the human body and also found in plants and other dietary sources, spermidine can be added to your diet through specific foods. Here are some excellent choices that are high in spermidine:
| Food category | Specific foods | Range of average spermidine content |
| Cereal | Rice, wheat germ, white bread | 2.8–2437 nmol/g |
| Legumes and soybean products | Chickpeas, lentils, peas, white beans, red kidney beans, soybean, soybean sprouts, soybean milk, tofu, soy sauce, miso | 1.0–1,425 nmol/g |
| Vegetables | Broccoli, cabbage, cauliflower, carrot, celeriac, courgette, cucumber, eggplant, green beans, green pepper, lettuce, mushroom, onion, potato, spinach, tomato | 6.9–398 nmol/g |
| Nuts and oilseeds | Almonds, chestnuts, pistachios, seeds | 41–383 nmol/g |
| Fruits | Apple, avocado, banana, cherry, kiwi, mandarin, orange, pear, peach, pineapple, strawberry, fruit juices | 6.9–98 nmol/g |
Including these nutrient-rich foods in your diet can supply your body with natural spermidine, which, again, is a key biogenic polyamine that supports cellular health and, in theory, helps promote a longer, healthier life.
Consider alternative supplement options to support longevity
If graceful aging is what you seek, it is worth considering the best NMN supplements.
For those seeking immune support, consider exploring the best ashwagandha supplements.
To elevate stress relief efforts, the best ashwagandha gummies may be worth trying.
When it comes to increasing your energy levels, consider the best NAD+ supplements.
If you need inflammation relief, the best resveratrol supplements are worth looking into.
If promoting mitochondrial health and aging well is your aim, the best Urolithin A supplements may be what you need.
FAQ
What is a substitute for spermidine?
Resveratrol. While there isn’t a perfect substitute for spermidine that matches all its benefits, resveratrol is a notable alternative worth considering. It is a polyphenol known for its potential anti-aging effects. Like spermidine, resveratrol can induce autophagy, which helps support healthy aging.
What is the richest source of spermidine?
Wheat germ. If you’re searching for a natural source of spermidine, wheat germ is your best bet. This by-product of the flour milling industry is packed with spermidine and spermine, making it one of the richest sources of these compounds.
Does spermidine increase testosterone?
It might, but the evidence is still limited. While there isn’t much scientific research directly linking spermidine supplementation to increased testosterone levels, a recent small study did find that supplementation with spermidine and spermine increased testosterone in men under 50.
How much spermidine does David Sinclair take?
1 mg per day. David Sinclair takes 1 mg of spermidine every morning. Sinclair is a leading expert in aging and longevity who believes that reaching 150 years — or even longer — is achievable. He argues that longevity supplements, which he personally takes, could help you live a longer life.
9 resources
- Autophagy. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
- Aging. Spermidine delays aging in humans.
- Nutrients. Extracts Rich in Nutrients as Novel Food Ingredients to Be Used in Food Supplements: A Proposal Classification.
- Biomolecules. Biogenic Polyamines and Related Metabolites.
- Integrative Medicine: A Clinician's Journal. Liposomes as Advanced Delivery Systems for Nutraceuticals.
- Journal of the American Dietetic Association. Development of a Polyamine Database for Assessing Dietary Intake.
- Frontiers. Spermidine Affects Cardiac Function in Heart Failure Mice by Influencing the Gut Microbiota and Cardiac Galectin-3.
- Open Journal of Endocrine and Metabolic Diseases. The Regulatory Effect of Biogenic Polyamines Spermine and Spermidine in Men and Women.
- Gerontology. Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review.
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