Spermidine has been in the limelight lately due to its potential health benefits. Emerging research suggests that spermidine supplements may enhance cellular function, improve cardiovascular health, and provide nutritional support for a healthy lifespan. This biogenic polyamine is found in various foods and plants, and its increasing evidence for therapeutic potential has sparked significant interest in recent years.
With its ability to induce autophagy — the body’s self-cleaning process — and support longevity, spermidine has become increasingly popular as people seek natural ways to improve their health and vitality.
Given the overwhelming variety of choices, finding the perfect spermidine supplement can be challenging. Therefore, in this review, we will look at the best spermidine supplements available on the market today.
Best spermidine supplements in 2024: shortlist
- GenuinePurity — the best spermidine supplement on the market
- partiQlar — best spermidine supplement with value for money
- Purovitalis — best spermidine supplement with vitamins
- Omre — best spermidine supplement for those starting out
- Oxford Healthspan — best bioavailable spermidine
- Spermidine LIFE — best science-backed spermidine
Choosing the best spermidine supplements
Choosing the right spermidine supplement requires careful consideration of several vital factors. Below, we provide a list of criteria and explain their importance in the decision-making process.
|Liposomal or specialized formulations
|cGMP-certified and FDA-approved
|Independent lab tested
|Adequate and safe
- Bioavailability. High bioavailability is fundamental for spermidine supplements, as it determines how effectively the body can absorb and utilize the compound. When bioavailability is low, the amount of spermidine you actually receive may fall short of what is indicated on the supplement label.
- Manufacturing. Products manufactured in cGMP-certified and FDA-approved facilities are subject to stringent quality control measures, which are pillars of high standards. This not only instills trust in consumers but also reduces the chances of contamination, potentially enhancing the safety and dependability of the products.
- Safety. Spermidine supplements that are third-party lab-tested offer transparency regarding product quality, safety, and accurate labeling. Independent testing helps consumers make informed choices, granting them unbiased results.
- Dosage. Adequate dosing may deliver desired benefits, maximizing the supplement's potential while minimizing risks to maintain overall health.
Spermidine supplement reviews in 2024
With a growing body of research supporting their benefits, spermidine supplements have taken the longevity market by storm. Due to their anti-inflammatory and antioxidant properties, as well as their role in cellular renewal processes, spermidine supplements have the potential to support longevity.
Sure enough, spermidine supplements on their own may not render your immune system impregnable or guarantee a significantly longer lifespan. However, recent studies indicate that spermidine has the potential to enhance cellular health and prolong life. To reap these benefits, consider incorporating one of the following supplements into your routine.
Continue reading to discover the best spermidine supplements on the market.
1. GenuinePurity — best spermidine supplement overall
Ticking all the boxes for what makes a market-leading supplement — from liposomal encapsulation and a formula devoid of unnecessary additives to quality assurance certifications and pricing — GenuinePurity's Spermidine possesses all the tools to become the next consumer favorite in the saturated spermidine supplement market.
Not only is this spermidine offering manufactured in a GMP-certified facility, but it is also third-party tested, with testing certification available on the brand's website. This is to ensure that you receive precisely what is stated on the label.
Within each serving of the product, you will find an 8 mg dose of spermidine derived from wheat germ extract. The manufacturer recommends taking 2 capsules daily, preferably with a meal.
With the added benefit of free shipping for all USA orders, you can get a month’s supply of GenuinePurity's Spermidine for just $59.95. Not to mention, the brand does offer even greater value options for those looking to secure their supplements for a longer period of time.
2. partiQlar — best spermidine supplement with value for money
Among the offerings on our list, partiQlar Pure Spermidine stands out as a great value-for-money choice. As per the creators, it boasts a spermidine purity concentration of 98% and has undergone third-party testing.
Supplied by EffePharm, this supplement by partiQlar is purposefully created to meet the market demand for products that are gluten-free, soy-free, and non-GMO.
The manufacturing of all partiQlar products takes place exclusively within US-based facilities that are registered with the FDA and NSF, upholding the strict GMP standards.
Pure Spermidine capsules contain 8 mg of natural spermidine each, and the manufacturer recommends a daily dosage of 1 capsule.
A single bottle of this spermidine supplement contains 60 vegan capsules and is priced at $39.99. You can purchase yours directly from their website.
3. Purovitalis — best spermidine supplement with vitamins
Packed with more than just spermidine, Purovitalis Liposomal Spermidine Fusion features an exceptional composition of 7 active ingredients, including B-group vitamins, vitamin D3, and zinc.
This spermidine supplement from Purovitalis, marketed as a blend for cellular protection, may support autophagy — a process that recycles and removes damaged components within cells. This makes it a promising choice for those seeking optimal cellular health.
Liposomal Spermidine Fusion is manufactured in a GMP-certified facility and undergoes third-party testing. The company establishes transparency by providing a Certificate of Analysis (COA).
Each capsule contains 5 mg of spermidine. The manufacturer recommends taking 1 capsule daily.
You can get your Liposomal Spermidine Fusion bottle containing 60 capsules for $55.
4. Omre — best spermidine supplement for those starting out
Omre Spermidine is a dietary spermidine supplement containing no artificial additives, designed to cater to those looking to kick-start their journey with a clean, potentially cellular autophagy-activating product that packs a punch.
To distinguish itself from low-quality spermidine supplement alternatives, Omre subjects its spermidine to third-party testing to confirm the dosage and purity of the ingredients. Additionally, the product undergoes tests for bacterial, fungal, and heavy metal contamination.
Omre's spermidine offering is produced in a GMP-compliant and FDA-registered facility located in the U.S.
According to the manufacturer's recommendations, the daily dosage consists of 2 capsules, providing 1000 mg of standardized wheat germ extract, which is equivalent to 10 mg of spermidine.
You can get a 30-day supply of Omre Spermidine for a fair value of $44.97 as a one-time purchase from the official website of the provider.
5. Oxford Healthspan — best bioavailable spermidine
Oxford Healthspan Primeadine is a pure, entirely food-derived spermidine supplement. It boasts high bioavailability and, along with prebiotic fiber, includes two additional polyamines — spermine and putrescine. These compounds may work together to keep optimal polyamine levels in the body.
Primeadine is manufactured in an FDA-registered facility under strict GMP standards. Besides that, it is third-party lab tested.
The manufacturer recommends gradually building up to a full, 3-capsule daily dosage over three consecutive days. Begin by taking 1 capsule on day one, followed by 2 capsules on day two, and finally, on day three, take 3 capsules.
Spermidine within Oxford Healthspan's offering is exclusively obtained from a concentrated Japanese wheat germ extract. A daily dose delivers exactly 1 mg of supplemental spermidine.
You can get your 30-day supply of Primeadine for $90 from the official Oxford Healthspan website.
6. Spermidine LIFE — best science-backed spermidine
Spermidine LIFE is an innovative dietary supplement formulated with a natural spermidine-rich wheat germ extract that has been Generally Recognized As Safe (GRAS) by the FDA. Crafted with lab-verified wheat germ extract, this supplement is designed to optimize the benefits of spermidine, supporting autophagy and enhancing cellular renewal.
The brand exclusively derives its spermidine from a natural, non-GMO wheat germ source. Through a unique extraction process developed in collaboration with elite researchers, the makers of the supplement use purified water as the sole agent to separate spermidine from wheat germ. This method ensures the quality of natural spermidine is preserved, along with all other vital substances present in the wheat germ extract.
Every batch of the supplement is clinically tested to ensure that every bottle of Spermidine LIFE contains the specified amount of natural spermidine.
The recommended daily dosage is 2 capsules, as suggested by the manufacturer. Each serving packs 800 mg of wheat germ extract, providing 1 mg of spermidine.
To make a purchase, simply visit the official Spermidine LIFE website, where a single bottle containing 60 capsules is priced at $69.
Comparison of the top 6 spermidine supplements
|Cost per bottle
|Servings per bottle/package
|Cost per serving
|Spermidine per serving
What is spermidine?
Spermidine is a biogenic polyamine, with emerging evidence supporting its effects on health, both as a component of foods and as a single ingredient supplement. It is a prominent figure among biogenic polyamines, including spermine and its precursor, putrescine. As an ingredient in biogenic polyamine supplements, spermidine represents a natural compound that serves as a biogenic polyamine essential for cell growth, playing a vital role in maintaining cellular balance.
Ensuring adequate spermidine levels throughout your life may support your heart health and help you live longer. However, as humans age, the levels of this biogenic polyamine in our bodies decrease, and studies suggest that this decline may be linked to age-related deterioration.
Additionally, spermidine's anti-aging properties are closely linked to its impact on various biological processes, particularly autophagy. Autophagy, a complex cellular mechanism, facilitates the elimination of cellular waste and promotes optimal cell functioning. By supporting autophagy, spermidine is not only suggested to revitalize cellular function but also to safeguard against cell death.
What is spermidine used for?
Spermidine plays an essential role in various cellular processes and acts as an antioxidant. What is particularly interesting is its newfound potential as a longevity supplement, especially when formulated in a liposomal delivery system. This system has the potential to increase the cellular permeability of the formulation, thereby enhancing the bioavailability of liposomal spermidine and making it worth considering.
This biogenic polyamine has been demonstrated in some emerging studies to have an effect on age-related conditions, potentially supporting heart health and cognitive function. Scientific studies on this autophagy-inducing agent have also demonstrated its protective effects against cognitive impairment in animal models.
Intriguingly, spermidine intake with food has shown some advantageous effects on aging. This discovery opens up an appealing possibility — employing a spermidine rich diet to increase its levels in the human body. This approach shows promise as a strategy to foster healthy aging. Keep in mind, the evidence in humans is still emerging.
Benefits of spermidine supplements
In recent years, spermidine has garnered significant attention due to its potential health benefits and role in supporting longevity. While research on spermidine is still emerging, supplements with spermidine may offer a multitude of benefits, including a role in autophagy, reduction of inflammation, cardiovascular health support, and enhanced cognitive function.
- Induces autophagy. At the molecular level, autophagy is the primary mechanism through which spermidine exerts its effects. As we grow older, the activity of autophagy diminishes. Therefore, dietary intake of bioactive compounds that may promote autophagy can be an important element for optimal cellular function and graceful aging.
- Supports cardiovascular health. Spermidine has shown promising effects on cardiovascular health. Studies on animal models have demonstrated its efficacy in lowering blood pressure, enhancing cardiac function, and improving overall cardiovascular health.
- Reduces Inflammation. Research suggests that spermidine has anti-inflammatory properties, making it a promising agent in reducing inflammation. Studies have shown that spermidine can effectively regulate immune responses and reduce the production of pro-inflammatory molecules. With these unique properties, spermidine shows potential as a therapeutic compound for reducing inflammation and improving overall health.
- Enhances cognitive function. Spermidine is believed to yield positive effects on cognitive function. Scientific studies suggest that supplementing with spermidine can boost memory and enhance learning abilities, as demonstrated in animal studies. The mechanism is thought to involve spermidine’s ability to induce autophagy in the brain, facilitating the elimination of protein aggregates and, thus, promoting better cognitive function.
Possible side effects of spermidine supplements
Although no adverse side effects of spermidine supplements have been reported to date, it is important to recognize that, like any other supplement, spermidine is not immune to potential side effects. Nevertheless, when consumed responsibly, it is generally considered safe.
While further research is necessary to gain a more in-depth understanding of the potential side effects and long-term safety of spermidine supplements, ongoing clinical trials examining the supplementation of spermidine rich plant extracts are showing promising results for safety and tolerability.
Is it safe to take spermidine?
Yes. Taking spermidine is generally regarded as safe. This natural compound is commonly found in the human body, making it well-tolerated and safe to consume, both in supplement form and through dietary food sources.
However, If you are taking specific medications, it is essential to exercise caution when combining them with spermidine. Therefore, it is advisable to consult a healthcare professional before starting any new supplement regimen, as they can provide personalized guidance based on your health status and any existing medications or conditions.
Recommended dosage of spermidine supplements
Currently, there is no universally established standard dosage for spermidine supplements. Nonetheless, studies have indicated that a daily dosage of up to 15 mg has not resulted in any reported side effects following supplementation. The recommended dose of spermidine supplements can vary depending on individual needs and health conditions, so it is always best to consult a healthcare professional before taking additional supplements.
While ongoing research aims to fully understand the effects of spermidine and determine optimal dosages, following the manufacturer's guidelines on supplement packaging is the recommended approach. Additionally, prioritizing a balanced diet that includes spermidine rich foods like wheat germ, soybeans, and certain fruits can help naturally obtain this compound.
How do I know if spermidine supplements work?
Determining the efficacy of spermidine supplements can be subjective, but several indicators can help assess their impact. It is important to remember to keep track of any specific health goals you had in mind when starting the supplements.
If you experience positive changes, such as improved energy levels, better memory, or reduced signs of aging, it might indicate a beneficial response. Additionally, it is recommended to monitor potential biomarkers, such as blood pressure, cholesterol, and inflammation levels, as spermidine has been linked to their regulation.
However, keep in mind that individual responses may vary. It is advisable to consult with a healthcare professional who can guide you through the process and, if necessary, conduct relevant tests. Their expertise will assist you in interpreting any changes and assessing the effectiveness of spermidine supplements for your specific needs.
Spermidine rich foods
Not only is spermidine present in all tissues of the human body, but it is also found in plants and other dietary sources. If you want to include spermidine in your diet, you will be glad to know that a good deal of specific foods are packed with this compound. Some excellent spermidine rich foods are:
|Range of average spermidine content
|Rice, wheat germ, white bread
|Legumes and soybean products
|Chickpeas, lentils, peas, white beans, red kidney beans, soybean, soybean sprouts, soybean milk, tofu, soy sauce, miso
|Broccoli, cabbage, cauliflower, carrot, celeriac, courgette, cucumber, eggplant, green beans, green pepper, lettuce, mushroom, onion, potato, spinach, tomato
|Nuts and oilseeds
|Almonds, chestnuts, pistachios, seeds
|Apple, avocado, banana, cherry, kiwi, mandarin, orange, pear, peach, pineapple, strawberry, fruit juices
Adding these nutrient-rich foods to your daily diet allows you to supply your body with an abundance of natural spermidine — an essential biogenic polyamine that plays a vital role in supporting cellular health and longevity.
Consider alternative supplement options to support longevity
If graceful aging is what you seek, it is worth considering the best NMN supplements.
For those seeking immune support, consider exploring the best ashwagandha supplements.
To elevate stress relief efforts, the best ashwagandha gummies may be worth trying.
When it comes to increasing your energy levels, consider the best NAD+ supplements.
If you need inflammation relief, the best resveratrol supplements are worth looking into.
What is a substitute for spermidine?
Resveratrol. While there is currently no definitive spermidine substitute that could mirror its properties and functions, several other compounds have been studied for their potential anti-aging effects, with resveratrol being one of them. Found in grapes, red wine, and certain berries, resveratrol is a polyphenol that has garnered attention for its potential anti-aging properties. Similar to spermidine, resveratrol can also induce autophagy, thereby supporting longevity.
What is the richest source of spermidine?
Wheat germ. If you’re looking for a natural source of spermidine, look no further than wheat germ extract — an important by-product of the flour milling industry known for its high content of spermidine and spermine.
Does spermidine increase testosterone?
It may. However, it is important to note that there is currently limited scientific evidence suggesting a direct relationship between spermidine supplementation and increased testosterone levels. Nevertheless, a recent small study found that supplementation with spermidine and spermine increased testosterone levels in men under the age of 50.
How much spermidine does David Sinclair take?
1 mg per day. Every morning, David Sinclair, a world-renowned scientific leader in the field of aging and longevity, takes 1 mg of spermidine. As a supporter of long life, Dr. Sinclair suggests that living up to 150 years or even longer is entirely possible, and he believes that these supplements, which he takes himself, may help you live longer.
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- Aging. Spermidine delays aging in humans.
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- Integrative Medicine: A Clinician's Journal. Liposomes as Advanced Delivery Systems for Nutraceuticals.
- Journal of the American Dietetic Association. Development of a Polyamine Database for Assessing Dietary Intake.
- Frontiers. Spermidine Affects Cardiac Function in Heart Failure Mice by Influencing the Gut Microbiota and Cardiac Galectin-3.
- Open Journal of Endocrine and Metabolic Diseases. The Regulatory Effect of Biogenic Polyamines Spermine and Spermidine in Men and Women.
- Gerontology. Molecular basis of the 'anti-aging' effect of spermidine and other natural polyamines - a mini-review.