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Best Spermidine Supplement In 2023: A Review Of Top 5 Products

Spermidine has been in the limelight lately due to its potential health benefits. Emerging research suggests that spermidine supplements may enhance cellular function, improve cardiovascular health, and even extend lifespan. This natural polyamine is found in various foods and plants, and its growing popularity has sparked significant interest in recent years.

With its ability to induce autophagy — the body’s self-cleaning process — and support longevity, spermidine has become increasingly popular as people seek natural ways to improve their health and vitality.

Given the overwhelming variety of choices, finding the perfect spermidine supplement can be challenging. Therefore, in this review, we will look at the best spermidine supplement options available on the market today.

Best spermidine supplement in 2023: shortlist

Choosing the best spermidine supplement

Choosing the right spermidine supplement requires careful consideration of several vital factors. Below, we provide a list of criteria and explain their importance in the decision-making process.

BioavailabilityLiposomal or specialized formulations
ManufacturingcGMP-certified and FDA-approved
SafetyIndependent lab tested
DosageAdequate and safe
  • Bioavailability. High bioavailability is fundamental for spermidine supplements, as it determines how effectively the body can absorb and utilize the compound. When bioavailability is low, the amount of spermidine you actually receive may fall short of what is indicated on the supplement label.
  • Manufacturing. Products manufactured in cGMP-certified and FDA-approved facilities are subject to stringent quality control measures, which are pillars of high standards. This not only instills trust in consumers but also reduces the chances of contamination, potentially enhancing the safety and dependability of the products.
  • Safety. Spermidine supplements that are third-party lab-tested offer transparency regarding product quality, safety, and accurate labeling. Independent testing helps consumers make informed choices, granting them unbiased results.
  • Dosage. Adequate dosing may deliver desired benefits, maximizing the supplement's potential while minimizing risks to maintain overall health.

Best spermidine supplement brands of 2023: an overview

With a growing body of research supporting their benefits, spermidine supplements have taken the longevity market by storm. Due to their anti-inflammatory and antioxidant properties, as well as their role in cellular renewal processes, spermidine supplements have the potential to support longevity.

​​Sure enough, spermidine supplements on their own may not render your immune system impregnable or guarantee a significantly longer lifespan. However, recent studies indicate that spermidine has the potential to enhance cellular health and prolong life. To reap these benefits, consider incorporating one of the following supplements into your routine.

Continue reading to discover the best spermidine supplement brands on the market.

1. Purovitalis — best spermidine supplement with vitamins


In the crowded spermidine supplement market, Purovitalis Liposomal Spermidine Fusion emerges as a consumer favorite, boasting an exceptional composition of 7 active ingredients, including spermidine, B-group vitamins, vitamin D3, and zinc.

By supporting autophagy — a process that recycles and removes damaged components within cells, Spermidine Fusion promotes cellular health and grants us tools to act against age-related health decline. This makes it an excellent choice for those seeking optimal cellular health.

What sets Spermidine Fusion apart from other best spermidine supplement options is its combination of composition, dosage, and delivery method. Purovitalis employs a liposomal delivery system, allowing you to get the most out of every capsule.

Each capsule contains 5 mg of spermidine. The manufacturer recommends taking 1 capsule daily.

Spermidine Fusion is manufactured in a GMP-certified facility and undergoes third-party testing. The company establishes transparency by providing a Certificate of Analysis (COA).

You can get your Spermidine Fusion bottle containing 60 capsules for €99.95.

2. Omre — best spermidine for those starting out


Omre Spermidine is a dietary spermidine supplement containing no artificial additives, designed to cater to those looking to kick-start their journey with a clean, potentially cellular autophagy-activating product that packs a punch.

To distinguish itself from low-quality spermidine supplement alternatives, Omre subjects its spermidine to third-party testing to confirm the dosage and purity of the ingredients. Additionally, the product undergoes tests for bacterial, fungal, and heavy metal contamination.

This spermidine supplement by Omre is produced in a GMP-compliant and FDA-registered facility located in the U.S.

According to the manufacturer's recommendations, the daily dosage consists of 2 capsules, providing 1000 mg of standardized wheat germ extract, which is equivalent to 10 mg of spermidine.

You can get a 30-day supply of Omre for a fair value of $44.97 as a one-time purchase from the official website of the provider.

3. Oxford Healthspan — best bioavailable spermidine

OXFORD Healthspan Primeadine Spermidine Supplement

Oxford Healthspan Primeadine is a pure, entirely food-derived spermidine. It boasts high bioavailability and sets itself apart from synthetic spermidine supplements by encompassing two additional polyamines, spermine, and putrescine, along with prebiotic fiber. By working synergistically and establishing recycling loops, these compounds enable your body to produce more spermidine.

This spermidine supplement is exclusively obtained from a concentrated Japanese wheat germ extract, providing a dosage of 1 mg of supplemental spermidine sourced from 900 mg of the extract.

The manufacturer recommends gradually building up to a full, 3-capsule daily dosage over three consecutive days. Begin by taking 1 capsule on day one, followed by 2 capsules on day two, and finally, on day three, take 3 capsules.

Oxford Healthspan Primeadine is manufactured under strict GMP standards. What’s more, this vegan-friendly supplement is third-party lab tested, and it adheres to the highest FDA standards.

You can get your 30-day supply of Primeadine for $90.00 from the official Oxford Healthspan website.

4. partiQlar — best spermidine supplement with value for money

partiQlar Pure Spermidine

Among the offerings on our list, partiQlar Pure Spermidine stands out as a great value-for-money choice. It boasts a spermidine purity concentration of 98% and has undergone third-party testing.

Supplied by EffePharm, this supplement by partiQlar is purposefully created to meet the market demand for products that are gluten-free, soy-free, and non-GMO.

The manufacturing of all partiQlar products takes place exclusively within US-based facilities that are registered with the FDA and NSF, upholding the strict GMP standards.

Pure Spermidine capsules contain 8 mg of spermidine each, and the manufacturer recommends a daily dosage of 1 capsule.

A single bottle of this spermidine supplement contains 60 vegan capsules and is priced at $39.99. You can purchase yours directly from their website.

5. Spermidine LIFE — best science-backed spermidine


Spermidine LIFE is an innovative dietary supplement formulated with a natural spermidine rich wheat germ extract that has been Generally Recognized As Safe (GRAS) by the FDA. Crafted with lab-verified wheat germ extract, this supplement is designed to optimize the benefits of spermidine, supporting autophagy and enhancing cellular renewal.

Spermidine LIFE exclusively derives its spermidine from a natural, non-GMO wheat germ source. Through a unique extraction process, developed in collaboration with elite researchers, the company employs purified water as the sole agent to separate spermidine from wheat germ. This method ensures the quality of spermidine is preserved, along with all other vital substances present in the wheat germ extract.

The recommended daily dosage is 2 capsules, as suggested by the manufacturer. Each serving packs 800 mg of wheat germ extract, providing 1 mg of spermidine.

Every batch of the supplement is clinically tested to ensure that every bottle of Spermidine LIFE contains the specified amount of natural spermidine.

To make a purchase, simply visit the official Spermidine LIFE website, where a single bottle containing 60 capsules is priced at $89.00.

Comparison of the top 5 spermidine supplements

BrandCost per bottle
Serving size
Servings per bottle/package
Cost per serving
Spermidine per serving
Active ingredients
Purovitalis€99.951 capsule60€1.665 mg7
Omre$44.972 capsules30$1.4910 mg1
Oxford Healthspan
$90.003 capsules30$3.001 mg1
partiQlar$39.991 capsule60$0.668 mg1
Spermidine LIFE$89.002 capsules30$2.961 mg3

What is spermidine?

Spermidine is a natural compound present in all living organisms that plays a vital role in maintaining cellular balance. Ensuring adequate spermidine levels throughout your life may lower the chances of developing cardiovascular diseases and help you live longer. However, as humans age, the levels of spermidine in our bodies decrease, and studies suggest that this decline may be linked to age-related deterioration.

Additionally, spermidine's anti-aging properties are closely linked to its impact on various biological processes, particularly autophagy. Autophagy, a complex cellular mechanism, facilitates the elimination of cellular waste and promotes optimal cell functioning. By supporting autophagy, spermidine not only revitalizes cellular function but also safeguards against cell death.

What is spermidine used for?

Spermidine is generally used to promote cellular health and support longevity. It has recently gained recognition as a potential longevity supplement that may help you age gracefully. This natural compound may prevent age-related conditions like cardiovascular diseases and neurodegenerative disorders. Scientific studies on this autophagy-inducing agent have also demonstrated its protective effects against cognitive impairment in animal models.

Intriguingly, when spermidine is externally supplemented, it has shown numerous advantageous effects on aging and age-related diseases across various model organisms. This discovery opens up an appealing possibility — employing a spermidine rich diet to increase its levels throughout the human body. This approach shows promise as a strategy to foster healthy aging.

Benefits of spermidine supplements

In recent years, spermidine has garnered significant attention due to its potential health benefits and role in supporting longevity. While research on spermidine is still emerging, this supplement offers a multitude of benefits, including support for autophagy, reduction of inflammation, cardiovascular health support, and enhanced cognitive function.

  • Induces autophagy. At the molecular level, autophagy is the primary mechanism through which spermidine exerts its effects. As we grow older, the activity of autophagy diminishes. Therefore, promoting the appropriate regulation of autophagy is essential to safeguard against aging processes and maintain optimal cellular function.
  • Supports cardiovascular health. Spermidine has shown promising effects on cardiovascular health. Studies on animal models have demonstrated its efficacy in lowering blood pressure, enhancing cardiac function, and improving overall cardiovascular health. Additionally, spermidine can potentially prevent cardiac hypertrophy, thereby delaying the progression to heart failure.
  • Reduces Inflammation. Research suggests that spermidine has anti-inflammatory properties, making it a promising solution for treating such conditions. Studies have shown that spermidine can effectively regulate immune responses and reduce the production of pro-inflammatory molecules. With these unique properties, spermidine shows excellent potential as a natural therapeutic agent for reducing inflammation and improving overall health.
  • Enhances cognitive function. Spermidine is believed to yield positive effects on cognitive function. Scientific studies suggest that supplementing with spermidine can boost memory and enhance learning abilities, as demonstrated in animal studies. The mechanism is thought to involve spermidine’s ability to induce autophagy in the brain, facilitating the elimination of protein aggregates and, thus, promoting better cognitive function.

Possible side effects of spermidine supplements

Although no adverse side effects of spermidine supplements have been reported to date, it is important to recognize that, like any other supplement, spermidine is not immune to potential side effects. Nevertheless, when consumed responsibly, it is generally considered safe.

While further research is necessary to gain a more in-depth understanding of the potential side effects and long-term safety of spermidine supplements, ongoing clinical trials examining the supplementation of spermidine rich plant extracts are showing promising results for safety and tolerability.

Is it safe to take spermidine?

Yes. Taking spermidine is generally regarded as safe. This natural compound is commonly found in the human body, making it well-tolerated and safe to consume, both in supplement form and through dietary food sources.

However, If you are taking specific medications, it is essential to exercise caution when combining them with spermidine. Therefore, it is advisable to consult a healthcare professional before starting any new supplement regimen, as they can provide personalized guidance based on your health status and any existing medications or conditions.

Currently, there is no universally established standard dosage for spermidine supplements. Nonetheless, studies have indicated that a daily dosage of up to 15 mg has not resulted in any reported side effects following supplementation. The recommended dose of spermidine supplements can vary depending on individual needs and health conditions, so it is always best to consult a healthcare professional before taking additional supplements.

While ongoing research aims to fully understand the effects of spermidine and determine optimal dosages, following the manufacturer's guidelines on supplement packaging is the recommended approach. Additionally, prioritizing a balanced diet that includes spermidine rich foods like wheat germ, soybeans, and certain fruits can help naturally obtain this compound.

How do I know if spermidine supplements work?

Determining the efficacy of spermidine supplements can be subjective, but several indicators can help assess their impact. It is important to remember to keep track of any specific health goals you had in mind when starting the supplements.

If you experience positive changes, such as improved energy levels, better memory, or reduced signs of aging, it might indicate a beneficial response. Additionally, it is recommended to monitor potential biomarkers, such as blood pressure, cholesterol, and inflammation levels, as spermidine has been linked to their regulation.

However, keep in mind that individual responses may vary. It is advisable to consult with a healthcare professional who can guide you through the process and, if necessary, conduct relevant tests. Their expertise will assist you in interpreting any changes and assessing the effectiveness of spermidine supplements for your specific needs.

Natural sources of spermidine

Spermidine can be found in various natural sources. If you're looking to include spermidine in your diet, you'll be glad to know that a wide range of food options are packed with this remarkable nutrient. Some excellent natural sources of spermidine rich foods include:

  • Wheat germ and whole grain products
  • Soybeans and soy products
  • Peas
  • Mushrooms
  • Cheddar and gouda cheese
  • Mangos
  • Grapefruit
  • Oranges
  • Bananas

Adding these nutrient-rich natural foods to your daily diet allows you to supply your body with an abundance of spermidine — an essential compound that plays an important role in supporting cellular health and longevity.

Consider alternative supplement options to support longevity

If graceful aging is what you seek, it's worth considering the best NMN supplements.

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You may elevate your stress relief efforts by integrating the best ashwagandha gummies into your routine.

When it comes to increasing your energy levels, the best NAD+ supplements could be your answer.

If you're in pursuit of inflammation relief, the best resveratrol supplements are worth looking into.


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