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Best Spermidine Supplement In 2024: A Review Of Top 6 Products

Spermidine has been in the limelight lately due to its potential health benefits. Emerging research suggests that spermidine supplements may enhance cellular function, improve cardiovascular health, and provide nutritional support for a healthy lifespan. This biogenic polyamine is found in various foods and plants, and its increasing evidence for therapeutic potential has sparked significant interest in recent years.

With its ability to induce autophagy — the body’s self-cleaning process — and support longevity, spermidine has become increasingly popular as people seek natural ways to improve their health and vitality.

Given the overwhelming variety of choices, finding the perfect spermidine supplement can be challenging. Therefore, in this review, we will look at the best spermidine supplements available on the market today.

Best spermidine supplements in 2024: shortlist

  1. GenuinePurity — best pure spermidine supplement
  2. Omre — best spermidine supplement for those starting out
  3. partiQlar — best spermidine supplement with value for money
  4. Oxford Healthspan — best bioavailable spermidine
  5. Purovitalis — best spermidine supplement with vitamins
  6. spermidineLIFE — best spermidine supplement sourced naturally

Choosing the best spermidine supplements

Choosing the right spermidine supplement requires careful consideration of several vital factors. Below, we provide a list of criteria and explain their importance in the decision-making process.

BioavailabilityManufacturingSafetyDosage
Liposomal or specialized formulationscGMP-certified and FDA-approvedIndependent lab testedAdequate and safe
  • Bioavailability. High bioavailability is fundamental for spermidine supplements, as it determines how effectively the body can absorb and utilize the compound. When bioavailability is low, the amount of spermidine you actually receive may fall short of what is indicated on the supplement label.
  • Manufacturing. Products manufactured in cGMP-certified and FDA-approved facilities are subject to stringent quality control measures, which are pillars of high standards. This not only instills trust in consumers but also reduces the chances of contamination, potentially enhancing the safety and dependability of the products.
  • Safety. Spermidine supplements that are third-party lab-tested offer transparency regarding product quality, safety, and accurate labeling. Independent testing helps consumers make informed choices, granting them unbiased results.
  • Dosage. Adequate dosing may deliver desired benefits, maximizing the supplement's potential while minimizing risks to maintain overall health.

What is spermidine?

Spermidine is a biogenic polyamine, with emerging evidence supporting its effects on health, both as a component of foods and as a single-ingredient supplement. It is a prominent figure among biogenic polyamines, including spermine and its precursor, putrescine.

As an ingredient in biogenic polyamine supplements, spermidine represents a natural compound that serves as a biogenic polyamine essential for cell growth, playing a vital role in maintaining cellular balance.

Ensuring adequate spermidine levels throughout your life may support your heart health and help you live longer. However, as humans age, the levels of this biogenic polyamine in our bodies decrease, and studies suggest that this decline may be linked to age-related deterioration.

Additionally, spermidine's anti-aging properties are closely linked to its impact on various biological processes, particularly autophagy. Autophagy, a complex cellular mechanism, facilitates the elimination of cellular waste and promotes optimal cell functioning. By supporting autophagy, spermidine is not only suggested to revitalize cellular function but also to safeguard against cell death.

Spermidine effectiveness: what science tells us

Spermidine plays an essential role in various cellular processes and acts as an antioxidant. What is particularly interesting is its newfound potential as a longevity supplement, especially when formulated in a liposomal delivery system. This system has the potential to increase the cellular permeability of the formulation, thereby enhancing the bioavailability of liposomal spermidine and making it worth considering.

This biogenic polyamine has been demonstrated in some emerging studies to have an effect on age-related conditions, potentially supporting heart health and cognitive function. Scientific studies on this autophagy-inducing agent have also demonstrated its protective effects against cognitive impairment in animal models.

Intriguingly, spermidine intake with food has shown some advantageous effects on aging. This discovery opens up an appealing possibility — employing a spermidine-rich diet to increase its levels in the human body. This approach shows promise as a strategy to foster healthy aging.

We must conclude that while spermidine shows promise as a natural compound with various potential health benefits, particularly in aging-related processes, evidence of this in humans is still emerging. More clinical studies are needed to fully elucidate its effectiveness.

How to choose the right spermidine supplement for you

In our search for the best spermidine supplements, we learned it was crucial to consider specific factors to compile a line-up that truly reflects the absolute best selections out there. Here's what we recommend looking into:

  • Research the source and quality. Prioritize supplements derived from natural sources like that of wheat germ. Also, products with third-party certifications like GMPs or certificates of analysis (COAs) can be a good indicator of quality.
  • Look for scientific backing. While spermidine is a relatively new area of study, products that reference or support their health claims with scientific evidence can offer more credibility.
  • Inspect the ingredient label. It's important to check the list of ingredients in the supplement. Avoid products with unnecessary fillers, additives, or allergens that might not align with your dietary preferences or restrictions. Choose supplements with minimal, clean ingredients.
  • Consider the price point. While cost shouldn't be the primary factor, it's important to assess the cost-effectiveness of different options. Compare prices per serving and consider any potential discounts or subscription offers for long-term use.

Spermidine supplement reviews in 2024

With a growing body of research supporting their benefits, spermidine supplements have taken the longevity market by storm. Due to their anti-inflammatory and antioxidant properties, as well as their role in cellular renewal processes, spermidine supplements have the potential to support longevity.

​​Sure enough, spermidine supplements on their own may not render your immune system impregnable or guarantee a significantly longer lifespan. However, recent studies indicate that spermidine has the potential to enhance cellular health and prolong life. To reap these benefits, consider incorporating one of the following supplements into your routine.

Continue reading to discover the best spermidine supplements on the market.

1. GenuinePurity Spermidine

GenuinePurity™ Spermidine

Amazon rating — 4.3 ⭐⭐⭐⭐

Trustpilot rating — hasn’t received any reviews yet

As someone who's recently been immersed in research on spermidine supplements, I can say that GenuinePurity’s Spermidine possesses all the necessary attributes to become the next consumer favorite. Let me walk you through why I believe it deserves the nomination for the best pure spermidine supplement on the market.

Firstly, let's talk about what sets GenuinePurity apart. That is its dedication to transparency and safety. Not only is the supplement manufactured in a GMP-certified facility, but it is also third-party tested. You can easily access the testing certification on their website, giving you peace of mind that you're getting exactly what you pay for.

But what really impressed me was the brand’s commitment to quality. One of the standout features is the liposomal encapsulation. This advanced delivery method is proposed to strengthen absorption so that you may get the most out of each dose. Plus, the formula is pure — free from unnecessary additives that can dilute the quality of the product.

And let's not forget about value. With free shipping on all U.S. orders, GenuinePurity offers both quality and affordability. At $59.95 for a month's supply, it's a fair investment for the potential health benefits. Plus, for those looking to stock up, there are even greater value options available for securing supplements for a longer period of time.

What users liked about the product

  • Noticeable benefits like better sleep and enhanced energy levels
  • Transparent testing information and detailed analysis
  • Easy-to-take capsules with no odor

What users didn’t like about the product

  • Quite a few customers thought the product was a bit pricey
  • Some found the dosing instructions unclear

As a final point, you can tell that there’s just something different about GenuinePurity's Spermidine. From its commitment to quality and transparency to its formulation and affordability, it ticks all the boxes for what I would look for in a spermidine supplement. So, if you're in the market for a high-quality product that delivers real results, I highly recommend giving GenuinePurity's Spermidine a try.

2. Omre Spermidine

omre SPERMIDINE

Amazon rating — 4.9 ⭐⭐⭐⭐⭐

Trustpilot rating — no reviews

If you’re looking to kick-start your spermidine supplementation journey with a clean product that packs a punch, Omre’s offering should be a frontrunner on your list.

This dietary supplement contains no artificial additives, and while this aspect alone makes it an ideal choice for those seeking a clean supplement, the positives don’t stop there.

Where Omre also excels is their testing protocol. See, before reaching the consumer, each batch must go through third-party testing to verify dose accuracy and ingredient purity. Additionally, the product passes tests for bacterial, fungal, and heavy metal contamination.

Manufactured in a GMP-compliant and FDA-registered facility in the U.S., Omre's commitment to quality and compliance is evident at every step of the production process.

In terms of value, Omre Spermidine offers a 30-day supply at a fair price of $44.97 when purchased directly from the official website. This represents an accessible entry point for those starting their journey towards supplementing with spermidine.

What users liked about the product

  • Tangible benefits such as better skin and increased energy levels
  • People are happy with the quality considering the price
  • Customer service has been reflected positively

What users didn’t like about the product

  • Apart from a few who might not have noticed immediate results, there aren't any negative reviews

In the end, with its emphasis on purity, rigorous testing standards, and affordability, Omre Spermidine is a compelling choice for those starting out.

3. partiQlar Pure Spermidine

partiQlar Pure Spermidine

Amazon rating — no reviews

Trustpilot rating — 4.5 ⭐⭐⭐⭐⭐

Price is always a consideration, whether we acknowledge it or not. And those who want quality without breaking the bank should really turn their heads to partiQlar Pure Spermidine.

Right away, the main thing that grabbed my attention about this spermidine supplement is its purity level of 98%, and the fact that it's reasonably priced made all the sense in the world for nominating it as the wallet-friendly option, so to speak.

Another appealing aspect of Pure Spermidine is its formulation. The supplement is purposefully created to meet the market demand for products that are gluten-free, soy-free, and non-GMO. This commitment to inclusivity and transparency speaks volumes about the brand's efforts to distinguish itself from other options on the market.

Plus, all partiQlar products, including this one, are manufactured in FDA and NSF-registered facilities within the U.S.

And finally, the price point. Despite its quality, Pure Spermidine remains surprisingly affordable, priced at just $39.99 for a 60-capsule bottle.

What users liked about the product

  • The non-synthetic and additive-free profile has been highly-regarded
  • Manufactured according to high market standards with relevant certificates
  • Easy-to-navigate website

What users didn’t like about the product

  • Several users experienced delayed deliveries
  • Delayed response from customer support
  • A few noted they didn't notice immediate results

In my book, whether you're new to spermidine or seeking a budget-friendly yet high-quality option, partiQlar’s offering has a good chance of exceeding your expectations.

4. Oxford Healthspan Primeadine

OXFORD Healthspan Primeadine Spermidine Supplement

Amazon rating — 4.3 ⭐⭐⭐⭐

Trustpilot rating — 4.5 ⭐⭐⭐⭐⭐

Now, if the price point is not your main concern, but instead bioavailability is — Oxford Healthspan and its Primeadine offering have a compelling case.

Primeadine is a pure, entirely food-derived spermidine supplement. According to the manufacturer, it boasts high bioavailability and, along with prebiotic fiber, includes two additional polyamines — spermine and putrescine.

The makers state that the presence of these additional polyamines increases the bioavailability of spermidine derived from food. Putrescine acts as the precursor to spermidine and spermine, forming a virtuous recycling loop that may help enhance your body's natural production of spermidine.

The supplement is manufactured in an FDA-registered facility under strict GMP standards. Besides that, it is third-party lab tested.

What’s also noteworthy is the feedback this Oxford Healthspan product receives from its customers. While the vast majority of customers express satisfaction with the Primeadine, there is a distinct pattern in their feedback — it relates to hair growth.

What users liked about the product

  • Positive reports include mentions of improved hair growth, healthier nails, and better sleep quality
  • Customers were pleased with how fast results were achieved.
  • Excellent and responsive customer service

What users didn’t like about the product

  • A number of customers felt the product was priced excessively
  • A few users had to opt for an alternative product because of the gluten in this product

While Primeadine may come at a premium price point of $90 for a 30-day supply, I believe the investment is well justified by both the product's makeup in terms of bioavailability and the resounding customer satisfaction across impartial platforms such as Trustpilot.

5. Purovitalis Liposomal Spermidine Fusion

purovitalis-liposomal-spermidine

Amazon rating — no reviews

Trustpilot rating — 4.7 ⭐⭐⭐⭐⭐

After weighing Purovitalis Liposomal Spermidine Fusion against its alternatives on the market, I'm convinced that it's the top choice for a spermidine supplement with added vitamins. Let me explain why the Fusion formula shines.

Purovitalis has blended spermidine with essential B-group vitamins, vitamin D3, and zinc, creating a powerhouse supplement that goes beyond traditional offerings. This blend may not only provide the purported benefits of spermidine but may also offer additional support for overall cellular health and vitality.

One of the key selling points of Purovitalis is the liposomal technology it employs. It is a delivery technique that uses liposomes to transport active ingredients to their desired destinations in the body. The technology works by encapsulating the active ingredients within liposomes to protect them from degradation and enhance their absorption in the gastrointestinal tract so that they could have a higher chance of being delivered to target cells.

When it comes to quality assurance, Purovitalis upholds stringent standards throughout the manufacturing process. Its products are manufactured in a GMP-certified facility and are also subjected to third-party testing.

What users liked about the product

  • Independent laboratory verifying the purity of the product
  • Many liked how convenient was the one-capsule serving size
  • Excellent customer service

What users didn’t like about the product

  • Custom taxes for U.S. orders
  • It was difficult for some to make returns
  • Many customer reviews point to consistent problems with the delivery process

A 30-day supply of Liposomal Spermidine Fusion is tagged at an attractive price point of $45. Considering the vitamin-infused formula and the brand's efforts toward quality assurance, this product looks to me as a compelling investment for someone who's looking for a well-rounded spermidine supplement.

6. spermidineLIFE

Spermidine-LIFE

Amazon rating — 4.3 ⭐⭐⭐⭐

Trustpilot rating — hasn’t received any reviews yet

Synthetic or natural — I believe most of us know which of the two we'd choose. And those who prefer a natural approach to supplementation should certainly consider spermidineLIFE.

spermidineLIFE is a brand driven by a shared belief within its circles in a natural approach to supplementation. Its primary source of spermidine is wheat germ extract — one of the richest natural sources of spermidine.

Another key pillar of spermidineLIFE's ethos is transparency. The company openly shares the origins of its products and provides a window into its sourcing practices and ingredient lists.

What users liked about the product

  • Measurable changes in hair growth
  • Mentions of noticeable effects on skin quality, sleep quality, and energy levels
  • Excellent customer service

What users didn’t like about the product

  • Some thought the spermidine dose was low
  • Others believed the product was too expensive
  • Given it contains gluten, some people found it difficult to incorporate the product into their diets

What also propelled us to place spermidineLIFE on our list is that its suggested benefits seem to align with the scientific community's consensus. So, if you're looking for a natural approach to your longevity efforts, a 60-count bottle of spermidineLIFE priced at $69 appears to be a deal worth cashing in.

Comparison of the top 6 spermidine supplements

BrandCost per bottle
Serving size
Servings per bottle/package
Cost per serving
Spermidine per serving
Active ingredients
GenuinePurity$59.952 capsules30$1.998 mg1
Omre$44.972 capsules30$1.4910 mg1
partiQlar$39.991 capsule60$0.668 mg1
Oxford Healthspan
$90.003 capsules30$3.001 mg1
Purovitalis$45.001 capsule30$1.505 mg7
spermidineLIFE$69.002 capsules30$2.961 mg3

Our list of the best spermidine supplements: what makes them stand out?

Spermidine supplements are not all created equal — they may differ in their formulations, how well they're absorbed, the price point, and overall quality. These factors can dictate how you choose to supplement with spermidine, with your final decision, of course, coming down to your preferences and needs. Recognizing this, as we compiled our list of the best spermidine supplements, our goal was to be as inclusive and considerate of these preferences and needs as possible.

Based on your priorities, if you're looking for a spermidine supplement that's without any extras, just pure spermidine — GenuinePurity would be our top pick. For those new to spermidine supplements, there's Omre — a product that embodies what seems to be the main features of a quality supplement, including third-party testing, a simple formulation, and affordability.

When keeping costs low is a priority, look no further than partiQlar. This supplement appears to strike the best balance between price and quality compared to others we've encountered in our research. Now, if you're more drawn to bioavailability rather than cost, consider Oxford Healthspan. This brand focuses on delivering supplements in a form that maximizes absorption for optimal results.

Those hunting for something extra in a market full of supplements containing solely spermidine should try Purovitalis — it goes beyond spermidine by adding essential vitamins.

And finally, if you prefer naturally sourced supplements, turn to spermidineLIFE — a brand distinguished by its commitment to sourcing spermidine only from natural origins.

In the end, no matter what you seek — purity, affordability, bioavailability, added micronutrients, or natural origins — our list has each category covered.

Benefits of spermidine supplements

In recent years, spermidine has garnered significant attention due to its potential health benefits and role in supporting longevity. While research on spermidine is still emerging, supplements with spermidine may offer a multitude of benefits, including a role in autophagy, reduction of inflammation, cardiovascular health support, and enhanced cognitive function.

  • Induces autophagy. At the molecular level, autophagy is the primary mechanism through which spermidine exerts its effects. As we grow older, the activity of autophagy diminishes. Therefore, dietary intake of bioactive compounds that may promote autophagy can be an important element for optimal cellular function and graceful aging.
  • Supports cardiovascular health. Spermidine has shown promising effects on cardiovascular health. Studies on animal models have demonstrated its efficacy in lowering blood pressure, enhancing cardiac function, and improving overall cardiovascular health.
  • Reduces Inflammation. Research suggests that spermidine has anti-inflammatory properties, making it a promising agent in reducing inflammation. Studies have shown that spermidine can effectively regulate immune responses and reduce the production of pro-inflammatory molecules. With these unique properties, spermidine shows potential as a therapeutic compound for reducing inflammation and improving overall health.
  • Enhances cognitive function. Spermidine is believed to yield positive effects on cognitive function. Scientific studies suggest that supplementing with spermidine can boost memory and enhance learning abilities, as demonstrated in animal studies. The mechanism is thought to involve spermidine’s ability to induce autophagy in the brain, facilitating the elimination of protein aggregates and, thus, promoting better cognitive function.

Possible side effects of spermidine supplements

Although no adverse side effects of spermidine supplements have been reported to date, it is important to recognize that, like any other supplement, spermidine is not immune to potential side effects. Nevertheless, when consumed responsibly, it is generally considered safe.

While further research is necessary to gain a more in-depth understanding of the potential side effects and long-term safety of spermidine supplements, ongoing clinical trials examining the supplementation of spermidine rich plant extracts are showing promising results for safety and tolerability.

Is it safe to take spermidine?

Yes. Taking spermidine is generally regarded as safe. This natural compound is commonly found in the human body, making it well-tolerated and safe to consume, both in supplement form and through dietary food sources.

However, If you are taking specific medications, it is essential to exercise caution when combining them with spermidine. Therefore, it is advisable to consult a healthcare professional before starting any new supplement regimen, as they can provide personalized guidance based on your health status and any existing medications or conditions.

Currently, there is no universally established standard dosage for spermidine supplements. Nonetheless, studies have indicated that a daily dosage of up to 15 mg has not resulted in any reported side effects following supplementation. The recommended dose of spermidine supplements can vary depending on individual needs and health conditions, so it is always best to consult a healthcare professional before taking additional supplements.

While ongoing research aims to fully understand the effects of spermidine and determine optimal dosages, following the manufacturer's guidelines on supplement packaging is the recommended approach. Additionally, prioritizing a balanced diet that includes spermidine rich foods like wheat germ, soybeans, and certain fruits can help naturally obtain this compound.

How do I know if spermidine supplements work?

Determining the efficacy of spermidine supplements can be subjective, but several indicators can help assess their impact. It is important to remember to keep track of any specific health goals you had in mind when starting the supplements.

If you experience positive changes, such as improved energy levels, better memory, or reduced signs of aging, it might indicate a beneficial response. Additionally, it is recommended to monitor potential biomarkers, such as blood pressure, cholesterol, and inflammation levels, as spermidine has been linked to their regulation.

However, keep in mind that individual responses may vary. It is advisable to consult with a healthcare professional who can guide you through the process and, if necessary, conduct relevant tests. Their expertise will assist you in interpreting any changes and assessing the effectiveness of spermidine supplements for your specific needs.

Spermidine rich foods

Not only is spermidine present in all tissues of the human body, but it is also found in plants and other dietary sources. If you want to include spermidine in your diet, you will be glad to know that a good deal of specific foods are packed with this compound. Some excellent spermidine rich foods are:

Food categorySpecific foodsRange of average spermidine content
CerealRice, wheat germ, white bread2.8–2437 nmol/g
Legumes and soybean productsChickpeas, lentils, peas, white beans, red kidney beans, soybean, soybean sprouts, soybean milk, tofu, soy sauce, miso1.0–1,425 nmol/g
VegetablesBroccoli, cabbage, cauliflower, carrot, celeriac, courgette, cucumber, eggplant, green beans, green pepper, lettuce, mushroom, onion, potato, spinach, tomato6.9–398 nmol/g
Nuts and oilseedsAlmonds, chestnuts, pistachios, seeds41–383 nmol/g
FruitsApple, avocado, banana, cherry, kiwi, mandarin, orange, pear, peach, pineapple, strawberry, fruit juices 6.9–98 nmol/g

Adding these nutrient-rich foods to your daily diet allows you to supply your body with an abundance of natural spermidine — an essential biogenic polyamine that plays a vital role in supporting cellular health and longevity.


Consider alternative supplement options to support longevity

If graceful aging is what you seek, it is worth considering the best NMN supplements.

For those seeking immune support, consider exploring the best ashwagandha supplements.

To elevate stress relief efforts, the best ashwagandha gummies may be worth trying.

When it comes to increasing your energy levels, consider the best NAD+ supplements.

If you need inflammation relief, the best resveratrol supplements are worth looking into.

If promoting mitochondrial health and aging well is your aim, the best Urolithin A supplements may be what you need.


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