Trans-resveratrol, being a more active form of resveratrol, is widely sought-after for its potential benefits, such as heart health support, inflammation reduction, and promotion of overall well-being.
However, not all supplements are created equally. With this in mind, our team has decided to look through some of the available trans-resveratrol products on the market and pick the ones that stand out due to their quality. Moreover, this article can serve as a guide for anyone looking for a trans-resveratrol supplement as our team looked into the scientific data surrounding this antioxidant and highlighted what is important to know before you commit to a purchase.
This article was written in close collaboration with our in-house research team who took time to evaluate the products and analyze the academic papers on resveratrol.
Best trans-resveratrol supplement: shortlist
Here is our short list of the best trans-resveratrol supplements:
- Best trans-resveratrol supplement with no additives: partiQlar
- Best trans-resveratrol supplement for beginners: GenuinePurity™
- Best low-dose trans-resveratrol supplement: Hello100
- Overall best trans-resveratrol supplement: ProHealth
- Best 600 mg trans-resveratrol supplement: Luma Nutrition
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What is trans-resveratrol?
Trans-resveratrol is a naturally occurring compound gaining attention for its potential to promote longevity, improve heart health, and enhance overall well-being. It’s one of several polyphenols—antioxidant compounds found in plant sources like grape skins, blueberries, and Japanese knotweed.
The “trans” form of resveratrol is reported to be the most bioavailable, meaning the body absorbs and uses it more effectively than other forms.
But why exactly has trans-resveratrol become such a sought-after supplement?
Its journey into the spotlight began with the “French Paradox” concept, introduced in 1992 when researchers Renaud and de Lorgeril observed that people in France had relatively low rates of coronary heart disease despite high-fat diets. It was hypothesized that moderate wine consumption, particularly red wine containing resveratrol, might explain these beneficial effects.
While the French Paradox remains debated due to mixed factors and study limitations, it sparked lasting interest in resveratrol.
Studies have shown that resveratrol possesses bioactivities like antioxidant, anti-inflammatory, and immunomodulatory effects.
It may have beneficial effects on cardiovascular diseases, cancer, liver diseases, diabetes, obesity, Alzheimer’s disease, and Parkinson’s disease. Also, researchers found that resveratrol can mimic calorie restriction in some ways and extend the lifespans of yeast, worms, flies, and fish.
Though promising, many findings are based on animal studies, and more research is needed to understand resveratrol’s healthful impact on humans. Since the amount of trans-resveratrol in foods like red wine is low, resveratrol supplements offer a concentrated dose, providing the benefits without drastically altering your diet.
How we chose the best trans-resveratrol supplements
In selecting the top trans-resveratrol supplements, we focused on key factors to ensure each product offers quality, manufacturer reputation, and good value for money. These factors are:
| Purity and quality | Third-party testing | Provider reputation | Value and price |
| 98–99%; no unnecessary additives | Independent lab testing for quality and label accuracy | Good brand history | $29.99–60 |
- Purity and quality. High-quality products offer pure (98–99%) trans-resveratrol without adulterants, unnecessary fillers, or additives. We looked for products that listed the percentage of trans-resveratrol and ensured minimal use of additives.
- Third-party testing. We prioritized products that undergo independent testing for quality and label accuracy. Third-party testing helps ensure the supplement contains the stated ingredients without contamination from heavy metals, pesticides, or other harmful substances.
-
Provider reputation. The reputation of the company producing the supplement is essential. We favored brands with a proven track record of transparency and commitment to quality.
- Value and price. While cost was considered, it wasn’t at the expense of quality. We focused on products that provide a good balance between price and quality.
How to decide on the right trans-resveratrol supplement for you
With so many options, selecting the right trans-resveratrol supplement can be challenging. Here's a simplified guide to help you make the best choice:
- Purity and ingredients. Look for supplements with 98–99% pure trans-resveratrol and avoid unnecessary fillers or additives. Transparent labeling is key. Make sure it specifies “trans-resveratrol” to help ensure better bioavailability.
- Third-party testing. Choose products that are third-party tested for quality and label accuracy. Certifications like GMP or NSF ensure high production standards. Check the product's website for third-party testing seals or lab results.
- Dosage. An optimal effective dose has not yet been established for any specific health benefit. Most adults use a daily dose of 250–1,000 mg. Start low if you're unsure and adjust as needed. Consult with a healthcare provider to determine the best dosage for your specific needs.
- Bioavailability. Absorption matters. Liposomal or micronized forms are proposed to improve bioavailability, potentially helping ensure your body absorbs more of the active compound. Look for supplements that mention enhanced absorption methods.
- Form. Choose a form that fits your lifestyle—capsules for convenience or powders/liquids for flexibility in dosage. Capsules are ideal for those seeking simplicity, while powders suit those who prefer mixing supplements into drinks.
- Price vs. Value. Balance quality with cost. Sometimes, paying more ensures better quality and peace of mind. Consider cost per serving for a clearer comparison.
Best trans-resveratrol supplement: an overview
In this section, we provide our in-depth analysis of what we think are the best trans-resveratrol supplements.
We’ll dive into the details of each product—who it’s best suited for, standout features, and what real users like (and don’t). You’ll also get insights into the companies behind these supplements, along with the pros and cons of each option.
Let's jump right in.
1. partiQlar — best trans-resveratrol supplement with zero additives
The partiQlar Pure Resveratrol capsules contain 500 mg of trans-resveratrol per serving without additives.
Each batch is produced in FDA-registered and NSF-certified facilities under strict GMP guidelines. All products go through third-party lab testing to help ensure their quality, and a Certificate of Analysis is available on their website.
The brand recommends taking one capsule daily.
Main ingredients
- Trans-resveratrol
Who might benefit the most from partiQlar Trans-Resveratrol?
Individuals who prefer a resveratrol supplement with no artificial additives.
Key features
- Amount of resveratrol per serving: 500 mg
- Purity: 99%
- Additional active ingredients: None
- Money-back guarantee: 60 days
- Delivery time: 2–5 business days for U.S. orders and 6–10 days for international orders
Company review
The company partiQlar is a health and wellness brand founded in 2023 that aims to support lives through advanced nutritional supplements. It offers a range of products, including NMN, resveratrol, TMG, spermidine, quercetin, apigenin, and calcium alpha-ketoglutarate, all formulated without additives.
With a commitment to clean, high-quality ingredients, partiQlar seeks to provide supplements that may support longevity and overall well-being.
Brief summary of partiQlar Trans-Resveratrol
The partiQlar Pure Resveratrol offers 500 mg of trans-resveratrol per capsule with no additives. It is produced in FDA-registered and NSF-certified facilities and is third-party tested for quality and safety.
A bottle of 60 servings costs $36.99. Customers appreciate its easy-to-swallow capsules and timely delivery, though there have been occasional complaints about order issues.
2. GenuinePurity™ — best trans-resveratrol supplement for beginners
GenuinePurity™ Trans-Resveratrol is a high-quality supplement that offers 500 mg of trans-resveratrol per serving. The company uses liposomal encapsulation technology aiming to support absorption.
Every bottle of this supplement is produced in the U.S. in cGMP-certified facilities to ensure top quality and safety from contaminants. The provider recommends taking two capsules daily with a meal.
Main ingredients
- Trans-resveratrol
Who might benefit the most from GenuinePurity Trans-Resveratrol?
This product may be a great option for people new to resveratrol supplements, as it comes with a risk-free trial period of over three months.
Key features
- Amount of resveratrol per serving: 500 mg
- Purity: 98%
- Additional active ingredients: None
- Money-back guarantee: 97 days
- Delivery time: One business day for U.S. orders
Company review
GenuinePurity™ is a health-focused brand created by Leading Edge Health, a company based in Canada. Dedicated to well-being, the company uses ethically sourced and high-quality ingredients to create supplements that may support health and longevity at the cellular level.
All products are made in the U.S. in FDA-inspected and cGMP-certified facilities. The brand combines nature and science to deliver supplements that align with its mission to support long-term health.
Brief summary of GenuinePurity Trans-Resveratrol
GenuinePurity™ Trans-Resveratrol provides 500 mg of trans-resveratrol per serving, enhanced with liposomal encapsulation for potentially better absorption. It is made in cGMP-certified facilities in the U.S.
The supplement is priced at $59.95 for 30 servings and comes with a 97-day money-back guarantee. Customers like its ease of swallowing, and one user reported improved energy and sleep, though a few find the price high and effects minimal.
3. Hello100 — best low-dose trans-resveratrol supplement
Hello100 Liposomal Resveratrol provides 250 mg of trans-resveratrol per serving, made with a liposomal formula that may support absorption. It does not contain unnecessary additives and is third-party tested.
Certificates of Analysis for quality and purity are available on the product page.
The brand recommends taking one capsule daily.
Main ingredients
- Trans-resveratrol
Who might benefit the most from Hello100 Trans-Resveratrol?
People who prefer a lower-dose resveratrol supplement.
Key features
- Amount of resveratrol per serving: 250 mg
- Purity: Over 98%
- Additional active ingredients: None
- Money-back guarantee: 60 days
- Delivery time: 2–5 business days for U.S. orders and 1–2 weeks for international orders
Company review
Hello100 is a Lithuanian longevity company founded in 2021. It is focused on developing supplements that may support healthy aging. Specializing in NMN and resveratrol products, Hello100 is dedicated to understanding cell genetics and the biological processes behind aging. Its supplements are manufactured and tested in the U.S. with ingredients sourced globally, aiming to improve overall quality of life.
Brief summary of Hello100 Trans-Resveratrol
Hello100 Liposomal Resveratrol provides 250 mg of trans-resveratrol per serving with a liposomal formula to support absorption. It is third-party tested, and Certificates of Analysis for quality, purity, and safety from contaminants are available online.
A 60-serving bottle costs $45. Users appreciate improved energy levels and easy-to-swallow capsules, though some have reported minimal changes.
4. ProHealth — overall best trans-resveratrol supplement
ProHealth Trans-Resveratrol is a supplement that delivers 1,000 mg of trans-resveratrol per serving. Other ingredients include quercetin, organic red wine extract, organic decaffeinated green tea extract, and BioPerine® (black pepper extract).
BioPerine® is included to potentially support resveratrol absorption, while the additional ingredients—quercetin, red wine extract, and green tea extract— may provide antioxidant support to promote overall well-being.
This supplement undergoes third-party testing to ensure quality, and a Certificate of Analysis can be accessed through the company’s website. Each batch is produced in an FDA-registered and GMP-certified facility.
ProHealth's recommended dosage is two capsules daily, taken in the morning with food.
Main ingredients
- Trans-resveratrol
- Quercetin
- Organic red wine extract
-
Organic decaf green tea extract
- BioPerine®
Who might benefit the most from ProHealth Trans-Resveratrol?
People looking for a resveratrol supplement with additional ingredients.
Key features
- Amount of resveratrol per serving: 1,000 mg
- Purity: 99.5%
- Additional active ingredients: Quercetin, organic red wine extract, organic decaf green tea extract, BioPerine®
- Money-back guarantee: 75 days
- Delivery time: 1–2 business days for U.S. orders and 2–6 weeks for international orders
Company review
ProHealth was established in 1988 by Rich Carson and headquartered in the U.S. The company was initially founded to support individuals dealing with chronic illnesses. Over time, the company broadened its focus to include supplements to support longevity.
All company products, including resveratrol, undergo third-party testing to ensure they are free from contaminants and meet high quality and production safety standards. Also, ProHealth operates in GMP-certified facilities. The company has earned a solid reputation among consumers for its transparency, quality ingredients, and dedication to health and wellness.
Brief summary of ProHealth Trans-Resveratrol
ProHealth Trans-Resveratrol offers 1,000 mg of trans-resveratrol per serving, combined with quercetin, organic red wine extract, organic decaf green tea extract, and BioPerine®. It is third-party tested, produced in GMP-certified facilities, and priced at $31.08 for a 30-serving bottle.
The product comes with a 75-day money-back guarantee and free U.S. shipping on orders over $30. While praised for quality, some users report minimal effects.
5. Luma Nutrition — best 600 mg trans-resveratrol supplement
Luma Nutrition Resveratrol stands out for its 600 mg of trans-resveratrol per serving and minimal use of additives. The brand mentions this product is third-party tested for quality and purity, but no Certificates of Analysis are available on the product page.
Each batch is produced in an FDA-registered and GMP-certified facility. Luma Nutrition recommends taking two capsules once daily, 20 to 30 minutes before a meal.
Main ingredients
- Trans-resveratrol
Who might benefit the most from Luma Nutrition Trans-Resveratrol?
This product may appeal to individuals who appreciate supporting veteran-owned businesses.
Key features
- Amount of resveratrol per serving: 600 mg
- Purity: 98%
- Additional active ingredients: None
- Money-back guarantee: 90 days
- Delivery time: 3–5 days for U.S. orders
Company review
Luma Nutrition was founded by Jake Langley, a former U.S. Army Infantry Officer with a mission to revolutionize health and wellness. The company focuses on providing high-quality, all-natural supplements, tested to potentially support various health concerns, from blood sugar control to mood enhancement.
With a strong commitment to natural health solutions, Luma Nutrition strives to help individuals prioritize their well-being through quality vitamins and supplements.
Brief summary of Luma Nutrition Trans-Resveratrol
Luma Nutrition Trans-Resveratrol offers 600 mg of trans-resveratrol per serving with minimal additives and is produced in FDA-registered and GMP-certified facilities.
It is priced at $29.99 for 30 servings and is third-party tested, though Certificates of Analysis are not available online. Users appreciate its quality and ease of use, but a few reported stomach issues.
Comparing the best trans-resveratrol supplements
Here is a quick comparison of the best trans-resveratrol supplements of 2024:
| Brand | Price | Price per serving | Serving size | Servings per container | Amount of trans-resveratrol per serving |
| ProHealth | $31.08 | $1.04 | 2 capsules | 30 | 1,000 mg |
| partiQlar | $36.99 | $0.62 | 1 capsule | 60 | 500 mg |
| GenuinePurity™ | $59.95 | $1.99 | 2 capsules | 30 | 500 mg |
| Hello100 | $45 | $0.75 | 1 capsule | 60 | 250 mg |
| Luma Nutrition | $29.99 | $0.99 | 2 capsules | 30 | 600 mg |
Why we think ProHealth is the best trans-resveratrol supplement
ProHealth emerges as Healthnew’s best pick because it offers the highest resveratrol dosage at 1,000 mg per serving (though a higher dosage doesn't necessarily mean a greater effect), combined with a well-rounded ingredient profile, potential bioavailability support and proven quality through third-party testing.
Despite a few negative reports, the overall customer feedback and value for money make ProHealth our top choice compared to its alternatives. It provides a more comprehensive approach to health support with its additional antioxidants, transparent manufacturing processes, and affordability.
Researcher’s insights
For this section of this article, we have decided to speak with our in-house researcher, Linas Černiauskas, who holds a master’s degree in medical biology and is a PhD candidate in medicine.
Firstly, we asked him to clarify what trans-resveratrol is.
Resveratrol comes in two forms, cis- and trans-resveratrol. Trans-resveratrol is a more widespread and abundant resveratrol form. Due to its abundance, trans-resveratrol is more researched and is often used in various supplement formulations.
Another question that we had was related to resveratrol’s absorption and bioavailability. Although resveratrol has a rather high absorption rate (around 75% when taken orally), its bioavailability is extremely low, only around 1%.
Explained simply, this means that if you were to take 100 mg of resveratrol, only around 75 mg would be absorbed in the gastrointestinal tract, and of those 75 mg, only around 0.75 mg of resveratrol would reach the bloodstream in its original resveratrol form.
Linas Černiauskas
To combat this, opt for brands that employ formulations that may increase absorption or bioavailability. As a practical tip, he advises scanning the products' labels or brands' websites for terms such as liposomes, emulsions, nanoparticles, Bioperine, or the inclusion of other polyphenols in the formula.
Why use a trans-resveratrol supplement?
Here, we’ll discuss the potential benefits of trans-resveratrol and why it may be a valuable addition to your wellness routine.
May improve brain function
Resveratrol acts as an antioxidant and may protect brain cells from oxidative stress and reduce inflammation, which are recognized as potential factors in cognitive decline and neurodegenerative diseases like Alzheimer’s.
For example, findings from a review study reported that while there are still few studies in humans, resveratrol has shown the potential to delay cognitive impairment in Alzheimer's patients when administered alone or in combination with glucose and malate.
However, more research is needed to confirm these effects and fully understand their role in Alzheimer's disease and brain health in general.
May support heart health
Preliminary scientific studies suggest that resveratrol may improve blood flow, reduce inflammation, and lower LDL cholesterol levels, all of which can contribute to better heart health.
In a study, a 270 mg dose of resveratrol given to individuals with overweight and mildly raised blood pressure showed a significant improvement in blood vessel function.
May help with obesity management
Resveratrol mimics some effects of calorie restriction in animal models, which may positively affect metabolism. It has the potential to reduce liver fat, lower glucose, and triglyceride levels, and activate certain enzymes that help with fat burning.
In one study, resveratrol supplementation decreased liver fat and reduced inflammation markers, which are often elevated in obesity.
May promote overall health
Resveratrol is known for its antioxidant properties, helping to reduce oxidative stress and inflammation in the body. In one trial, resveratrol supplementation increased antioxidant capacity in the blood, leading to reduced DNA damage and inflammation markers like TNF-α.
This supports its potential role in chronic conditions like heart disease and diabetes.
Integrating trans-resveratrol into your wellness routine
Here are some practical tips to help you get started:
- Start with a lower dose. If you're new to resveratrol, starting with a lower dose of 150–250 mg per day is a good idea. Since supplements come in various strengths, easing into them and paying attention to how your body responds may help. While there isn't an officially established beneficial dose for resveratrol, consulting a healthcare provider can help you determine the most suitable dose for your needs.
- Take it with food. To enhance absorption, take resveratrol with food, ideally with a meal that includes healthy fats like avocado or olive oil. This may help the body absorb the compound more effectively.
- Try to be consistent. Resveratrol’s benefits are reported to accumulate over time. Incorporating it consistently into your daily routine, like a multivitamin, will most likely yield the best results.
Common mistakes to avoid when taking trans-resveratrol supplements
While trans-resveratrol might be a useful addition to your wellness regimen, there are a few common pitfalls to watch out for:
- Not considering potential interactions with other supplements or medications. Suppose you're taking other supplements or medications, especially blood thinners like warfarin, aspirin, or anti-inflammatory drugs such as ibuprofen or naproxen. In that case, consulting with a healthcare provider before starting resveratrol is essential. For example, resveratrol can enhance the effects of blood thinners, which may increase the risk of bleeding.
- Taking excessive doses. Many people assume that taking higher doses of resveratrol will bring quicker or better results, but this can lead to unwanted side effects like nausea, diarrhea, and stomach discomfort. Clinical trials have shown that resveratrol is generally safe and well-tolerated. However, when doses reached 2.5 to 5 g, participants reported gastrointestinal issues such as nausea, flatulence, loose stools, and abdominal discomfort.
Best trans-resveratrol supplement — conclusion
Trans-resveratrol continues to be a promising supplement, offering potential benefits for heart health, inflammation reduction, and overall wellness.
But with so many supplements on the market, finding the right one requires careful consideration.
We hope this guide has highlighted some of the top trans-resveratrol supplements available today, and offered valuable insights to help you navigate the options. Factors like ingredient transparency, third-party testing, and user experiences are crucial when selecting a supplement that truly fits your needs.
FAQ
How effective is trans-resveratrol for anti-aging?
Trans-resveratrol has shown potential in anti-aging by protecting cells from damage and activating longevity-related proteins like SIRT1. While animal studies and early human trials are promising, more research is needed to confirm its effectiveness in promoting long-term anti-aging benefits in humans.
How do I store trans-resveratrol supplements?
Store trans-resveratrol supplements in a cool, dry place, away from sunlight and humidity. Keeping the bottle tightly sealed preserves the supplement's integrity. Follow specific storage instructions provided by the manufacturer for best results.
Are there any side effects of taking trans-resveratrol?
While trans-resveratrol is generally considered safe and well-tolerated based on clinical trials, some side effects have been reported, particularly at higher doses. Participants taking doses of 2.5 to 5 g of resveratrol experienced gastrointestinal issues such as nausea, flatulence, loose stools, abdominal discomfort, and diarrhea.
Can trans-resveratrol be taken with other supplements?
Mostly. Trans-resveratrol can be taken with compounds like NMN, quercetin, and piperine, among others. However, caution is advised when combining it with supplements that may slow blood clotting, such as garlic, ginger, ginkgo, nattokinase, and Panax ginseng, as this can increase the risk of bleeding. It’s always best to consult a healthcare provider before combining trans-resveratrol with other supplements or medications to ensure safe use.
9 resources
- NIH. Dose-dependency of resveratrol in providing health benefits.
- MDPI. Resveratrol for the management of human health: how far have we come? A systematic review of resveratrol clinical trials to highlight gaps and opportunities.
- MDPI. Health benefits and molecular mechanisms of resveratrol: a narrative review.
- NIH. How resveratrol may fight aging.
- Journal of Translational Medicine. Advancements in NMN biotherapy and research updates in the field of digestive system diseases.
- PLoS One. A molecular mechanism for direct sirtuin activation by resveratrol.
- NIH. Beneficial effects of betaine: a comprehensive review.
- MDPI. Health effects of resveratrol: results from human intervention trials.
- Springer Link. Effects of resveratrol supplementation on the cognitive function of patients with Alzheimer's disease: a systematic review of randomized controlled trials.
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