NMN Supplements: Do They Cause or Treat Insomnia?

No studies have found Nicotinamide mononucleotide (NMN) consumption leading to side effects of insomnia. Yet, if you are new to the marketed dietary supplement, you might’ve seen bits on Reddit or other social media sites with individuals highlighting their newfound inability to sleep after taking NMN.

Key takeaways:
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    Some studies suggest nicotinamide mononucleotide (NMN) can increase sleep performance in older adults.
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    No current side effects exist when consuming up to 500 mg/day of NMN for adults varying in age.
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    Mice study suggests NMN may be able to treat insomnia, no human trials have yet been conducted.

NMN is a naturally occurring molecule in all life forms, composed structurally of a nicotinamide group, a ribose and a phosphate group. It is the direct precursor to nicotinamide adenine dinucleotide (NAD+), used by numerous proteins in the body to repair damaged DNA.

Mitochondria, known as the powerhouses of the cell, generate chemical energy that our bodies use — which require NAD+. Alertness increases with higher NAD+ levels. If NMN users don’t compensate for their increased energy levels with higher levels of physical or mental activity, the likelihood of insomnia may rise if increased energy levels are not matched.

Some NMN brands recommend magnesium one to two hours prior to sleep for new NMN users struggling to accommodate the increase in energy levels. Magnesium is a crucial nutrient for the body, regulating muscle and nerve function, blood sugar levels, and blood pressure and making protein, bone, and DNA.

Conducted testing has proved magnesium to assist insomnia, primarily in elderly patients. This probe out of Iran contained 46 elderly adults split into a magnesium group consuming 500 mg/day, and a placebo group, finding magnesium recipients scored higher in sleep efficiency, sleep time and sleep onset latency, and early morning awakening.

Another study from the University of Tsukuba observed the effects of NMN on sleep quality, fatigue, and physical performance in Japanese adults over the age of 65. The study included four groups split randomly, with the participants receiving 250 mg/day in the evening showing superior results in the 5-times sit-to-stand (5-STS) tests. Those consuming NMN in the evening also found their sleep quality increased.

It must be noted that these NMN studies take a presence in older adults who have decreased NAD+ levels. Studies have not evaluated large quantities of NMN dosage in younger adults, therefore leaving those effects unknown.

Could NMN actually help insomnia?

NAD+ is a compound that decreases as we age, leading to associations of cognitive decline, cancer, metabolic disease, sarcopenia and frailty. With NMN proving to be a precursor of NAD+, helping battle the aging process, could it possibly help those suffering from insomnia as well?

No human studies exist, but a Chinese research study in Dec. 2021 probed the effects of NMN and NMN-rich product (NMNP) intervention on p-chlorophenyl alanine (PCPA)-induced sleep disorders on five to six-week old mice.

Their conclusion found NMN and NMNP treatment assisted PCPA-induced sleep disorders through the regulation of oxidative stress, SIRT1 pathway, 5-HTergic, GABAergic and immune systems.

Are there any side effects of concern when taking NMN?

Current research surrounding side effects of NMN are scarce, putting consumers in uncharted waters. Some NAD+ supplements such as nicotinamide riboside (NR) have led to side effects such as nausea, bloating, and skin problems including perspiration and itching.

No side effects have been discovered amongst NMN consumers, and even human trials have been concluded to ensure so. Studies have shown dosages ranging from 100 mg/day to 500 mg/day to be safe for consumption with no significant negative effects in the short term.

Long-term studies assessing any damage caused by NMN have not happened, but a 12-month mice study found no serious side effects to the mice. With little to no evidence of any malousness caused by NMN, it is safe to say the supplement could be vital to fighting the aging process.

Aging has always been viewed as eminent, but with marketed dietary supplements such as NMN and technological advancements — many are attacking the aging process head-on versus the diseases that come along with the up-tick in years.

NMN seems to be a viable option in combating aging, but the supplement currently is in threat of no longer being available on U.S. marketplaces. As of Oct. 11, 2022, the FDA declared NMN is currently under investigation as a new drug, therefore revoking its New Dietary Ingredient (NDI) status.

Brands selling NMN products believe the supplement was marketed as a NDI prior to the commencement of a new drug investigation into NMN. Products containing NMN are still available for purchase in the U.S., despite the FDA telling supplement manufacturers to halt production of NMN products.


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