Regular vs Liposomal NMN: Which Is Better?

Nicotinamide mononucleotide (NMN) has gained momentum in combating age-related diseases due to findings concluding NMN to be a precursor to nicotinamide adenine dinucleotide (NAD+). In this article we, discuss the benefits and drawbacks of multiple forms of the supplement that include both regular and liposomal NMN.

Key takeaways:
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    Liposomes have been under investigation as a potential drug delivery system since the 1970's.
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    Dr. Christopher Spade highlights that the liposomal NMN version provides faster and more efficient absorption of the compound.
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    However, liposomal NMN has its own drawbacks: higher costs, possibility of instability, and poor manufacturing leading to top NMN Brands on Amazon falsely representing the purity of their product.
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    It is important to beware of NMN scams; proper research of the liposomal version of the product must be conducted before a purchase.

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Liposomes derive from lipids, molecules, including triglycerides, fatty acids, and cholesterol. Lipids are insoluble in water, playing an important role in supporting cellular membranes' function and structure in the body.

The human gastrointestinal (GI) tract contains harsh acidic conditions, in many cases destroying potential nutrients. Liposomal delivery is considered to be more efficient than other forms because of their small size along with hydrophobic and hydrophilic character (besides biocompatibility).

Liposomes have been under investigation as a potential drug delivery system since the 1970's, but it wasn’t until the 1990’s that liposomal technology came to fruition.

Currently, there is no substantial evidence supporting that liposomal NMN is superior to other forms of the compound. However, a study from Colorado State University found greater bioavailability of vitamin C when delivered via liposomes compared with unencapsulated vitamin C. The same has been found for other nutraceuticals — begging the question, is liposomal NMN superior to other forms?

Liposomal NMN benefits

Dr. Christopher Spade is the founder of Quicksilver Scientific, which specializes in products featuring liposomal delivery. Shade ​​is an expert on mercury and liposomal delivery systems, addressing doctors domestically in the U.S. and internationally regarding the subject of mercury, heavy metals, and the human detoxification system.

In a conversation with Integrative Medicine: A Clinician’s Journal, Spade highlighted the benefit of liposomal NMN.

“The liposomal version provides faster absorption, more efficient absorption, and it’s not breaking down in your gut; with normal capsules, you’re trying to absorb it, but rather you’re breaking it down as it’s going down through your GI tract, <...> The absorption into the system is a really big deal,” Spade said.

According to a study from Spadeh, here are the benefits of liposomal delivery:

  • High bioavailability and absorption compared with other oral forms of supplements.
  • Noninvasive, avoids pain and discomfort associated with injections and decreases the contamination risk.
  • Micronized encapsulation protects against the harsh environment of the GI tract and increases transmucosal (oral) uptake and absorption.
  • Increased intracellular delivery.
  • Can hold both hydrophilic and hydrophobic compounds.
  • Ideal for those for whom swallowing a tablet is not possible.
  • Allow for adjustable and incremental dosing for children and adults.
  • Cost effective by being able to take a lower dose for the same effect.

Other forms of NMN include capsules, allowing for a slower release of NMN into the bloodstream, powder mixed in water or liquid of choice, and by sublingual powder or lozenges.

Are there any liposomal NMN drawbacks?

Spade does admit that there are some negatives to liposomal delivery, including higher costs, possibility of instability, and poor manufacturing. The latter is relevant to all NMN products based on a study from Oct. 21, 2021, which found some of the top NMN Brands on Amazon falsely representing the purity of their product.

ChromaDex research found 64% of the 22 brands with the highest market share contained a less-than-advertised NMN dosage.

The following brands were found to have 0 mg of NMN despite the advertised 500 mg dosage per serving:

  • ChriBubble NMN.
  • Paragon Health NMN.
  • Komprocha NMN & Resveratrol.

Only 3 of the NMN brands were found to have a higher or a correct amount as labeled:

  • ProHealth Longevity NMN Pro 300.
  • MAAC10 NMN 250 mg.
  • Infinite Age NMN.

It is important to beware of NMN scams, proper research of the product must be conducted before a purchase.

Status of NMN is currently in question

Dr. David Sinclair is a Harvard Professor and unlike Spade, prefers to take NMN powder in his morning bowl of yogurt. Sinclair is also a co-founder of Metro International Biotech, a private pharmaceutical company that is seeking FDA approval in its probe as an investigational new drug (IND). The group has developed a proprietary version of B-NMN titled MIB-626.

NMN has been available to purchase as a featured ingredient in dietary supplements due to its acceptance as a New Dietary Ingredient (NDI) from the FDA. The FDA rescinded the NDI for NMN, as it is currently under investigation as a new drug with many believing Metro International Biotech behind the FDA’s decision.

The overrule comes after Mongolia Kingdomway Pharmaceutical Limited’s NDI inquiry of NMN for dietary supplement purposes submitted in July of this year. The reasoning is due to section 201(ff) of the Federal, Food, Drug, and Cosmetic Act, prohibiting the marketing of dietary supplements under investigation as a new drug that is under publicly conducted clinical investigations.

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