What Are Health Influencers Saying About the B-NMN Supplement Ban?

Nicotinamide mononucleotide (NMN) is a vitamin B3 derivative with increasing popularity in the longevity community due to its proclaimed anti-aging properties. Research studies have shown that NMN has excellent therapeutic potential in age-related chronic conditions like cardiovascular disease, diabetes, and cognitive impairment. However, the FDA recently excluded NMN from dietary supplements because NMN is being investigated as a new drug.

Key takeaways:
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    Nicotinamide mononucleotide (NMN) is a Vitamin B3 derivative naturally produced in the body and found in fruits and vegetables like cabbage and cucumber.
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    Beta-NMN is the only available active form of NMN, and it is not different from NMN.
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    NMN is a Nicotinamide Adenine Dinucleotide (NAD+) precursor and is metabolized to NAD+ in the body.
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    The FDA has excluded NMN from dietary supplements because NMN is being investigated as a new drug.

What is NMN? Why did the FDA ban NMN supplements? What are health influencers like Dr. Stan Bradford saying about this ongoing issue that could be the end of NMN supplements?

Read on as we answer these questions.

What is NMN?

Nicotinamide mononucleotide (NMN) is a Vitamin B3 derivative naturally produced in the body and found in fruits and vegetables, including cabbage, cucumber, tomato, and avocado. Beta-NMN (B-NMN) is not different from NMN; it is the active anomer of NMN and the only available form found in NMN supplements. The National Center for Biotechnology Information listed B-NMN as a synonym of NMN.

NMN is an NAD+ (Nicotinamide Adenine Dinucleotide) precursor and is metabolized to NAD+ in cells. NAD+ is an essential molecule implicated in many body cell processes, including energy production. It also serves as a substrate for your longevity genes called sirtuins. NAD+ levels in your body decline as you age; this is where NMN comes in. NAD+ boosters such as NMN can help replenish NAD+ levels in the body.

By supplementing with NMN, you can boost your NAD+ levels. This has been associated with better DNA repair, improved mitochondrial function, and overall health promotion. These effects translate to improved exercise endurance and recovery and better sleep quality, among other benefits.

Several research studies have been conducted to demonstrate the anti-aging effects of NMN. One study used mice to assess NMN's effects on aging neurovascular coupling. Results from the study found a link between NMN and improved cognitive performance in the subjects.

Proper clinical investigations are needed on the efficacy and safety of NMN supplementation.

What is going on with NMN?

The FDA announced in a letter released on October 11, 2022, in response to a notification submission by Inner Mongolia Kingdomway Pharmaceutical Limited, intending to market NMN as a bulk dietary ingredient for use in supplements. They stated that NMN is excluded from the dietary supplement definition under 21 U.S.C. § 321(ff)(3)(B)(ii) and may not be marketed as or in a dietary supplement.

The FDA stated in the letter that NMN is an article “authorized for investigation as a new drug by the FDA.” This new drug is called MIB-626, owned by Metro International Biotech.

This stance has nothing to do with the efficacy and safety of NMN supplements, as seen above.

What health influencers are saying

Healthnews dug deeper to find out what health influencers in the longevity space have to say about this issue. Here’s what we found.

Dr. Brad Stanfield’s take

Dr. Brad, a general practitioner at Devonport Health Center and an advocate for extending healthspan stated in one of his videos concerning this issue that people should be allowed to buy NMN supplements. This is because, in his words, “after all, NMN is just a type of vitamin B3 and people can buy vitamin C supplements over the counter, so should it not be the same for NMN?”.

He advised focusing on a great diet, regular exercise, and quality sleep, even though supplements can be a helpful addition.

Holly thinks MIB-626 should be differentiated from NMN supplements

Holly Mann is an army veteran and the owner of the Life and DIY YouTube channel, to name a few. The channel is focused on promoting healthy living inside and out. She also works in marketing for Renue By Science, which is said to be the largest seller of NMN supplements worldwide.

In an article on her website detailing the NMN situation, she stated that it makes more sense to her that MIB-626 is its proprietary product and should be differentiated from commonly sold NMN supplements. She went on to say that this is just her opinion and that there are numerous possibilities in the situation.

What Rimon thinks Dr. David Sinclair will do

Rimon, a metabolic researcher with 15 years of experience in the longevity space, also shared his thoughts on the issue on his YouTube channel. Rimon is hopeful about the situation, and he believes that Dr. David Sinclair as a co-founder and advisor of the same company that requested the removal of NMN supplements from the market, will ask the company to remove this request because, as stated by Rimon, he doesn’t think it will be good for Dr. Sinclair’s reputation. This is likely because Dr. Sinclair is a great advocate of the supplement.

In a video, he clearly stated that a warning announcement from the FDA differs from enforcement, and he hopes that freedom wins in the FDA’s final decision.

Marcel James’s view

Mr. Marcel owns a YouTube channel, The Pulse, aimed at living a quality life. He started taking Resveratrol in 2019 and NMN in 2020. Mr. Marcel expressed his views in many of his recent videos. He stated that the FDA could be litigated against by the dietary supplement lobby groups and consumer advocacy groups representing these interests. Mr. Marcel believes NMN should continue to be sold as a supplement and discussed in one of his videos that the supplement industry will likely win control over NMN, meaning it will still be available for sale as usual through the enforcement discretion policy.

Finally, he proposed the creation of a new ingredient classification called “natural medicine” which will represent natural ingredients that can be sold both as a drug and as a supplement.

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Comments

Jeff Gilligan Jeff Gilligan
prefix 1 month ago
The FDA is following the law. What evidence that NMN occurs in cabbage and avocados? In any case, taking NR (nicotinamide riboside) goes into the cells and becomes NMN, and then NAD. NAD is what you want, but that mileage is too large as well to enter a cell.