Mounjaro Leads to Greater Weight Loss Than Ozempic

People who took Mounjaro lost significantly more weight than Ozempic users, according to a new study.

Both tirzepatide (Mounjaro, Zepbound) and semaglutide (Ozempic, Wegovy) have been shown to cause significant weight loss in clinical trials. However, data comparing their effectiveness head-to-head remains limited.

A new study published in JAMA Internal Medicine suggests that tirzepatide leads to 6.9% more significant weight loss than semaglutide.


The trial included over 41,000 adults with overweight and obesity. Of those, 32,029 took semaglutide, and 9,193 used tirzepatide.

During the one-year period, 81.8% of those receiving tirzepatide achieved 5% or greater weight loss compared to 66.5% in the semaglutide group.

Among those taking tirzepatide, 62.1% lost at least 10% of their body weight, compared to 37.1% of semaglutide users.

Over four in ten (42.3%) patients on tirzepatide achieved a weight loss of 15% or more, compared to 18.1% in the semaglutide group.

Weight reductions were found to be larger in the participants without type 2 diabetes. While the underlying reasons are unclear, authors hypothesize that patients without the condition may have different motivation levels for weight loss and engage in other weight loss activities differently.

Individuals taking tirzepatide and semaglutide had a similar risk of adverse gastrointestinal events like bowel obstruction, stomach paralysis, and pancreatitis, among others.

Last year, the U.S. Food and Drug Administration approved tirzepatide under the name Zepbound for weight loss. Analysts predict that tirzepatide will become the top-selling drug in its category by 2029.

Both tirzepatide and semaglutide belong to a class of medications called GLP-1 receptor agonists. These medications work by suppressing appetite and reducing food intake. Initially developed for treating type 2 diabetes, the drugs are increasingly being used off-label for weight loss.


While the study suggests that tirzepatide may be more effective for weight loss than semaglutide, do not initiate or change medications without your doctor’s supervision.


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