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Scientists Link Arthritis to the Gut Microbiome

Gut health refers to having a healthy gut microbiome and limited digestive symptoms. An unhealthy gut may lead to various health problems, including constipation, heartburn, bloating, and acne. Scientists now say there is an intricate connection between gut health and inflammatory diseases.

Our digestive system is responsible for dissolving solids and liquids into their chemical constituents, such as carbs, lipids, and proteins, so the body may absorb them as nutrients and utilize them for energy, cell growth, and repair. Having a healthy digestive system is crucial to maintain power and invigorating health.

To pinpoint a connection between patient-related inflammatory arthritis and changes in the gut microbiota, the Inflammatory Arthritis Microbiota Consortium conducted research involving 440 participants.

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Previous research on illnesses like inflammatory bowel disease has shown a connection between changes in gut flora and inflammatory disorders. Patients who suffer from these illnesses have unusual alterations in their microbiomes.

Researchers are currently examining whether similar connections apply to other chronic immunological diseases.

The study found a connection between particular changes in gut flora and the severity of various inflammatory illnesses. Of the 440 participants, 221 adults were diagnosed with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis.

In the inflammatory arthritis patients, the gut microbiome was different, with higher concentrations of potentially harmful bacteria like Escherichia coli and Ruminococcus gnavus and lower concentrations of helpful bacteria like Faecalibacterium prausnitzii and Roseburia intestinalis.

These findings show that people living with inflammatory arthritis have a unique gut flora that differs from healthy people.

The study examined the functional effects of these changes on the gut microbiota and found that they affected how well the gut absorbed iron and vitamin B from the diet.

Some of these alterations, such as those for B vitamin metabolism, could represent mechanisms for long-term prevention, risk reduction or treatment, as could microbial iron sequestration during arthritis-linked anemia.

- Inflammatory Arthritis Microbiota Consortium

The authors point out that their findings do not prove a causal relationship. They note that this is particularly significant about the gut bacteria-inflammation connection since many changes in bacteria may occur in reaction to immune system changes rather than the other way around.

Current knowledge of the gut microbiome's function in inflammatory arthritis has improved due to the study, and the information gathered may guide future microbiome-based treatments. Scientists warn that additional study is necessary to completely comprehend the processes underlying this association and to create tailored therapies for enhancing gut health in individuals with these illnesses.

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Nick Arrizza
prefix 10 months ago
A healthy gut microbiome results from the consumption of a high fibre whole plant based diet.