Looking for the best liposomal NMN supplement? You're not alone.
Many health enthusiasts are turning to this innovative form of nicotinamide mononucleotide (NMN) to potentially boost their NAD+ levels.
Unlike regular NMN, liposomal NMN is encapsulated in tiny fat bubbles to enhance absorption. But with so many options out there, it's crucial to choose wisely — that's why we've done the legwork, researching top-quality liposomal NMN products to help you make an informed choice.
Read on to find our specially curated list of the best liposomal NMN supplements on the market.
Best liposomal NMN: shortlist
- Best liposomal NMN for ingredient purity: Hello100
- Best liposomal NMN made in the EU: Purovitalis
- Best liposomal NMN blend with trans-resveratrol and TMG: ProHealth
- Overall best liposomal NMN: GenuinePurity™
- Best liposomal NMN in a comprehensive longevity blend: Perpetua Life
Your well-being is our top priority. Our in-house Research team and expert fact-checkers diligently review every content piece, ensuring you receive accurate, safe, and up-to-date health information to support your health decisions. Get an inside look at our thorough testing framework.
Comparing liposomal NMN options in the market
| Brand | Price per bottle | Price per serving | Number of servings | NMN purity | NMN dose per serving | Number of active ingredients |
| Hello100 | $84.00 | $1.40 | 60 | 99.5% | 250 mg | 1 |
| Purovitalis | $65.00 | $2.16 | 60 | 99% | 250 mg | 1 |
| ProHealth | $73.50 | $2.45 | 30 | Not provided | 500 mg | 3 |
| GenuinePurity™ | $79.95 | $1.33 | 60 | 96% | 250 mg | 1 |
| Perpetua Life | $79.00 | $2.63 | 30 | Not provided | 400 mg | 13 |
Why did we choose Hello100 as our top liposomal NMN?
After careful consideration of various factors, our team has selected Hello100 as our top liposomal NMN supplement. This decision is based on the evaluation of key criteria that we believe are crucial for consumers seeking high-quality liposomal NMN supplements.
Hello100 stands out for its ingredient purity, which is the highest on our list, with 99.5% NMN. It has a generous 250 mg dose per capsule, it offers a high-quality product at a competitive price point of $1.40 per serving. The 60-day supply per bottle provides excellent value for long-term users.
We appreciate Hello100's focus on a single, top-quality ingredient, especially for those seeking to improve absorption and cellular uptake through advanced liposomal technology delivery. While the company is young, it quickly gained praise for its approach to longevity supplementation and solidified its position as our top choice for liposomal NMN.
Best liposomal NMN in 2025: overview
Our list of top-rated products and best liposomal NMN supplement reviews was created keeping in mind the NMN product’s price, proof of quality, and formulation.
1. Hello100 — best liposomal NMN for ingredient purity
Hello100 Liposomal NMN offers a cutting-edge approach to NMN supplementation, focusing on enhanced bioavailability through advanced liposomal technology. This brand has gained attention in the longevity supplement market for its high-quality formulation.
The product provides a potent dose of NMN encapsulated in liposomes, aiming to improve absorption and cellular uptake. Each serving is designed to support NAD+ levels, potentially contributing to various aspects of cellular health and energy production.
Hello100 emphasizes quality in its manufacturing process, with products tested and approved by third-party labs. The supplement is produced in facilities that adhere to strict quality control standards, ensuring product safety and efficacy.
Main ingredients
β-nicotinamide mononucleotide (NMN) and a liposomal delivery matrix.
Key features of Hello100 Liposomal NMN
- The highest purity on our list with 99.5% NMN
- Third-party tested
- Manufactured under GMP in FDA-registered facilities
- 250 mg of NMN per serving
Company review
Hello100 is a relatively new player in the longevity supplement market but has quickly gained recognition for its innovative approach to longevity supplementation.
The company emphasizes scientific research and transparency in its product development. Its commitment to quality is evident through the use of third-party testing and adherence to GMP in its FDA-inspected manufacturing facility.
A 60-day supply costs $84.00 ($1.40 per serving), with significant discounts available for bulk purchases. Additionally, the company offers a 60-day money-back guarantee, giving customers a risk-free opportunity to experience the potential benefits.
2. Purovitalis — best liposomal NMN made in the EU
Purovitalis liposomal NMN is a premium supplement designed to support cellular health and energy production. Hailing from Amsterdam, the Netherlands, the brand has gained popularity among health enthusiasts seeking high-quality liposomal NMN supplements.
The product offers a potent formula — 250 mg of 99% pure NMN per serving, encapsulated in a liposomal delivery system. This approach may enhance absorption and bioavailability, potentially maximizing the benefits of NMN supplementation.
Produced in cGMP-certified facilities, Purovitalis liposomal NMN adheres to strict quality control standards. The supplement is free from gluten, soy, eggs, dairy, wheat, and sugar, catering to most dietary requirements.
Main ingredients
Nicotinamide mononucleotide (NMN) and liposomal delivery matrix.
Key features
- 99% pure NMN
- 125 mg of NMN per capsule
- Third-party tested
- Manufactured under cGMP
- Free from common allergens and additives
- Made in the EU
Company review
Purovitalis is a Dutch company focused on developing high-quality longevity supplements — including NMN. They emphasize scientific research and transparency in their product development. The company's commitment to quality is evident through its use of third-party testing, transparent ingredient sourcing, and adherence to cGMP protocols.
Priced at $65.00 for a month’s supply ($2.16 per serving), the brand offers a subscription option with a 16% discount.
3. ProHealth — best liposomal NMN blend with trans-resveratrol and TMG
ProHealth Liposomal NMN Pro Complete offers a unique blend of liposomal NMN, trans-resveratrol, and trimethylglycine (TMG). This American company has been serving customers for over three decades, focusing on providing high-quality supplements for various health needs.
The product delivers 500 mg of NMN per serving, along with complementary ingredients designed to enhance its effects and further support longevity. This comprehensive approach aims to provide a well-rounded supplement for those interested in supporting cellular health and energy production.
ProHealth Liposomal NMN Pro Complete is manufactured in the U.S. in an FDA-inspected manufacturing facility, working under GMP. The supplement is free from major allergens and suitable for various dietary preferences.
Main ingredients
Liposomal NMN (Uthever®), trans-resveratrol, and trimethylglycine (TMG).
Key features of ProHealth Liposomal NMN Pro Complete
- 500 mg of NMN per serving
- Blended with trans-resveratrol and TMG
- Third-party tested
- Manufactured under GMP
- Made in the U.S.
Company review
ProHealth has been a reputable player in the supplement industry since 1988, focusing on products for chronic health conditions and general wellness. The company emphasizes scientific research and quality in product development.
A bottle containing 90 capsules is priced at $73.50 ($2.45 per serving) with a subscribe and save option offering a 30% discount. The company provides a 75-day money-back guarantee, allowing customers to try the product risk-free.
4. GenuinePurity™ — overall best liposomal NMN
GenuinePurity, a Canadian brand, has been serving customers in over 130 countries for over two decades. Recognized as the best NMN product of 2024, it employs advanced liposomal technology aimed at enhancing NMN absorption.
The product boasts a straightforward formula with 96% pure NMN as its sole ingredient, delivering 250 mg of NMN per capsule. The dosage is designed to simplify the daily supplementation routine, eliminating the need for multiple capsules.
Manufactured in cGMP-certified facilities, GenuinePurity™ liposomal NMN demonstrates high-quality and safety standards. The formula is free from allergens and preservatives, making it suitable for all dietary preferences thanks to its vegetable capsule shell.
Main ingredients
β-nicotinamide mononucleotide (NMN) and a liposomal delivery matrix.
Key features of GenuinePurity™ liposomal NMN
-
250 mg of NMN per capsule
- Third-party tested
- Manufactured under cGMP
- 96% pure NMN
- Made in the U.S.
Company review
GenuinePurity™ Liposomal NMN is manufactured by Leading Edge Health, a Canadian company that has established itself as a reputable player in the natural supplement market over the past 20 years. They are known for their commitment to quality, as evidenced by their rigorous testing procedures and generous money-back guarantee.
Each bottle contains 60 servings and is priced at $79.95 ($1.33 per serving). The additional 67-day money-back guarantee may make it an appealing choice for those looking for liposomal NMN supplementation as a way to support healthy aging.
5. Perpetua Life — best liposomal NMN in a comprehensive longevity blend
Based in New York, Perpetua Life AEON offers NMN in a comprehensive blend with riboflavin, vitamin B6, B12, and 10 other longevity-supporting ingredients, such as spermidine, quercetin, and resveratrol, among others.
NMN is delivered in concert with nicotinamide riboside (NR), another natural precursor to NAD+ in our bodies. The overall NMN and NR amount is 500 mg, the same dose that clinical trials have used.
AEON is manufactured in cGMP-certified facilities in the U.S. and undergoes rigorous third-party testing for potency and purity. It is free from preservatives, additives, gluten, and animal-derived ingredients, catering to a wide range of dietary preferences.
Main ingredients
Nicotinamide DUO™ (NMN and NR blend), fisetin, quercetin, resveratrol, astragalus, epigallocatechin gallate (EGCG), trimethylglycine (TMG), L-theanine, spermidine, and piperine.
Key features of Perpetua Life AEON NAD Longevity Complex
- Comprehensive 10-compound longevity formula with vitamin B6, B12, and riboflavin
- Third-party tested
- Manufactured under GMP in an FDA-registered facility
- Free from common allergens, additives, and GMO
- Made in the U.S.
Company review
Perpetua Life is a relatively new player in the longevity supplement market but has quickly gained recognition for its innovative approach to NAD+ enhancement.
The company emphasizes transparency and research in product development. All ingredients in the supplement formulations have some scientific backing.
A 30-day supply is priced at $79.00 ($2.63 per serving), with a subscribe and save option offering a 20% discount. The company offers a 90-day money-back guarantee, allowing customers to try the product with confidence.
How we ranked the best liposomal NMN products
| Ingredient quality | Third-party testing | Manufacturing certifications | Price |
| Purity and source of NMN and liposomes | Independent lab verification of product claims | GMP and ISO 9001 certificates | $1.30–2.70 per serving |
- Ingredient quality. We looked at the purity and source of NMN and the liposomal encapsulation. High-quality ingredients are crucial for potential effectiveness and safety.
- Third-party testing. Independent lab verification ensures the product contains what it claims and is free from contaminants. This provides an extra layer of trust and transparency.
- Manufacturing certifications. We looked for adherence to industry standards like cGMP (good manufacturing practices) or equivalent. Such certifications indicate a commitment to quality and safety throughout the production process.
- Price. We looked at the price in relation to the quality and quantity of liposomal NMN provided.
Understanding liposomal NMN
Liposomal technology is an innovative approach to improving the bioavailability of supplement substances. The method encapsulates supplement molecules within tiny lipid bubbles called liposomes to enhance absorption and bioavailability.
When it comes to regular absorption of NMN, the suggested liposome benefits are based on the following logic — traditional NMN supplements, such as oral tablets or powders, face challenges in the digestive system. Stomach acid, digestive enzymes, and gut microbiota may break down a significant portion of the NMN before it reaches the bloodstream, potentially reducing its effectiveness.
Liposomal delivery aims to protect NMN from degradation in the gastrointestinal tract. The liposome's structure allows it to pass through the stomach and intestines relatively intact with the goal of delivering a higher percentage of active NMN into your bloodstream. This may result in improved absorption rates compared to non-liposomal forms.
While research is ongoing, some studies suggest that liposomal delivery can increase bioavailability compared to traditional oral supplements. However, it's important to note that individual results may vary, and more research is needed to fully understand the long-term benefits of liposomal NMN supplementation.
Expert opinion
As we explored the potential of liposomal NMN supplements, we realized how important it is to provide our readers with a clear and balanced perspective to separate fact from marketing hype. Thankfully, our in-house researcher, Gabija Dimšaitė, BSc, shared her expertise to help us uncover what’s worth knowing and what requires a closer look.
Insights from our research team
Not that long ago, the NMN market exploded with widespread attention for its potential to address aging-related issues such as declining NAD+ levels, oxidative stress, DNA damage, and inflammation. The buzz around its benefits caused a surge in demand, leading to skyrocketing sales and shelves being cleared as people eagerly sought this promising supplement.
Today, to expand the NMN market, many brands have introduced liposomal NMN, often marketing it as a superior option due to its potentially improved absorption by the body.
Healthnews researcher Gabija Dimšaitė explains how liposomal technology works and whether it truly adds value to NMN.
Liposomal delivery systems may enhance the absorption of compounds like NMN by encapsulating them in tiny, fat-based structures called liposomes. These liposomes have a phospholipid bilayer that may fuse with cell membranes and help NMN reach the bloodstream, as it is currently believed to not be able to easily cross cell membranes on its own.
Gabija Dimšaitė
Gabija adds, “In theory, liposome encapsulation may protect NMN from being broken down by enzymes and harsh conditions in the digestive tract, such as stomach acid and digestive enzymes. This protection could potentially improve its bioavailability, making the compound more available for use in the body. However, when it comes to NMN specifically, these benefits remain unproven in clinical studies.”
Things to keep in mind
While the science behind liposomes is intriguing, Gabija advises a healthy dose of skepticism:
There are various production techniques for liposomal formulations that require diligence and high-quality control. We cannot ascertain whether the lipid encapsulation of NMN conducted by supplement manufacturers is executed correctly or if it can indeed enhance absorption and bioavailability. Unfortunately, supplement brands rarely, if ever, discuss these critical factors.
Gabija Dimšaitė
“Additionally, liposomal NMN supplements are often marketed with promises of superior results, but these claims lack solid evidence. While liposomal technology is intriguing, there’s no guarantee it makes NMN more effective, as there are no studies looking at such formulations. It’s essential to approach these products with realistic expectations, especially given their higher price.”
Making the right choice
For those considering NMN, Gabija recommends focusing on reputable brands that prioritize transparency and quality.
Until more research confirms the benefits of liposomal formulations, don’t be swayed by bold claims. Look for products backed by credible testing and consider whether the added cost is worth it.
Gabija Dimšaitė
She adds, "Don't assume liposomal products are automatically better — they might not justify their higher price.”
In short, liposomal NMN holds promise but remains a speculative option for now.
Proven benefits of liposomal NMN
While liposomal NMN is relatively new, research on NMN, in general, has shown promising results in various areas of health and longevity.
Notably, the cornerstone studies have been conducted with non-liposomal forms of NMN. The specific effects of liposomal delivery are still being investigated to demonstrate improved bioavailability and subsequent effects.
Supporting cellular energy production
NMN is a precursor to NAD+, a crucial molecule for cellular energy production.
Some studies suggest that NMN supplementation may help maintain NAD+ levels, which naturally decline with age.
This could potentially support overall energy levels and metabolic function, though more research is needed to confirm these effects in humans.
Promoting healthy aging
Animal studies have shown promising results in using NMN to support various aspects of healthy aging.
For example, a 2016 study found that NMN supplementation in mice improved insulin sensitivity, eye function, and other age-related physiological declines. However, it's crucial to note that these results have not yet been replicated in human trials.
Supporting cardiovascular health
Some research in animals suggests that NMN may have potential benefits for heart health.
A 2014 study in the Journal of Molecular and Cellular Cardiology found that NMN supplementation protected the hearts of mice from ischemia-reperfusion injury (when blood flow temporarily stops and resumes, causing damage). While these results are promising, human studies are needed to confirm any cardiovascular benefits.
Potential cognitive support
Preliminary research indicates that NMN might indirectly have neuroprotective properties.
A 2019 study in Redox Biology found that NMN supplementation in mice improved cognitive function and reduced neuroinflammation. However, these effects have not yet been demonstrated in human trials.
How to pick a quality liposomal NMN supplement
Several key factors should be considered when choosing a liposomal NMN supplement to ensure a high-quality product.
First, look for supplements with high NMN purity, ideally 95% or above. The liposomal encapsulation technology should be clearly explained, as this is essential for potentially enhanced absorption.
Dosage and concentration are important — scientific studies have used doses between 250–500 mg of NMN daily. Also, look for third-party testing and supplements manufactured in GMP-certified facilities to ensure quality and safety standards are met.
Lastly, price is a consideration, as NMN supplements can be costly. Look for a balance between quality and affordability, especially as NMN should be used long-term. Therefore, consider subscription options or bulk purchases for better value.
Ultimately, the best liposomal NMN supplement will depend on individual needs and budget. Always consult with a healthcare professional before starting any new supplement regimen.
FAQ
Is liposomal NMN better than regular NMN?
While liposomal NMN may offer improved absorption compared to regular NMN, more research is needed to confirm this. Liposomal forms might be beneficial for those who have difficulty absorbing regular NMN.
How does liposomal delivery enhance NMN absorption?
These liposomes can potentially protect NMN from degradation in the digestive system and facilitate its passage into the bloodstream. This could lead to more efficient delivery of NMN to cells, potentially increasing its bioavailability compared to non-liposomal forms.
How do I choose the best liposomal NMN supplement?
When selecting a liposomal NMN supplement, consider factors like NMN purity (95%+), dosage (250–500 mg daily), and third-party testing. Look for products manufactured in GMP-certified facilities. Always consult a healthcare professional before starting any new supplement regimen.
6 resources
- Journal of Food Science and Technology. An overview of liposomal nano-encapsulation techniques and its applications in food and nutraceutical.
- Frontiers inCell and Developmental Biology. Nicotinamide mononucleotide: A promising molecule for therapy of diverse diseases by targeting NAD+ metabolism.
- Nutrients. Pharmacokinetic analyses of liposomal and non-liposomal multivitamin/mineral formulations.
- Cell. Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging.
- Cell Metabolism. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice.
- Nature Aging. Healthy aging and muscle function are positively associated with NAD+ abundance in humans.
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