Plenity Pills: First FDA-Cleared Weight Management Tool

We’ve all repeatedly heard that the key to weight loss and maintaining a healthy lifestyle requires a balanced diet and regular exercise. Still, it’s easier said than done for the millions of individuals struggling to lose weight. Sometimes we need a boost to kickstart our metabolism and lose the first few pounds. Unlike the endless weight loss drugs, procedures, and quick-fix fads, researchers have developed better solutions to help individuals lose weight.

Key takeaways:
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    Plenity is the first FDA-approved weight management tool, using gel particles and the body’s natural abilities to promote satiety and fullness.
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    31% of adults are considered overweight, with a BMI of 25 to 29.9, and 43% of adults who are obese have a BMI of 30.
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    Unlike other weight loss alternatives, those with lower BMIs (starting at 25) can qualify to take Plenity.

For example, Plenity, the first FDA-cleared weight management tool, uses gel particles to keep you feeling sated after and between meals for extended periods. Plenity was founded by biotherapeutics company Gelesis, where founder and CEO Yishai Zohar sought a solution to help America’s obesity epidemic.

"For many people, using expensive drugs chronically or resorting to surgery are not viable options,... In fact, many don’t even qualify for these treatments, which are only available to those with a higher BMI."

Yishai Zohar

The National Health and Nutrition Examination Survey (NHANES) results show that approximately 74% of adults are overweight (if not obese), with a BMI of 25 or more. Plenity allows consumers to manage their weight safely and effectively for those with a BMI starting at a BMI of 25.

How does Plenity work?

Three Plenity capsules are taken orally 20 minutes before a meal with 16 ounces of water. As the capsules disintegrate in the stomach, they release thousands of gel-like particles that occupy approximately 25% of your stomach volume. The gel combines with the ingested food, promoting satiety and fullness. As the gel reaches the large intestine, it is partially broken down by enzymes and releases most of the water. Plenity then leaves the body as part of the natural digestive process.

Plenity’s Gelesis Loss Of Weight (GLOW) trial examined the weight management tool with a study of 436 excessively overweight or obese adults: 223 who received Plenity and 213 who received a placebo (with or without type 2 diabetes). The study lasted 24 weeks, with each patient consuming three capsules twice daily (20 minutes before each meal with water). The results in the treatment group showed that 59% of Plenity responders lost, on average, 10% of their body weight (approximately 22 pounds).

Price of Plenity pills

Unlike several alternative weight loss options, Plenity offers a reasonable price at just $1.75 per meal ($98 for a 4-week supply), or you can save 15% and purchase a 12-week supply for $249 ($1.48 per meal). Plenity requires a prescription, but your insurance may be able to cover at least part of the cost.

Who should take Plenity?

Plenity should be prescribed to those with excess weight or obesity who have a body mass index (BMI) of 25 to 40 kg/m2. Combining the weight management tool with a balanced diet and moderately-intense exercise is also necessary. To get started, check your BMI using the CDC’s calculator and then go to the official Plenity website or discuss the weight management option with your primary physician.

Is Plenity safe for everyone?

Whether setting up a consultation with one of Plenity’s physicians or talking to your primary care doctor, they can assess if this is a safe option for you. If so, they can make sure that none of your current medications will interact negatively with it.

Generally, you should avoid Plenity altogether if you're pregnant or allergic to the following:

  • Cellulose;
  • Citric acid;
  • Sodium stearyl fumarate;
  • Gelatin;
  • Titanium dioxide.

Others who should avoid it are those with a history of esophageal abnormality, suspected strictures (Crohn’s disease), or any previous gastrointestinal (GI) surgery that may have altered motility through the GI tract.

Side effects of Plenity

In clinical studies, there was no difference in side effects between subjects who received the treatment and subjects who received a placebo. The most common side effects listed are the following:

  • Fullness;
  • Bloating;
  • Gas;
  • Abdominal pain.

Other than these few mild side effects, Plenity is natural and safe. The drug has a proven safety profile and a clinical study proving Plenity is as safe and tolerable as a placebo (inactive ingredients) and is non-habit forming. It’s also a non-stimulant; therefore, unlike many weight loss drugs, no restrictions exist on how long it can be taken.

While some may have different results, Plenity is an entirely new option in weight management that offers consumers a healthy and affordable way to lose weight, whether 100 pounds or 30 pounds. If we have learned anything, there are no quick fixes and dropping all the weight overnight isn’t feasible. Plenity is a sensible option that uses science to work with your body’s natural abilities to lose weight and adapt to a healthy lifestyle with the help of diet and exercise.

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