As much as most people love a good night out, a casual catch-up with friends, and one too many drinks, the aftermath of a hangover is haunting. As you get older, even the thought of dealing with the headache, fatigue, stomach distress, irritability, and dehydration the next day may prevent you from going out. There are way more common symptoms associated with hangovers, but let’s be honest: if you are looking for a way to avoid it, you know what yours are.
Ahhh, if only there were a way to prevent rough mornings…
There actually might. AfterDrink by Omre is a dietary supplement containing a blend of vitamins, amino acids, and herbal extracts that supposedly work to ease the hangover symptoms, leaving you more refreshed and productive after a night of drinking.
We have reviewed AfterDrink to give you a realistic, unbiased, and in-depth product analysis. We go into the science behind the ingredients in AfterDrink, possible benefits, safety, user experience, and value for money.
Your well-being is our top priority. Our in-house Research team and expert fact-checkers diligently review every content piece, ensuring you receive accurate, safe, and up-to-date health information to support your health decisions. Get an inside look at our thorough testing framework.
What is AfterDrink?
Omre has created AfterDrink as a supplement designed to reduce hangover symptoms when taken before and after consuming alcohol. The formula contains a carefully selected blend of ingredients that may be able to support the body’s natural ability to metabolize alcohol, detox, hydrate, support liver function, and increase recovery.
Key ingredients
- Ampelopsis grossedentata (vine tea) with dihydromyricetin (DHM)
- Milk thistle
- Ginger root extract
- Prickly pear extract
- Korean ginseng
- Electrolytes
- Vitamin complex
- Bioperine
To ensure adherence to the label, AfterDrink is third-party tested for label accuracy in an independent lab. The product is vegan and gluten-free, making it suitable for a wider audience.
What makes this product stand out is its ingredients, which are picked to work at different stages of alcohol metabolism to provide more support for the body. The formula is also free of artificial ingredients.
AfterDrink: a quick review
Replenish lost nutrients and improve your morning recovery after a heavy night with AFTERDRINK®.
How and why we chose to review AfterDrink
Due to the growing popularity of hangover pills with bold claims and catchy marketing, we found it necessary to review one of the most popular products: AfterDrink. We aim to help you discern facts from fiction regarding hangover prevention without the obvious “don’t drink” advice. Furthermore, the supplement market is dietary supplements less regulated compared to medication, meaning an even more significant need for unbiased and critical evaluation exists.
We aim to equip our readers with accurate and reliable information and the skills to make informed decisions about hangover supplements and other remedies.
AfterDrink ingredients and usage
Below, we break down each of AfterDrink's active ingredients, provide the recommended use, and examine potential side effects and medication interactions.
Dihydromyricetin (DHM)
DHM is a flavonoid compound found in a range of botanicals originating in East Asia, including Ampelopsis grossedentata (vine tea). It has been used as a hangover cure in traditional Asian medicine for centuries.
It is currently proposed in animal model studies that DHM may have an effect in decreasing blood alcohol concentrations, promoting alcohol clearance, and enhancing the alcohol metabolic enzyme alcohol dehydrogenase and acetaldehyde dehydrogenase activity. One in-human Phase 1 open-label, dose-escalation study for DHM's role in alcoholic liver disease is currently running. However, there is no clinical evidence of DHM’s efficacy and safety for hangover management.
Milk Thistle (Silymarin)
Silybum marianum has also been used as a natural hangover remedy in certain cultures. However, there is no clinical evidence for such activity. The connection of this botanical to alcohol is made chiefly due to pre-clinical evidence of milk thistle extract potential for a range of liver conditions.
Ginger root extract
Ginger root is considered a common herbal remedy thanks to its antioxidant properties. A study done in male albino rats found that high doses of ginger extract have some protective effects against alcohol-induced renal damage.
Another small crossover clinical study of ten healthy adult volunteers examined a Kamishoyosan (KSS) formula with ginger, tangerine, and brown sugar. The study found that when KSS was ingested before the first alcoholic drink, the severity of digestive symptoms seemed to be reduced. Furthermore, the overall wellbeing of individuals experiencing a hangover seemed better. However, it is unclear what role ginger played in the formulation. There is also a general lack of scientific research in terms of ginger's role in hangover reduction.
Prickly pear extract
An extract from the skin of the prickly pear fruit Opuntia ficus indica (OFI), given 5 hours before alcohol consumption, reduced nausea, dry mouth, and lack of appetite. According to a double-blind, placebo-controlled, crossover trial with 64 healthy young adult volunteers, the overall symptom index was reduced by 2.7 points on average. Additionally, the risk of a severe hangover was reduced by half when compared to placebo administration.
Although the exact mechanisms of action are still unclear, it is proposed that OPI works by inhibiting the production of specific inflammatory mediators associated with alcohol use.
Korean ginseng
A specific form of Korean ginseng — red ginseng has been studied in a randomized crossover study with 25 healthy men who consumed a drink containing 0.321 mg/ml of the compound within 5 min of consuming alcohol. The study reported that participants who consumed red ginseng had lowered plasma alcohol concentrations at 30, 45, and 60 minutes after alcohol consumption compared to placebo. Furthermore, the participants reported feeling less tired than usual, having fewer stomach aches, feeling less thirsty or dehydrated than under normal conditions, and experiencing less difficulty concentrating and less memory loss compared to the placebo group.
This study alone is not enough to prove the benefits of red ginseng. However, it highlights the potential and the need for further research.
Electrolytes
Alcohol may cause dehydration, which also leads to an electrolyte imbalance. Hence, restoring electrolyte balance can reduce the symptoms of a hangover, help with hydration, and support morning recovery. Furthermore, electrolyte drinks often come in pleasant flavors and can help boost your water intake the morning after.
Vitamin complex
Alcohol is a diuretic; thus, alongside the excretion of more fluids, more water-soluble vitamins can potentially be excreted as well. Alcohol-induced dehydration thus leads to a drop in water-soluble vitamins, such as the vitamin B complex and vitamins C and E. Hence, supplementation can help restore the micronutrient balance and improve wellbeing and recovery.
Minerals and amino acids
Dehydration and often poor nutrition choices during a hangover make it hard to get all the essential minerals and amino acids that are crucial for recovery and homeostasis. Hence, supplementing with minerals such as magnesium, zinc, and copper can be beneficial. L-theanine, which is involved in many metabolic functions, may contribute to normal body functioning and reduce hangover symptoms.
Although extended use of L-theanine for several weeks may have mental health benefits and contribute to stress reduction, it is unlikely to help with "hangxiety" after a single ingestion following alcohol consumption.
Omre recommends taking three capsules before your first drink and three more after your last drink for best results.
Unboxing experience
AfterDrink packaging reflects the brand’s no-nonsense approach to health. The supplement is packaged in a sleek brown bottle that is easy to store and carry, making it convenient for on-the-go use or spontaneous plans. One bottle has enough stock to help with morning recovery after eight alcohol-laced nights.
The product comes with an informative label with the key ingredients and clear instructions on how and when to take the supplement for optimal potential effectiveness.
AfterDrink effectiveness and safety
While we went into detail about each of the active ingredients above, highlighting their potential benefits and research, there is a lack of scientific data to say that this (or any other) supplement can reduce hangovers. There are no studies looking at this particular product’s effectiveness. Just because an ingredient has some potential, it does not mean that specific formulations will provide the same potential benefits. Furthermore, key herbal ingredients have been studied in clinical doses; thus, the potential effectiveness may differ in AfterDrink.
That being said, individuals using herbal remedies when drinking alcohol may be more likely to drink more water and make better food choices, thereby improving their morning recovery indirectly.
Safety, side effects, and interactions
- Safety. The ingredients in AfterDrink are safe when used in recommended daily doses. However, some ingredients are higher than recommended daily values (RDV) and may cause trouble for those who are more sensitive. Vitamins and minerals should be consumed within safe limits to avoid imbalances or any potential side effects.
- Potential Side Effects. Although uncommon, some users may experience mild gastrointestinal upset, primarily from higher vitamin C, DHM, or milk thistle doses.
- Drug Interactions. Milk thistle may interact with medications metabolized by the liver, such as blood thinners or statins. It may also be able to lower blood sugar. B vitamins, particularly B6, should be monitored in individuals taking certain medications, such as those for high blood pressure. B vitamins may interact with blood pressure medications.
- Herbal ingredients. Some of the ingredients may not have an RDV, and the potential side effects may depend on each individual health status; thus, before using supplementation with herbal ingredients, it is always recommended to consult with a healthcare provider.
User experience and results
Overall, AfterDrink has mostly positive feedback, with customers praising the all-natural ingredients and effective hangover symptom reduction. Some have noted that AfterDrink helps them feel around "50% better" the next day. However, results seem to vary substantially among individuals and are influenced by age, the amount of alcoholic beverages consumed, and other factors. In essence, AfterDrink may help alleviate hangovers to some extent, but it is not a miracle cure.
What people liked
- Noticeable reduction in hangover symptoms
- Faster recovery after drinking
- Supported natural energy and mood
- Easy to incorporate into social events
What people didn't like
- Limited effectiveness for some users
- High price point
- Some reported mild side effects (e.g., upset stomach)
Expert opinion
To provide an even more comprehensive review, we have asked healthcare experts for an opinion.
Sazan Sylejmani, a pharmacist with over 15 years of experience, says, “An over-the-counter supplement is unlikely to directly address these systemic effects of alcohol.” Adding that the impact of alcohol varies greatly among individuals, making it unlikely that a standardized supplement would account for personal differences. “Supplements may provide psychological reassurance, but biologically are unlikely to undo the damage caused by excessive alcohol consumption or intoxication.”
Dr. Mark Anton further added, “I believe AfterDrink's claims are irresponsible. Overall wellbeing depends on balanced choices and self-care, not unproven supplements,“ and suggested focusing on moderation when drinking.
However, most experts agree that the ingredients, especially the electrolytes, may provide more relief than doing nothing at all.
Tips for using AfterDrink effectively
Omre recommends three capsules before starting drinking and three capsules after finishing drinking. However, supplements alone should not be relied on, so here are some practical tips that can help reduce a hangover.
- Stay hydrated
- Eat a balanced meal before drinking
- Avoid mixing drinks
- Eat a healthy breakfast
- Avoid greasy food
How much does AfterDrink cost and where to buy it?
Replenish lost nutrients and improve your morning recovery after a heavy night with AFTERDRINK®.
A container contains servings for eight nights. A one-time purchase costs $35 ($4.38 per serving). Subscribing to regular deliveries saves you 5%. Buying a pack of 2 saves you an additional 5%, and buying 3 saves you 15%.
The product can be purchased on the official Omre website.
If you are dissatisfied with the product, Omre offers a 30-day money-back guarantee on your first purchase and will even cover the shipping cost.
Comparison to other hangover remedies
With several hangover pills on the market we have provided a quick comparison to help you choose the product most suited for your needs.
| Product | Key Ingredients | Price | Key Benefit | User Reviews | Unique Feature |
| AfterDrink | Dihydromyricetin (DHM), milk thistle, ginger root extract, prickly pear extract, Korean ginseng, electrolytes, vitamin complex | $35 | May reduce hangover severity and support alcohol metabolism | Highly positive | Several active ingredients that may support liver health and recovery |
| Myrkl | Vitamin B12, probiotics, L-cysteine | $34.50 | Claims to break down alcohol in the gut before it enters the bloodstream | Mixed | Probiotic-based formulation |
| Future Kind | B12 | $19.99 | May support natural energy; replenish cobalamin | Positive | Environment friendly |
| Flyby | Vitamins, minerals, DHM, milk thistle, and prickly pear | $31.47 | May help with nausea, hydration, and dry mouth | Positive | Addresses dry mouth |
| Waterboy | Vitamins, minerals, L-theanine, ginger root | $49.99 | Supports metabolic function, reduces nausea, and weakness | Positive | Combines electrolytes with other active ingredients |
| Bulletproof | Magnesium | $16.99 | May help with weakness and muscle aches | Mixed | Minimal ingredients |
Final verdict: is AfterDrink the hangover cure?
AfterDrink stands out as a well-formulated hangover supplement featuring ingredients like DHM, Milk Thistle, ginger root, and vitamins. These components have some potential benefits in supporting liver function, reducing alcohol-related inflammation, and restoring nutrients lost during alcohol consumption. However, conclusive scientific evidence is lacking.
The product may be best suited for occasional drinkers or those looking for a natural remedy to ease the symptoms of mild to moderate hangovers. Hence, while AfterDrink is not a "cure" for hangovers, it may offer a difference the morning after when appropriately used, particularly if paired with responsible drinking habits.
FAQ
When should I take Afterdrink?
The brand recommends taking 3 pills before drinking alcohol and 3 pills after finishing drinking.
Does Afterdrink have DHM?
Yes, AfterDrink contains 520 mg of DHM.
Are hangover pills healthy?
Hangover pills, like AfterDrink, typically contain ingredients such as vitamins, minerals, and herbal extracts. While they are generally safe when used correctly, it’s essential to consult a healthcare professional, especially if you have underlying health conditions or are taking other medications. They also do not replace responsible and moderate drinking habits.
What is best to remove hangover?
The best way to reduce hangovers includes hydration, rest, and replenishing lost electrolytes and nutrients. Try to avoid giving in to food cravings and eat simple yet balanced meals or prep something the night before if you know you will be too lazy to cook. Soups like Phở may be a good choice.
8 resources
- The Journal of neuroscience : the official journal of the Society for Neuroscience. Dihydromyricetin as a novel anti-alcohol intoxication medication.
- ClinicalTrials.gov. Phase I, dose-escalation study of dihydromyricetin (DHM) to treat alcohol-associated liver disease.
- Psychotherapy Research. Milk thistle (Silybum marianum): a concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
- Indian journal of experimental biology. Protective effect of ginger against alcohol-induced renal damage and antioxidant enzymes in male albino rats.
- Journal of natural medicine. Clinical effectiveness of KSS formula, a traditional folk remedy for alcohol hangover symptoms.
- Arch Intern Med. Effect of opuntia ficus indica on symptoms of the alcohol hangover.
- Food & Function. Red ginseng relieves the effects of alcohol consumption and hangover symptoms in healthy men: a randomized crossover study.
- Frontiers in nutrition. L-Theanine: a unique functional amino acid in tea (Camellia sinensis L.) with multiple health benefits and food applications.
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