With the whirlwind and hustles of everyday life, many may feel a sudden mist in their minds, struggling to focus on tasks or forgetting things more often. However, gaining clarity within the cognitive forest may be possible with Alpha GPC — a nootropic especially targeted to support memory, attention, and overall brain health.
To explore its potential to boost mental and physical performance, we have delved into some of the best alpha GPC supplements on the market and selected those products that strive for a perfect balance between quality and affordability.
Best alpha GPC supplement: shortlist
- Natural Stacks — best alpha GPC supplement with added ingredients
- Momentous — best vegan alpha GPC supplement
- BulkSupplements.com — best affordable alpha GPC supplement
- Double Wood — best alpha GPC nootropic for motivation
- Nutricost — best supplement alpha GPC with bottle options
How we ranked the best alpha GPC supplement?
There are several supplements on the market to support brain health, making it challenging to select the right one for your needs. Therefore, we have compiled some key criteria to determine, in our opinion, the best alpha GPC products for a wide range of customers.
|Manufacturing information and additional certification
|High-quality formulas backed up by science
|Independent laboratory testing
- Brand Transparency. We considered those alpha GPC best brands that disclose their manufacturing practices and formulas on their websites. As the FDA does not screen dietary supplements, it is essential to have access to all the product information before purchasing it.
- Formulas. Our selection considered those formulas that included Alpha GPC in doses similar to clinical studies to potentially enhance memory, cognition, and physical performance.
- Third-party testing. We selected those formulas that undergo third-party testing, ensuring that ingredients align with the label in terms of quantity and identity.
- Price. We strived for those products that deliver science-backed and high-quality formulas while maintaining competitive prices.
Best alpha GPC supplements: an overview
Selecting the right Alpha GPC product involves careful consideration. Each formula features unique ingredients to reap the potential properties of this compound, including support of memory, motivation, or physical performance.
In our selection of Alpha GPC, you may find the right match for your needs — with top-notch formulas designed to foster and support cognition and overall well-being.
1. Natural Stacks — best formula in an Alpha GPC supplement
Natural Stacks stands out in the nootropic market, delivering full ingredient traceability and remarkable quality for those looking for supplements that may assist memory and cognitive function
Acetylcholine Brain Food™ is designed to increase the production of choline. This essential nutrient plays a vital role in maintaining the structure and function of cells and supporting various physiological processes. Moreover, choline may increase the production of acetylcholine which is a key neurotransmitter that supports several brain functions including arousal, attention, memory, and motivation.
The brand recommends taking 3 capsules on days when higher mental speed is needed or as directed by the healthcare provider. Moreover, the supplier discourages exceeding 8 capsules per day and abstaining from consumption if the individual is pregnant, nursing, or taking medications.
It is available for $39.95 and includes a 30-day money-back guarantee.
2. Momentous — best alpha GPC supplement for vegans
Momentous Alpha GPC is a supplement designed to support cognitive function and build focus and clarity in those individuals seeking to protect and nurture long-term brain health.
Alpha GPC may enhance neuronal communication, promote neural tissue health, and aid overall brain function, which may be crucial for maintaining brain agility and wellness.
For this reason, Alpha GPC may be a good fit to support various mental concerns, including focus or memory, among others. Moreover, the brand emphasizes the safety of its supplements, even though individuals are encouraged to consult with their healthcare provider before taking the product.
The recommendation is one capsule per day, preferably in the mornings. Users are also advised to engage in a healthy lifestyle and use the supplement consistently to yield the best results.
It is available for $39.96 and includes a money-back guarantee policy.
3. BulkSupplements.com — best budget-friendly alpha GPC supplement
Bulk Supplement offers an affordable nootropic that may support cognition, motivation, and athletic performance. The supplement aligns with a wide range of customers delivering capsules free from gluten, additives, and allergens.
Alpha GPC Capsules combine 300 mg of alpha GPC with two added ingredients to potentially support well-being.
Boasting a current Good Manufacturing Practice (cGMP) certification, Bulk Supplements shines in brand transparency. The product is thoroughly inspected for quality and undergoes third-party testing to ensure the formula aligns with the label, delivering precise quantities and products free from undisclosed substances.
Bulk Supplement recommends two servings (600 mg) once or daily with water. Moreover, consumers are advised to consult with their healthcare provider before taking the product, especially in the case of pregnant, lactating women or those with existing medical conditions.
It is available for $19.96 and includes 90 servings.
4. Double Wood Supplements — best alpha GPC supplement for motivation
Double Wood, boasting 600 mg of alpha GPC per serving, is designed to support those with decreased motivation and problem-solving abilities.
In some research studies, supplementation with alpha GPC has been linked to improved physical and mental performance. The latter is linked to the release of acetylcholine, a key actor in facilitating learning and memory.
The brand provides a transparent and outstanding experience for its customers — boasting a GMP certification and COA (Certificate of Analysis). Furthermore, Double Wood Supplements is inclusive of various dietary preferences, making their pills free from soy and gluten.
The brand recommends taking 1–2 capsules daily or as a healthcare provider instructs. The brand claims possible side effects after consumption, including heartburn, insomnia, and dizziness.
It is available for $49.95 and includes 180 capsules and a 100-day-back guarantee.
5. Nutricost — best supplement alpha GPC with bottle size options
For those looking for an alpha GPC supplement to support focus and clarity, Alpha GPC Capsules may be the right match. The supplement delivers 600 mg of Alpha GPC with two bottle options so that you can choose the most suitable one for your needs.
When ingested orally, alpha GPC is metabolized into choline — a key nutrient to support normal body function. Choline should be incorporated with a good diet, however, supplementation with alpha GPC may also be a good option to enhance choline levels and foster overall well-being.
The supplement is third-party tested, gluten-free, and non-GMO. Furthermore, it is made in a GMP-compliant facility under FDA guidelines.
It is available for $19.95 and includes a 60-day money-back guarantee.
Comparison of the best alpha GPC supplement
|Price per serving
|Alpha GPC per serving
|Vitamin B1, pantethine, white peony extract, and acetyl-L-carnitinine
|Calcium and phosporus
|Double Wood Supplements
Explaining alpha GPC and its working mechanism
Alpha GPC is a naturally occurring choline compound found in breast milk and is also present in the brain tissue as a product of phospholipid (lecithin) metabolism. Alpha GPC is also present in certain meat products and organ meats. However, most supplements that contain this compound are made semi-synthetically, usually from egg or soy lecithin.
Alpha GPC benefits lie in its potential to increase choline levels, an essential nutrient that plays a role in various physiological functions in the body. This nutrient is so crucial that its deficiency is linked to liver problems, tissue damage, and an impact on brain structure and function. Moreover, choline levels may also boost the release of acetylcholine, a neurotransmitter that helps the nerve cells communicate better — potentially facilitating memory, learning, and overall cognitive function.
What is alpha GPC used for?
Alpha GPC is associated with a plethora of potential benefits due to its capacity to increase choline levels in the body. While most brands market their formulas towards focus and brain agility, choline is also linked with physical performance or motivation.
Alpha GPC is metabolized into choline, which is suggested to act as a precursor of acetylcholine, a neurotransmitter crucial to promoting healthy cognition and brain function. Acetylcholine may enhance communication between nerve cells and between neurons, as well as support the brain’s ability to store and recall information. Moreover, some initial evidence points out its benefits for some individuals facing problems in orientation, memory, and language.
In some clinical research, alpha GPC supplementation has been linked to an increase in physical performance in athletes. Some evidence suggests that supplementation with this compound may prevent exercise-induced reductions in choline levels and potentially increase endurance and growth hormone blood levels.
Furthermore, the link between alpha GPC and athletic performance is reported by a multiple studies — reaching a consensus on its positive outcome on strength, power, velocity, and reduction of fatigue.
A study from the journal Nutrients in 2021 investigated the link of alpha GPC supplementation with feelings and emotions, including motivation, reward processing, anxiety, and depression. While evidence surrounding anxiety and depression was inconclusive, individuals showed an increase in motivation after taking the supplement, especially at night. However, the study is very limited and suggests that further research is needed to explore the mechanisms behind this finding.
Considerations before taking alpha GPC supplements
Even though the FDA generally considers a daily intake of 196.2 mg of alpha GPC as safe, there are some considerations to ponder before consuming the product:
Alpha GPC is often sourced from soy or egg lecithin, therefore, individuals with soy or egg allergies should carefully read the product label and, in case of allergen, withhold from consumption. In any case, it is always advisable to explore the ingredient list of supplements to determine if the product aligns with your nutritional needs.
This supplement is reported to interact with scopolamine — a drug especially engineered to reduce cholinergic transmission. In any case, consulting with your healthcare provider is best to avoid interactions and select the best dosage for you.
Risk of stroke
According to a cohort study from 2021 with 12 million men and women aged 50, with no underlying stroke, cardiovascular disease, or Alzheimer's, alpha GPC was linked with a higher 10-year incident risk of stroke (in a dose-dependent manner). For this reason, the consumption of this supplement should be considered carefully and with the help of a doctor.
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Can I take alpha GPC every day?
Yes. The FDA determined that 196.2 mg per day is generally recognized as safe (GRAS). However, there is limited evidence on the use of Alpha GPC supplements and it is essential to consult with your doctor on the right dosage for you.
Is alpha GPC simply choline?
No. Alpha GPC is a pro-drug of choline, meaning that only after consumption alpha GPC is metabolized into choline.
Can you overdose alpha GPC?
Alpha GPC is no different than other supplements, meaning that it is important to adhere to recommended dosages of consumption. Taking excessively high doses of alpha GPC or any substance can lead to adverse effects and potentially be harmful.
- Nutrition. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults.
- Journal of the International Society of Sports Nutrition. The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength.
- The American Journal of Clinical Nutrition. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
- Nutrition Reviews. Choline: an essential nutrient for public health.
- Nutrients. Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study.