Alpha lipoic acid (ALA) is an organic compound that has been gaining attention in the health and wellness space. Our bodies produce it naturally, but it is also found in various foods like meat and potatoes and available as a dietary supplement.
In past and recent years, ALA has been studied for its potential health benefits, including its role in diabetic neuropathy and skin health.
This article will provide our top 5 selections for the best alpha lipoic acid supplements in 2024. These choices are the result of extensive research based on the quality of ingredients, brand reputation, scientific support, and price. We will discuss the definition of ALA and its potential health benefits and offer practical tips on incorporating it into your daily routine.
Best alpha lipoic acid supplements: a shortlist
Choosing the right supplement can be challenging, given the number of options on the market. To make this easier for you, we have curated our own list of the best alpha lipoic acid supplements in 2024.
- GNC — best alpha-lipoic acid supplement for energy metabolism
- Nature's Craft — best affordable alpha-lipoic acid supplement
- Nutricost — best alpha-lipoic acid supplement for neuropathy
- Bulk Supplements — best sugar-free alpha-lipoic acid supplement
- Thrivous — best alpha-lipoic acid supplement for nerve pain
How we compiled the list of the best alpha lipoic acid supplements?
We considered the following criteria to select the best alpha lipoic acid supplements in 2024.
|High quality ingredients with no harmful fillers or additives
|Brand values and customer reviews
|Backed by science
|Use of ingredients with supporting scientific evidence
- Ingredient. We prioritized supplements that contain high-quality, pure alpha lipoic acid without harmful fillers or additives.
- Provider reputation. We selected products from companies with a good track record of customer satisfaction and adherence to good manufacturing practices. We also considered customer reviews and ratings.
- Backed by science. Alpha lipoic acid has been studied for its antioxidant properties and potential health benefits. We looked for supplements containing ALA doses that align with those used in scientific studies.
- Price. We aimed to find products that offer good value for money.
Best alpha lipoic acid supplements: an overview
This section will provide a comprehensive guide to some of the best alpha lipoic acid supplements currently available. We have carefully evaluated each product based on the criteria mentioned earlier, including quality and price. Stay tuned as we delve into the specifics of each product, encompassing aspects like features, key ingredients, dosage, safety, directions for use, and price.
GNC — best alpha-lipoic acid to support energy metabolism
The GNC alpha-Lipoic Acid supplement is formulated to support cell energy metabolism and the regeneration of antioxidants like glutathione in the body.
Each serving contains 600 mg of alpha-lipoic acid, and it comes in a caplet form with no added artificial flavors.
GNC adheres to the USP (United States Pharmacopeia) specifications for caplet weight and disintegration, ensuring that each supplement is produced with consistency and meets the quality standards.
The provider recommends taking one caplet daily. There are 60 servings per container, and each container is priced at $29.99 for a one-time purchase. Every order comes with a 30-day money-back guarantee.
Nature's Craft — best budget-friendly alpha-lipoic acid supplement
Nature’s Craft Alpha Lipoic Acid supplement contains two key ingredients that may support energy production: alpha-lipoic acid and acetyl L-carnitine.
Each serving contains 450 mg of alpha-lipoic acid and 1050 mg of acetyl L-carnitine. This supplement is formulated in GMP-certified facilities in the United States and is reported to have no harmful fillers.
It's recommended that a user takes two capsules daily of Nature's Craft product, preferably with meals. The price for a bottle of 30 servings is $14.55, making it an affordable option for those looking to incorporate it into their routine. The provider offers a 100% risk-free money-back guarantee.
Nutricost — best alpha-lipoic acid for neuropathy
The Nutricost Alpha Lipoic Acid is designed to provide 600 mg of alpha-lipoic acid per serving. The single active ingredient - alpha-lipoid acid - is reported to have antioxidant properties and may help in the management of oxidative stress, potentially protecting tissues from cellular damage.
The supplement contains 300 mg of alpha-lipoic acid in each capsule, and the provider recommends taking two capsules at once or one capsule in the morning and one in the evening, according to your preference. It comes in two size bottles: one with 240 capsules (120 servings) and another with 120 capsules (60 servings).
Quality and safety are ensured through 3rd party testing by ISO-accredited laboratories. The product is made in a facility that complies with Good Manufacturing Practices (GMP). It is suitable for vegetarians, free from genetically modified organisms (GMOs), and does not contain soy or gluten.
A one-time purchase of a bottle containing 120 capsules costs $27.95. The provider offers a 60-day money back guarantee which underscores the provider’s confidence in their product and their commitment to customer satisfaction.
Bulk Supplements — best alpha-lipoic acid supplement with no added sugar
The Bulk Supplements Alpha Lipoic Acid provides 600 mg of alpha-lipoic acid per serving. It comes in capsule form, and each bottle contains 240 capsules (120 servings).
Bulk Supplements have high manufacturing and testing standards. The supplement is produced in an ISO 17025-accredited lab, ensuring that it meets international standards for testing and calibration. Furthermore, it is manufactured according to current Good Manufacturing Practices (cGMP) standards, which contributes to its manufacturing quality and safety. Also, the product is third-party tested.
The provider recommends a daily consumption of two capsules at once. The product is gluten-free and contains no added sugar.
The price for a one-time purchase of this supplement is $21.96, which offers value for the quality and safety assurances that come with this product.
Thrivous — best alpha-lipoic acid for nerve pain
Thrivous Alpha Neuroprotector is a supplement packed with ingredients that offer potential brain and nerve health benefits.
The supplement provides 150 mg of R-alpha lipoic acid, an antioxidant that may aid in lowering blood sugar levels and improving nerve function. It also includes 300 mg of alpha glycerylphosphorylcholine (alpha GPC), which has been reported to improve cognitive function in animal studies.
In addition, the supplement contains 500 mg of acetyl L-carnitine, known for transporting fatty acids into cells to be burned for energy, potentially aiding energy production in the brain.
It also contains 100 mg of phosphatidylserine, a fatty substance that helps transmit messages in the brain to help cognitive function. Lastly, it includes 90 mg of Ginkgo Biloba, which is rich in antioxidants and may help support brain function.
The product is thoroughly tested for quality and composition, adhering to FDA regulations, and manufactured in certified U.S. facilities.
The provider recommends taking four capsules daily with meals. Priced at $51.90 for a one-time purchase of a bottle containing 30 servings, this supplement offers value for its quality.
Comparing the best alpha lipoic acid supplements
This table shows a brief comparison of the main features of the best alpha-lipoic acid supplements.
|Price per serving
|Servings per container
|ALA dose per serving
|Additional key ingredients
|Acetyl L-carnitine, alpha GPC, Ginkgo Biloba, phosphatidylserine
* — prices vary depending on the product's serving size
What is alpha lipoic acid, and why is it important?
Alpha lipoic acid (ALA) is an organic compound that is naturally produced in the body and also found in various natural food sources like red meat, organ meats like liver, and vegetables like spinach, broccoli, and tomatoes. It is made inside the mitochondria, where it helps enzymes turn nutrients into energy.
ALA is water- and fat-soluble, allowing it to enter and work in every cell or tissue in the body. It is an antioxidant, meaning it helps neutralize free radicals that may damage cells at the genetic level.
The first clinical application of ALA occurred in 1959 when German scientists used it to treat acute poisoning caused by death-cap mushrooms. Since then, it has been considered as a potential aid in diabetic nerve pain and oxidative stress-associated conditions such as ischemia-reperfusion or radiation injury.
However, there is still a need for more research studies on ALA’s benefits in other conditions.
Health benefits of alpha lipoic acid
The antioxidant properties of alpha lipoic acid have been the subject of many scientific studies for years. This section delves into the health benefits of ALA, exploring its role in nerve health, blood sugar regulation, and skin health.
Role in supporting nerve health
High blood sugar levels may lead to an overproduction of reactive oxygen species and other free radicals in our body's cells, causing oxidative stress, which can cause harm to the cells lining our blood vessels and nerves. Alpha lipoic acid may support the nervous system by potentially preventing nerve damage from the harmful free radicals.
It is also said to improve nerve blood flow and nerve conduction of sensory and motor signals.
In a comprehensive analysis of various studies conducted in 2024, researchers found that using ALA for diabetic polyneuropathy provided relief for sensory symptoms. However, it did not show significant effects on muscle strength, vibration perception, and nerve conduction.
Potential healthy blood sugar levels support
Several studies over the past years have demonstrated that ALA may increase glucose (blood sugar) uptake. Specifically, a study by Eason and others found that when the muscles of ob/ob mice, which are typically used as animal models for insulin resistance and obesity, were treated with ALA, glucose absorption saw a significant increase.
It is thought that one of the ways ALA may help regulate blood sugar is by stimulating an enzyme known as AMPK (AMP-activated protein kinase), which aids in the conversion of glucose into energy, thereby potentially helping to manage high blood sugar levels.
This suggests that ALA may be beneficial and a potential candidate for supplements to lower blood sugar.
Potential skin health support
Alpha lipoic acid has also shown promise in helping the skin. Its high antioxidant content is proposed to have benefits for skin health.
One of its suggested benefits for skin is the potential to lighten dark spots. In 2019, a study conducted on guinea pigs investigated the impact of applying alpha lipoic acid (ALA) to the skin using a novel nanocapsule method. The findings revealed that when ALA was applied in this manner, it reduced pigmentation resulting from UV exposure.
However, limited research is available on the skin benefits of alpha lipoic acid, and more studies are needed for further investigation.
Incorporating alpha lipoic acid supplements into your routine
In this section, we will provide you with practical tips and important points to consider before incorporating alpha lipoic acid supplements into your routine. We’ll also discuss the possibility of interactions with other medications or supplements you may be taking.
Timing and dosage of alpha lipoic acid supplements
The timing and dosage of ALA supplements can vary depending on individual health goals and needs.
Most manufacturers suggest taking an oral capsule of 300 mg or 600 mg of ALA once daily for up to 6 months. However, it is always best to follow the supplement packaging instructions or consult a healthcare provider for personalized advice.
Ways to incorporate ALA into your daily routine
Incorporating ALA into your daily routine can be as simple as taking a supplement once a day with your meal. However, you can also boost your ALA intake naturally by including foods rich in ALA into your diet. These foods include spinach, broccoli, red meat, and organ meats.
Remember, consistency is key when it comes to benefiting from any supplement. You could also consider setting a reminder on your phone or marking it on your calendar to ensure you don’t forget to take your supplement.
While ALA is generally safe, it is important to be aware of potential interactions with other supplements or medications.
For instance, ALA may lower blood sugar levels, so if you’re taking other supplements with similar effects, like bitter melon and aloe supplements, or you're on blood-sugar-lowering medication, it could lead to excessively low blood sugar. ALA might also slow blood clotting, so it is vital to be cautious if you take other supplements or medications with the same effect, such as those containing ginger.
Always consult a healthcare provider before starting any new supplement regimen to ensure safe integration into your wellness routine.
Best alpha lipoic acid supplements – conclusion
In conclusion, alpha lipoic acid is an antioxidant with potential health benefits, including supporting nerve health, regulating blood sugar levels, and promoting skin health.
Incorporating it into your daily routine may be simple and beneficial, whether through diet or supplements. However, as with any supplement, it is crucial to consult a healthcare provider to ensure safe use.
We hope that our top 5 picks for the best ALA supplements of 2024, backed by extensive research, will guide you in making an informed decision.
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What form of alpha-lipoic acid is best?
R-alpha lipoic acid is the natural form, while S-alpha lipoic acid is the synthetic form. Research suggests R-ALA may be more biologically active, but both forms may offer antioxidant benefits. Choose a high-quality supplement from reputable brands and consider consulting a healthcare professional for personalized advice.
What supplements should not be taken with alpha-lipoic acid?
Alpha-lipoic acid has the potential to lower blood sugar levels. Hence why, caution is advised when it is taken alongside other supplements with similar effects. These include bitter melon, aloe, cassia cinnamon, and chromium supplements. However, the effect can vary depending on the individual and other factors like dosage.
Do doctors recommend alpha-lipoic acid?
Yes. Many doctors recognize the potential benefits of alpha-lipoic acid, especially for conditions like diabetic neuropathy. However, recommendations vary based on individual health needs. Before incorporating it into your routine, consult a healthcare professional to discuss your medical history, current medications, and potential interactions.
- BMC. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases.
- NIH. Alpha-Lipoic Acid.
- NIH. Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes?
- NIH. Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy.
- NIH. Lipoic acid increases glucose uptake by skeletal muscles of obese-diabetic ob/ob mice.
- NIH. Novel nanocapsule of α-lipoic acid reveals pigmentation improvement: α-Lipoic acid stimulates the proliferation and differentiation of keratinocyte in murine skin by topical application.
- NIH. Effects of Oral Alpha-Lipoic Acid Treatment on Diabetic Polyneuropathy: A Meta-Analysis and Systematic Review.