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Best Apigenin Supplements of 2024: Top Picks for Health and Longevity

Even though the secret to slowing down aging and preserving optimal health has long been the subject of debate, the topic of longevity has recently become particularly popular. As new research is coming out, apigenin, a dietary flavonoid, has emerged as the newest center of focus, drawing significant interest.

Associated with antioxidant and anti-inflammatory properties, apigenin has even been investigated for its potential role in cancer prevention. And while research on apigenin supplementation is still in its early stages, the potential health benefits do look enticing.

Without further delay, let us delve into all the intricacies surrounding apigenin and present a selection of the best apigenin supplements based on our research.

Best apigenin supplement: shortlist

  1. Vitruvin — the best apigenin supplement overall
  2. ProHealth — best apigenin supplement for those over the age of 40
  3. Momentous — expert-verified apigenin supplement
  4. Double Wood — great apigenin supplement for those starting out
  5. Vitality Pro — best natural apigenin supplement
  6. Codeage — best liposomal apigenin supplement
  7. Life Extension — best apigenin supplement to take weekly
  8. Do Not Age — most potent single-ingredient apigenin supplement
  9. Natural Stacks — good apigenin supplement for sleep support
  10. Nootropics Depot — apigenin supplement that comes in different options

How have we compiled the list of best apigenin supplements?

Our list of the best apigenin supplements was put together taking into account specific criteria. This encompassed factors such as the supplement's formulation, the brand's standing, price point, and input from customers.

FormulationPresence of additional compounds
Brand reputationLevel of transparency
PriceVarying price points
ReviewsPatterns in customer feedback
  • Formulation. While the majority of apigenin supplements on the market consist solely of apigenin, some also combine it with other bioactive compounds for synergistic effects. We made sure to consider both.
  • Brand reputation. With reputable brands often having a history of manufacturing quality supplements, we prioritized those that shed light on their manufacturing, testing, and or research practices.
  • Price. When putting together our list, we made an effort to include brands offering their apigenin supplements at various price points, allowing you to choose one that aligns with your budget.
  • Reviews. We looked for patterns in customer feedback, focusing specifically on users who have actually purchased and used the product. This approach allowed us to get a better grasp of individual experiences.

Best apigenin supplement of 2024: product reviews

With apigenin continuing to garner attention for its potential health benefits, let's now hone in on a handful of apigenin supplements that have emerged as standout choices based on our research findings.

1. Vitruvin — the best apigenin supplement overall

Vitruvin Apigenin

Combining what we consider essential for creating a promising supplement, from the non-GMO, vegan, and gluten-free profile to third-party testing and manufacturing according to Good Manufacturing Practices (GMPs), Vitruvin Apigenin is our top choice when it comes to the best apigenin supplements.

Designed to deliver all the benefits of apigenin, Vitruvin’s product is advertised to help reduce stress, promote better sleep, and induce a deep state of relaxation.

According to the brand, Vitruvin supplements are created using only the highest quality ingredients sourced globally.

And while the ingredients come from around the world, the supplement itself is manufactured in the United States. The brand holds FDA approval and GMP certification as a testament to its commitment to quality assurance.

For optimal effects, stick to the manufacturer's directions and take 2 capsules each day.

The Vitruvin Apigenin is available for purchase at the price of $31. There are also subscription options, including monthly, 6-month, or yearly plans, all of which provide convenience and attractive savings for extended use.

2. ProHealth — best apigenin supplement for those over the age of 40

ProHealth Full Spectrum Apigenin Plus

With a combination of natural apigenin, organic parsley powder, and piperine, ProHealth’s Full Spectrum Apigenin Plus supplement is a tad bit different than the majority of apigenin products on the market. As assured by the makers, this formulation not only enhances the absorption of apigenin but also should provide greater benefits for those over the age of 40.

While some apigenin products on the market often contain an isolated form of apigenin, in this ProHealth product, you will find full-spectrum apigenin — meaning a full range of flavonoids were used.

The brand manufactures its entire product line, including its apigenin offering, in an FDA-registered and GMP-certified facility. Additionally, every batch undergoes third-party testing in US laboratories, and COAs are present and available.

The manufacturer recommends taking 2 capsules daily with food. It is preferable to take them with a healthy, fat-containing meal, or otherwise, as advised by your healthcare professional.

A 60-capsule bottle of Full Spectrum Apigenin Plus, good to last for a month, is priced at $45.74

3. Momentous — expert-verified apigenin supplement

Momentous Apigenin

Apigenin from Momentous is another product on our list that appears to meet all the criteria for a reliable product. This supplement is both GMO and gluten-free, and it has received approval from the brand's board of partner experts. Notably, Dr. Andrew Huberman, who has a strong appreciation for apigenin's potential in improving sleep, is among these experts.

As noted by its makers, the brand prides itself on bringing the very best supplements to the markets. This, they say, is achieved by using the highest quality ingredients and subjecting every single product to independent third-party testing.

Notably, Momentous works with both NSF and Informed Sport, a global testing and supplement certification program, to independently certify the quality of its products.

The brand recommends taking 1 capsule 30 to 60 minutes prior to bedtime. Emphasizing the importance of consistent use, they point out that some individuals may experience benefits within the first couple of days, while others may take a few weeks.

This apigenin supplement is currently available for $19.95 as a one-time purchase. If you're seeking a regular supply, consider exploring the brand’s subscription options for added convenience.

4. Double Wood — great apigenin supplement for those starting out

Double Wood Apigenin

For those on a budget but keen on reaping the benefits of apigenin, Double Wood Apigenin looks to be a go-to choice. Its soy and gluten-free, vegan profile, combined with non-GMO ingredients, positions it as a budget-friendly supplement for those mindful of their financial constraints.

To help you understand everything about its supplement, including a detailed breakdown of ingredients, potency levels, and safety measures, the brand makes the Certificate of Analysis (COA) available for viewing on its website.

While designed to support both sleep quality and reduce stress, the manufacturer specifies two ways to take the supplement for these purposes. They recommend taking it right before bedtime for improved sleep. As for reducing stress and anxiety levels, it is recommended to take the supplement in the morning with breakfast.

You can secure this apigenin supplement for $24.95 when opting for a one-time purchase. For those looking to save even more, consider taking advantage of Double Wood's 'buy more, save more' initiative. Buying in packs can grant you appealing savings.

5. Vitality Pro — best natural apigenin supplement

Vitality Pro Apigenin

If you're someone who wants to avoid everything artificial, the Vitality Pro Apigenin supplement might be the one for you.

Labeled as a 'healthy aging support' in dietary supplement form, this product claims to be free from GMOs, artificial colors, preservatives, flavors, and allergens. On top of it all, it contains apigenin of natural origin — derived from grapefruit peel.

See, quality is paramount at Vitality Pro. This is particularly evident in the brand’s adherence to GMP standards throughout the manufacturing process and third-party testing of its entire product line.

In line with recommendations from some of the other brands on our list, the makers of Vitality Pro Apigenin suggest taking 1 to 3 capsules of their supplement for sleep support right before bedtime. For other benefits, they advise taking 2 to 4 capsules throughout the day.

A bottle, mind you, 100% biodegradable, is currently priced at $32 for a one-time purchase. You can acquire yours from the brand's official website.

6. Codeage — best liposomal apigenin supplement

GNC CODEAGE Liposomal Apigenin

Codeage's Liposomal Apigenin is the only product on our list that utilizes the liposomal delivery method. This, in simple terms, means that the apigenin is intended to be delivered more efficiently to the target sites.

In addition to its liposomal formulation, this Codeage apigenin product is cGMP-certified, vegan-friendly, and free from GMOs.

The maker suggests a daily intake of 1 capsule, to be taken with water or your preferred drink. Whether you have it with or without food is your choice.

A bottle of Liposomal Apigenin, which contains 90 capsules, is available for purchase at the price of $29.99 on the official GNC website. You can easily access it through the link below.

Shipping of this product is restricted to specific countries, with the exception of the United States, make sure to check if your country is not included.

7. Life Extension — best apigenin supplement to take weekly

Life Extension Senolytic Activator®

If you've been looking to support your cellular health without the need for daily supplementation, Senolytic Activator from Life Extension could be the solution you've been seeking.

This dietary supplement combines black tea theaflavins, plant-derived apigenin, fisetin, and a patented, more absorbable form of quercetin, as claimed by the brand. These ingredients are suggested to help manage senescent cell burden, promote healthy cellular function, and support systemic rejuvenation.

Now what sets this product apart from the rest of the apigenin supplements on our lineup is its dosing schedule. Unlike many supplements that require daily intake, Senolytic Activator only needs to be taken once a week — just three capsules. This is a huge benefit for those with busy schedules or who simply prefer a more hands-off approach to supplementation.

Each bottle of Senolytic Activator contains 36 vegetarian-friendly capsules, good for a three-month supply if you follow the recommended once-a-week dosing. This not only makes it a cost-effective choice but also ensures you are stocked up for a substantial period. At a current price of $19.50 per bottle, it looks to be a great value pick for the quality and quantity provided.

8. Do Not Age — most potent single-ingredient apigenin supplement

Do Not Age’s Pure Apigenin, unlike many apigenin products on the market, is formulated with beta glycosides, these are suggested to promote stability of the apigenin, as claimed by the makers.

Among the supplements listed in our article, this particular one contains a potent dose of 250 mg of apigenin in each capsule. This adds up to a total of 500 mg per day, considering the recommended dose of 2 capsules daily.

All Do Not Age products are produced to GMP and ISO9001 standards, with the latter being a globally recognized benchmark for quality.

The 60-capsule version of Pure Apigenin is priced at $51.50 for a one-time purchase. For those looking to stock up, there is also an option with 366 capsules. Opting for this option can get you serious savings compared to buying every month.

9. Natural Stacks — good apigenin supplement for sleep support

Marketed as an advanced sleep support by its creators, Apigenin+ by Natural Stacks contains not only apigenin sourced from Citrus paradisi but also two additional ingredients for synergistic effects — lemon balm and passion flower, both of which are plant-based and natural.

Adding credibility to the sleep support claim is lemon balm — an ingredient known for its anti-stress and calming effects.

What's particularly intriguing about Natural Stacks is their 'Open Source' transparency program, which offers ingredient traceability and third-party lab test results for every batch the brand produces, including Apigenin+.

In line with the brand’s instructions, taking 2 capsules per day is the recommended approach.

Manufactured and packaged in FDA-registered facilities, this supplement is currently available for the price of $23.96 as a one-time purchase.

10. Nootropics Depot — apigenin supplement that comes in different options

Concluding our overview of the best apigenin supplements is the offering from Nootropics Depot — an option that, more than others on this list, caters to those seeking specific dosage options.

Apigenin Capsules, labeled to contain a minimum of 98% of apigenin, are available in multiple options. These include an option of 200 mg of apigenin per serving, available in either a 30-capsule or 120-capsule bottle, and an alternative of 50 mg of apigenin, which comes in either a 60-capsule or 180-capsule bottle.

In addition to being tested and verified in an ISO-certified lab, Nootropics Depot's Apigenin supplement is manufactured in accordance with current GMPs.

To obtain your preferred bottle, simply visit Nootropic Depot's official website. Prices start at $17.99 for the 60-capsule option, which contains 50 mg of apigenin.

Comparison of the best apigenin supplements

BrandPrice per containerPrice per servingTotal servingsServing sizeAmount of apigenin per servingAdditional active ingredients
Vitruvin$31.00$0.51602 capsules50 mgNone
ProHealth$45.74$1.52302 capsules500 mgOrganic parsley powder, piperine
Momentous$19.95$0.33601 capsule50 mgNone
Double Wood$24.95$0.201201 capsule50 mgNone
Vitality Pro$32.00$0.35901 capsule100 mgNone
$29.99$0.33901 capsule50 mgNone
Life Extension$19.50$1.62123 capsules50 mgBlack tea theaflavins, fisetin, and quercetin
Do Not Age$51.50$1.71302 capsules500 mgNone
Natural Stacks$29.95$0.49602 capsules50 mgLemon balm powder, passion flower extract
Nootropics Depot$17.99*$0.29601 capsule50 mgNone

* — prices vary depending on serving totals and apigenin strength.

Apigenin benefits and side effects

Apigenin is a natural compound belonging to the flavonoid class, commonly found in ​​parsley, chamomile, celery, vine spinach, artichokes, and oregano. Known for its antioxidant and anti-inflammatory properties, apigenin has recently gained popularity due to its potential health benefits. However, when discussing benefits in a general context, one must also consider the potential for associated side effects. We expand upon this in the following sections.

Apigenin benefits

Apigenin is linked to various health benefits, including:

  • Antioxidant action. Apigenin's potent antioxidant properties can help neutralize harmful free radicals in the body — these are molecules that can damage cells and contribute to aging.
  • Anti-inflammatory effects. It is thought to demonstrate anti-inflammatory properties. This potentially can help reduce inflammation in the body.
  • Potential anti-cancer activity. Apigenin has been researched for its potential role in cancer prevention. Some studies have shown that it may inhibit the growth of cancer cells and induce cell death in certain types of cancer.
  • Calming properties. It may have anxiety-reducing and sedative effects. This could potentially contribute to its use in promoting relaxation, including better sleep.
Safety note
It's important to note that while there is promising research on the potential health benefits of apigenin, more studies are needed to fully understand its mechanisms and effectiveness.

Apigenin side effects

Though generally deemed safe, apigenin is not without its potential side effects:

  • Gastrointestinal discomfort. High doses of apigenin may cause gastrointestinal discomfort. This can manifest as symptoms like nausea, upset stomach, or diarrhea.
  • Allergic reactions. Some people may be allergic to apigenin. Reactions can include symptoms such as itching, rash, and swelling. Mind you, in rare cases.
  • Drug interactions. Chance for interactions with certain medications. This necessitates caution, especially for those on blood-thinning medications.
  • Effect on the endocrine system. Apigenin may have estrogenic effects, which could potentially impact hormonal balance.

How to pick the right apigenin supplement for your health needs

When it comes to picking the right apigenin supplement that aligns with your health needs and preferences, several factors need consideration. So, before you make your decision, take a moment to review the tips we have provided below to help you make an informed choice.

  • Third-party testing. Prioritize those apigenin supplements that have undergone third-party testing. This is an indication that the labeling is accurate.
  • Ingredients. Look for supplements that clearly list apigenin as a primary ingredient. Check the apigenin amounts in a serving size to make certain it aligns with your preferences.
  • Transparency in labeling. Brands that prioritize transparency ensure that their product labels provide clear information about apigenin content, serving size, and any additional ingredients. Opt for such products.
  • Allergen information. If you are someone who has allergies or dietary restrictions, be sure to verify whether the supplement contains any allergens or ingredients linked to food sensitivities.

What the research says: the science behind apigenin

Few human clinical studies specifically focus on the effects of apigenin as a single compound. This scarcity may be attributed to the fact that apigenin is rather unstable when isolated. Besides, it has low bioavailability; only around 30% of the administered dose is typically absorbed into the systemic circulation. Therefore, much of our understanding of apigenin's clinical effects in humans is derived from studies involving the plants or foods from which it originates.

At this moment, when it comes to the effects often associated with apigenin, there is some evidence for the following:

  • Antioxidant
  • Anti-inflammatory
  • Multiple studies have reported that apigenin possesses anticancer properties
  • Therapeutic potential of apigenin in the context of certain conditions

The best time to take apigenin

As of today, there are no research studies that suggest that taking apigenin at any specific time of day, with or without food, can have particular benefits or drawbacks.

However, one thing to keep in mind is that while apigenin does not have muscle relaxant or sedative effects at conventional doses, those being 3 to 10 milligrams per kilogram of body weight, sedation was observed at doses 3 and 10 times higher — 30 to 100 milligrams per kilogram of body weight.

Therefore, higher doses of apigenin must not be taken before participating in any activities requiring awareness and diligence, for example, operating a vehicle or working in construction.

Additionally, for supplements, it is always recommended to follow the manufacturer's guidelines and discuss appropriate timing with a healthcare provider.

Best apigenin supplement: conclusion

Yes, apigenin supplements are currently being sought after for their potential health benefits, including antioxidant properties, anti-inflammatory effects, and a role in promoting relaxation. But while the early research is promising, optimal dosages and long-term safety have not yet been firmly established. Given this, those considering apigenin supplementation should approach it with reasonable caution, especially if they have existing health conditions or take medications.

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