Even though the secret to slowing down aging and preserving optimal health has long been the subject of debate, the topic of longevity has recently become particularly popular. As new research is coming out, apigenin, a dietary flavonoid, has emerged as the newest center of focus, drawing significant interest.
Associated with antioxidant and anti-inflammatory properties, apigenin has even been investigated for its potential role in cancer prevention. And while research on apigenin supplementation is still in its early stages, the potential health benefits do look enticing.
Without further delay, let us delve into all the intricacies surrounding apigenin and present a selection of the best apigenin supplements based on our research.
Best apigenin supplement: shortlist
- ProHealth — best apigenin supplement for those over the age of 40
- partiQlar — best apigenin supplement for inflammation relief
- Do Not Age — most potent single-ingredient apigenin supplement
- Vitruvin — best apigenin supplement to alleviate stress
- Momentous — expert-verified apigenin supplement
- Double Wood — great apigenin supplement for those starting out
- Vitality Pro — best natural apigenin supplement
- Codeage — best liposomal apigenin supplement
- Life Extension — best apigenin supplement to take weekly
- Natural Stacks — good apigenin supplement for sleep support
- Nootropics Depot — apigenin supplement that comes in different options
Comparison of the best apigenin supplements
| Brand | Price per container | Price per serving | Total servings | Serving size | Amount of apigenin per serving | Additional active ingredients |
| ProHealth | $45.74 | $1.52 | 30 | 2 capsules | 500 mg | Organic parsley powder, piperine |
| partiQlar | $29.99 | $0.49 | 60 | 2 capsules | 100 mg | None |
| Do Not Age | $51.50 | $1.71 | 30 | 2 capsules | 500 mg | None |
| Vitruvin | $31.00 | $0.51 | 60 | 2 capsules | 50 mg | None |
| Momentous | $19.95 | $0.33 | 60 | 1 capsule | 50 mg | None |
| Double Wood | $24.95 | $0.20 | 120 | 1 capsule | 50 mg | None |
| Vitality Pro | $32.00 | $0.35 | 90 | 1 capsule | 100 mg | None |
| Codeage | $29.99 | $0.33 | 90 | 1 capsule | 50 mg | None |
| Life Extension | $19.50 | $1.62 | 12 | 3 capsules | 50 mg | Black tea theaflavins, fisetin, and quercetin |
| Natural Stacks | $29.95 | $0.49 | 60 | 2 capsules | 50 mg | Lemon balm powder, passion flower extract |
| Nootropics Depot | $17.99* | $0.29 | 60 | 1 capsule | 50 mg | None |
* — prices vary depending on serving totals and apigenin strength.
Best apigenin supplement of 2024: product reviews
With apigenin continuing to garner attention for its potential health benefits, let's now hone in on a handful of apigenin supplements that have emerged as standout choices based on our research findings.
1. ProHealth — best apigenin supplement for those over the age of 40
With a combination of natural apigenin, organic parsley powder, and piperine, ProHealth’s Full Spectrum Apigenin Plus supplement is a tad bit different than the majority of apigenin products on the market. As assured by the makers, this formulation not only enhances the absorption of apigenin but also should provide greater benefits for those over the age of 40.
While some apigenin products on the market often contain an isolated form of apigenin, in this ProHealth product, you will find full-spectrum apigenin — meaning a full range of flavonoids were used.
The brand manufactures its entire product line, including its apigenin offering, in an FDA-registered and GMP-certified facility. Additionally, every batch undergoes third-party testing in US laboratories, and COAs are present and available.
The manufacturer recommends taking 2 capsules daily with food. It is preferable to take them with a healthy, fat-containing meal, or otherwise, as advised by your healthcare professional.
A 60-capsule bottle of Full Spectrum Apigenin Plus, good to last for a month, is priced at $45.74
2. partiQlar — best apigenin supplement for inflammation relief
Pure Apigenin from partiQlar is a dietary supplement that is advertised for its strong antioxidant and anti-inflammatory properties.
Made right here in the U.S., partiQlar’s Pure Apigenin is produced in FDA-registered and GMP-certified production facilities. This means it meets strict quality standards.
If you’re about transparency, you’ll be glad to know that this supplement, as the makers assure, goes through third-party testing for purity and label accuracy. You can also check out the quality reports on the brand's website, which is always a big plus.
Each bottle of Pure Apigenin packs 120 capsules, with each containing 50 mg of what is believed to be the longevity-promoting molecule. If taken as recommended, one bottle will last you two months.
At $29.99, we think this apigenin supplement by partiQlar is keenly priced, especially considering the manufacturing standards and thorough testing it is subjected to.
3. Do Not Age — most potent single-ingredient apigenin supplement
Do Not Age’s Pure Apigenin, unlike many apigenin products on the market, is formulated with beta glycosides, these are suggested to promote stability of the apigenin, as claimed by the makers.
Among the supplements listed in our article, this particular one contains a potent dose of 250 mg of apigenin in each capsule. This adds up to a total of 500 mg per day, considering the recommended dose of 2 capsules daily.
All Do Not Age products are produced to GMP and ISO9001 standards, with the latter being a globally recognized benchmark for quality.
The 60-capsule version of Pure Apigenin is priced at $51.50 for a one-time purchase. For those looking to stock up, there is also an option with 366 capsules. Opting for this option can get you serious savings compared to buying every month.
4. Vitruvin — best apigenin supplement to alleviate stress
Combining what we consider essential for creating a promising supplement, from the non-GMO, vegan, and gluten-free profile to third-party testing and manufacturing according to Good Manufacturing Practices (GMPs), Vitruvin Apigenin ranks high on our list of the best apigenin supplements.
Designed to deliver all the benefits of apigenin, Vitruvin’s product is advertised to help reduce stress, promote better sleep, and induce a deep state of relaxation.
According to the brand, its supplements are created using only the highest quality ingredients sourced globally.
And while the ingredients come from around the world, the supplement itself is manufactured in the United States. The brand holds FDA approval and GMP certification as a testament to its commitment to quality assurance.
For optimal effects, stick to the manufacturer's directions and take 2 capsules each day.
The Vitruvin Apigenin is available for purchase at the price of $31. There are also subscription options, including monthly, 6-month, or yearly plans, all of which provide convenience and attractive savings for extended use.
5. Momentous — expert-verified apigenin supplement
Apigenin from Momentous is another product on our list that appears to meet all the criteria for a reliable product. This supplement is both GMO and gluten-free, and it has received approval from the brand's board of partner experts. Notably, Dr. Andrew Huberman, who has a strong appreciation for apigenin's potential in improving sleep, is among these experts.
As noted by its makers, the brand prides itself on bringing the very best supplements to the markets. This, they say, is achieved by using the highest quality ingredients and subjecting every single product to independent third-party testing.
Notably, Momentous works with both NSF and Informed Sport, a global testing and supplement certification program, to independently certify the quality of its products.
The brand recommends taking 1 capsule 30 to 60 minutes prior to bedtime. Emphasizing the importance of consistent use, they point out that some individuals may experience benefits within the first couple of days, while others may take a few weeks.
This apigenin supplement is currently available for $19.95 as a one-time purchase. If you're seeking a regular supply, consider exploring the brand’s subscription options for added convenience.
6. Double Wood — great apigenin supplement for those starting out
For those on a budget but keen on reaping the benefits of apigenin, Double Wood Apigenin looks to be a go-to choice. Its soy and gluten-free, vegan profile, combined with non-GMO ingredients, positions it as a budget-friendly supplement for those mindful of their financial constraints.
To help you understand everything about its supplement, including a detailed breakdown of ingredients, potency levels, and safety measures, the brand makes the Certificate of Analysis (COA) available for viewing on its website.
While designed to support both sleep quality and reduce stress, the manufacturer specifies two ways to take the supplement for these purposes. They recommend taking it right before bedtime for improved sleep. As for reducing stress and anxiety levels, it is recommended to take the supplement in the morning with breakfast.
You can secure this apigenin supplement for $24.95 when opting for a one-time purchase. For those looking to save even more, consider taking advantage of Double Wood's 'buy more, save more' initiative. Buying in packs can grant you appealing savings.
7. Vitality Pro — best natural apigenin supplement
If you're someone who wants to avoid everything artificial, the Vitality Pro Apigenin supplement might be the one for you.
Labeled as a 'healthy aging support' in dietary supplement form, this product claims to be free from GMOs, artificial colors, preservatives, flavors, and allergens. On top of it all, it contains apigenin of natural origin — derived from grapefruit peel.
See, quality is paramount at Vitality Pro. This is particularly evident in the brand’s adherence to GMP standards throughout the manufacturing process and third-party testing of its entire product line.
In line with recommendations from some of the other brands on our list, the makers of Vitality Pro Apigenin suggest taking 1 to 3 capsules of their supplement for sleep support right before bedtime. For other benefits, they advise taking 2 to 4 capsules throughout the day.
A bottle, mind you, 100% biodegradable, is currently priced at $32 for a one-time purchase. You can acquire yours from the brand's official website.
8. Codeage — best liposomal apigenin supplement
Codeage's Liposomal Apigenin is the only product on our list that utilizes the liposomal delivery method. This, in simple terms, means that the apigenin is intended to be delivered more efficiently to the target sites.
In addition to its liposomal formulation, this Codeage apigenin product is cGMP-certified, vegan-friendly, and free from GMOs.
The maker suggests a daily intake of 1 capsule, to be taken with water or your preferred drink. Whether you have it with or without food is your choice.
A bottle of Liposomal Apigenin, which contains 90 capsules, is available for purchase at the price of $29.99 on the official GNC website. You can easily access it through the link below.
Shipping of this product is restricted to specific countries, with the exception of the United States, make sure to check if your country is not included.
9. Life Extension — best apigenin supplement to take weekly
If you've been looking to support your cellular health without the need for daily supplementation, Senolytic Activator from Life Extension could be the solution you've been seeking.
This dietary supplement combines black tea theaflavins, plant-derived apigenin, fisetin, and a patented, more absorbable form of quercetin, as claimed by the brand. These ingredients are suggested to help manage senescent cell burden, promote healthy cellular function, and support systemic rejuvenation.
Now what sets this product apart from the rest of the apigenin supplements on our lineup is its dosing schedule. Unlike many supplements that require daily intake, Senolytic Activator only needs to be taken once a week — just three capsules. This is a huge benefit for those with busy schedules or who simply prefer a more hands-off approach to supplementation.
Each bottle of Senolytic Activator contains 36 vegetarian-friendly capsules, good for a three-month supply if you follow the recommended once-a-week dosing. This not only makes it a cost-effective choice but also ensures you are stocked up for a substantial period. At a current price of $19.50 per bottle, it looks to be a great value pick for the quality and quantity provided.
10. Natural Stacks — good apigenin supplement for sleep support
Marketed as an advanced sleep support by its creators, Apigenin+ by Natural Stacks contains not only apigenin sourced from Citrus paradisi but also two additional ingredients for synergistic effects — lemon balm and passion flower, both of which are plant-based and natural.
Adding credibility to the sleep support claim is lemon balm — an ingredient known for its anti-stress and calming effects.
What's particularly intriguing about Natural Stacks is their 'Open Source' transparency program, which offers ingredient traceability and third-party lab test results for every batch the brand produces, including Apigenin+.
In line with the brand’s instructions, taking 2 capsules per day is the recommended approach.
Manufactured and packaged in FDA-registered facilities, this supplement is currently available for the price of $23.96 as a one-time purchase.
11. Nootropics Depot — apigenin supplement that comes in different options
Concluding our overview of the best apigenin supplements is the offering from Nootropics Depot — an option that, more than others on this list, caters to those seeking specific dosage options.
Apigenin Capsules, labeled to contain a minimum of 98% of apigenin, are available in multiple options. These include an option of 200 mg of apigenin per serving, available in either a 30-capsule or 120-capsule bottle, and an alternative of 50 mg of apigenin, which comes in either a 60-capsule or 180-capsule bottle.
In addition to being tested and verified in an ISO-certified lab, Nootropics Depot's Apigenin supplement is manufactured in accordance with current GMPs.
To obtain your preferred bottle, simply visit Nootropic Depot's official website. Prices start at $17.99 for the 60-capsule option, which contains 50 mg of apigenin.
How have we compiled the list of best apigenin supplements?
Our list of the best apigenin supplements was put together taking into account specific criteria. This encompassed factors such as the supplement's formulation, the brand's standing, price point, and input from customers.
| Formulation | Brand reputation | Price | Reviews |
| Presence of additional compounds | Level of transparency | Varying price points | Patterns in customer feedback |
- Formulation. While the majority of apigenin supplements on the market consist solely of apigenin, some also combine it with other bioactive compounds for synergistic effects. We made sure to consider both.
- Brand reputation. With reputable brands often having a history of manufacturing quality supplements, we prioritized those that shed light on their manufacturing, testing, and or research practices.
- Price. When putting together our list, we made an effort to include brands offering their apigenin supplements at various price points, allowing you to choose one that aligns with your budget.
- Reviews. We looked for patterns in customer feedback, focusing specifically on users who have actually purchased and used the product. This approach allowed us to get a better grasp of individual experiences.
Apigenin benefits and side effects
Apigenin is a natural compound belonging to the flavonoid class, commonly found in parsley, chamomile, celery, vine spinach, artichokes, and oregano. Known for its antioxidant and anti-inflammatory properties, apigenin has recently gained popularity due to its potential health benefits. However, when discussing benefits in a general context, one must also consider the potential for associated side effects. We expand upon this in the following sections.
Apigenin benefits
Apigenin is linked to various health benefits, including:
- Antioxidant action. Apigenin's potent antioxidant properties can help neutralize harmful free radicals in the body — these are molecules that can damage cells and contribute to aging.
- Anti-inflammatory effects. It is thought to demonstrate anti-inflammatory properties. This potentially can help reduce inflammation in the body.
- Potential anti-cancer activity. Apigenin has been researched for its potential role in cancer prevention. Some studies have shown that it may inhibit the growth of cancer cells and induce cell death in certain types of cancer.
- Calming properties. It may have anxiety-reducing and sedative effects. This could potentially contribute to its use in promoting relaxation, including better sleep.
Apigenin side effects
Though generally deemed safe, apigenin is not without its potential side effects:
- Gastrointestinal discomfort. High doses of apigenin may cause gastrointestinal discomfort. This can manifest as symptoms like nausea, upset stomach, or diarrhea.
- Allergic reactions. Some people may be allergic to apigenin. Reactions can include symptoms such as itching, rash, and swelling. Mind you, in rare cases.
- Drug interactions. Chance for interactions with certain medications. This necessitates caution, especially for those on blood-thinning medications.
- Effect on the endocrine system. Apigenin may have estrogenic effects, which could potentially impact hormonal balance.
How to pick the right apigenin supplement for your health needs
When it comes to picking the right apigenin supplement that aligns with your health needs and preferences, several factors need consideration. So, before you make your decision, take a moment to review the tips we have provided below to help you make an informed choice.
- Third-party testing. Prioritize those apigenin supplements that have undergone third-party testing. This is an indication that the labeling is accurate.
- Ingredients. Look for supplements that clearly list apigenin as a primary ingredient. Check the apigenin amounts in a serving size to make certain it aligns with your preferences.
- Transparency in labeling. Brands that prioritize transparency ensure that their product labels provide clear information about apigenin content, serving size, and any additional ingredients. Opt for such products.
- Allergen information. If you are someone who has allergies or dietary restrictions, be sure to verify whether the supplement contains any allergens or ingredients linked to food sensitivities.
What the research says: the science behind apigenin
Few human clinical studies specifically focus on the effects of apigenin as a single compound. This scarcity may be attributed to the fact that apigenin is rather unstable when isolated. Besides, it has low bioavailability; only around 30% of the administered dose is typically absorbed into the systemic circulation. Therefore, much of our understanding of apigenin's clinical effects in humans is derived from studies involving the plants or foods from which it originates.
At this moment, when it comes to the effects often associated with apigenin, there is some evidence for the following:
- Antioxidant
- Anti-inflammatory
- Multiple studies have reported that apigenin possesses anticancer properties
- Therapeutic potential of apigenin in the context of certain conditions
The best time to take apigenin
As of today, there are no research studies that suggest that taking apigenin at any specific time of day, with or without food, can have particular benefits or drawbacks.
However, one thing to keep in mind is that while apigenin does not have muscle relaxant or sedative effects at conventional doses, those being 3 to 10 milligrams per kilogram of body weight, sedation was observed at doses 3 and 10 times higher — 30 to 100 milligrams per kilogram of body weight.
Therefore, higher doses of apigenin must not be taken before participating in any activities requiring awareness and diligence, for example, operating a vehicle or working in construction.
Additionally, for supplements, it is always recommended to follow the manufacturer's guidelines and discuss appropriate timing with a healthcare provider.
Best apigenin supplement: conclusion
Yes, apigenin supplements are currently being sought after for their potential health benefits, including antioxidant properties, anti-inflammatory effects, and a role in promoting relaxation. But while the early research is promising, optimal dosages and long-term safety have not yet been firmly established. Given this, those considering apigenin supplementation should approach it with reasonable caution, especially if they have existing health conditions or take medications.
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FAQ
What is apigenin supplement used for?
For multiple reasons. While apigenin supplements are commonly taken by those seeking potential health benefits, such as antioxidant and anti-inflammatory effects, emerging research suggests that apigenin may also have the potential to support relaxation and alleviate anxiety. This is why some individuals often choose to incorporate this compound in supplement form before sleep.
What are the side effects of apigenin?
Generally mild and infrequent. Apigenin is abundant in a variety of natural sources, including fruits and vegetables, and is generally well-tolerated when consumed as a part of a diet. However, excessive intake or supplement use in high doses can lead to potential side effects, often including gastrointestinal discomfort, interactions with medications, and, in some cases, allergic reactions.
When to take apigenin for sleep?
Around 30 to 60 minutes before bedtime. For optimal results, try taking apigenin 30 to 60 minutes prior to bedtime, but remember that achieving healthy sleep goes beyond supplements. Maintaining a consistent sleep schedule, creating a relaxing bedtime routine, and reducing screen time are integral components.
How much apigenin should I take per day?
The exact dose remains uncertain for now. Currently, there are no official recommendations regarding the daily intake of apigenin. However, for general health, it is advised to consume multiple servings of fruits and vegetables each day, as they should provide sufficient amounts of apigenin—estimated to be less than 5 mg. When considering supplements, it is always advisable to follow the recommendations of healthcare providers.
Can women take apigenin?
Yes. For women, incorporating apigenin into their diet is usually safe. Nevertheless, pregnant or breastfeeding women should approach apigenin supplements with extra care and seek guidance from a healthcare professional before considering them.
3 resources
- Journal of food biochemistry. Functionality of apigenin as a potent antioxidant with emphasis on bioavailability, metabolism, action mechanism and in vitro and in vivo studies: A review.
- International journal of molecular sciences. The Therapeutic Potential of Apigenin.
- Inflammopharmacology. The effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models: a systematic review and meta-analysis of preclinical evidence.
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