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Best Berberine Supplement 2024 Reviews: Top 6 Brands

Berberine, a powerful natural compound found in plants, may improve cardiovascular health, regulate blood sugar levels, and support weight loss.

Selecting the best berberine supplement that suits your needs can be a challenge. Therefore, after analyzing the top berberine supplements in the market, we have curated a list of the best berberine brands, which we present in this article.

Within our list of options, you will find not only the best quality berberine supplements but also those recognized for their specific benefits, such as the best berberine supplement for weight loss support. We invite you to read along to learn how berberine works and the goals it can help you achieve.

Best berberine supplement in 2024: shortlist

  1. partiQlar — top rated berberine supplement
  2. Utzy Naturals — best berberine for weight loss
  3. BerbaPrime — high-dose berberine supplement
  4. Vitality Pro — top rated berberine supplement
  5. HUM — best berberine supplement to support healthy glucose levels
  6. ProHealth — most bioavailable berberine supplement

How we compiled our list of the best berberine supplements in 2024

When putting together the best berberine supplement 2024 list, we carefully considered these criteria:

Ingredient qualityHigh-quality and tested
Third-party testingLabel accuracy
BioavailabilityEnhanced formulations
  • Ingredient quality. A berberine supplement crafted from high-quality ingredients is more likely to provide the expected benefits of berberine. Therefore, selecting supplements from reputable, best berberine brands that prioritize quality and subject their products to testing can significantly enhance product safety.
  • Dosage. Considering that studies use berberine doses with pharmacological effects starting from 400 mg per day, it is crucial to choose those top berberine supplements that offer effective dosages without posing the risk of adverse effects.
  • Third-party testing. Best quality berberine supplements and third-party testing go hand in hand. In essence, third-party testing verifies the accuracy of the ingredient list and ensures the absence of harmful contaminants, so that you receive precisely what is stated on the label.
  • Bioavailability. Most bioavailable berberine supplements should be a key consideration for those interested in berberine supplementation. Since berberine naturally has low bioavailability, specific formulations, such as those containing the acclaimed best form of berberine known as dihydroberberine, can potentially enhance its bioavailability, in turn, ensuring that a greater amount of this compound is absorbed.

Berberine best brands in 2024: an overview

In this part we overview our hand-picked berberine supplements that we think cater for the widest range of needs. Deep diving into each brand, we take into consideration five criteria — ingredient and manufacturing quality, brand reputation, dosage, third-party testing, and bioavailability enhancements, we analyze and summarize the top six best berberine brands.

1. partiQlar — top rated berberine supplement

partiQlar Berberine

We kick our list off with what we deem the top rated berberine supplement by partiQlar, a product that is non-GMO, contains no artificial colors or flavors, is suitable for vegans, and features a berberine purity of 97%, as per its makers.

Each bottle contains 60 vegan capsules, with each capsule set to deliver 600 mg of Berberine Hydrochloride derived from Berberis aristata.

The recommended dosage by the provider is 1 capsule per day.

All of partiQlar's products are manufactured in FDA and NSF-registered facilities located within the United States.

As of today, partiQlar offers its berberine supplement at a price of $25.99, and you can conveniently purchase it directly from the official provider's website.

2. Utzy Naturals — best berberine for weight loss

Utzy Berbercol

Berbercol by Utzy Naturals, a formula crafted to naturally balance blood sugar levels, stands out as the best berberine for weight loss among those supplement options featured in our list. Specifically designed to balance both HDL and LDL cholesterol, it may also promote healthy cardiovascular function.

Each bottle contains a blend of Bergamonte® and Himaberb®, clinically shown to maintain cholesterol within the normal range. As a secondary benefit, these herbal ingredients may stabilize blood sugar levels and enhance insulin sensitivity, further supporting weight management and normal metabolism.

The serving size is 60 capsules per bottle, with the provider’s suggested dosage being 2 capsules daily.

All Utzy products, including Berbercol, undergo third-party testing. The testing details for this product are accessible through a Certificate of Analysis (COA), which is available on the brand's website for your examination.

Berbercol is priced at $51.50, with free shipping within the USA. Customers can also avail a 15% discount when purchasing 3 bottles.

3. BerbaPrime — high-dose berberine supplement


Marketed as a dietary supplement intended to support healthy metabolism, cholesterol, and blood sugar levels, BerbaPrime is an excellent choice for those seeking a high-dose berberine supplement.

While each BerbaPrime capsule packs 500 mg of berberine HCL, a commonly used starting dose, the brand suggests taking 1 capsule three times a day. It also advises spreading the total daily dose of 1500 mg of berberine evenly throughout the day.

According to the people behind BerbaPrime, their product undergoes lab testing and is manufactured in the United States, following Good Manufacturing Practice (GMP) guidelines. Mind you, despite the testing, there is no COA available for you to examine.

A one-time purchase of this berberine supplement, which is, in fact, shipped for free within the USA, is currently available for $59.99.

4. Vitality Pro — best berberine supplement for blood sugar control

Vitality Pro Advanced Berberine

Advanced Berberine by Vitality Pro is a dietary supplement made with berberine sourced from the roots of the Berberis tree. It may help to regulate blood sugar and cholesterol.

To enhance the bioavailability of Berberine, the supplement includes Milk Thistle, a herb known for its ability to prevent the P-glycoprotein transporter that limits Berberine absorption.

A single bottle of Advanced Berberine contains 120 capsules. Each capsule includes 500mg of Berberine HCl and 125mg of Milk Thistle. For optimal results, the manufacturer recommends taking 1 capsule 2-3 times daily with water, which equates to a dosage of 500mg to 1500mg of Berberine HCl.

The product contains no GMOs, artificial colors, preservatives, flavors, or allergens.

All Vitality Pro products, including this third party tested berberine, are manufactured in accordance with GMP standards.

Advanced Berine is priced at $44.00, with a subscription option available for a 5% discount.

5. HUM — best berberine supplement to support healthy glucose levels

HUM Berberine capsules

If you are looking for the best berberine supplement to help support healthy glucose levels, HUM’s offering is a strong contender. The Best of Berberine is a vegan supplement, free of major allergens and third-party tested for composition and label accuracy.

Each daily serving of 2 capsules should provide 1200 mg of berberine, complemented by 5 mg of BioPerine® — a patented formula of black pepper extract designed for better absorption of berberine.

All of HUM’s products, including the Best of Berberine, are crafted in facilities certified to adhere to the GMPs mandated by the FDA.

A bottle of HUM Best of Berberine, which contains 60 capsules intended for a 30-day supply, is available at a one-time price of $35.

6. ProHealth — most bioavailable berberine supplement

ProHealth Longevity Berberine Pro 1,200 mg

Berberine Pro by ProHealth Longevity is a natural supplement designed to support healthy aging, heart health, and blood sugar management. The product is formulated to combat aging AMPK activation, improve body composition, enhance heart health, and aid in blood sugar management.

With Bioperine, which may help increase absorption, among its primary ingredients, ProHealth’s Berberine Pro stands out as potentially the most bioavailable berberine supplement. The formula also includes lipoic acid, which has been shown to support blood sugar levels.

Each bottle contains 60 capsules, with the provider’s suggested daily dosage of 1 capsule.

According to reviews, many users have reported weight loss benefits due to improved metabolism and reduced cravings.

ProHealth Longevity ensures the quality of its products by conducting third-party lab testing and adhering to GMP standards and FDA-registered manufacturing processes.

The product is available for $29.95, with free shipping on orders over $30 in the U.S. The brand also offers a 75-day money-back guarantee, emphasizing its commitment to customer satisfaction.

6 top-rated berberine supplement brands compared

BrandPrice per serving*Number of servingsPrice per bottleBerberine amount per servingBerberine formNumber of ingredients
partiQlar$0.4360$25.99600 mgHCL1
Utzy Naturals$1.7230$51.50600 mgHCL2
BerbaPrime$1.9930$59.991500 mgHCL1
Vitality Pro$0.37120$44.00500 mgHCL5
HUM$1.1630$35.001200 mgHCL2
ProHealth $0.4560$29.95600 mgHCL5

*— better pricing may be available through subscription.

What is berberine?

Berberine, a bioactive compound found in various plants, including the Berberis family, exhibits antimicrobial, anti-inflammatory, and antioxidant properties. Having a history deeply rooted in traditional Chinese and Ayurvedic medicine, berberine has recently gained recognition for its potential health benefits.

Promisingly, berberine has demonstrated potential in regulating blood sugar levels and potentially lowering LDL cholesterol, thus supporting heart health. Not only that, berberine has been explored for its role in weight management, and while research is ongoing, the use of berberine for weight loss has been gaining popularity.

How does berberine work?

Berberine operates by activating AMP-activated protein kinase (AMPK), commonly referred to as the 'metabolic master switch.' This enzyme plays a pivotal role in the regulation of metabolism. Berberine's activation of AMPK results in enhanced insulin sensitivity, reduced hepatic glucose production, and decreased lipid levels.

While modern science increasingly recognizes its potential benefits, it is vital to consult a healthcare professional before starting any new supplement regimen, as its mechanisms of action can vary depending on the specific health condition.

Berberine supplements for weight loss, can it help?

Berberine has become a topic of interest for its possible role in managing weight, though it should not be considered a magic solution. By activating the enzyme AMPK, the best berberine for weight loss supplements have the potential to enhance insulin sensitivity, boost fat breakdown, and inhibit fat storage, thereby aiding in weight management efforts.

With that said, be mindful that no supplement, including the best berberine for weight loss, can replace a balanced diet and regular exercise when it comes to weight management. Berberine should complement, not replace, a healthy lifestyle.

If you have found your best berberine supplement for weight loss and intend to start taking it, it is advisable to consult with a healthcare provider or a registered dietitian, as lifestyle changes remain fundamental for weight control.

Best form of berberine supplements

When included in supplements, Berberine is typically available in two forms: Berberine HCL and dihydroberberine.

Berberine HCL is the conventional form, and there is growing evidence of its potential benefits in managing metabolic health. However, its bioavailability is relatively low, which limits its efficacy.

Dihydroberberine is another form of berberine commonly found in supplements. Although the mechanisms are not fully understood yet, emerging evidence suggests that this form may have superior bioavailability, potentially making it the most effective form of berberine.

With both Berberine HCL and dihydroberberine available on the market, the best form of berberine may depend on factors such as your specific health goals, dosage preferences, and how your body responds to each form. That said, current studies indicate that dihydroberberine may be the most effective form of berberine.

How berberine supplements can help with various health concerns

While further research is necessary to fully understand the mechanisms and effectiveness of berberine supplements, berberine generally shows promise in studies addressing these concerns.

  • Type 2 diabetes and high blood sugar levels. Berberine may help improve insulin sensitivity, reduce insulin resistance, and lower blood sugar levels in individuals with type 2 diabetes.
  • Polycystic ovary syndrome (PCOS). By having an effect on hormones and metabolic dysfunction, berberine may alleviate symptoms associated with PCOS.
  • Weight management. Some studies suggest that berberine may help with weight loss efforts by affecting metabolism and reducing fat storage.
  • High cholesterol. Berberine's lipid-lowering effects can contribute to a healthier cholesterol profile.

In contrast to the specific cases outlined above, the best berberine supplements available on the market are not intended to treat diseases. However, they can support your health by delivering benefits for blood sugar control, cholesterol, and weight management. People with diabetes, PCOS, or other conditions should consult a healthcare provider for a tailored approach to managing their conditions, which may include considering dietary supplements like berberine.

Can berberine replace metformin?

No. While berberine has shown promise in managing type 2 diabetes and has been compared to metformin, a common diabetes medication, in some studies, berberine is best viewed as a potential adjunctive supplement, rather than a replacement for traditional diabetes medications.

Both berberine and metformin work by improving insulin sensitivity and reducing blood sugar levels. However, while berberine's effects are promising, it is not considered a replacement for metformin. Although some research suggests it could be as effective as metformin, more extensive and rigorous studies are needed to confirm these results.

Moreover, berberine's bioavailability and potential interactions with other medications complicate its use.

It's critical for individuals with diabetes to consult their healthcare provider before making any changes to their medication regimen, including substituting or supplementing with berberine.

When is the best time to take berberine supplements?

Berberine supplements are typically recommended to be taken with a meal, or immediately before, to improve its absorption and minimize potential gastrointestinal side effects, such as nausea or upset stomach. This is because food stimulates bile production, which can enhance berberine's bioavailability.

Some studies have suggested splitting the daily dose into 2-3 smaller doses, rather than taking it all at once, to maintain steady levels in the body and maximize efficacy. If berberine is being used for blood sugar regulation, taking it with meals containing carbohydrates can be particularly beneficial.

However, the timing can also depend on the specific health concern being addressed and individual tolerability. It's always best to follow the advice of a healthcare professional.

What are the side effects of berberine and who should avoid it?

While berberine has many potential benefits, it also carries certain risks and side effects.

Common side effects can include digestive discomfort, such as constipation, diarrhea, or stomach cramps. More seriously, berberine can interact with medications, including cyclosporine, certain antibiotics, and anticoagulants like warfarin, potentially affecting their efficacy or increasing the risk of adverse effects.

Certain individuals should exercise caution or avoid berberine altogether. These include pregnant and breastfeeding women, as berberine could potentially harm the fetus or nursing infant. Individuals with liver disease should also be cautious, as berberine is processed in the liver and could exacerbate existing conditions.

Additionally, people with low blood pressure should avoid berberine, as it could further lower their readings. As with any supplement, it's crucial to consult a healthcare provider before starting berberine.

How to choose the best berberine supplement?

Choosing the best berberine supplement requires careful consideration. Here are the five criteria you should take into account.

IngredientsNatural, no unnecessary additives
Brand reputationTrusted, transparent company
DosageAligns with scientific research
Third-party testingIndependent lab-verified
BioavailabilityHigh absorption
  • Ingredients. Ensure the supplement contains high-quality, natural ingredients. Avoid products with fillers, artificial colors, or unnecessary additives.
  • Brand reputation. Since reputable brands are generally more likely to offer the safest and most effective berberine supplements available, it is worth looking into a company's background, reading independent customer reviews, and considering their transparency regarding ingredient sourcing and manufacturing processes.
  • Dosage. The best berberine supplement should provide an effective dosage in alignment with scientific research. Excessively high or low doses can be ineffective or pose toxicity risks.
  • Third-party testing. Look for third party tested berberine supplements that go through independent labs before they are released to the market. This ensures the product meets quality standards and does not contain harmful contaminants.
  • Bioavailability. Consider choosing a form with enhanced bioavailability for better absorption and effectiveness.

What are berberine alternatives?

Several natural supplements may serve as alternatives to berberine for promoting health, managing diabetes, and supporting weight management:

  • Cinnamon. It has been linked to improved insulin sensitivity and blood glucose control.
  • Fish oil. Rich in omega-3 fatty acids, it promotes heart health and has anti-inflammatory properties.
  • Folic acid. Important for cell growth and metabolism, it may also support heart health.
  • Coenzyme Q10. This antioxidant may help regulate blood sugar levels and boost heart health.
  • Vitamin D. Known for its role in bone health, it's also vital for immune function.
  • Green tea extract. It's often used for weight management due to its potential metabolism-boosting effects.

What is the best berberine supplement: conclusion

As ongoing research continues to delve deeper into the mechanisms behind berberine's effects, its supplements are surging in popularity. The appeal of the best berberine supplements lies in their potential to help regulate blood sugar, manage cholesterol levels, and assist with weight loss efforts.

When in search of the best berberine supplement, give preference to third party tested berberine supplements, as this elevates the quality and reliability of the product. Among the choices in our list, you can choose from the top rated berberine supplements — those catering to general preferences and those featured for specific concerns, such as berberine for weight loss.

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