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Best Berberine Supplement 2024 Reviews: Top 7 Brands

Berberine, a powerful natural compound found in plants, may improve cardiovascular health, regulate blood sugar levels, and support weight loss.

Selecting the best berberine supplement that suits your needs can be a challenge. Therefore, after analyzing the top berberine supplements in the market, we have curated a list of the best berberine brands, which we present in this article.

Within our list of options, you will find not only the best quality berberine supplements but also those recognized for their specific benefits, such as the best berberine supplement for weight loss support. We invite you to read along to learn how berberine works and the goals it can help you achieve.

Best berberine supplement in 2024: shortlist

  1. partiQlar — overall best berberine supplement
  2. ProHealth — most bioavailable berberine supplement
  3. Luma Nutrition — best berberine to support healthy aging
  4. Utzy Naturals — best berberine for weight loss
  5. Vitality Pro — top-rated berberine supplement

How we compiled our list of the best berberine supplements in 2024

When putting together the best berberine supplement 2024 list, we carefully considered these criteria:

Ingredient qualityDosageThird-party testingBioavailability
High-quality and testedScience-backedLabel accuracyEnhanced formulations
  • Ingredient quality. A berberine supplement crafted from high-quality ingredients is more likely to provide the expected benefits of berberine. Therefore, selecting supplements from reputable, best berberine brands that prioritize quality and subject their products to testing can significantly enhance product safety.
  • Dosage. Considering that studies use berberine doses with pharmacological effects starting from 400 mg per day, it is crucial to choose those top berberine supplements that offer effective dosages without posing the risk of adverse effects.
  • Third-party testing. Best quality berberine supplements and third-party testing go hand in hand. In essence, third-party testing verifies the accuracy of the ingredient list and ensures the absence of harmful contaminants, so that you receive precisely what is stated on the label.
  • Bioavailability. Most bioavailable berberine supplements should be a key consideration for those interested in berberine supplementation. Since berberine naturally has low bioavailability, specific formulations, such as those containing the acclaimed best form of berberine known as dihydroberberine, can potentially enhance its bioavailability, in turn, ensuring that a greater amount of this compound is absorbed.

Berberine best brands in 2024: an overview

In this part we overview our hand-picked berberine supplements that we think cater for the widest range of needs. Deep diving into each brand, we take into consideration five criteria — ingredient and manufacturing quality, brand reputation, dosage, third-party testing, and bioavailability enhancements, we analyze and summarize the top seven best berberine brands.

1. partiQlar — overall best berberine supplement

partiQlar Berberine

When we're talking about the best supplement on the market, it's not just about the label or the promises. Rather, it's about the tangible benefits it brings to the table. And partiQlar's berberine offering appears to be as well-rounded of a supplement as it gets.

What initially caught my attention was the brand's commitment to quality. Its supplement is non-GMO, free from artificial colors or flavors, and vegan-friendly. These aren't just buzzwords — they signify a dedication to purity and inclusivity, allowing everyone to benefit from it.

Now, let's talk numbers. With a berberine purity of 97%, you're set to receive a concentrated dose with every capsule. This means you'll know exactly how much and what type of compound you will be consuming.

If you prioritize safety and trust, you'll likely agree that it's not only about what's in the bottle — the standards maintained throughout the production process also matter. That's why you'll be reassured to know that partiQlar manufactures its products in FDA and NSF-registered facilities within the U.S.

As we can see, partiQlar's berberine supplement hasn't been nominated as the 'overall best' for no reason. It has earned that recognition through the brand's commitment to quality, safety, and inclusivity. And when it comes to price, at $25.99 per bottle, this offering offers excellent value for your money. So, if you were to ask me for the optimal choice in berberine supplements, partiQlar is the one I'd be pointing to.

2. ProHealth — most bioavailable berberine supplement

ProHealth Longevity Berberine Pro 1,200 mg

Next on our list is Berberine Pro by ProHealth Longevity, a berberine supplement that, according to its makers, may support healthy aging, heart health, and blood sugar management. With Bioperine and alpha-lipoic acid as additional active ingredients, this supplement is formulated with optimal absorption and bioavailability in mind.

One key highlight of Berberine Pro is its user reviews. Many users have reported weight loss benefits, improved metabolism, and reduced cravings after incorporating this supplement into their routine. These firsthand experiences underscore the potential of Berberine Pro in supporting overall wellness.

Similar to other offerings on our list, quality is non-negotiable for ProHealth Longevity. Their commitment is evident in their third-party lab testing, adherence to GMP standards, and manufacturing processes carried out in FDA-registered facilities.

At $29.95 per bottle, with free shipping on orders over $30 in the U.S. and a 75-day money-back guarantee, Berberine Pro is one of the best value options on our list. This said, if you're searching for a highly bioavailable berberine supplement that works as promised, I'd recommend checking out Berberine Pro.

3. Luma Nutrition — best berberine to support healthy aging

Luma Nutrition Berberine

When evaluating top-tier berberine supplements to support healthy aging, Luma Nutrition emerges as an excellent choice. As we navigate different stages of life, it may be beneficial to address wellness concerns like immunity, cardiovascular function, or blood sugar level management. Luma's berberine supplement, derived from barberry root extract, effectively supports these crucial areas, promoting graceful aging.

What makes this supplement stand out is its impressive dose. Each capsule boasts 600 mg of barberry, which amounts to 1200 mg of berberine daily, as recommended by the brand. This becomes a unique selling point for those seeking a supplement with a higher dose of berberine.

Following other supplements in our list, Luma Nutrition holds stringent standards in its manufacturing and production practices. Third-party tested and crafted under U.S. soil, they deliver unmatched quality for consumers. This level of scrutiny and care is what we look for in high-caliber supplements.

Priced at $29.99 and featuring 60 capsules per bottle, this supplement is a fine option for a 30-day supply of berberine.

4. Utzy Naturals — best berberine for weight loss

Utzy Berbercol

After reviewing several berberine options on the market, one product stood out to me as the perfect companion for my weight loss journey.

Designed to balance both HDL and LDL cholesterol, Berbercol by Utzy Naturals is a formula that goes beyond traditional supplements to promote overall cardiovascular health. By potentially helping maintain cholesterol levels within the normal range, Berbercol may establish a foundation for a healthier heart while also aiming to support weight management efforts.

The secret lies in its blend of Bergamonte® and Himaberb®, two herbal ingredients supported by clinical research. According to the brand, together, they may help regulate cholesterol levels and contribute to stabilizing blood sugar while enhancing insulin sensitivity. This dual action may aid in weight management and help support a normal metabolism, potentially making progress toward your weight loss goals more attainable.

Trust is paramount when it comes to health supplements, which is why I appreciate Utzy Naturals' commitment to transparency. All their products, including Berbercol, undergo third-party testing, and detailed results are accessible through a Certificate of Analysis (COA) on their website. It's this dedication to quality assurance that instills confidence.

Considering all these factors, although the price of $51.50 per bottle is relatively high, it's more than justified. So, if you're ready to take charge of your health and see real results, Berbercol is the supplement for you.

5. Vitality Pro — top rated berberine supplement

Vitality Pro Advanced Berberine

Up next, we have Advanced Berberine from Vitality Pro, a dietary supplement that stands out from the rest. In its category, it towers above others with an exceptional 4.9-star rating out of 5 on Trustpilot — an impartial review platform where customers openly share their experiences.

After going over several pages of Trustpilot reviews, it's clear that customers are highly satisfied with Advanced Berberine. Many reviewers praise the excellent customer service, product quality, and overall experience when it comes to shopping with Vitality Pro. This highlights the professionalism and reliability of the company.

This resoundingly positive feedback clearly stems from Vitality Pro's commitment to quality and transparency. Their products, including Advanced Berberine, undergo third-party testing and are manufactured in accordance with GMP standards.

But what really seems to set this product apart from others is its formulation. Berberine, sourced from the Berberis tree, is combined with Milk Thistle in this supplement. Milk Thistle is believed to help prevent the P-glycoprotein transporter from limiting berberine absorption. Due to this interaction, your body may be able to utilize berberine more efficiently.

I think that priced at $44 per bottle, with a subscription option that includes a 5% discount, Advanced Berberine offers great value for a supplement that is rated the best by real users. Additionally, the absence of GMOs, artificial colors, preservatives, flavors, and allergens adds to the brand's commitment to delivering a product that's clean and reliable.

6. BerbaPrime — high-dose berberine supplement

BerbaPrime

In case you're on the lookout for a high-dose berberine supplement, BerbaPrime is the one you should consider.

BerbaPrime capsules contain 500 mg of berberine HCL each, which is a commonly recommended starting dose. The brand recommends taking 1 capsule three times a day, spreading the total daily dose of 1500 mg evenly throughout the day.

The emphasis on quality with BerbaPrime is evident as well. The brand's offerings undergo lab testing and are manufactured in the U.S. under GMP guidelines. Although a COA isn't publicly available, adherence to GMP standards provides assurance of quality.

At $59.99 for a one-time purchase with free shipping within the U.S., BerbaPrime is an excellent choice for those seeking a quality berberine supplement. While the price reflects the product's makeup, the potential health benefits make it a worthwhile investment in your health, in my book.

HUM Best of Berberine
  • Contains 5 mg of BioPerine® (black pepper extract)
  • Crafted in FDA-certified facility and third-party tested
  • Contains beneficial bacteria and promotes healthy gut microbiome

If you are looking for the best berberine supplement to help support healthy glucose levels, look no further than HUM's Best of Berberine. This supplement is not just a contender, and let me tell you why that is.

First of all, quality and safety are top priorities at HUM. All their products, including Best of Berberine, are third-party tested for composition and label accuracy. Also, the fact that it is crafted in FDA-certified facilities adhering to GMP standards embodies reliability.

Another point to highlight is that the berberine in the formulation is complemented by 5 mg of BioPerine® — a patented formula of black pepper extract included to improve berberine’s absorption.

A bottle of HUM Best of Berberine contains 60 capsules, providing a 30-day supply at a price of $35. Given the brand's commitment to quality assurance and its efforts to optimize the supplement's bioavailability, coupled with its affordable price point, I see no reason why Best of Berberine couldn't be your supplement of choice if you're looking for additional help in taking control of your glucose levels.

7 top-rated berberine supplement brands compared

BrandPrice per serving*Number of servingsPrice per bottleBerberine amount per servingBerberine formNumber of ingredients
partiQlar$0.4360$25.99600 mgHCL1
ProHealth $0.4560$29.95600 mgHCL5
Luma Nutrition$0.9930$29.991200 mgHCL1
Utzy Naturals$1.7230$51.50600 mgHCL2
Vitality Pro$0.37120$44.00500 mgHCL5
BerbaPrime$1.9930$59.991500 mgHCL1
HUM$1.1630$35.001200 mgHCL2

*— better pricing may be available through subscription.

What is berberine?

Berberine, a bioactive compound found in various plants, including the Berberis family, exhibits antimicrobial, anti-inflammatory, and antioxidant properties. Having a history deeply rooted in traditional Chinese and Ayurvedic medicine, berberine has recently gained recognition for its potential health benefits.

Promisingly, berberine has demonstrated potential in regulating blood sugar levels and potentially lowering LDL cholesterol, thus supporting heart health. Not only that, berberine has been explored for its role in weight management, and while research is ongoing, the use of berberine for weight loss has been gaining popularity.

How does berberine work?

Berberine operates by activating AMP-activated protein kinase (AMPK), commonly referred to as the 'metabolic master switch.' This enzyme plays a pivotal role in the regulation of metabolism. Berberine's activation of AMPK results in enhanced insulin sensitivity, reduced hepatic glucose production, and decreased lipid levels.

While modern science increasingly recognizes its potential benefits, it is vital to consult a healthcare professional before starting any new supplement regimen, as its mechanisms of action can vary depending on the specific health condition.

Berberine supplements for weight loss, can it help?

Berberine has become a topic of interest for its possible role in managing weight, though it should not be considered a magic solution. By activating the enzyme AMPK, the best berberine for weight loss supplements have the potential to enhance insulin sensitivity, boost fat breakdown, and inhibit fat storage, thereby aiding in weight management efforts.

With that said, be mindful that no supplement, including the best berberine for weight loss, can replace a balanced diet and regular exercise when it comes to weight management. Berberine should complement, not replace, a healthy lifestyle.

If you have found your best berberine supplement for weight loss and intend to start taking it, it is advisable to consult with a healthcare provider or a registered dietitian, as lifestyle changes remain fundamental for weight control.

Best form of berberine supplements

When included in supplements, Berberine is typically available in two forms: Berberine HCL and dihydroberberine.

Berberine HCL is the conventional form, and there is growing evidence of its potential benefits in managing metabolic health. However, its bioavailability is relatively low, which limits its efficacy.

Dihydroberberine is another form of berberine commonly found in supplements. Although the mechanisms are not fully understood yet, emerging evidence suggests that this form may have superior bioavailability, potentially making it the most effective form of berberine.

With both Berberine HCL and dihydroberberine available on the market, the best form of berberine may depend on factors such as your specific health goals, dosage preferences, and how your body responds to each form. That said, current studies indicate that dihydroberberine may be the most effective form of berberine.

How berberine supplements can help with various health concerns

While further research is necessary to fully understand the mechanisms and effectiveness of berberine supplements, berberine generally shows promise in studies addressing these concerns.

  • Type 2 diabetes and high blood sugar levels. Berberine may help improve insulin sensitivity, reduce insulin resistance, and lower blood sugar levels in individuals with type 2 diabetes.
  • Polycystic ovary syndrome (PCOS). By having an effect on hormones and metabolic dysfunction, berberine may alleviate symptoms associated with PCOS.
  • Weight management. Some studies suggest that berberine may help with weight loss efforts by affecting metabolism and reducing fat storage.
  • High cholesterol. Berberine's lipid-lowering effects can contribute to a healthier cholesterol profile.

In contrast to the specific cases outlined above, the best berberine supplements available on the market are not intended to treat diseases. However, they can support your health by delivering benefits for blood sugar control, cholesterol, and weight management. People with diabetes, PCOS, or other conditions should consult a healthcare provider for a tailored approach to managing their conditions, which may include considering dietary supplements like berberine.

Can berberine replace metformin?

No. While berberine has shown promise in managing type 2 diabetes and has been compared to metformin, a common diabetes medication, in some studies, berberine is best viewed as a potential adjunctive supplement, rather than a replacement for traditional diabetes medications.

Both berberine and metformin work by improving insulin sensitivity and reducing blood sugar levels. However, while berberine's effects are promising, it is not considered a replacement for metformin. Although some research suggests it could be as effective as metformin, more extensive and rigorous studies are needed to confirm these results.

Moreover, berberine's bioavailability and potential interactions with other medications complicate its use.

It's critical for individuals with diabetes to consult their healthcare provider before making any changes to their medication regimen, including substituting or supplementing with berberine.

When is the best time to take berberine supplements?

Berberine supplements are typically recommended to be taken with a meal, or immediately before, to improve its absorption and minimize potential gastrointestinal side effects, such as nausea or upset stomach. This is because food stimulates bile production, which can enhance berberine's bioavailability.

Some studies have suggested splitting the daily dose into 2-3 smaller doses, rather than taking it all at once, to maintain steady levels in the body and maximize efficacy. If berberine is being used for blood sugar regulation, taking it with meals containing carbohydrates can be particularly beneficial.

However, the timing can also depend on the specific health concern being addressed and individual tolerability. It's always best to follow the advice of a healthcare professional.

What are the side effects of berberine and who should avoid it?

While berberine has many potential benefits, it also carries certain risks and side effects.

Common side effects can include digestive discomfort, such as constipation, diarrhea, or stomach cramps. More seriously, berberine can interact with medications, including cyclosporine, certain antibiotics, and anticoagulants like warfarin, potentially affecting their efficacy or increasing the risk of adverse effects.

Certain individuals should exercise caution or avoid berberine altogether. These include pregnant and breastfeeding women, as berberine could potentially harm the fetus or nursing infant. Individuals with liver disease should also be cautious, as berberine is processed in the liver and could exacerbate existing conditions.

Additionally, people with low blood pressure should avoid berberine, as it could further lower their readings. As with any supplement, it's crucial to consult a healthcare provider before starting berberine.

How to choose the best berberine supplement?

Choosing the best berberine supplement requires careful consideration. Here are the five criteria you should take into account.

IngredientsBrand reputationDosageThird-party testingBioavailability
Natural, no unnecessary additivesTrusted, transparent companyAligns with scientific researchIndependent lab-verifiedHigh absorption
  • Ingredients. Ensure the supplement contains high-quality, natural ingredients. Avoid products with fillers, artificial colors, or unnecessary additives.
  • Brand reputation. Since reputable brands are generally more likely to offer the safest and most effective berberine supplements available, it is worth looking into a company's background, reading independent customer reviews, and considering their transparency regarding ingredient sourcing and manufacturing processes.
  • Dosage. The best berberine supplement should provide an effective dosage in alignment with scientific research. Excessively high or low doses can be ineffective or pose toxicity risks.
  • Third-party testing. Look for third party tested berberine supplements that go through independent labs before they are released to the market. This ensures the product meets quality standards and does not contain harmful contaminants.
  • Bioavailability. Consider choosing a form with enhanced bioavailability for better absorption and effectiveness.

What are berberine alternatives?

Several natural supplements may serve as alternatives to berberine for promoting health, managing diabetes, and supporting weight management:

  • Cinnamon. It has been linked to improved insulin sensitivity and blood glucose control.
  • Fish oil. Rich in omega-3 fatty acids, it promotes heart health and has anti-inflammatory properties.
  • Folic acid. Important for cell growth and metabolism, it may also support heart health.
  • Coenzyme Q10. This antioxidant may help regulate blood sugar levels and boost heart health.
  • Vitamin D. Known for its role in bone health, it's also vital for immune function.
  • Green tea extract. It's often used for weight management due to its potential metabolism-boosting effects.

What is the best berberine supplement: conclusion

As ongoing research continues to delve deeper into the mechanisms behind berberine's effects, its supplements are surging in popularity. The appeal of the best berberine supplements lies in their potential to help regulate blood sugar, manage cholesterol levels, and assist with weight loss efforts.

When in search of the best berberine supplement, give preference to third party tested berberine supplements, as this elevates the quality and reliability of the product. Among the choices in our list, you can choose from the top rated berberine supplements — those catering to general preferences and those featured for specific concerns, such as berberine for weight loss.


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