Thanks to its myriad of potential benefits, berberine has been gaining popularity in the health and wellness market. The supplement has some reports on improving blood sugar control and insulin sensitivity and potentially supporting weight management. However, most benefits are still being researched.
According to our research, most berberine use in clinical studies has been focused on its reported ability to influence metabolic processes, making it an increasingly popular weight loss supplement.
We know that selecting a supplement to suit your needs and preferences can be challenging, so we have analyzed the best berberine supplements on the market and developed a shortlist. Our comprehensive review evaluated 20 different berberine supplements and selected the top six products recognized for their unique characteristics.
Continue below to discover what berberine supplements can offer.
Best berberine supplement in 2024: shortlist
- Utzy Naturals — best berberine to support metabolism
- ProHealth — best berberine supplement designed to increase bioavailability
- Health Nutrition — best high-dose berberine supplement
- partiQlar — overall best berberine supplement
- HUM — best berberine supplement to support healthy glucose levels
- Vitality Pro — top-rated berberine supplement
Your well-being is our top priority. Our in-house Research team and expert fact-checkers diligently review every content piece, ensuring you receive accurate, safe, and up-to-date health information to support your health decisions. Get an inside look at our thorough testing framework.
What is the best quality berberine on the market?
We have picked Utzy Natural Berbercol. The product stands out from the rest because it is explicitly designed to support metabolic health, laying the foundation for a healthier body and perhaps even supporting weight loss efforts.
What truly makes the product stand out is its blend of Bergamonte® and Himaberb®. According to the brand, these two herbal ingredients may work synergistically to help regulate cholesterol and blood sugar levels while increasing insulin sensitivity. These processes can help improve overall health and metabolic function, potentially aiding weight loss as an additional benefit.
Furthermore, Utzy Naturals is committed to quality and transparency. Hence, all their products are third-party tested with certificates of analysis available on their website. We checked!
How to choose the right berberine
We understand how frustrating and confusing navigating the supplement market can be, especially with something reasonably new like berberine. To educate our readers, we suggest a few factors to consider when choosing a product most suited to their needs and goals.
- Ingredients. Ensure the supplement contains high-quality, natural ingredients. Avoid products with fillers, artificial colors, or unnecessary additives.
- Third-party testing. Look for third-party testing certificates to ensure adherence to the label, quality, and safety from contaminants.
- Brand reputation. Brand transparency, reputation, and customer reviews are worth examining to determine whether the manufacturer is trustworthy and produces quality products.
- Dosage. Although research has yet to determine this, a good berberine supplement should have an adequate amount of the compound and clear dosage guidelines on the package. If no official or clinical guidelines are available, it is important to review what doses were used in clinical research and were reported to be safe.
- Additional ingredients. Berberine can be poorly absorbed by the body, so some products may include added BioPerine or milk thistle to boost absorption and bioavailability.
Is berberine as powerful as metformin?
Both berberine and metformin are associated with improvements in insulin sensitivity and reduced blood sugar levels. However, while berberine's effects are promising, it is not considered a replacement for metformin. These compounds have different classifications and different mechanisms of action.
Metformin is a prescription medication used to treat type 2 diabetes. It may also be used to prevent this condition in prediabetic individuals. Sometimes, metformin is prescribed to manage PCOS symptoms but is not officially approved for the condition. Either way, there is extensive evidence in humans that it lowers blood sugar levels and improves how your body handles insulin.
Berberine is a natural compound available as a dietary supplement. According to a limited amount of studies, it may improve blood sugar levels. A three-month trial done on type 2 diabetes patients found that berberine could lower blood glucose levels in a similar way to metformin; however, 34.5% of patients suffered from transient gastrointestinal side effects.
Both compounds are proposed to be able to support weight loss by increasing insulin sensitivity and improving blood sugar levels; however, metformin is not a weight-loss drug, while berberine has limited evidence from clinical studies for any indication.
How did we evaluate the best berberine supplements?
We wanted to ensure we correctly delved into the research behind berberine, so our research team spent several days reading peer-reviewed articles to confirm the product lineup. Then, we spent a few more days analyzing each product in depth to deliver a comprehensive review. Below are some of the factors we paid attention to.
Ingredient quality | Dosage | Third-party testing |
High-quality and tested | Science-backed | Label accuracy |
- Ingredient quality. The ingredients' quality determines the supplement's quality and value, so we picked products from reputable brands that are transparent about their manufacturing processes and ingredient quality.
- Dosage. Research on the safe daily dose of berberine is still ongoing, so it would be best to consult your doctor. Start with supplements at a lower dose and never exceed the recommended dose on the label.
- Third-party testing. Third-party testing is essential to ensure adherence to the label, quality, and the absence of cross-contamination.
Best berberine supplements: detailed list
Below, we dive into each product on our list in detail. Read on to learn more about the products, their key features and ingredients, and customer reviews to get a full picture.
1. Utzy Naturals — best berberine to support metabolism
Utzy Naturals’ website — 4.4 ⭐⭐⭐⭐
Amazon — 4.6 ⭐⭐⭐⭐
Utzy Naturals formula goes beyond traditional supplements to promote metabolic and cardiovascular health. According to the manufacturers, it is designed to balance HDL and LDL cholesterol, which may help improve heart health while supporting weight management efforts.
The secret lies in its blend of Bergamonte® and Himaberb®, which, according to the brand, may work synergistically to help regulate cholesterol levels and contribute to stabilizing blood sugar by enhancing insulin sensitivity. This dual action may help support a healthy metabolism, making progress toward your weight loss goals more attainable.
We appreciate the brand’s commitment to transparency. All its products, including Berbercol, undergo third-party testing, and detailed results are accessible through a certificate of analysis on its website.
The serving size is two capsules daily. A single container with a 30-day supply costs $44.95 ($1.50 per serving).
Who might benefit the most from Berbercol?
This product may be suitable for people looking for a natural supplement to support blood sugar control and balance their cholesterol levels. Those looking for extensive testing and outstanding quality may also consider this product.
Key features of Berbercol
- 600 mg berberine HCl hydrate (Himaberb®)
- Bergamonte®
- Third-party tested
- 90-day money-back pledge
Ingredients
What users like about the product
- Cholesterol-lowering effect. Several users report improvements in their cholesterol levels after implementing this product.
- Natural ingredients. Most users appreciate the blend of all-natural ingredients.
- Well tolerated. A couple of users were happy about this product's lack of adverse side effects.
What users don't like about the product
- Slow results. A few customers found that it takes some time to notice the benefits after consistently using the product.
- Cost. The price was too high for some.
- Taste. Although the supplement comes in capsules, some found they leave an unpleasant aftertaste.
Company review
We have reviewed several Utzy Naturals products separately. The company stands out with its premium products made from natural ingredients and thorough testing for quality and label accuracy.
Furthermore, we appreciated that the company aims to cater to a broad audience by ensuring its products are gluten, yeast, artificial flavor, and color-free. All products have USDA Organic and third-party testing certificates. Lastly, the 90-day Empty Bottle Guarantee, meaning you can return the product 90 days after purchase, even if the bottle is empty, showcases commitment to customer satisfaction.
Special offers
Subscribing to monthly deliveries saves you 10%.
2. ProHealth — best berberine supplement designed to increase bioavailability
ProHealth website — 4.8 ⭐⭐⭐⭐
Amazon — 4.3 ⭐⭐⭐⭐
Berberine Pro by ProHealth Longevity is formulated to support healthy aging, heart health, and blood sugar control.
This product packs 600 mg of berberine HCl per capsule, the daily serving being two capsules. The addition of bioperine and alpha lipoic acid may provide additional benefits. Alpha lipoic acid may support the potential berberine's heart health and blood sugar balancing properties, while bioperine extract may increase berberine’s bioavailability.
Moreover, the product does not contain any artificial ingredients, dairy, egg, soy, fish, gluten, or wheat.
Each batch is third-party tested to ensure adherence to the label. Everything is also produced in an FDA-registered, GMP-certified facility.
A 60-capsule container costs $29.95 ($1 per serving).
Who might benefit the most
This product may be suitable for people who are looking for a high-quality berberine supplement formulated to support heart health and aging.
Key features of Berberine Pro
- 1,200 mg of berberine HCl per daily serving
- Addition of bioperine extract and alpha lipoic acid
- Third-party tested
- 75-day money-back guarantee
Ingredients
What users like about the product
- Blood sugar control. Many users report improved blood sugar control and fewer glucose spikes throughout the day.
- Energy boost. Some users report feeling more energetic when taking the supplement.
- Dosage. Many customers appreciate the 1,200 mg dosage, which is higher than many competing products.
What users don't like about the product
- Price. Some users found the product too expensive for regular use.
- Pill size. A few customers had difficulties swallowing the pills, as they are on the bigger side.
- Time to see results. The reviews mention needing to wait quite a while to start experiencing the benefits.
Company review
Rich Carson founded ProHealth Longevity in 1988. The California-based company focuses on high-quality products that can support healthy aging. According to the brand, all ingredients are science-backed, even though clinical research is still in its infancy.
In addition to offering high-quality supplements, ProHealth also aims to educate its customers by publishing guides and articles about longevity. If that is not enough to help you pick the supplement most suited for your needs, the brand can connect you with its in-house nutrition advisors for more personalized advice.
Special offers
Subscribing to regular deliveries gets you 30% off.
3. Health Nutrition — best high-dose berberine supplement
Health Nutrition website — 4.7 ⭐⭐⭐⭐
BerbaPrime berberine by Health Nutrition is one of the highest-dose options on the market, packing 1,500 mg of berberine HCl in a daily serving. However, the dose is spread out across three capsules, so you can opt for less if that is what you prefer or were advised to do so.
The supplement does not contain any additional active ingredients. Everything is manufactured in a GMP-certified facility to ensure the quality of the product. However, a certificate of analysis or third-party testing certificate is unavailable.
A bottle of 30 servings costs $59.99 ($2 per serving).
Who might benefit the most from BerbaPrime
People who are looking for minimal ingredients and a bigger dose of berberine supplement may like this product.
Key features of BerbaPrime
- 1,500 of berberine HCl per serving
- 3-capsule daily serving
- No additional active ingredients
Ingredients
What users like about the product
- Effectiveness. Many customers say they feel that this product has supported their weight loss efforts.
- Increased energy. Several users experienced improved energy levels with consistent use.
- Natural formula. The customers appreciate the simple formula with no artificial fillers or additives.
What users don't like about the product
- Price point. Some customers feel like the price is too steep for regular use.
- Limited availability. Some users wish the product was available on more sites or their local store.
- Lack of transparency. The lack of clarity regarding third-party testing is concerning to some.
Company review
Health Nutrition makes a variety of health and wellness supplements to support overall health. Most of their products focus on weight management support to fight the obesity epidemic.
They aim to offer effective, high-quality, science-backed products to support and optimize their customer nutrition.
Special offers
Offer | Savings |
Subscribe and save | 20% off first order |
Subscribe and save | 30% off second order |
Subscribe and save | 40% off the third order onward |
4. partiQlar — overall best berberine supplement
partiQlar website — 5 ⭐⭐⭐⭐⭐
Pure Berberine HCl by partiQlar contains more than 97% pure berberine, making it one of the purest on the market. You know exactly how much of the pure active compound you are getting in each capsule.
Each capsule contains 600 mg of berberine, which is ensured through thorough third-party testing. The supplement is non-GMO, free from artificial colors or flavors, and vegan-friendly. All claims are supported with certificates to avoid empty promises.
A bottle with 60 capsules costs $25.99 ($0.43 per capsule).
Who might benefit the most from Pure Berberine HCl?
People who are seeking a pure berberine supplement free of any unnecessary ingredients may prefer this product.
Key features of Pure Berberine HCl
- 600 mg of berberine HCl per capsule
- Above 97% purity
- Free of artificial ingredients and additives
- Third-party tested
- 60-day money-back guarantee
Ingredients
What users like about the product
- High purity. Most customers choose this product for its high purity.
- High quality. Third-party testing and certificates of analysis are appreciated by many.
- Minimal ingredient. The absence of any additional ingredients is valued by most customers.
What users don't like about the product
Unfortunately, the brand does not provide negative reviews.
Company review
We have reviewed other products by partiQlar and overall found that the brand is dedicated to producing high-quality longevity supplements. The brand focuses on simple formulas and high purity of the active ingredients.
As the name suggests, the manufacturer is particular about its products. Hence, all supplements undergo rigorous third-party testing to ensure adherence to the label and quality. The certificates of analysis are available on their website, so customers know exactly what they are getting.
Special offers
Offer | Savings |
Subscribe and save | 10% off |
Buy a pack of 3 | 19% off |
Buy a pack of 6 | 29% off |
5. HUM — best berberine supplement to support healthy glucose levels
HUM website — 4.6 ⭐⭐⭐⭐
HUM’s Best of Berberine is formulated to support healthy glucose levels and help with weight management. The daily serving size contains 1,200 mg of berberine HCl, which is complemented with 5 mg of BioPerine® — black pepper extract, which may increase bioperine’s absorption.
The Best of Berberine is third-party tested to help ensure quality and adherence to the label. It is also manufactured in FDA-registered facilities and has a cGMP certificate.
The product does not include any artificial colors, sweeteners, flavors, or preservatives. It is also free of the top 12 allergens.
A 30-day supply costs $35 ($1.17).
Who might benefit the most from Best of Berberine
People who are looking to balance their blood glucose levels and support their weight loss journey may like this product.
Key features of Best of Berberine
- 1,200 mg of berberine HCl per serving
- Contains 5 mg of BioPerine®
- Third-party tested
- Free of artificial ingredients
- Vegan
Ingredients
What users like about the product
- Blood glucose management. Many users report experiencing more stable blood glucose levels when using the product.
- Weight management. Several users report positive effects on weight management.
- Formula. The majority of customers appreciate the clean ingredients and vegan capsules.
What users don't like about the product
- Capsule size. Some users found the capsules to be bigger than expected.
- Gastrointestinal problems. A few customers reported initial stomach sensitivity when starting with the supplement.
Company review
HUM Nutrition is focused on providing science-backed wellness supplements for supporting health, wellness, and beauty from within. The brand emphasizes the use of clinically researched ingredients and transparency about their formulations.
Each HUM product targets specific health goals and undergoes third-party testing to ensure quality and adherence to the label. The blend of natural ingredients and thorough testing makes HUM one of the leaders in the wellness industry.
Special offers
Save 10% by buying any 3 HUM products.
6. Vitality Pro — top-rated berberine supplement
Vitality Pro website — 5 ⭐⭐⭐⭐⭐
Trustpilot — 4.9 ⭐⭐⭐⭐
Advanced Berberine by Vitality Pro stands out for its high rating and positive customer reviews on Trustpilot.
The product is made to the highest quality standards, undergoes third-party testing, and is manufactured in accordance with GMP standards. The certificate of analysis is available on their website.
However, the key selling point of the Advanced Berberine is its formulation. Each capsule contains 500 mg of berberine HCl and 125 mg of milk thistle. The latter is added for its potential to make it easier for the body to absorb berberine.
The manufacturer recommends taking one capsule 2–3 times per day, depending on the dose recommended by your doctor.
A 120-capsule container costs $44 ($0.37 per capsule).
Who might benefit the most from Advanced Berberine?
People looking for a berberine supplement with potentially improved absorption may prefer this product. Those who want to adjust their daily intake based on personal needs may also find the 500 mg per capsule dose convenient.
Key features of Advanced Berberine
- 500 mg of berberine HCl per capsule
- Milk thistle added for better absorption
- Third-party tested
- Vegan
- Non-GMO and artificial additive-free
Ingredients
What users like about the product
- Customer service. Most customers praise the customer service, fast shipping, and how quickly any issues are resolved.
- Quality. Most of the reviews praise the quality of this supplement as well as the sturdy packaging.
- Effectiveness. Users find this product to effectively support their weight loss goals.
What users don't like about the product
Unfortunately (or fortunately), negative reviews are unavailable.
Company review
Vitality Pro aims to support its customers on their wellness journey by providing high-quality supplements. Based on the principles of natural health and a holistic approach to well-being, Vitality Pro offers a wide range of products to support different goals and needs.
All products are made from high-quality ingredients with science-backed formulations. To ensure quality and adherence to the label, Vitality Pro third-party tests all their products and makes the certificate of analysis easily accessible.
Special offers
Subscribing saves you 5%.
Comparing the top berberine supplements
Brand | Cost per serving | Berberine dosage per serving | Claimed benefits | Additional active ingredients | Berberine form |
Utzy Naturals | $1.50 | 600 mg | Balances HDL and LDL cholesterol, improves heart health, supports weight loss | Bergamonte® | HCL |
ProHealth | $1 | 1,200 mg | Supports healthy aging, blood sugar control | Bioperine, alpha lipoic acid | HCL |
Health Nutrition | $2 | 1,500 mg | Supports metabolism, supports healthy cholesterol levels, balances blood sugar levels | - | HCL |
partiQlar | $0.43 (per capsule) | 600 mg | Blood sugar control, cholesterol management, anti-inflammatory, antimicrobial, weight management, neuroprotective | - | HCL |
HUM | $1.17 | 1,200 mg | Supports healthy glucose levels, weight management | BioPerine® | HCL |
Vitality Pro | $0.37 (per capsule) | 500 mg | Regulates blood sugar, manages cholesterol | Milk thistle extract | HCL |
Can you take berberine long-term?
There are no conclusive studies on long-term berberine use in humans, so it would be best to consult your healthcare provider about taking the supplement.
Is berberine bad for the gut?
Berberine’s effect on the gut is complicated.
On the one hand, the supplement may have a positive effect on gut health by reducing inflammation and promoting the growth of beneficial bacteria, as shown in animal studies. However, in some individuals, berberine may cause gastrointestinal issues such as diarrhea, constipation, or cramping, especially when taken in large doses or on an empty stomach.
If you are experiencing side effects, consult your doctor. You can also try sticking to lower doses and taking the supplement with food to minimize gut irritation.
What strength berberine should I take?
There are no official recommendations on the appropriate and safe dosing of berberine for any indication, and limited safety and efficacy data from clinical studies exist.
Most berberine supplements range between 500 mg and 1,500 mg per day. The strength most suited to you can depend heavily on your personal goals and factors such as age, weight, and any underlying condition. It's important to start with a lower dose and discuss and always consult a healthcare provider to determine the best dosage for your specific needs.
You may also be interested in
Berberine vs. Metformin: can one replace the other?
Berberine supplements: benefits, uses, and side effects
A must-read guide to berberine
FAQ
What is the most natural form of berberine?
The most natural form of berberine is derived from plants such as Berberis aristata or Berberis vulgaris (also known as barberry). Berberine can be extracted from these plants and used in supplements.
What cannot be taken with berberine?
Berberine can interfere with blood pressure medication, blood thinners, metformin, other blood sugar-lowering drugs, and drugs metabolized by the liver. If you are taking prescription medication, it is always best to consult your doctor before starting a new supplement.
Is 1,000 mg of berberine enough?
There are no official recommendations on appropriate and safe dosing of berberine for any indication, as there is limited safety and efficacy data from clinical studies, therefore, it is difficult to determine whether a 1,000 mg dose is appropriate to see any results. Readers are encouraged to consult a healthcare professional before starting supplementation.
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