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The Best Supplements for Brain Health — Top Brands in 2024

If you are searching for the best brain supplements, you have a lot of options to consider. After all, this category of supplements includes a wide variety of products: from omega-3 capsules to Lion's mane extracts.

To help you make a more informed decision, our team selected the top five brain health supplements that, according to us, are of high quality and may potentially offer cognitive benefits.

Our picks of the 5 best brain supplements: shortlist

  1. Real Mushrooms — best Lion’s mane supplement for cognition
  2. Performance Lab — best omega-3 supplement for brain health
  3. Purovitalis — best resveratrol supplement for brain health
  4. Oweli — best brain supplement featuring wide range of ingredients
  5. Pro Health — best magnesium supplement for brain health

Criteria we follow for choosing the best supplements for brain health

When crafting this article, we only included products that may, in our opinion, be worth considering based on the criteria below.

IngredientsPriceBrand transparencyCustomer experience
Science-backed ingredients$29.95–59.99Tested by independent laboratories and made in GMP-certified or NSF-certified facilitiesGenerous refund policies, free shipping
  • Ingredients. When curating this list, we analyzed what ingredients may be beneficial for brain health. We only picked products that include ingredients that have at least some scientific basis for their usage.
  • Price. The prices of brain supplements vary quite drastically depending on such factors as ingredients, additional certifications, and manufacturing quality. We picked products that do not compromise on quality.
  • Brand transparency. We preferred products that were third-party tested and made in certified facilities.
  • Customer experience. We preferred products that include a reasonable refund policy and free shipping.

Our picks of the 5 best supplements for brain health: an overview

Since brain health supplement is a broad term, it may be hard to figure out what products are worth your consideration.

If you are looking into purchasing high-quality supplements for brain function, our team has curated a list of possible options.

1. Real Mushrooms — best lion’s mane brain supplement

Real Mushrooms lions mane supplement bottle

Organic Lion's Mane Extract Capsules by Real Mushrooms stands out as one of our top choices for brain supplements made from mushrooms. It contains one active ingredient, lion’s mane mushroom extract. This mushroom is widely consumed in Asian countries for its possible health benefits.

It has been postulated that Lion’s mane may help to improve cognitive function and alleviate low mood with prolonged use. This mushroom contains hericenones and erinacines, substances that may have neuroprotective properties. Emerging animal studies also note that Lion’s mane may be helpful in delaying neuronal cell death in some neurodegenerative diseases. As for now, no human studies have been conducted to confirm this theory.

This Real Mushrooms supplement is made in an NSF-certified facility and adheres to strict production regulations. Moreover, all products from this manufacturer are extensively tested before hitting the shelves.

A bottle containing 120 capsules is currently priced at $29.95. The recommended daily dosage is 2 capsules, meaning this supplement would cost you $0.50 per day. Unopened packages may be returned within 30 days after the delivery date.

2. Performance Lab — best omega-3 supplement

Performance Labs Omega3

It is a well-known fact that omega-3 is important for one’s heart health. Nevertheless, this essential fatty acid plays a pivotal role in brain health as well. Considering that certain individuals might lack omega-3 in their diets, Performance Lab Omega-3 emerges as an excellent dietary supplement for those seeking the best brain supplements.

Most omega-3 supplements come from fish, and thus might not be suitable for vegans and vegetarians — people who often lack this fatty acid in their diet. Omega-3 in this Performance Lab supplement is derived directly from its original sources in aquatic ecosystems, algae. For this reason, not only is it vegan-friendly but, according to the manufacturer, it does not leave an unpleasant fishy aftertaste.

Performance Lab supplements are manufactured in FDA-registered and NSF cGMP-compliant facilities. Moreover, this omega-3 product has been third-party tested by Clean Label Project.

One month's supply (90 softgels) will cost you $49.00. The recommended daily dose is 3 softgels, therefore this supplement would cost you $1.63 per day.

If you have not tried Performance Lab products before, you are eligible for the 30-day money-back guarantee. If you do not see any desired results within 30 days of usage, you can claim a refund on your purchase. Subsequent purchases will be subject to the 14-day refund policy.

3. Purovitalis — best resveratrol supplement for brain

Purovitalis Quercetin

Resveratrol, a natural compound found in various foods such as grapes, is a popular ingredient in brain supplements. Some animal studies suggest that resveratrol may boost blood circulation and, in turn, potentially foster cognitive function.

This Purovitalis supplement is renowned for its bioavailability as it uses liposomes to encase resveratrol within the capsule. As claimed by the manufacturer, this approach enhances absorption ensuring more efficient utilization of the compound by the body. Each serving contains 240 mg of resveratrol.

Purovitalis undergoes rigorous third-party testing to guarantee its quality, purity, and adherence to the highest standards of excellence for each batch. Moreover, this supplement is made in a GMP-certified facility.

One bottle (60 capsules) of this Purevitalis supplement is currently available for $45. As one serving is one capsule per day, this supplement would cost you $0.75 per day.

4. Oweli — best brain supplement with a wide range of ingredients

Oweli Neuro-comm

Neuro by Oweli is a brain supplement made from two main groups of ingredients: essential micronutrients and a proprietary blend.

The first group includes various micronutrients that we must get from our diets. Low levels of some of the included micronutrients (e.g. selenium) are associated with cognitive dulling such as fatigue and mental fog.

The proprietary blend, on the other hand, includes various substances that are not essential but may be beneficial for brain health, for example, DMAE, GABA, Bacopa Monnieri, and huperzine A. Together, as claimed by Oweli, they may boost cognitive function, help fight stress, and increase mood. However, there is no information about the individual amount of active ingredients in the proprietary blend, meaning it makes it harder to judge the product’s effectiveness.

As the manufacturer claims, it may take 30 days to experience the full effects of this supplement. Oweli Neuro is protected by a 100-day money-back guarantee and allows customers to return empty bottles for a full refund.

Moreover, all Oweli products are manufactured in FDA-registered and cGMP-compliant facilities, ensuring strict adherence to safety regulations.

One bottle containing 30 servings retailed at $59.99. If taken daily as recommended, this product would cost you $2.00 per day.

5. Pro Health — best magnesium supplement for brain health

ProHealth ProBrain-Mag Pro Magnesium L-Threonate

As this ProHealth features magnesium L-threonate, it is a great option if you are seeking magnesium supplements for brain health.

Several animal studies have indicated that magnesium L-threonate could potentially be the most effective magnesium form for promoting brain health. Additionally, this magnesium form has gained popularity in brain supplements because preliminary clinical trials have shown potential benefits for cognitive functions such as memory.

As claimed by the manufacturer, this ProHealth supplement has been tested by an independent lab to ensure high quality. Moreover, this supplement was made in GMP-certified facilities.

At the moment, you can get one bottle (or 90 capsules) of this product for $30.47. As one recommended serving is 3 capsules, Brain-Mag Pro would cost you $1.02 per day. You have the option to receive a refund for the unused portion of the product within 75 days of delivery.

Comparison of the best supplements for brain health

ProductPrice per container*Price per serving*Main active ingredients Refund policyBrand transparency
Real Mushrooms Organic Lion’s Mane$29.95$0.50Lion’s mane extract30-dayMade in an NSF-certified facility, third-party tested
Performance Lab Omega-3$49.00$1.63Omega-314-dayMade in FDA-registered and NSF cGMP-compliant facilities, third-party tested
Purovitalis$45.00$0.70Resveratrol30-dayMade in GMP-compliant facilities, third-party tested
Oweli Neuro$59.99$2.00B-group vitamins, other vitamins, zinc, calcium, selenium, and other minerals, proprietary blend (DMAE bitartrate, green tea extract, GABA, Bacopa Monnieri, huperzine A, etc.)100-dayMade in FDA-registered and GMP-compliant facilities
ProHealth$30.47$1.02 Magnesium L-threonate75-dayMade in GMP-compliant facilities, third-party tested

* — If purchasing as a one-time purchase.

While some individual active ingredients in dietary supplements may have been studied for their potential benefits discussed in this article, their interactive effects, as well as the safety and effectiveness of the overall formulation has not been fully established.

Before buying supplements for brain health: what to consider

Choosing a supplement that aligns with your needs is not as straightforward as it may seem at first glance. There are many factors that are worth considering.


Ingredients are of utmost importance when choosing the best supplements for cognitive function. As the composition of brain supplements can differ significantly, it is crucial to be diligent when choosing the most suitable product for you. It is advised to read the label carefully before starting to take any supplements.

Other medications you may be taking

If you take any medications or even other supplements, it is recommended to consult a healthcare professional before including a new product in your routine. Some active ingredients may pose risks when taken in large quantities or have adverse effects when combined with other substances.


Price is undeniably an important factor to consider when choosing supplements. However, keep in mind that some compounds in supplements may be more costly. In addition, always check the quality to make sure the manufacturer is not compromising on it to reduce the price. Look for certifications or information on facilities where the supplement is produced.


Supplements for brain health may come in different forms such as soft gels, capsules, powders, etc. It's important to assess whether you can incorporate these supplements into your daily routine. For example, certain powders may have an unpalatable taste for some individuals. However, they may be more suitable for people who have difficulties swallowing pills.

Supplements for brain health: do they work?

While dietary supplements are not used to treat, cure, or prevent any diseases, they may be beneficial for one’s health, including brain health.

The category of brain supplements is a broad one. It includes supplements that may have an impact on brain function owing to their potential antioxidative, anti-inflammatory, and neuroprotective abilities. These properties may contribute to enhanced memory, increased focus, improved mental sharpness, and some other advantages. The specific benefits of each supplement can vary, depending on their unique active ingredients.

Not all active ingredients in these brain supplements have been clinically tested, meaning their effectiveness is not guaranteed. It is crucial to check the label and do some research to better understand whether the ingredient is scientifically validated for its claimed cognitive benefits. Consulting with a healthcare professional for more information is encouraged.

Ingredients used in supplements for cognitive function

Brain supplements typically consist of a diverse array of active ingredients. Here you will find a list of the ingredients commonly present in these supplements. Keep in mind that each product will have a unique formula, so it's crucial to review the label for specific details.

B-group vitamins

B-group vitamins are linked to brain function. Deficiencies in these vitamins may increase one’s risk of developing cognitive impairments, such as memory loss or reduced reasoning abilities.


Omega-3 is an essential fatty acid found in food such as fish. While it is well-known that omega-3 is crucial for one’s heart, this nutrient is important for brain function as well. Supplementation of omega-3 may improve memory in individuals who lack this fatty acid in their diet.


L-tyrosine is an amino acid involved in the production of certain neurotransmitters in the brain. Some studies show that supplementation with L-tyrosine may support working memory, especially during stressful and cognitively demanding situations.


GABA is a naturally occurring neurotransmitter that blocks chemical signals in the brain. It may have a calming effect and increase sleep quality. However, scientists have not reached a consensus on whether the supplementation of this substance may be beneficial.

Huperzine A

Huperzine A is a chemical compound that comes from Chinese club moss. Some studies have suggested that supplementation of this compound might increase cognitive function in patients with Alzheimer's disease. Currently, there is no consensus on this ingredient as most trials testing huperzine A were of low quality.

Lion’s mane

Emerging animal studies on hericenones and erinacines, compounds found in Lion’s mane mushroom supplements, show that they may have benefits for brain health. It has been postulated that these compounds have neuroprotective properties, and thus may perhaps delay neuronal cell death. No clinical trials have proven this, but both in vitro studies and in vivo animal models show promising results.

Should I include brain supplements in my diet?

Healthy individuals may include brain supplements in their routine although a healthy and balanced diet is encouraged first. In some cases, it is harder to get certain nutrients in one’s diet, and supplements may be a way to ensure there are no nutritional deficiencies. For example, vegans may lack B-group vitamins and thus could consider taking supplements.

If you are experiencing persistent symptoms related to your brain function such as memory problems, you should contact your healthcare provider before starting a new supplement. Brain supplements are not used to cure, treat, or prevent any disorders.

Prescription drugs vs. OTC supplements for brain health

Prescription drugs are medications that have FDA approval to treat, cure, or prevent a disease. They must show effectiveness in clinical trials and undergo stringent testing for safety.

Dietary supplements, on the other hand, do not need to be approved by the FDA, thus their manufacturing does not have to be overseen by official institutions. While they can not cure or prevent any diseases, they may be beneficial for the overall brain health of healthy individuals. In addition, many of the ingredients in brain supplements may have been clinically tested and shown some effectiveness.

OTC supplements are not a substitute for prescription drugs.

Best supplements for brain health — conclusion

Together with a balanced diet, good sleep hygiene, physical and mental activities, brain supplements may be used to support a healthy brain.

If you decide to opt for supplements for cognitive function, it is important to consider various factors. Firstly, it is important to examine the active ingredients contained within the supplement. This helps to select supplements that align with your specific needs. Secondly, it is advised to assess whether the active ingredients in these supplements have any scientific support. This allows you to better understand whether the supplement may deliver the desired results.

Discover other products that may be helpful for cognitive function

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Best Lion’s mane supplements that may be helpful for cognitive function.


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