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Best Choline Supplements: Your Complete Buying Guide for 2024

Choline is a crucial nutrient that is often overlooked when discussing the body's nutritional needs. Choosing the best choline supplement is crucial for supporting brain health, liver function, and overall well-being.

Choline is a crucial nutrient that is often overlooked when discussing the body's nutritional needs.

With this article, we invite you on a journey to explore the various top-rated choline supplements, comparing forms, reviewing product quality, manufacturing standards and quality testing, and customer feedback to help you make an informed decision.

Whether you're looking for cognitive enhancement, metabolic support, or general health benefits, understanding the different types of choline supplements and their unique features will guide you in selecting the best option for your needs. Read on to discover the top choline supplements available today.

Best choline supplement: a shortlist

  1. Nested Naturals — best choline supplement to combine with a healthy diet
  2. Double Wood Supplements — best choline supplement for bioavailability
  3. Nature Made — best choline supplement with the highest dose per serving
  4. NOW — best choline supplement with inositol
  5. Nutricost — best choline supplement for those on a budget

How we compiled our list of the best choline supplements

FormAdditional ingredientsQuality certificationsCustomer reviewsPrice
Type of choline usedPresence of synergistic compoundsProduct testing and manufacturing standardsFeedback from actual users$0.05–1.00 per serving
  • Form. We evaluated whether the product uses phosphatidylcholine or citicoline, considering these as the best forms of choline for absorption and potential neurological support.
  • Additional ingredients. Supplements that include complementary elements, which may support choline's absorption or its benefits, were prioritized.
  • Quality certifications. Products that have been verified for purity and potency by independent laboratories received higher rankings to ensure they meet high standards.
  • Customer reviews. Feedback from users provided insights into the real-world effectiveness and satisfaction with the supplement, guiding our recommendations.
  • Price. We considered affordability to ensure that the best choline supplements are accessible for regular use by a wide audience.

Best choline supplements: an overview

To support choline intake, a large number of supplement providers have emerged with promising products.

Our list of the top five choline supplements aims to overview how each brand fares in delivering essential nutrients and fulfilling claims like mental clarity and liver health. We have examined the ingredients, customer satisfaction, and manufacturing quality data to help you on your quest to find the best choline supplement.

1. Nested Naturals — best choline supplement to combine with a healthy diet

Nested Naturals Choline Bitartrate 500mg

Nested Naturals Choline Bitartrate supplement offers a simple way for anyone to cater to their choline needs. Thanks to its high-quality choline bitartrate, the product contains sufficient dosage to provide an additional boost to choline levels in combination with a healthy diet. The choline dose is 91% of the full recommended daily intake.

The product undergoes rigorous third-party testing and holds certifications, ensuring purity and safety. The product is also manufactured under good manufacturing practices (GMP), ensuring no batch-to-batch variation and overall product integrity. It features clean, non-GMO ingredients and is well-regarded by users for its ease of use.

On the whole, the customer reviews are very positive, celebrating the affordability, quality, and transparency that the brand offers.

A bottle of 45 day supply costs $22.95 ($0.51 per two-capsule serving).

2. Double Wood Supplements — best choline supplement for bioavailability

Double Wood CDP Choline

Double Wood Supplements' CDP Choline (Citicoline) is a standout choice for those seeking the most bioavailable form of choline. This supplement uses high-quality citicoline, known for its excellent absorption and brain health benefits, making sure that the majority of the 300 mg of citicoline per serving finds its way into the bloodstream.

The product undergoes rigorous third-party testing, ensuring that Double Wood’s citicoline is free from toxins and harmful substances. The capsules are non-GMO and gluten-free, catering to various dietary needs, although the capsules are made of gelatin, making them non-vegan.

As evidenced by more than 2,000 customer reviews, the product is praised for its effectiveness in enhancing focus, memory, and mental clarity.

A bottle of 60 servings cost $24.95 ($0.42 per one-capsule serving).

3. Nature Made — best choline supplement with the highest dose per serving

Nature Made Choline Extra Strength Dosage

Nature Made Extra Strength Choline offers a potent 800 mg of choline per serving. This high-dose formula is designed to provide a substantial boost to your choline levels and support health parameters across multiple targets, like brain and liver health.

The supplement is made with high-quality ingredients and adheres to strict manufacturing standards, although third-party testing is not claimed to be carried out.

Confident in its product, the brand manages to achieve good customer satisfaction — nearly 40 happy customers appreciate its effectiveness in enhancing cognitive function and overall wellness.

The vegetarian-friendly formula makes it accessible for those with dietary requirements.

A 20-day supply costs $24.99 ($0.83 per three-capsule serving).

4. NOW — best choline supplement with inositol

NOW Supplements Choline & Inositol

NOW Supplements Choline & Inositol is a fantastic choice for those looking to support their brain health. This product combines choline, essential for neurotransmitter synthesis (in other words) making chemical messengers), with inositol, known to support cellular health. Moreover, choline and inositol synergize and may produce an overall enhancement to your neurons, working together to fortify the composition of nerve cell membranes.

The supplement’s one capsule per serving provides 250 mg of choline, which should be sufficient to achieve the synergistic effect with 250 mg of inositol.

The ingredients are of high quality, and NOW Supplements adheres to good manufacturing practices (GMP), ensuring product safety and integrity.

Customer reviews are copious, with over six thousand customers highlighting mental clarity, enhanced weight loss, and improved overall well-being. The capsules are easy to take and are suitable for vegetarians.

A 100-day supply costs $9.17 ($0.09 per one-capsule serving).

5. Nutricost — best choline supplement for those on a budget

Nutricost Choline Bitartrate 650mg

Nutricost’s choline supplement offers an excellent way to supplement with choline. A decent choline dose of 260 mg per single capsule caters for the majority of choline needs, supporting a healthy diet.

Nutricost ensures that the ingredients in this supplement are safe. The brand manufactures their choline supplement in an FDA-registered, GMP-compliant manufacturing facility, ensuring top quality and no batch-to-batch variation.

Lastly, customer reviews speak volumes about user satisfaction. With nearly 400 reviews, the product has garnered praise for the number of servings in the container and affordable price per serving.

240 capsules cost $16.95 ($0.07 per one-capsule serving).

Comparing the best choline supplements

BrandPrice per bottlePrice per servingNumber of servingsAmount of choline per servingThird-party tested?Choline form
Nested Naturals$22.95$0.5145500 mgYesBitartrate
Double Wood Supplements$24.95 $0.4260300 mgYesCiticoline
Nature Made$24.99$0.8320800 mgNoBitartrate
NOW$9.17$0.09100250 mgNoBitartrate
Nutricost$16.95 $0.07240260 mgNoBitartrate

What is choline?

Choline is an essential nutrient crucial for various bodily functions. These include maintaining cell membrane integrity, synthesizing neurotransmitters (chemical messengers) like acetylcholine, and supporting lipid metabolism and methylation processes (or, in simpler terms, it supports the metabolism of fatty compounds and other biochemical processes).

It plays a significant role in liver function, muscle movement, brain development, and nervous system health. Though the body produces some choline, dietary intake is necessary to meet physiological needs.

Dietary sources of choline include eggs, liver, fish, nuts, beans, and cruciferous vegetables such as broccoli and Brussels sprouts. Ensuring adequate choline intake is essential for overall health, particularly for pregnant women, as it supports fetal brain development and reduces the risk of neural tube defects.

Health benefits of choline supplements

Read on to explore several key choline benefits that are solid reasons to keep your choline levels sufficiently high.

Brain health

Choline plays a critical role in brain function by supporting the synthesis of acetylcholine, a neurotransmitter involved in memory, mood, and muscle control.

Studies have shown that adequate choline intake may enhance cognitive performance and reduce the risk of neurodegenerative conditions like Alzheimer's disease.

A 2011 study also found that higher dietary choline intake was associated with better cognitive performance in middle-aged men. This evidence suggests that choline supplements may help support brain health and cognitive function, especially as one ages.

However, further studies are still needed to confirm the evidence behind this potential benefits.

Liver function

Choline is essential for liver health, primarily due to its role in lipid metabolism and preventing fat accumulation in the liver. Without adequate choline, the liver may develop a condition known as nonalcoholic fatty liver disease, which can lead to more severe liver damage.

Research studies have demonstrated that choline deficiency could lead to liver damage and dysfunction. Choline supplements may potentially help prevent or alleviate symptoms of liver conditions by ensuring the proper metabolism of fats and maintaining liver health.

Role in metabolism

Choline is integral to metabolism, particularly in the breakdown and utilization of fats. It aids in the formation of lipoproteins (molecules made of fats and proteins), which transport fats through the bloodstream.

A study on rapid weight loss in female athletes demonstrated that choline supplementation could improve fat metabolism and help with weight management.

By supporting lipid metabolism, choline supplements may indirectly help individuals maintain a healthy weight and improve overall metabolic health. However, further large-scale studies are needed to support this benefit.

Signs you might need choline supplementation

When choline levels dwindle, symptoms of deficiency start manifesting. When your body starts running low on choline, it lets you know through symptoms such as muscle damage and liver issues like nonalcoholic fatty liver disease.

Demographics that might benefit from choline supplementation include older adults, vegetarians, and those with liver conditions. Since these groups might not get enough choline from their diets, they may need supplements to meet their nutritional needs.

If you feel that you may be experiencing any symptoms of choline deficiency or you belong to the said high-risk groups, you should seek your medical professional’s opinion. Your doctor is there to give personalized advice and to provide appropriate supplementation recommendations.

Types of choline supplements

Choline supplements come in various forms, each offering distinct benefits and bioavailability.

  • Choline bitartrate is an affordable option with moderate absorption, suitable for general supplementation.
  • Choline chloride is another form, often used in research and supplements for its water-soluble properties.
  • Citicoline (CDP-Choline) is highly bioavailable and supports brain health by effectively crossing the blood-brain barrier.
  • Phosphatidylcholine is derived from lecithin and supports liver health.
  • Alpha-GPC is known for its excellent absorption and cognitive benefits.

How to safely use choline supplements

The recommended choline dosage varies by age and health status. Adults typically need 425–550 mg of choline per day, depending on gender and dietary intake. Exceeding these amounts can lead to potential side effects like low blood pressure, sweating, and gastrointestinal distress.

Choline supplements may interact with medications, such as anticholinergic drugs, affecting their efficacy. It's essential to consult a medical professional before starting supplementation to determine the appropriate dosage and to minimize the risk of adverse effects.

Best choline supplement — conclusion

Choosing the best choline supplement involves considering factors like the form of choline, additional ingredients, quality certifications, customer reviews, and price. You should expect to see benefits like brain health, liver function, metabolism, and pregnancy support.

Different types of supplements, such as choline bitartrate, phosphatidylcholine, and alpha-GPC, offer varied bioavailability and absorption rates. It's important to follow recommended dosages and consult a healthcare professional to ensure safe use and avoid potential side effects and interactions with medications.


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