On the journey toward peak wellness, fisetin stands out as a formidable ally, offering potential antioxidant and anti-inflammatory properties to tackle the effects of aging. However, despite its presence in foods, achieving therapeutic levels through diet alone may be insufficient. Fisetin supplements emerge as a strong ally that can potentially shield against chronic stress and enhance cognitive function.
In this article, we will review our pick of the best fisetin supplement products, including their features and benefits.
Best fisetin supplement: a shortlist
- GenuinePurity — best overall fisetin supplement
- ProHealth Longevity — best fisetin supplement with additional ingredients
- Double Wood Supplements — best fisetin supplement for vegans
- vitalityPRO — best third-party tested fisetin supplement
- Life Extension — best affordable fisetin supplement
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Comparing the top fisetin supplements in 2024
| Brand | Price | Price per serving | Fisetin amount per serving | Serving size | Servings per container |
| GenuinePurity | $59.95 | $1.00 | 150 mg | 1 capsule | 60 |
| ProHealth Longevity | $37.00 | $0.62 | 125 mg | 1 capsule | 60 |
| Double Wood Supplements | $22.95 | $0.38 | 100 mg | 1 capsule | 60 |
| vitalityPRO | $38.00 | $0.63 | 100 mg | 1 capsule | 60 |
| Life Extension | $10.13 | $0.34 | 8 mg | 1 capsule | 30 |
Best fisetin supplement: overview
If you’re looking for the best fisetin supplement, our in-depth overview of selected products may serve as your guide.
While most products provided on our list have a similar formulation, they may contain some additional ingredients.
We classified the supplements according to our specific criteria and nominations, highlighting the features, benefits, certifications, and serving size. We also provided the pros and cons of each product.
1. GenuinePurity — best overall fisetin supplement
Discover the power of GenuinePurity™ Liposomal Fisetin, a cutting-edge supplement designed to combat oxidative stress in your body by potentially removing hazardous free radicals from the cells.
Each serving delivers 150 mg of fisetin extract, which may provide antioxidant support for cognitive health, heart health, and overall well-being.
The supplement also uses liposomal encapsulation technology for enhanced absorption.
Certified for authenticity, the product is cGMP-certified, third-party tested, and provides a Certificate of Analysis, indicating its quality.
GenuinePurity™ Fisetin is available for $59.95. Additional significant savings on larger orders and a 97-day money-back guarantee are also included, offering a risk-free investment in your health.
2. ProHealth Longevity — best fisetin supplement with additional ingredients
Step into a world of longevity and brain health with ProHealth's Fisetin Pro Longevity supplement.
Each capsule contains 125 mg of Novusetin® fisetin extract, sourced from the Japanese fruit wax tree. It also includes quercetin, a beneficial antioxidant that may protect against cellular damage, and MCT oil powder, which may improve the absorption.
ProHealth ensures quality by conducting third-party lab testing and adhering to GMP standards.
ProHealth Fisetin Pro Longevity is available for $37.00, with an option to subscribe and save 10%, reducing the price to $33.30. It also comes with a 75-day money-back guarantee, offering customers flexibility and assurance.
3. Double Wood Supplements — best fisetin supplement for vegans
Enhance your well-being with highly-rated fisetin capsules by Double Wood Supplements, a potential support for cognitive and cellular health.
Each serving contains 100 mg of fisetin, a potent antioxidant that may promote the scavenging of free radicals.
The product is soy-free, gluten-free, non-GMO, and vegan, catering to a wide range of dietary needs. It is also third-party tested for quality by independent laboratories.
Double Wood Supplements is committed to science and transparency, providing a Certificate of Analysis for each batch. The brand also offers a 30-day money-back guarantee, ensuring customer satisfaction.
With its top-notch customer service, Double Wood's Fisetin might be the right supplement for those looking to improve their cognitive and cellular health, all available for $22.95.
4. vitalityPRO — best third-party tested fisetin supplement
For those who are interested in top-notch longevity products, vitalityPRO offers a highly-rated fisetin supplement tailored to support healthy aging and general health.
The unique flavonoid — fisetin is known for its potent antioxidant and anti-inflammatory effects that play a role in optimal cellular health.
Each serving of the supplement contains 100 mg of fisetin.
According to the brand, vitalityPRO Fisetin is third-party tested for over 95.2% purity, delivering the highest quality. It's also suitable for vegans and contains no GMOs, artificial colors, preservatives, flavors, or major allergens.
The product comes with 100% biodegradable packaging, which reflects the brand's commitment to sustainability.
vitalityPRO Fisetin is priced at $38.00. It is also available for subscription with a 10% discount, making it a potentially valuable investment in your health.
5. Life Extension — best affordable fisetin supplement
Bio-Fisetin by Life Extension offers an innovative approach to cellular, cognitive, and longevity support.
With a combination of fisetin and galactomannan compounds from fenugreek seeds, the supplement stands out for its unique formulation. It may protect fisetin from degradation in the GI tract and, as the brand claims, enhance the bioavailability of fisetin up to 25 times more than regular fisetin, allowing more bioactive compounds to reach target areas.
Each serving in the proprietary blend contains 8 mg of fisetin and 15 mg of galactomannans.
The product is non-GMO, gluten-free, and vegetarian, catering to different user needs.
Bio-Fisetin by Life Extension is available for $10.13 or $9.00 for AutoShip subscribers, providing an affordable way to support your health at the cellular level.
How we ranked the best fisetin supplement
To provide a comprehensive review of the best fisetin supplements, we analyzed specific criteria, such as ingredient quality, customer feedback, safety, and price comparison.
| Ingredient quality | Customer feedback | Safety | Price comparison |
| Natural sources, no additives | Positive reviews | Third-party tested, GMP-certified | Cost vs. quantity |
- Ingredient quality. We chose products featuring high-quality ingredients with no unnecessary fillers or artificial additives, ideally derived from natural sources.
- Customer feedback. We paid close attention to products with positive feedback and ratings, indicating high customer satisfaction.
- Safety. It is important to choose supplements with quality ingredients, which is why we selected products with third-party testing or good manufacturing practices (GMP).
- Price comparison. Lastly, we compared the number of servings and price of each product, picking the ones with good value for the right cost.
Combining fisetin with other supplements: synergy & benefits
Fisetin, a natural flavonoid, has shown promising synergistic effects when combined with various other supplements. Its neuroprotective properties may be enhanced when paired with other flavonoids like quercetin. This combination has been noted to offer a broader spectrum of brain health benefits, potentially supporting cognitive functions.
Additionally, fisetin's anti-inflammatory and antioxidant effects may be amplified when taken with supplements that target similar pathways, such as curcumin or resveratrol, leading to multi-targeted effects and overall well-being.
These synergistic combinations may not only offer additional benefits together with the effects of fisetin but also provide a more holistic approach to supporting general health.
Fisetin and brain health: insights into cognitive enhancement
Fisetin has garnered attention for its neuroprotective properties and potential to support brain health. Some animal studies indicate that fisetin can protect the brain against cognitive impairment, particularly by safeguarding against neuroinflammation. It's suggested to play a role in such cognitive functions as memory by supporting several aspects of neuronal health.
Furthermore, fisetin has shown therapeutic potential against the development and progression of several neurodegenerative diseases in animal models, including Alzheimer’s disease and Parkinson’s disease.
These findings underscore fisetin's potential as a supplement for brain health, making it a promising candidate for further research and application as an agent with neuroprotective properties.
Are fisetin supplements suitable for vegans?
To find out what is the best fisetin supplement for vegans, it's essential to check the formulation and sources. Many fisetin supplements are available in vegan capsules, often made from cellulose or other plant-based materials instead of gelatin.
Vegans should look for supplements that contain no ingredients from animal sources. However, many substances have to be tested on animals to make sure they are safe and to establish safe doses.
Additionally, the supplements should have sustainable sourcing, with a focus on minimal environmental impact.
It's also best to choose brands that are transparent about their production process and third-party testing to ensure the supplements meet vegan standards
How fisetin may benefit metabolic health
Aside from other benefits, fisetin has also shown the potential to support metabolic health. It's been found to improve insulin sensitivity and glucose regulation, both of which are vital in maintaining optimal metabolic health.
Cell studies suggest that fisetin can be a prospective option in diabetes management by addressing insulin resistance and inflammation.
While fisetin is a promising agent in the management of metabolic disorders, the evidence is only emerging. More studies are needed to understand the molecular mechanisms of this compound and its potential application in clinical settings.
Best fisetin supplement: conclusion
Fisetin emerges as a promising compound with anti-inflammatory properties that may support graceful aging. However, it's important to note that research into fisetin supplements is still ongoing, and the evidence is emerging.
Before including fisetin or any new supplement into your regimen, it's best to consult with a healthcare specialist for personalized advice. This way, you’ll be able to make sure the supplement aligns with your specific health needs, helping you make informed decisions for your well-being.
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FAQ
How long does It take to experience fisetin's benefits?
The time it takes to experience fisetin's benefits may vary from person to person. Some studies suggest improvements in certain cellular health parameters within weeks Consistent daily supplementation over months is typically recommended by the manufacturers to notice beneficial health effects.
Can fisetin supplements be used by pregnant women?
No. The safety of fisetin supplements for pregnant or breastfeeding women is not well-studied. While some flavonoids have been deemed safe during pregnancy, the specific effects of fisetin are unclear; therefore, these supplements are not recommended during this life stage.
Should fisetin supplements be taken with or without food?
Fisetin supplements are best taken with food to enhance absorption. They can be consumed with a source of healthy fats, like avocados or Greek yogurt. Combining fisetin with food could also prevent gastrointestinal discomfort or similar issues.
7 resources
- Biomolecules. Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential.
- Frontiers in Pharmacology. The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress.
- Genes & Nutrition. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin.
- European Journal of Pharmacology. Fisetin provides neuroprotection in pentylenetetrazole-induced cognition impairment by upregulating CREB/BDNF.
- Food & Function. Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation.
- eBioMedicine. Fisetin is a senotherapeutic that extends health and lifespan.
- Brain Plasticity. Preventing and Treating Neurological Disorders with the Flavonol Fisetin.
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