Glutathione is a powerful antioxidant found in food and is unique because your body can produce it. It has gained popularity for its potential to help reduce oxidative stress and support the immune system.
However, picking a glutathione supplement to support your health can be difficult as there are many products to choose from, and they come in several forms.
In this article, we explore our picks of the best glutathione supplements. To help you make your decision, we compare brands based on several criteria, discuss glutathione research, and share tips for selecting your product.
Best glutathione supplements: shortlist
- ProHealth — best single-ingredient glutathione
- Performance Lab — best overall glutathione
- partiQlar — best sustained-release glutathione
- Double Wood — best absorbable glutathione
- Cymbiotika — best liposomal glutathione
- BulkSupplements.com — best value glutathione
- Swanson — best budget glutathione
- Nature's Craft L-Glutathione — best glutathione for liver support
- Thorne — best glutathione for athletics
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Comparing our best glutathione supplements
| Supplement | Total cost | Price per serving | Daily dose | Servings per container | Vegan-friendly |
| ProHealth | $74.72 | $1.25 | 1 capsule | 60 | Yes |
| Performance Lab | $34.00 | $1.13 | 1 capsule | 30 | Yes |
| partiQlar | $34.99 | $0.58 | 1 capsule | 60 | Yes |
| Double Wood | $64.95 | $1.08 | 1 capsule | 60 | No |
| Cymbiotika | $88.00 | $3.52 | One pouch daily for six days and one day off | 25 | Yes |
| BulkSupplements.com | $112.96 | $0.11 | ⅕ tsp or 500 mg | 1,000 | Yes |
| Swanson | $12.74 | $0.12 | 1 capsule | 100 | No |
| Nature's Craft | $42.99 | $0.71 | 1 capsule | 60 | No |
| Thorne | $49.00 | $0.82 | 1 capsule two or three times daily | 60 | No |
Best glutathione supplements: an overview
Determining what is the best glutathione to take can be a challenging task. To help you with your research, we’ve compiled a list containing the potential advantages of each supplement. We included details about the supplier and the pros and cons associated with each product.
While creating this list, we examined a range of brands and products offering glutathione supplements. Although all of these are glutathione products, they each provide unique blends, compositions, and potential benefits.
1. ProHealth — best single-ingredient glutathione
ProHealth S-Acetyl Glutathione supplement is designed to support antioxidant system, brain health, cellular function, and healthy aging.
We chose ProHealth as the best single-ingredient glutathione for its simple, no-extra-ingredient formula, which makes it appealing to users looking for an isolated glutathione option.
Each capsule contains 300 mg of S-acetyl glutathione, known for its enhanced stability in the gut and bioavailability.
The potential benefits include protecting against oxidative stress, supporting liver function and mitochondrial health, essential for maintaining cellular functionality.
Additionally, the supplement comes with 60 servings, while the manufacturer’s recommended serving size of one capsule per day.
The product is third-party tested for quality and manufactured in the USA in FDA-registered and GMP-certified facilities.
ProHealth is available for a one-time purchase of $74.72, including a 75-day money-back guarantee.
2. Performance Lab — best overall glutathione
We chose Performance Lab’s Immune supplement as the best overall glutathione supplement for its unique blend of glutathione, postbiotics, vitamins, and minerals designed to support your immune defenses. Each capsule contains 250 mg of Setria® Glutathione and is free of common allergens, artificial colors, and preservatives.
Performance Lab works hard to deliver the cleanest and most effective nutrition supplements. The ingredients are plant-based, and their patented NutriCaps® are made from prebiotic fiber approved for vegans and optimized for optimal absorption.
Supplements are created with cutting-edge technology that adheres to the highest quality and clean label standards, and each batch undergoes third-party testing.
The serving recommendation is one capsule taken with food daily. The bottle contains 30 servings.
A one-month supply of Performance Lab’s Immune supplement costs $34.
3. partiQlar — best sustained-release glutathione
partiQlar Pure L-Glutathione offers a vegan-friendly formula for antioxidant support, immune health, and liver function.
We chose partiQlar as the best sustained-release glutathione for its enteric-coated capsules, suggested by the brand to provide superior absorption and bioavailability. This supplement may help to protect cells from oxidative damage, enhance skin health, and support brain function.
Each serving delivers 500 mg of reduced glutathione and contains no unnecessary fillers, binders, or artificial additives.
The recommended serving size is 1 capsule per day with a meal. Each bottle includes 60 capsules/servings.
partiQlar L-Glutathione undergoes third-party testing for quality and is manufactured in FDA-registered, GMP-certified facilities.
The product is priced at $34.99 and comes with a 60-day money-back guarantee.
4. Double Wood — best absorbable glutathione
We chose Double Wood’s S-Acetyl L-Glutathione supplement as the best absorbable glutathione because of its acetylene-enhancing absorption. Each serving contains 100 mg of S-acetyl L-glutathione in a gelatin capsule, which is claimed to travel better through the digestive tract and liver and get where your body needs it.
Double Wood is strongly committed to transparency and the quality of its products. Each supplement undergoes third-party testing, and a certificate of analysis is provided. The glutathione supplement is soy and gluten-free and does not contain GMOs.
The suggested serving is one capsule daily with food, and each bottle contains 60 servings.
One bottle of Double Wood S-Acetyl L-Glutathione supplement costs $64.95.
5. Cymbiotika — best liposomal glutathione
Cymbiotika Liposomal Glutathione is proposed by the brand to combat premature aging, enhance energy metabolism, and promote gut health. Each pouch contains 150 mg of glutathione and other beneficial ingredients, such as alpha lipoic acid, vitamin B-12, ubiquinol, and PQQ.
We chose Cymbiotika as the best liposomal glutathione because of its liposomal technology that helps the nutrients safely pass through the acidic environment of the stomach without being broken down and enter the small intestine for optimal absorption.
Cymbiotica has very high production standards and runs all ingredients through third-party testing. The supplement contains no sugar, soy, or gluten and is vegan-friendly.
The serving recommendation is one packet taken on an empty stomach at least 20 minutes before meals six days a week and skipping a packet on the seventh day.
One month's supply of Cymbiotika Liposomal Glutathione pouches is $88.
6. BulkSupplements.com — best value glutathione
BulkSupplements.com Reduced Glutathione is a source of antioxidants and may help support immune and liver health. Each serving contains 500 mg of glutathione in powdered form and has no other added ingredients.
BulkSupplements.com is committed to producing the highest quality products. The ingredients are always raw, with no added flavors or fillers. Their facilities are FDA-registered and have Good manufacturing practices (cGMP-adhering), and each product undergoes third-party testing, making this one of the best glutathione brands.
The serving recommendations are 500 mg or approximately ⅕ tsp of glutathione powder once or twice daily or as directed by your doctor.
We chose BulkSupplements.com Reduced Glutathione as the best value glutathione because of how long one container will last. One container has about 1000 servings and costs $112.96, making each serving only 0.11 cents.
7. Swanson — best budget glutathione
Swanson’s L-Glutathione supplement features their patented Setria® Glutathione ingredient and may help support your defenses against oxidative stress. Each capsule contains 100 mg of L-glutathione.
Since 1969, Swanson has been committed to producing high-quality health products. The ingredients of each supplement go through testing at various stages during production, and the final products are put through third-party testing to ensure ingredient identity and label accuracy. Made in the U.S., Swanson also offers a money-back guarantee for each of their items, making it one of the best L-glutathione supplements.
The recommended serving is one capsule daily. Each bottle contains 100 capsules.
We chose Swanson's glutathione as the best budget option because of their commitment to low prices with high standards. One bottle of Swanson’s L-Glutathione supplement costs $12.74.
8. Nature's Craft L-Glutathione — best glutathione for liver support
Nature's Craft L-Glutathione supplement claims to help protect your body from free radical damage and support the health of your liver, brain, skin, and immune system. We chose Nature's Craft supplement as the best glutathione for liver support because each serving contains 500 mg of L-Glutathione as well as 100 mg of Milk Thistle extract to support liver health and 50 mg of alpha lipoic acid.
Nature’s Craft has been making supplements since 2013. They are proud to produce non-GMO products that support your well-being. They back their formulas with scientific research and put their products through third-party testing to ensure the highest quality, making it one of the best glutathione options in the USA.
The recommended dose is one capsule daily with water 20–60 minutes before eating or as directed by your medical professional.
One bottle of Nature's Craft L-Glutathione supplement contains 60 servings and costs $42.99.
9. Thorne — best glutathione for athletics
Thorne’s Glutathione-SR supplement contains 175 mg glutathione in each capsule. The sustained-release capsule is claimed to effectively deliver the antioxidant that may support the health of the liver, brain, heart, lungs, and eyes.
We chose Thorne's glutathione as the best for athletics because of its extra commitment to supplement quality for athletes. Thorne is a highly trusted brand that is NSF Certified for Sport®, which means it has undergone a testing program to confirm it does not contain substances banned by many major athletic organizations and is considered one of the best forms of glutathione.
The product is free of soy, gluten, and dairy but is not claimed to be vegan-friendly.
The suggested serving is one capsule taken two or three times daily or as recommended by a health practitioner. Each bottle contains 60 capsules.
One bottle of Thorne’s Glutathione-SR supplement costs $49.
How we compiled our list of the best glutathione supplements?
| Ingredient quality | Third-party certifications | Price comparison | Provider reputation |
| Prioritized quality natural ingredients | Independent laboratory certification | $12.74–112.96 | Established reputable companies |
- Ingredient quality. We looked for products that prioritized natural ingredients while avoiding artificial additives.
- Third-party certifications. We selected products that undergo third-party testing to ensure the product meets the highest quality standards.
- Price comparison. We opted for products that pair reasonable prices with quality ingredients. Consider the supplement that supports health for optimal value.
- Provider reputation. We chose brands known for positive feedback, quality supplements, and transparency throughout their manufacturing process.
What is glutathione?
Glutathione is a powerful antioxidant made up of three amino acids: cysteine, L-glutamic acid, and glycine. It’s found in high quantities throughout much of your body and helps protect cells from damage caused by oxidative stress.
Unlike many other antioxidants you only get through consumption, your body can naturally produce glutathione in the liver.
You can purchase glutathione as an oral supplement in capsule or powder form or find skin care products like creams, lotions, and serums that contain glutathione.
Several foods are naturally high in glutathione, such as fresh fruit and vegetables (especially avocado, spinach, and asparagus), raw or very rare meat, and unpasteurized milk and dairy.
Cooking diminishes the strength of glutathione, so it’s best to try and consume it through raw and fresh fruits and veggies.
Potential health benefits of glutathione supplements
Glutathione is a powerful antioxidant that helps combat oxidative stress in your body.
Oxidative stress is when your body has an imbalance between free radicals (unstable molecules that can cause damage to cells) and antioxidants (molecules that neutralize free radicals).
Glutathione helps protect against free radicals from:
- Pollution
- Radiation
- Cigarette smoke
- Certain medications
Because free radicals are unavoidable and all around, it’s important to have a steady flow of antioxidants available. Without them, free radicals can cause damage to your cells and contribute to various diseases. Glutathione is proposed to be one of the strongest antioxidants available.
Essential research and safety of glutathione supplementation
While there is some research on glutathione supplementation, the information available is still limited, and studies are small. Here is some information on recent studies.
One three-week study examined the effects of glutathione supplementation (GSH) on insulin sensitivity in males with obesity. Half of the participants in the study group took 1000 mg of GSH daily for three weeks, while the other half took a placebo.
Insulin sensitivity was measured before and after the three-week trial, and participants who took GSH were shown to have a significantly better insulin sensitivity than the control group.
A four-week study looked to determine the effect of taking GSH on oxidative stress biomarkers.
For four weeks, volunteers took 500 mg GSH twice daily. The study concluded that no significant changes in biomarkers of oxidative stress were found.
A 12-week study examined how glutathione supplementation could help the skin. One group took 250 mg daily of GSH, a second group took 250 mg daily of the oxidized form of glutathione (GSSG), and the third group took the placebo.
After 12 weeks, researchers found that both forms of glutathione helped increase skin elasticity and decreased sunspots. The GSH group also showed a significant reduction in wrinkles.
When selecting a glutathione supplement, it’s important to check for third-party testing to ensure the safety and quality of the product. Also, check for certifications such as the Good Manufacturing Practice (cGMP) or the National Sanitation Foundation (NSF).
Side effects and contraindications for glutathione use
Like all supplements and skin care products, glutathione can have side effects, which makes it essential to discuss supplements or new skincare products with your doctor before starting.
If you are allergic to glutathione, topical glutathione may cause irritation, redness, swelling, or hives. Before starting a topical application, be sure to use it on a small test spot. People with darker skin tones may want to consider an alternative to glutathione as it may alter skin pigmentation.
Glutathione oral supplements are generally considered safe but may cause loose stool, increased intestinal gas, red spots on the skin, and fatigue.
Studies have shown that acetaminophen, aspartame, smoking cigarettes, and drinking alcohol can deplete glutathione levels, making it important to avoid or limit these things if you are trying to increase your levels.
Glutathione supplements can also decrease zinc levels. If you are going to take glutathione supplements for an extended period, it’s a good idea to talk to your doctor about monitoring your zinc levels.
Best glutathione supplements: conclusion
Glutathione is a vital antioxidant and, as a supplement, is recognized as having several potential health benefits, such as helping enhance the immune system, supporting liver function, and as an antioxidant protecting you from free radicals.
Research on glutathione as a supplement is still limited, but recent studies show it may help increase insulin sensitivity, increase skin elasticity, and reduce sun spots.
Glutathione is typically thought to be a safe supplement. However, it's always best to check with your doctor before taking it. This precaution is necessary as interactions with other medications or conditions can occur. Some individuals may experience side effects such as loose stool, increased intestinal gas, red spots on their skin, and fatigue after taking glutathione.
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FAQ
What is the best glutathione to take?
Selecting the best glutathione supplement depends on your personal needs and preferences. It’s a good idea to select a product from a reputable brand with good reviews, and their products undergo third-party testing. Talking with your medical professional can also help you identify a suitable option based on your health goals.
What is the most effective form of glutathione?
The effectiveness of a glutathione supplement can vary based on its form. Liposomal and acetylated glutathione are claimed to have higher bioavailability, meaning your body can absorb it more easily. However, each person’s response to a supplement can vary, and it’s important to consult with your medical provider for guidance.
What to avoid when taking glutathione?
If you are trying to boost your glutathione levels, it’s advisable to avoid or limit alcohol, smoking cigarettes, and taking medications containing acetaminophen. Research has shown these may significantly lower your glutathione levels.
Which is better, to drink collagen or glutathione?
The choice between collagen and glutathione depends on your health goals. Collagen supplements primarily support skin and joint health, while glutathione is known for supporting your immune health by supplying antioxidants. Discussing your health goals with your primary healthcare provider and the difference between these supplements can help you decide which is best for you.
6 resources
- Nutrients. A Review of Dietary (Phyto)Nutrients for Glutathione Support.
- Appl Physiol Nutr Metab. The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes: a randomized trial.
- Journal of Alternative and Complementary Medicine. Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers.
- International Journal of Biomedical Science. Free Radicals, Antioxidants in Disease and Health.
- Clinical, Cosmetic and Investigational Dermatology. Glutathione and its antiaging and antimelanogenic effects.
- Journal of Food Science and Technology. The importance of antioxidants and place in today’s scientific and technological studies.
Article history
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