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Best GlyNAC Supplement in 2024: Top 5 Brands Reviewed

Elevated oxidative stress and mitochondrial dysfunction have been linked to many age-related diseases and disorders, such as chronic inflammation, insulin resistance, obesity, and cardiovascular conditions. Antioxidants in the body help reduce the oxidative stress causing cell and tissue damage, the most common being glutathione.

During aging, glutathione synthesis decreases, which places cells at an increased risk of oxidative stress. GlyNAC products contain glycine and cysteine (in the form of N-acetylcysteine), the glutathione precursors, to potentially aid the body in the synthesis of the antioxidant to help reduce the oxidative stress often more prevalent in aging.

In this article, we present our list of the best GlyNAC supplements on the market to help navigate the overwhelming number of available products.

Best GlyNAC supplement: shortlist

  1. Vitality Pro — best overall GlyNAC product
  2. Pure Encapsulations — best GlyNAC powder
  3. HealthSpan Plus Labs — best GlyNAC product with high-dose glycine
  4. Nature's Fusions — best GlyNAC product maximizing absorption
  5. Youth and Earth — best GlyNAC product offering worldwide delivery

How we ranked the best GlyNAC supplements?

Price and value$29.99–$35.60 for a 30-day supply
Third-party testingIndependent lab testing
Ingredient qualityFree of artificial colors, preservatives, and flavors
Reputable manufacturercGMP and ISO 9001 compliant and certified
  • Price and value. GlyNAC supplements can range in price, which can affect the value level of the product. Thus, we choose products based on providing a high level of value for a reasonable price.
  • Third-party testing. The use of an independent laboratory to verify the quality and contents of the product is important to ensure the safety of the product.
  • Ingredient quality. Using high-quality sources that are free of artificial colors, preservatives, and flavors can improve the overall product quality.
  • Reputable manufacturer. Selecting a manufacturer with a long track record of producing high-quality products is important to ensure the consistency and quality of the supplement.

Best GlyNAC supplements: an overview

Oxidative stress and glutathione deficiency have been linked to various age-related health problems and are thought to be associated with the health decline seen in the aging population. GlyNAC product use may benefit the body by providing the needed precursors to help re-establish glutathione levels.

Therefore, we have developed our list of the best GlyNAC products on the market. However, it is essential to consult your doctor before starting any compound to ensure its safe use.

1. Vitality Pro — overall best GlyNAC supplement

Vitality Pro GlyNAC

Vitality Pro manufactures a GlyNAC product that contains 350 mg of glycine and 350 mg of N-acetylcysteine per capsule to potentially help support the body's synthesis of glutathione. Each capsule is free of GMOs and artificial colors, preservatives, and flavors.

GlyNAC by Vitality Pro is manufactured in facilities compliant with the current Good Manufacturing Practices and meeting ISO 9001 standards. Each capsule is further verified using third-party testing to ensure its purity and absence of heavy metals.

Vitality Pro recommends a NAC and glycine dosage of two to three capsules per day taken with water either before or after a meal. This results in a daily dosage of 1,400 to 2,100 mg of GlyNAC, with each bottle costing $32.00 and providing a 30-day supply.

2. Pure Encapsulations — best available GlyNAC powder

Pure Encapsulations NAC +

Pure Encapsulations manufactures NAC + Glycine powder to contain 1,800 mg of NAC and 1,800 mg of glycine per scoop of powder. Following strict allergen protocols, each container of powder is free from nuts, sesame, gluten, artificial colors and flavors.

Pure Encapsulations uses manufacturing facilities compliant with current Good Manufacturing Practices to ensure the production of high-quality products. Third-party testing is also used to ensure each powder is free of contaminants and contains the labeled amounts of NAC and glycine.

The manufacturer's recommended dosage is one scoop of powder mixed with eight ounces of water taken daily between meals. Each container provides a 30-day supply using these dosage guidelines and costs $35.60, which includes free shipping.

3. HealthSpan Plus Labs — best high-dose glycine GlyNAC product

HealthSpan Plus Labs GlyNAC Glycine & NAC

HealthSpan Plus Labs manufactures a GlyNAC product that contains 1,000 mg of glycine and 600 mg of NAC per serving. Each capsule is made using high-quality ingredients and does not contain any GMO products and is gluten-free.

This GlyNAC product is manufactured using Food and Drug Administration (FDA) registered facilities to ensure the highest level of manufacturing. An independent third-party laboratory tests each product to ensure accurate ingredient content and lack of contaminants.

The recommended dosage by HealthSpan Plus Labs is to use four capsules per day taken with water. With each bottle containing 120 capsules, a 30-day supply will cost $29.99.

4. Nature's Fusions — best GlyNAC supplement to maximize absorption

Nature's Fusions GlyNAC-ET NAC

Natural Fusions manufactures Nutri GlyNAC-ET capsules that contain 1,050 mg of glycine and 100 mg of NAC ethyl ester per capsule. According to the brand, this NAC formulation is better absorbed and believed to obtain 20x the levels of traditional NAC. Each capsule also contains the trace minerals selenium and molybdenum.

GlyNAC-ET is manufactured in an FDA food-grade registered facility that is compliant with the current Good Manufacturing Practices. Each product is third-party tested to ensure the highest quality products.

Natural Fusions recommends a dosage of one to two capsules daily. Using the higher dosage recommendation, a 30-day supply will cost $29.99 and comes with a forever money-back guarantee.

5. Youth and Earth — best GlyNAC brand offering worldwide delivery

Youth and Earth manufactures its capsules to contain 500 mg of glycine and 500 mg of NAC per serving. Using only the finest ingredients, each capsule is guaranteed to be soy, gluten, and GMO-free and vegan friendly.

The manufacturing of this product is performed in facilities compliant with current Good Manufacturing Practices and that have received the HACCP food and safety certification. Third-party laboratory testing is utilized to ensure each product is free of contaminants and contains the labeled dosages of glycine and NAC.

Youth and Earth recommends a dosage of 2 capsules taken in the morning either before or after breakfast. Using this dosing regimen, a 30-day supply of GlyNAC will cost $31.59.

Comparison of the best GlyNAC supplement

BrandPricePrice per servingServing sizeGlycine and NAC per serving sizeAmount per bottle
Vitality Pro$32.00$0.71–$1.072–3 capsules700–1050 mg glycine, 700–1050 mg NAC90 capsules
Pure Encapsulations$35.60$1.191 scoop1,800 mg glycine, 1,800 mg NAC5.6 ounces
HealthSpan Plus Labs$29.99$0.994 capsules1000 mg glycine, 600 mg NAC120 capsules
Nature's Fusions$29.99$0.49–$0.991–2 capsules1,050–2,100 mg glycine, 100–200 mg NAC60 capsules
Youth and Earth$31.59$1.052 capsules500 mg glycine, 500 mg NAC60 capsules

Please be aware that according to the FDA, NAC currently has been excluded from the dietary supplement category and cannot lawfully be marketed as a dietary supplement in the U.S. However, it is important to note that since we are not a manufacturer or retailer, we do not take any responsibility for the availability of the product as a dietary supplement while its future status is under investigation.

What is GlyNAC and its benefits

GlyNAC products supply the body with two important amino acids: glycine and cysteine. The cysteine is provided in the form of N-acetylcysteine (NAC), hence the name. These two amino acids can work independently or together and potentially produce a wide range of health benefits. Although there are studies that have identified some health benefits, it should be noted that additional research is needed to confirm these effects in the general population.

Glutathione levels

Glycine and cysteine are essential in the body's production of glutathione which is the most abundant antioxidant in the human body. As we age, the body's ability to produce adequate levels of glutathione decreases; however, taking GlyNAC may help restore the body's cellular levels of glutathione, which are important for the overall health of the cell.

May reduce oxidative stress

Excessive reactive oxygen species and other free radicals can result in oxidative stress, that may damage components of the cell, like DNA, and impair the cell's ability to produce energy. The use of GlyNAC may help to provide the body with the necessary components to produce glutathione, which plays a significant role in reducing the damaging effects of free radicals and oxidative stress.

Reduced inflammation

NAC has also been shown to potentially help suppress the production of molecules that promote inflammation in the body, which contributes to the anti-inflammatory properties of GlyNAC products. In addition, glutathione produced using glycine and NAC has properties that may lead to a reduced level of inflammation in the body.

Improve muscle strength

Glycine and cysteine are important amino acids needed for the production of proteins important in muscle development. Additionally, glycine is needed to synthesize creatine in the body, which may have beneficial effects on muscle strength and endurance. It has been shown that GlyNAC supplementation may increase walking speed and muscle strength in older individuals, but additional research is needed to confirm these findings.

How to choose the right GlyNAC supplement

The popularity of GlyNAC products continues to increase, leading to more manufacturers introducing it to the market. Therefore, choosing the right glycine + NAC option for you can be difficult. However, when evaluating a product, here are some criteria to consider:

  • Choose a reputable manufacturer. Selecting a manufacturer known for developing high-quality products can help ensure the product will meet the highest quality standards.
  • Look for certifications. Products that are produced in facilities registered with the FDA and adhere to the current Good Manufacturing Practices (cGMP) can help ensure the product was made under the highest standards.
  • Independent testing. Products that undergo independent third-party testing are important to verify that the product contains the labeled ingredients and is free of contaminants.

GlyNAC supplement dosage: how much to take for results

The best GlyNAC supplement dosage to produce the health benefits associated with glycine and NAC has yet to be determined. Additionally, many products on the market provide a wide range of different portions that can make it difficult to identify adequate amounts.

In regards to glycine, dosages ranging from 2.4 to 7 grams per day have been used in scientific studies and have been shown to be well tolerated. At these amounts, the health benefits of glycine have been identified including the increase in glutathione levels in individual cells.

When looking at NAC, the dosages have ranged from 1.2 to 7 grams per day, and in most scientific studies, the portions of NAC and glycine used were the same. These high quantity ranges of NAC have been shown to provide benefits for a wide range of health conditions.

Overall, the most effective dosage of GlyNAC and its individual components is still being debated. Therefore, it is important to talk to your doctor or pharmacist to determine the appropriate dosages and safety of using a GlyNAC product.

GlyNAC supplement side effects: are there any?

When reviewing the available studies, which there are few of, GlyNAC supplement side effects are typically regarded as mild, with studies reporting GlyNAC to be well tolerated by the participants. However, like with all supplements and medications, side effects can occur and should be monitored.

The common side effects associated with GlyNAC products include:

  • Nausea and vomiting
  • Diarrhea or constipation
  • Upset stomach

Despite the relatively mild side effects seen in studies, it is important to discuss the use of GlyNAC products with your doctor to ensure no additional monitoring is necessary.

Taking GlyNAC with other supplements

The use of more than one longevity or anti-aging supplement is referred to as stacking. Some companies will offer stacking regimens or bundles for purchase that include several different supplements.

While this may be an attempt to maximize GlyNAC benefits, it can also lead to an increased risk of side effects and drug interactions. Additionally, studies still need to be done to evaluate if a combination of supplements is safe and/or effective when taken together.

You might be considering taking NAC and NMN in combination, which both are popular supplements in the anti-aging literature. There is no contraindication to taking these supplements together; however, the added benefit has only been shown in a study involving cell cultures.

The combination of GlyNAC and other longevity supplements such as taurine, Resveratrol, or alpha-ketoglutarate should be done cautiously and only after a discussion with your doctor.

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