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Best Supplements to Support the Immune System in 2023: 5 Brands

The immune system is a dynamic network of cells and organs involved in processes responsible for protecting the body against harmful foreign pathogens such as bacteria, viruses, and fungi.

This system requires adequate levels of essential vitamins and minerals to strengthen its physical and chemical barriers and function properly. While a balanced diet is fundamental for supporting immune functions, certain populations may experience deficiencies or heightened demands.

Supplements may be an option for individuals looking to support their immune systems and address potential nutrient gaps. With that in mind, we've compiled a selection of our top immune system supplements.

Best supplements to boost the immune system: shortlist

  • BESTFACTOR — best supplement to support the immune system with probiotics
  • future kind+ — best formula in a supplement to support the immune system
  • Cymbiotika — best supplement to support immunity with elderberry
  • Clear Wellness — best supplement to support immunity and digestive health
  • vitapost — best budget-friendly supplement to support immune function

Our criteria for choosing the best immunity supplements

When selecting a supplement for immune support, several factors that should be considered. An informed decision can lead to selecting a product that supports your immunity and overall well-being. These factors include:

IngredientsBacked by science and high-quality
Brand TransparencyDisclosure of manufacturing practices and certification
DosageAdequate dosage to support immunity
Formulation Various formulations to cater to consumer’s preferences
  • Price. We've conducted a thorough assessment of various brands and compiled our list with providers that offer the perfect balance between quality and affordability.
  • Ingredients. Prioritizing ingredients backed by scientific research is key when selecting a supplement. Furthermore, the quality and ethical sourcing of these ingredients are important to ensure they meet high standards.
  • Brand Transparency. We opted for products and brands that are transparent about their manufacturing practices and hold certifications from reputable third-party organizations. Additionally, we've scrutinized Certificates of Analysis (COAs) to verify product label claims.
  • Dosage. Our selection includes products that contain adequate ingredients and dosages to support the immune system.
  • Formulation. We've examined a variety of supplement formulations, Including gummies, capsules, and others. We believe that supplements should be easy to incorporate into one's daily routine, so personal preference plays a determining factor.

Best immune support supplements: an overview

Selecting immune system supplements for adults may be challenging due to the multitude of formulations available on the market. Nonetheless, we have thoroughly reviewed different brands and curated our top choices for the best supplements for immunity.

Our selection includes a diverse range of formulations and ingredients that may help to support the immune system during challenging periods or when seeking resilience against common ailments like colds and allergies.

1. BESTFACTOR — best supplement for immune system with probiotics


Immune System Booster introduces a vegan supplement with potentially anti-inflammatory and antioxidant ingredients.

This supplement boasts 100 billion CFU of Lactobacillus and Bifidobacterium. These probiotics may play a role in maintaining gut microbiota balance, potentially reducing the risk of gastrointestinal issues, and may support immune defenses.

In addition to probiotics, this supplement incorporates other beneficial ingredients like turmeric, melatonin, and beta-glucan. These components are thought to further enhance immune function, particularly by supporting immune cells. Turmeric, in particular, is renowned for its potential capacity to reduce inflammation.

BESTFACTOR operates in an FDA-registered facility and manufactures all of its products on US soil. They also hold cGMP certification and claim to be scientifically formulated.

The recommended daily serving consists of 2 capsules, best taken 30–60 minutes before bedtime with a glass of water.

It is available for $39.71 and includes 60 vegan capsules.

2. Future kind+ — best mineral and vitamin combination in an immunity supplement

Future Kind Organic Vegan Immunity gummies

Organic Vegan Elderberry Vitamin C & Zinc Immunity Gummies present a formula targeted to fortify the body’s resilience and promote overall well-being. This product combines essential vitamins and minerals to support the immune system against pathogens and aid in recovering from illnesses.

The supplement includes elderberry and vitamin C, celebrated for their potential anti-inflammatory and antioxidant properties, which may contribute to aiding the immune system by reducing oxidative stress.

The brand prides itself on using clean ingredients sourced and manufactured in the USA at an FDA-registered facility. Their supplements are non-GMO and undergo rigorous third-party testing to ensure the accuracy of label claims.

The recommended serving is 2 gummies per day to support immunity and enhance skin and hair health.

It is available for $24.99 and includes 30 servings per package.

3. Cymbiotika — best immune supplement with elderberry

CYMBIOTIKA Liposomal Elderberry

Cymbiotika Liposomal Elderberry introduces an innovative technology that utilizes liposomes to encapsulate a multi-vitamin formula targeted to support the immune system during periods of stress or illness.

This supplement features a blend of key ingredients, including Echinacea, Elderberry, and vitamins C and E. These vitamins are well known for their potent antioxidant properties and may help combat free radicals and oxidative stress. Additionally, Echinacea and Elderberry have shown promising potential in clinical trials as aids in easing cold and influenza symptoms, potentially reducing both the duration and severity of illness.

Cymbiotika places a strong emphasis on transparency and sustainable practices. They proudly create products that are cruelty-free and non-GMO, using GMP-certified production facilities.

The brand recommends taking 1 pouch daily between meals, either by squeezing it into the mouth or stirring it into a drink. Each serving includes 10 ml of the product.

It is available for $48.00 and includes 26 pouches.

4. Clear Wellness — best immune supplements to support digestive health

Clear Gut & Immunity

Clear Gut & Immunity offers a blend of probiotics and additional ingredients aimed at promoting digestive health and overall well-being.

The formula boasts 20 billion CFU of Lactobacillus rhamnosus and Bifidobacterium longum, two probiotic strains renowned for their potential to restore gut microbiome balance while also contributing to support immune health and digestive well-being.

In addition to probiotics, the supplement includes Slippery Elm Bark and Reishi mushrooms. The latter has been associated with immunomodulatory and anti-inflammatory effects, which may support and enhance the body's resilience against infections.

These supplements are proudly manufactured in the USA and operate in FDA-registered facilities. Additionally, they also hold cGMP certifications.

The brand recommends a daily intake of 2 capsules, with or without food, emphasizing consistency. Customers have the flexibility to pair these supplements with other probiotics from the brand, and refrigeration is not required.

It is available for $39.00 and includes 60 capsules.

5. Vitapost — most affordable supplement to support the immune system

Vitapost Turmeric curcumin plus

Vitapost Turmeric introduces a curcumin-based formula aimed at promoting joint and muscle health while enhancing overall wellness.

At the heart of this formula is curcumin, renowned for its anti-inflammatory, antioxidant, and immunomodulatory properties. It is believed that curcumin cooperates with various immune cells to potentially enhance the body’s defense capacity.

VitaPost Turmeric Curcumin is proudly manufactured in FDA-registered facilities in the USA, adhering to rigorous GMP guidelines to ensure the best possible experience for its customers.

The brand recommends a daily intake of 2 capsules with food or as directed by a healthcare professional. It's worth noting that the brand emphasizes that these supplements are most effective when incorporated into a healthy diet and an exercise program.

It is available for $23.95 and includes 60 capsules per bottle.

Comparison of the best immune system supplements

ProductPriceActive ingredientsCertificationServingTotal amount of product
BESTFACTOR$39.71Probiotics, turmeric, melatonin, and beta-glucancGMP2 capsules60 capsules
future kind+$24.99Elderberry, vitamin C, and zinccGMP and Certified B Corporation2 gummies30 gummies
Cymbiotika$48.00 Elderberry, Echinacea, and vitamin CcGMP1 pouch26 pouches
Clear Wellness$39.00Reishi mushroom, probiotics, and Slippery Elm Bark cGMP2 capsules60 capsules
Vitapost $23.95CurcumincGMP2 capsules60 capsules

How to choose the best supplements for immune support?

Navigating the complexities of the supplement market can be a time-consuming and challenging task. However, there are several critical factors to consider when selecting the best supplements for immune system support:

  • Ingredients. Opt for supplements that feature clean, tested, and preferably natural ingredients to maximize their potential benefits. Keep in mind that consumer preference can also influence your choice, as some products may only boast vitamins, while others may combine them with other ingredients such as probiotics or mushrooms.
  • Diet. While supplements should never replace a balanced diet, they can be particularly valuable for individuals with specific deficiencies or increased nutritional needs. Consider supplements that align with your dietary requirements and may enhance your immune function.
  • Third-party testing. Many supplements lack comprehensive testing of their formulations. Prioritize brands that undergo rigorous testing and openly share information about their production practices.

How can supplements help boost the immune system?

A balanced diet rich in vitamins, minerals, and essential nutrients is vital for the proper functioning of physical and chemical immune barriers and immune cells. However, various aspects can lead to dietary deficiencies, potentially weakening the immune system and increasing the susceptibility to infections.

Supplements can serve as a valuable option to potentially support the immune system in several ways:

Anti-inflammatory response

Inflammation is usually the immune system’s response to the invasion of foreign objects such as pathogens, damaged cells, or toxic substances.

While inflammation is crucial for defense, it can also lead to chronic inflammation that strains the immune system.

A healthy diet, exercise, and supplements containing anti-inflammatory and antioxidant ingredients may help alleviate inflammation.

Improved defense system

Supplements may enhance the immune system's defense mechanisms. Vitamins may reinforce physical immune barriers, preventing the entry of harmful substances and supporting the function of immune cells.

Additionally, ingredients like beta-glucan, often included in supplements, have reported immunomodulatory effects, playing a role in both innate and adaptive immune responses.

Improved recovery from infection

Supplements containing ingredients like elderberry may be associated with shorter illness durations and reduced severity during infections.

Probiotics may also support the immune system and aid in bacterial infection recovery by supporting bacterial balance after antibiotic use.

What are the top immunity supporting ingredients?

Numerous micronutrients and other supplement ingredients have been studied for their potential to support immune cells and various immune mechanisms. Some of the most researched include:

  • Vitamin C. Supplements with this vitamin may play a crucial role in the production of white blood cells, which are essential in both innate and adaptive immunity. A deficiency in this vitamin may increase susceptibility to infections.
  • Curcumin. Curcumin is believed to work in collaboration with various immune cells to bolster the body's defenses and support anti-inflammatory processes.
  • Elderberry. Elderberry is thought to have anti-inflammatory, antiviral, antimicrobial, and immune-stimulating effects. Some reports suggest that this fruit may contribute to shorter illness duration and lower disease severity.
  • Probiotics. Living microorganisms that may confer health benefits to the host. They can potentially improve immune function in various ways, including enhancing gut barrier function, promoting anti-inflammatory cytokine production, and supporting the activity of white blood cells.

Signs of a weakened immune system

Immune response requires plenty of resources from the body and can potentially lead to collateral damage as it combats the invading pathogen. When the body is weakened due to nutrient deficiencies, the immune system's effectiveness may be compromised, resulting in frequent illnesses, prolonged recovery periods, or chronic inflammation.

To support the immune system and optimize its performance, it's crucial to maintain a well-balanced diet rich in essential vitamins and minerals. In cases of deficiencies or heightened dietary requirements, supplements can be considered, but it's essential to do so under the guidance of a physician

Are supplements for immune system safe?

Maintaining a balanced diet is the foremost strategy to fortify your body against infections. Nevertheless, natural supplements for immune system may offer support when specific dietary needs aren't met.

It is important to note that individuals should thoroughly review brands and formulations to ensure the best use of the products. Furthermore, paying close attention to dosage is fundamental, as it ensures that supplements are tailored to your requirements and deliver precise amounts of essential nutrients.

Additionally, certain populations such as pregnant women, kids, and those taking medication should be cautious. A consultation with a doctor is recommended before taking any supplement.

Other ways to support our immune systems

Supporting the immune system is fundamental for promoting overall well-being. There are various ways to nurture and strengthen the body, reducing the risk of infections:

  • Healthy diet. Proper nutrition is vital for optimal immune cell function. Certain micronutrients and dietary components also play specific roles in immune system development and maintenance, potentially reducing chronic inflammation.
  • Exercise. Exercise may be another option to support the immune system. Some evidence suggests that frequent and consistent exercise may be an important immune system adjuvant that can reduce inflammation and support healthy immune system activity.
  • Nature exposure. Various forms of exposure to natural environments, such as living near or spending time in nature, can have a positive impact on human health. This includes improved mood, reduced anxiety, and potential immune system support.

Additionally, vaccination should always be considered to enhance immunity against viruses and other pathogens. Vaccination plays a crucial role in protecting individuals from infectious diseases.

Best immune system supplements — conclusion

Establishing good sleeping habits, engaging in regular exercise, and maintaining a healthy diet can play a crucial role in supporting the immune system. Adequate levels of vitamins and minerals are essential for proper bodily function, and deficiencies in these nutrients can compromise immunity and increase susceptibility to infections.

Supplements may be a valuable option to reinforce the body's defenses when deficiencies or specific dietary requirements need addressing. However, the introduction of supplements should always be overseen by a healthcare professional.

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