NMN (nicotinamide mononucleotide) is a potent food supplement increasing youth molecule levels therefore it is gaining popularity among people aiming for healthy aging and longevity. The growing market of NMN products is not free of scams or inefficient products. When choosing the best NMN supplements, you should consider essential criteria among purity and bioavailability.
With these factors in mind, we have reviewed several NMN supplement brands and picked the 6 best brands to help you make an informed choice.
Best NMN supplement providers: a shortlist
- Wonderfeel — overall best and top-rated NMN supplements
- Hello100 — top-class liposomal formula for beginners
- Purovitalis — excellent pure NMN formula
- Toniiq — effective and affordable NMN supplements
- Forest Leaf — ideal allergen-free NMN
- NOVOS — solid NMN supplement option with a stable formula
How to choose the right NMN supplement for me?
When choosing the right NMN supplements for you, besides looking for the most affordable price in the market and the most efficient doses, here are some other aspects to consider:
|Third-party tested||Independent lab testing|
|Manufacturing standards||GMP and FDA-compliant factories|
- Purity. The purity standard is 98% and is the primary aspect of NMN supplements. NMN purity test ensures the absence of harmful substances.
- Bioavailability. With low bioavailability, you will not receive the promised amount on the supplement label.
- Third-party tested. NMN supplements tested by an independent and authoritative to ensure unbiased opinion regarding the quality, stability, and absorption.
- Manufacturing standards. Get your NMN supplements from a manufacturer complying with GMP and FDA-approved standards. Good Manufacturing standards ensure your body will not get exposed to harmful chemicals.
Best NMN supplement providers in 2023
The following list of best supplement providers was created considering NMN bioavailability, price, quality, customer trust, formula, and storage requirements.
1. Wonderfeel — best NMN supplements with great customer reviews
Wonderfeel Youngr NMN is made in the USA and meets all the good manufacturing standards. The supplements are third-party tested and are highly bioavailable.
The NMN supplements are non-GMO, vegan, do not contain preservatives, and are allergen-free. Besides NMN, the capsule contains 2 mg ergothioneine, 50 mg trans-resveratrol, 40 mg hydroxytyrosol, and 10 mcg of vitamin D3.
The supplements do not need refrigeration but should be kept in a cool, dark, and moisture-free area.
To increase the absorption of resveratrol in the capsule, the provider advises taking it with healthy fat-rich food.
The provider’s daily dosage recommendation is 2 capsules containing 450 mg of NMN each (total of 900 mg daily). Safe doses range from 500–1000 mg daily.
You can obtain your NMN supplements from Wonderfeel’s official website. They also offer free shipment in the USA for orders over $60.
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- 5-star customer review
- Optimal dosage
- Offers only one NMN product
2. Hello100 — top-class liposomal NMN formula for beginners
Hello100 manufactures its liposomal NMN supplements in the USA in GMP and HACCP-compliant facilities. NMN capsules are vegetarian and contain 100 mg of liposomal NMN.
Liposomal technology enhances the supplement's bioavailability. The latter ensures the promised amount of NMN reaches cells and tissues. Besides 95% pure NMN, each Hello100 capsule contains 4 other ingredients — TMG (betaine), trans-resveratrol, vitamin B12, and folate (vitamin B9).
The company recommends taking 2 capsules daily — in the morning on an empty stomach and in the afternoon to synchronize NAD+ rise with your circadian rhythms. Hello100 offers free shipping in the USA. Currently, it doesn’t have a monthly subscription, yet it offers high discounts to its customers and first-time buyers.
You can obtain your Hello100 NMN supplements for 1, 3, and 6 months' supply with a 60-day money-back guarantee.
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- High bioavailability
- No refrigeration needed
- 5-in-1 formula
- Comparably higher price
- No monthly subscription
3. Purovitalis — excellent pure NMN supplement formula
Purovitalis provides high-purity (99%) NMN supplements produced in Europe within GPM-certified facilities. Purovitalis solved the bioavailability challenge by adding liposomal technology to its NMN supplements.
Purovitalis capsules contain 125 mg NMN and are easy to swallow. The company recommends taking 2 capsules daily — in the morning and at night.
The company offers 30, 60, and 120 capsules for half, 1, and 2-month supplies. Also, you can get pure NMN powder in bottles containing 15, 30, 60, and 120 grams. Also, the brand offers a bundle of NMN with resveratrol for a 2-month supply.
Purovitalis offers worldwide shipping with low cost applied — standard shipping within the USA for $6.99, and express shipping for $14.99. Orders above $75 are shipped free. With a subscription, you can save 15% for your consecutive orders.
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- High bioavailability
- UV protection glass container
- Comparably higher price
- Low dose
4. Toniiq — effective and affordable NMN supplements
Toniiq is a USA-based company with a wide range of health, beauty, and longevity products. You can find powder and encapsulated NMN supplements at affordable prices on the company’s website.
Starting as a “white-label” supplements provider, Toniiq now creates its supplements with no middleman suppliers. Toniiq offers 40 g and 80 g bottles containing pure NMN powder. You can also get your 1 or 3-month supply of NMN supplements in vegetarian capsules.
Toniiq supplements are third-party tested and contain 98% pure NMN. The NMN company recommends taking 250 g NMN powder, 2–4 times daily. As for the capsules, the company recommends taking 2 capsules containing 150 mg NMN 2–4 times a day.
The daily recommended pill count is high since Toniiq NMN is not liposomal. And to increase the bioavailability, increased doses are needed.
This NMN brand offers the best affordable price in the market, plus you can save 15% with a monthly subscription. Toniiq NMN delivered its NMN supplements in the USA only. However, free shipping is applied to orders above $99.
- High purity
- No refrigeration needed
- Only available in the USA
- Low dosage
- Free shipping above $99 spent
5. Forest Leaf — ideal allergen-free NMN
Forest Leaf is a USA-based company committed to providing allergen-free and high-quality supplements. The brand may be the best NMN choice if you’re looking for fish-free, nut-free, dairy-free, and gluten-free supplements.
However, the company doesn’t provide information regarding the NMN purity percentage.
Forest Leaf’s NMN is manufactured in FDA and GMP-approved facilities. A single bottle contains 60 vegetable capsules that are third-party tested for absorption only. Each capsule contains 125 mg NMN. The NMN company recommends taking 2 capsules daily, in the morning and at night.
A one-time purchase will cost you $39.95, yet, the company offers a 25% discount for first-time subscription and 15% off for recurring orders. For orders over $49.99, the company offers free shipment.
- Worldwide shipping
- No purity information
- Low dosage
6. NOVOS — solid NMN supplement option with a stable formula
Novos is a longevity company established in the USA offering NOVOS Boost NMN supplements. NOVOS bottle contains 60 capsules, each containing 125 mg of highly pure NMN.
NMN supplements are third-party tested for purity, quality, and stability. The company’s recommendation for beginners is 1–2 capsules, 2–4 as a minimum dose, and 3–7 capsules to achieve an energy boost.
The serving size may be due to the low concentration of NMN in the capsule and the non-liposomal formula. The monthly cost will increase if you want to take higher than 250 mg daily. However, NOVOS offers discounts for monthly and yearly subscriptions.
- High purity
- No refrigeration needed
- Low dosage
- Low bioavailability
What is NMN and how does it work?
NMN (nicotinamide mononucleotide) is a molecule that naturally exists in all living forms. NMN is a precursor to the NAD+ molecule (nicotinamide adenine dinucleotide) and was granted the status of an anti-aging agent.
NAD is the general term for the molecule existing in two forms — NAD+ and NADH, which is the oxidized form of NAD+. Without NAD in the body, people would die in seconds. Among numerous other NMN benefits, it participates in activities such as DNA stability, turning food into energy, regulating circadian rhythms, and slowing down organismal aging.
NMN is not the same as vitamin B3, however, it’s a derivative of vitamin B3, meaning they are similar but have different atomic structures. The atomic difference makes NMN a more effective NAD+ precursor.
Besides NMN, NR (nicotinamide riboside) is another well-known NAD+ precursor and a form of Vitamin B3. Most people prefer NR over NMN due to its lower price. Yet, NR is two steps farther from becoming NAD. At the same time, NMN is considered a direct precursor taking one step to convert into NAD.
Though, as we age, both NMN and NAD+ levels decline to cause the onset of aging-related diseases. Raising NMN and NAD levels naturally through a balanced diet containing NMN foods is possible. Yet, the NMN content in foods may not be enough for NAD+ levels elevation. Thus, NMN supplements can come in handy.
Is it safe to take NMN supplements?
Yes. NMN is generally known to be safe as an anti-aging supplement. According to numerous studies with people and mammals, NMN supplements do not pose any significant health risk. However, sticking to the recommended daily NMN dosage is crucial to avoid side effects.
A clinical study conducted in Japan with 10 healthy men showed that the daily administration of 100, 250, and 500 mg NMN carries no significant adverse effects. The lab results demonstrated lower blood glucose levels and balanced serum bilirubin levels indicating proper liver function.
NMN supplements are widely available in the anti-aging and longevity market with various dosages ranging from 250 mg to 600 mg in a capsule. However, more human clinical trials are needed to assess the safety measures of NMN supplements.
What is the best way to take NMN?
NMN supplementation can be administered via injection, capsules, sublingual tablets, and powder.
The best way to take NMN supplements is in the form of capsules or sublingual tablets. You can also consider taking liposomal NMN to ensure the supplement's bioavailability and protect it from stomach acid.
Although many people prefer pure NMN powder due to its affordability, it’s recommended to consume NMN with resveratrol or TMG (betaine) to increase both the effectiveness and absorption of the supplement.
What does David Sinclair say about NMN supplements?
"When you give the body NMN, the body gets all the necessary components — sugars, phosphate, and Vitamin B3 attached — to make NAD+. Studies with mammals demonstrated that mice supplemented with NMN showed longer lifespan and stamina."David Sinclair
David Sinclair takes 1000 mg of powder NMN daily. This dose may seem high, however, the dosage is reasonable considering that most of the NMN get destroyed in the stomach acid. To increase the bioavailability and efficacy of the supplement, Sinclair takes his NMN with resveratrol, mixed with olive oil or natural yogurt, in the morning on an empty stomach.
When is the best time to take NMN supplements?
Once you get up in the morning, the NAD+ levels peak in your body. This is the best time to take your NMN supplements on an empty stomach to further enhance NAD+ and energy production during the day. If you are taking your supplement twice a day, consider consuming the second serving after 12–3 p.m. when the second rise of NAD+ occurs. Taking NMN later in the evening can increase your energy and hinder sleep.
How to know if NMN supplements work?
Health and anti-aging effects are only sometimes tangible, making people doubt the results of NMN supplements.
The best method to estimate if your NMN supplements work is doing blood work. It is recommended to test the levels of NAD+ molecules and other longevity genes before and after NMN supplementation to picture the intrinsic changes better.
Most NMN users report health improvements already after a week of the supplementation. Others feel no significant improvements after their first week or even month of NMN supplementation.
The reasons may vary depending on the body, consumption method and time, dosage, and supplement form. You can increase the NMN effectiveness by choosing liposomal NMN, which will also help absorption. If you are considering higher doses, consult your doctor first.
What are the potential benefits of NMN supplements?
The reported health benefits of NMN usage include better sleep, energy boost, and better cognitive function. Numerous studies with mammals and humans showed NMN supplements to be highly potent in increasing central-for-life molecules and inducing the below-discussed health benefits.
1. Age-related weight gain suppression
Age-related weight gain and NAD+ decline are interconnected. With age, NAD+ gets exhausted, eventually slowing down metabolism and leading to weight gain.
Obesity due to a poor diet and an inactive lifestyle can also lead to declining NAD+ levels. NMN supplementation can increase NAD+ levels, thus suppressing unwanted weight gain.
2. Muscle endurance
One of the most studied longevity genes called SIRT1 (Sirtuin 1) was shown to stimulate blood flow and endurance. With NAD+ decline, SIRT1 activity also declines, leading to low exercise capability and muscle density. Studies demonstrated that regular NMN consumption can increase NAD+ levels consequently enhancing SIRT1 activity and positively affecting muscle endurance.
3. Increased sleep quality
Taking NMN early in the morning and the afternoon can regulate circadian rhythms. It may also help to fall asleep faster and sharpen the cognitive function the other day.
4. Boosted brain function
Proper oxygen supply and cerebral blood flow slow down with age, SIRT1, and NAD+ decline. Studies with people having Alzheimer's disorder and aged mice showed that NMN supplementation raises NAD+ and SIRT1 activity in the brain improving cognitive function.
Can you take NMN supplements with Resveratrol?
Yes. As David Sinclair believes, NMN and Resveratrol work synergetically increasing both NAD+ levels and Sirtuin gene activation double-fold. Many NMN providers incorporate NMN and Resveratrol in a capsule.
What brand of NMN supplements should I take?
Our top pick is Wonderfeel. Keep in mind that, besides looking for the best affordable price in the market, you should also look for an NMN company that provides reliable third-party testing, optimal doses, is established, meets good manufacturing standards, and is positively reviewed by customers.
Can NMN cause damage to the liver?
Studies demonstrated that 300 mg NMN administration poses no damage to the liver, cells, heart, or kidneys. On the contrary, proper dosage of regular NMN usage reduces oxidative stress in the mentioned organs.
Do NMN supplements really work?
Numerous studies assessing the health benefits, anti-aging effects, and safety of NMN, leave no space to doubt these supplements don’t work.
As of October 11, 2022, beta-nicotinamide mononucleotide (Β-NMN) is under an investigation as a potential new drug by the FDA, meaning that it might lose its dietary supplement status. However, until retailers haven’t officially received a warning letter, they continue with distribution of the NMN products.
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