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Best Nootropic Mushroom Supplement in 2024

Not all mushrooms are the same, and in the realm of natural cognitive enhancers, certain mushrooms have gained significant attention for their nootropic properties.

Nootropic mushrooms, such as lion's mane, reishi, cordyceps, and maitake, have been revered for quite a while now and are studied for their ability to support memory, focus, and overall mental clarity. With their unique bioactive compounds, nootropic mushroom supplements hold promise as valuable allies in the pursuit of optimal cognitive health.

With that being said, we welcome you to explore the best nootropic mushroom supplements currently available on the market.

Best nootropic mushroom supplement: shortlist

  1. Oweli — best anti-inflammatory nootropic mushroom supplement
  2. Real Mushrooms RealClarity — best mushroom for cognitive function
  3. Nummies — best nootropic mushroom gummies for better mood
  4. FOCL — best-tasting nootropic mushroom supplement
  5. Mind Lab Pro — best science-backed nootropic mushroom supplement
  6. Real Mushrooms Lion's Mane — best mushroom for brain health
  7. London Nootropics — best nootropic mushroom bundle

How we compiled our list of the best nootropic mushrooms in 2024

In order to compile this list of the best nootropic mushrooms, we relied on a number of criteria. These criteria encompassed brand reputation, ingredients, mushroom content, and value for money. Below, we provide a more comprehensive insight into each of them:

  • Brand reputation. We looked for reputable brands known for their positive track record and transparent sourcing and manufacturing practices. Such brands are more inclined to have a proven history of crafting high-quality products, adhering to stringent manufacturing standards, and subjecting their products to third-party testing.
  • Ingredients. Our focus was on selecting supplements that feature particular types of mushrooms renowned for their nootropic effects. These may encompass well-known nootropic mushrooms such as lion's mane, reishi, cordyceps, and maitake. We made a deliberate effort to avoid supplements containing fillers, additives, or preservatives.
  • Mushroom content. It's essential to consider the amount of mushroom content in nootropic mushroom supplements, as extremely high dosages may lead to side effects, while suboptimal dosages may result in no benefits at all. Therefore, we have sought out supplements with doses commonly used in scientific research.
  • Value for money. While it's important to consider the supplement's price, the cheapest option might not always guarantee the best quality. We focused on selecting supplements that balance pricing and meeting standards for ingredients and dosages.

Best nootropic mushroom in 2024: overview

Known for their nootropic-rich properties and potential to offer cognitive support, nootropic mushroom supplements have captured widespread interest and gained popularity. So, if you're looking to harness these benefits, look no further than incorporating one of the following supplements into your daily routine.

Stick around as we present the best nootropic mushroom supplements available on the market, helping you discover the ideal one that aligns with your preferences.

1. Oweli — best anti-inflammatory nootropic mushroom supplement


Oweli 10 SHROOMS, a nootropic mushroom supplement, boasts a high content of beta-glucans, which are associated with anti-inflammatory effects. This makes it an excellent choice for those seeking support for their cognitive health and immunity.

Oweli 10 SHROOMS is a comprehensive mushroom formula that contains a blend of 10 of the most researched medicinal mushrooms, 6 of which are added to the supplement as part of a proprietary blend.

This nootropic mushroom supplement by Oweli is manufactured in a pharmaceutical-grade facility that is FDA-registered and compliant with cGMP standards. Additionally, every ingredient present is thoroughly tested to meet industry quality standards.

The manufacturer recommends a daily dosage of 2 capsules, with each serving delivering 266 mg of lion's mane, cordyceps, reishi, and shiitake extracts, respectively.

One bottle of the nootropic mushroom supplement, which contains 30 servings, costs $29.99. You can purchase your bottle from the official Oweli website.

2. Real Mushrooms RealClarity — best mushroom for cognitive function

Real Mushrooms RealClarity Lion's Mane, Ashwagandha, Rhodiola and Bacopa

Crafted from certified organic ingredients and boasting an ingredient mix of lion's mane mushroom with ashwagandha, rhodiola rosea, and bacopa monnieri extracts, Real Mushrooms RealClarity is designed to support healthy cognitive function and stress management.

RealClarity's blend comprises solely organically sourced ingredients, subjected to both hot water and dual extraction processes to unlock beneficial compounds like beta-glucans.

What's more, the RealClarity mushroom nootropic supplement contains no grains or starchy fillers, setting it apart from rival supplements.

The manufacturer recommends a daily serving size of 2 capsules, providing a total daily extract dose of 500 mg of lion's mane, 250 mg of ashwagandha, 150 mg of rhodiola rosea, and 100 mg of bacopa.

RealClarity comes in a 30-serving bottle priced at $29.95 for a one-time purchase. You can get yours from the official Real Mushrooms website.

3. Nummies — best nootropic mushroom gummies for better mood

Nummies Functional Mushroom Gummies new

Nummies introduces Functional Mushroom Gummies — a dietary supplement created with 10 organic functional mushrooms, including lion's mane, shiitake, reishi, and turkey tail. The combined benefits of these mushrooms are suggested to support brain health, sharpen focus, and address oxidative stress.

What’s even better is that these raspberry-flavored gummies are designed for those who watch their diet. They are vegan, gluten-free, lactose-free, and free from both seeds and nuts, which are major allergens.

Within each serving, you will find 2500 mg of functional mushroom extracts from the fruiting bodies. The makers of the product recommend taking 2 gummies per day.

For your Nummies mushroom supplement, head to the brand's official site. It's $32.99 per 60-count bottle, and there's a subscription discount available for better savings.

4. FOCL — best-tasting nootropic mushroom supplement

FOCL Better Brain Gummies

In its pursuit to provide an optimal mushroom supplement experience, FOCL incorporates a blend of adaptogenic mushrooms, including lion's mane, cordyceps, and reishi, into its supplement, all while keeping taste in mind.

In every serving of FOCL's Functional Mushroom Gummies, you will find 300 mg of lion's mane, 100 mg of cordyceps, and 10 mg of reishi.

The brand, committed to quality and safety, subjects its products to third-party testing. This evaluation includes checks for pesticides, heavy metals, microbial contaminants, residual solvents, and mycotoxins.

For best outcomes using this mushroom product, the manufacturer recommends consuming 2 to 3 gummies daily.

A single container of this nootropic mushroom offering by FOCL is priced at $59 as a one-time purchase. You can purchase yours by visiting the provider's official website.

5. Mind Lab Pro — best science-backed nootropic mushroom supplement

Mind Lab Pro comm

Mind Lab Pro is a nootropic mushroom supplement made using premium-grade, research-backed ingredients — all ethically sourced and presented with a clean label. It is specifically designed to help you perform at your peak, potentially enhancing daily mental performance and supporting brain function.

This mushroom nootropic is composed of 11 research-backed nootropic ingredients, carefully selected and formulated to enhance their synergistic effects.

Mind Lab Pro stands by its science-backed label, as it has been proven effective in placebo-controlled human trials conducted independently by Leeds University. The results demonstrate a positive impact on memory and an improved ability to concentrate and process information.

The provider claims that Mind Lab Pro is the cleanest and greenest brain supplement available, boasting a 100% plant-based composition that is sustainably sourced and produced in GMP-certified, FDA-registered facilities. The product is further packaged and shipped using recyclable boxes.

A one-month supply of this nootropic mushroom supplement is priced at $69. Keep in mind that subscribing or buying in bundles will allow you to enjoy additional benefits and discounts.

6. Real Mushrooms Lion's Mane — best mushroom for brain health

Real Mushrooms lions mane supplement bottle

Formulated to support the immune system, this lion's mane supplement from Real Mushrooms is crafted from certified organic mushrooms through a hot water extraction of the mushroom fruit body. Mind you, without any fillers, mycelium, or grain.

This lion's mane product, confirmed through testing at third-party laboratories, contains more than 25% beta-glucans, the nutraceutical compounds found in mushrooms.

It is produced within a U.S. facility that holds NSF certification — one of today’s most respected independent product testing certificates.

According to the brand's instructions, it is suggested to take 2 capsules daily. This should deliver a total of 1000 mg of organic lion's mane mushroom extract per serving.

You can get your bottle of Real Mushrooms Lion’s Mane, containing 120 capsules, for just $29.95 as a one-time purchase.

7. London Nootropics — best nootropic mushroom bundle

London Nootropics Starter Bundle

The Starter Bundle from London Nootropics is a selection that comprises a trio of adaptogenic coffee blends, each infused with nootropics. All blends are created with barista-style coffee and high-quality adaptogens.

Within the three blends, there are ingredients like organic dual-extracted cordyceps and lion's mane mushroom extracts, ashwagandha root extract, and even broad-spectrum water-soluble CBD.

Comprising Flow for mental clarity and focus, Mojo for energy and endurance, and Zen for calmness, this coffee package is intended to keep you balanced all day long.

As of today, a one-time purchase of the Starter Bundle, which includes 12 sachet boxes for every London Nootropics adaptogenic coffee blend, is priced at £40. Visit their official website to secure yours.

Comparison of the top 7 nootropic mushroom supplements

BrandPrice per bottleServing sizeServings per bottlePrice per servingDosage per serving*Active ingredients
Oweli$29.992 capsules30$0.991330 mg of mushroom content10
Real Mushrooms RealClarity$29.952 capsules30$0.99500 mg of mushroom content4
Nummies$32.992 gummies30$1.092500 mg of mushroom content10
FOCL$59.001 gummy30$1.96410 mg of mushroom content4
Mind Lab Pro$69.002 capsules30$2.30500 mg of mushroom content 11
Real Mushrooms Lion's Mane$29.952 capsules60$0.491000 mg of mushroom content1
London Nootropics£40.001 sachet36£1.11Exact amount not mentionedDepends on the blend

* — specific amounts of mushroom extracts, powders, or proprietary blends can be found on providers' websites.

What are nootropic mushrooms?

Nootropic mushrooms belong to a group of medicinal fungi renowned for their cognitive-boosting attributes. Among the common mushroom varieties are lion’s mane, reishi, cordyceps, chaga, and maitake, each rich in bioactive substances, which might contribute to promoting brain health and supporting its function.

The bioactive substances present in these mushrooms include polysaccharides, such as beta-glucans, and flavonoids, that possess antioxidant properties believed to support brain function and improve mental clarity.

The documented potential of nootropic mushrooms to support cognitive health, coupled with their natural origin, has significantly contributed to the increasing popularity of these mushrooms.

What are the benefits of nootropic mushrooms?

The benefits of incorporating nootropic mushrooms into one's diet are manifold. These fungi have the potential to enhance memory, boost focus, and may yield neuroprotective benefits. Additionally, they are thought to alleviate inflammation and combat stress.

In the case of lion's mane, this nootropic mushroom may enhance cognitive functions, including memory and learning, by stimulating the production of nerve growth factor — a protein essential for the growth and maintenance of brain cells.

Nootropic mushrooms like reishi are also rich in antioxidants and may have anti-inflammatory properties, which can potentially attenuate cognitive impairment caused by aging.

This being said, the evidence is only emerging and comes mostly from animal and cell studies. More research is needed to confirm that these health-beneficial effects of nootropic mushrooms translate to humans.

Mushrooms that have nootropic properties

Given the increased focus on the nootropic properties of various medicinal mushrooms and their potential to improve cognitive function, it is imperative to delve deeper into their unique characteristics and the benefits they offer.

Lion's mane

Lion's mane, a nootropic mushroom renowned for its cognitive enhancement properties, contains compounds such as hericenones and erinacines, which stimulate nerve growth factor synthesis.

Moreover, lion's mane has gained widespread recognition for its therapeutic activities that promote nerve and brain health, making it a popular choice among individuals interested in natural nootropics. Evidence from animal studies further supports the neuroprotective properties of lion's mane, which play a crucial role in maintaining a healthy brain as it ages.


Reishi, labeled the mushroom of immortality due to its longstanding and revered history in traditional medicine, holds nootropic properties as well. Its key bioactive compounds, like triterpenoids and polysaccharides, exhibit neuroprotective qualities, safeguarding the brain against oxidative stress and inflammation.

Consistently using supplements containing reishi can offer a range of benefits for nootropic support, making it a highly sought-after mushroom for those striving to optimize their mental and physical health. On top of that, reishi has shown promise as a natural ergogenic, offering potential benefits for enhancing athletic performance.


Cordyceps is a rare type of fungus typically found in the high-altitude regions of the Himalayas. For many years, it has been utilized as a medicinal mushroom in traditional Chinese medicine. Like other medicinal mushrooms, cordyceps contains various bioactive compounds, with cordycepin being the most prominent due to its therapeutic and nutraceutical potential. Notably, cordycepin has been shown to have anti-inflammatory effects in animal models with chronic inflammatory conditions.


Regarded as a nutritious food with a sweet and umami taste, mainly attributed to its high content of amino acids, maitake has been a focus of research in recent years. In particular, studies have linked the health effects of maitake polysaccharides — a type of sugar molecule — to gut microbiota-modifying effects.

Additionally, as evidence from cell and animal studies indicates, small compounds found in maitake mushrooms play a role in reducing inflammation, stabilizing blood sugar levels, and providing antioxidant properties.

How to choose the best nootropic mushroom in 2024?

Several considerations come into play when on the lookout for the best nootropic mushroom supplement, making them essential in finding a product precisely tailored to your needs.

We utilize the following criteria to guide you through this process and assist you in selecting a high-quality nootropic mushroom supplement option:

Safety profileThird-party tested
ManufacturingFDA-regulated and cGMP-certified
Mushroom typeSpecific properties
  • Ingredients. Opting for nootropic mushroom supplements rich in science-backed ingredients is crucial, as the support of scientific research provides reassurance that the active ingredients are likely to deliver the suggested benefits.
  • Safety profile. Seek out products that have been tested by independent third-party laboratories or hold relevant certifications to make certain that the content in the mushroom nootropic supplements aligns with the ingredients listed on the label.
  • Manufacturing. Give priority to those nootropic mushroom products produced in facilities that hold cGMP certification and comply with FDA regulations. This reflects greatly on the manufacturing standards and overall quality of the supplements.
  • Mushroom type. Different types of mushrooms have specific therapeutic properties due to their unique active compounds. By considering these properties, you can make informed decisions when choosing nootropic mushroom supplements that align with your goals.

Do nootropic mushrooms have side effects?

Although nootropic mushrooms generally have a good safety profile, certain individuals may still encounter side effects. The severity and likelihood of side effects vary from person to person and may depend on individual sensitivities or underlying health conditions.

Some individuals may encounter typical side effects when using nootropic mushrooms, which could include:

  • Upset stomach
  • Allergic reactions
  • Headaches
  • Interactions with medications

Before considering the use of nootropic mushrooms, individuals who fall into these categories are advised to consult a healthcare professional to avoid any potential side effects:

  • Pregnant or breastfeeding women
  • People with known allergies to mushrooms or fungi
  • People with serious underlying medical conditions or undergoing treatments
  • Children

Keep in mind that it is crucial to acquire nootropic mushroom supplements from reputable brands that subject their products to third-party testing and adhere to stringent manufacturing standards. This commitment speaks volumes about the safety and quality of the product. Moreover, it is advisable to seek guidance from a healthcare professional before incorporating nootropic mushrooms into your daily regimen — a prudent choice to ensure optimal results.

Read more about how to boost your cognitive function

For those striving for optimal health, the best mushroom supplements are worth considering.

For a convenient way to consume nootropics, look no further than the best nootropic drinks.

If you have a sweet tooth, the best mushroom gummies are a must-try.

When it comes to improving brain health, the best lion's mane supplements deserve your attention.

To improve cognitive function, try mushroom supplements for brain health.


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