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A Review of Top 5 Best Prebiotic and Probiotic Combination in 2023

Prebiotics and probiotics both have potential benefits in maintaining gut health. Probiotics are live microorganisms that may enhance the bacterial balance in the gut, while prebiotics are plant fiber degraded by gut microbiota that may nourish these microorganisms. The primary difference lies in their functions: probiotics introduce beneficial bacteria, whereas prebiotics stimulate and support their growth.

In this article, we have compiled a list of prebiotic and probiotic products with a comprehensive overview of their benefits and features.

The best prebiotic and probiotic combination: a shortlist

  • Unbloat — best probiotic with high-quality prebiotic fiber
  • Ritual — best prebiotic, probiotic, and postbiotic blend
  • Bioma Health — best delayed-release synbiotic
  • YourBiology — best-personalized blend of prebiotics and probiotics
  • Bulletproof — best synbiotic with a large CFU count

How did we choose the best prebiotic and probiotic combination?

We looked at brands and products that offer the best combination of prebiotics and probiotics.

The recommended products in this list adhere to specific standards such as quality, safe ingredients, and adequate dosage-price ratio. Additionally, we considered the brand's reputation to ensure the authenticity of the products.

Quality ingredients Evidence-based
Synbiotic formulationContains prebiotics and probiotics
Adequate dosage and pricePrice vs. quantity
Provider reputationCustomer feedback and ratings
  • Quality ingredients. Our chosen supplements feature evidence-based ingredients. Many products on the market lack robust evidence, which makes it essential to choose supplements with proven effectiveness.
  • Synbiotic formulation. We focused on products that work synergistically to support optimal gut health containing both prebiotics and probiotics in their formulation.
  • Adequate dosage and price. We assessed the dosage and cost of each product featured on our list.
  • Provider reputation. We highlighted brands with a track record of producing high-quality products. Additionally, we recognized the value of customer reviews and ratings in gauging the experiences and contentment of previous consumers.

The best prebiotic and probiotic combination: an overview

It is crucial to identify high-quality products designed for individual needs. While numerous prebiotic and probiotic products might have similar ingredients, their individual formulations can bring varied results. Considering this is key when aiming for specific health goals.

The products in this list are organized using a classification highlighting their particular benefits, ingredients, and additional attributes. Moreover, the list offers a deeper insight into the pros and cons of each product.

1. Unbloat — top-tier probiotic complemented by high-quality prebiotic fiber

Unbloat Daily Capsules

Unbloat Daily Capsules are formulated to address persistent bloating using a combination of 40 unique anti-bloating ingredients, including prebiotics and probiotics. The official website indicates that users could potentially get relief from bloating-related discomfort within 6 hours post-ingestion.

This supplement boasts probiotic strains such as Lactobacillus and Bifidobacterium and prebiotic fiber, renowned for their positive effects on gut health. The product also includes 25 billion CFUs of probiotics in every serving, potentially making it an effective support for bloating and assisting users in feeling more harmonized with their physical state. Furthermore, this product might enhance digestion and support the immune system.

Produced in the USA, Unbloat Capsules cater to vegetarians, lack gluten, and steer clear of genetically modified ingredients. However, the website doesn't provide an in-depth overview of its quality checks and certifications.

A single package holds 60 capsules, and the provider’s suggested dosage is 2 capsules daily.

The product is available at $59.99 for standalone orders, but discounts are available for those selecting the periodic subscription options.

2. Ritual — top combination of prebiotics, probiotics, and postbiotics


Ritual is known for its Synbiotic+ supplement, which combines prebiotics, probiotics, and postbiotics in a single blend. This special mix is designed to bolster gut health and support overall well-being. A notable characteristic is its delayed-release design, ensuring the capsule bypasses stomach acid and only breaks down in the small intestine. This feature allows users to consume the supplement without aligning it with meal time.

Ritual Synbiotic+ is third-party tested by independent labs and does not contain genetically modified ingredients. The product incorporates the Made Traceable® feature, granting users clarity regarding the supplement's composition, sources, and purpose.

Potential benefits of Ritual Synbiotic+ include enhanced digestion and relief from bloating and gas.

Each Ritual Synbiotic+ bottle contains 30 capsules. The manufacturer suggests a daily intake of 1 capsule.

A one-month supply of Ritual Synbiotic+ is available at $54.00. The product is accessible via a subscription model and includes free shipping.

3. Bioma Health — leading synbiotic with a delayed-release feature

Bioma Health probiotics

Bioma Health offers a scientifically formulated product designed to provide relief from common digestive issues such as diarrhea, gas, bloating, and constipation. According to the website, the supplement may support metabolism and digestion while restoring and strengthening the gut balance.

The product contains key ingredients like dietary fibers that feed natural gut bacteria, probiotics comprised of Bifidobacterium genus to increase the count of beneficial bacteria in the gut, and tributyrin to protect the gut lining and reduce inflammation.

Based on the brand’s claims, Bioma Health products are non-GMO, stimulant-free, and vegan-friendly. However, there is no available information on the testing methods.

The recommended dosage is 2 capsules before breakfast, with each bottle containing 30 servings (60 capsules) meant for a 30-day supply.

As for the pricing model, a 1-month supply costs $47.59 per bottle. There are also options for 3-month and 6-month supplies, with prices decreasing per bottle for bulk purchases.

4. YourBiology — best tailored blend of prebiotics and probiotics


YourBiology offers a specialized supplement tailored to individual needs. This product features a combination of 4 bacterial strains: Lactobacillus acidophilus, Lactobacillus paracasei, Lactobacillus plantarum, and Bifidobacterium lactis, known to support the digestive system and equilibrium in the gut. It also includes natural prebiotic fibers fructo-oligosaccharides that may nourish good bacteria.

The brand creates custom probiotic blends after performing thorough gut microbiome analyses. Based on the gut bacteria assessment, YourBiology presents a probiotic mixture with 40 billion CFUs designed to address microbial imbalances.

Each bottle contains 60 capsules, with the brand’s suggested dosage of 2 capsules daily.

Produced in the USA, YourBiology undergoes third-party testing and has a GMP certification, showcasing its compliance with the standards set by the Food & Drug Administration (FDA).

The cost for a one-month supply of YourBiology supplements is $64.99. A three-month bundle (including an additional month) is available for $129.99, while a package for five months (with two bonus months) is offered at $194.99.

3. Bulletproof — top synbiotic with a large CFU count

Bulletproof Express 3-in-1 Probiotic

Express 3-in-1 Probiotic by Bulletproof is a holistic supplement designed for those aiming to achieve optimal gut health. According to the brand, this unique blend is formulated to provide rapid and sustained support to the gut, combining the benefits of postbiotics, probiotics, and prebiotics.

The product boasts 1 billion CFUs of probiotics with other ingredients containing the postbiotic Tributyrin, which may increase short-chain fatty acid production in the gut, a prebiotic blend that may nourish good bacteria, and the probiotic strain Bifidobacterium lactis, known for its extensive clinical research and effectiveness in supporting a healthy gut microbiome.

According to the website, Bulletproof products undergo rigorous quality checks, although specific details about their testing and certifications are not explicitly mentioned on the site.

A single bottle contains 90 capsules (30 servings) with a manufacturer’s recommended dosage of 3 capsules daily.

The product is priced at $47.95 for a one-time purchase. However, customers can also opt for a subscription to save 20% on their orders

Comparing the best prebiotic and probiotic combinations

BrandPricePrice per servingDaily doseCapsules in a bottleReview
Unbloat$59.99$2.00 2 capsules60Unbloat review
Ritual$54.00$1.801 capsule30Ritual Synbiotic+ review
Bioma Health$47.59$1.59 2 capsules60N/A
YourBiology$64.99$2.17 3 capsules 60YourBiology review
Bulletproof$47.95 $1.603 capsules90N/A

What are prebiotics?

Prebiotics are non-digestible food compounds that may feed gut microbes and stimulate the growth of healthy bacteria. They may play a pivotal role in gut health by inducing shifts in microbial composition and directly affecting mucosal immunity, promoting regular bowel movements.

What are probiotics?

Probiotics are live microorganisms that, when taken in adequate amounts, may offer various health benefits. This includes supporting intestinal health, improving digestion, and reducing lactose intolerance. Their effectiveness is rooted in their live nature and ability to positively influence the gut microbiome.

How do prebiotics and probiotics work together?

Prebiotics are non-digestible fibers that may selectively support the growth of beneficial gut bacteria, known as probiotics. Together, they establish a synbiotic relationship: prebiotics may feed and enhance probiotics, optimizing their role in supporting gut health and nourishing a healthy microbiome.

Benefits of prebiotic and probiotic combination

Combining prebiotics and probiotics may provide significant support for gut health. The potential benefits of this synergy may include:

  • Balancing the intestinal ecosystem
  • Improved digestion
  • Immune system support

Side effects and risks to consider

While prebiotics and probiotics are generally considered safe, they may have some side effects. Potential side effects, especially at the beginning of administration, can include gas, bloating, diarrhea, and constipation. Therefore, it is essential to ensure product quality and choose prebiotics and probiotics that suit your individual needs. For a personalized plan, it is recommended to consult with a healthcare specialist.

Tips on how to choose the best prebiotic and probiotic supplement for you

When selecting a prebiotic and probiotic supplement, it's essential to consider several key factors to ensure optimal benefits and safety.

  • Recommended dosage. Always check the label for the recommended dose to ensure effective results.
  • Proper storage. Ensure the probiotics are stored correctly, as they must be consumed alive for health benefits.
  • Food intake. Consider if the supplement should be taken with food for better absorption and if you consume probiotic-rich foods already.
  • Additional ingredients. Review the label for additional ingredients in the supplement to avoid unnecessary additives or side effects.

The best prebiotic and probiotic combination – conclusion

The combination of probiotics and prebiotics may provide supporting benefits for gut health. Certain bacterial strains, such as Lactobacillus and Bifidobacterium, may play a significant role in maintaining a healthy microbiome, while prebiotic fibers may nourish these good bacteria.

However, it's crucial to recognize that individual needs may differ. While these supplements present numerous potential benefits, they should never be used as a substitute for medical treatments. Always consult with a healthcare professional before making any dietary changes.

Explore other health benefits of probiotics

Best probiotics for constipation may increase bowel movements.

Best probiotics for IBS can help restore the balance of bacteria in the gut.

Best probiotics for women may support digestive and vaginal health.

Best probiotics for weight loss can help support weight management.

Best probiotics for kids may reduce the symptoms of eczema in children.

Best probiotics for oral health may also protect your gums and teeth.

Best prebiotics might help promote growth of good bacteria in your gut.


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