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A Review of Top 5 Best Prebiotic and Probiotic Combination in 2024

Prebiotics and probiotics both have potential benefits in maintaining gut health. Probiotics are live microorganisms that may enhance the bacterial balance in the gut, while prebiotics are plant fiber degraded by gut microbiota that may nourish these microorganisms. The primary difference lies in their functions: probiotics introduce beneficial bacteria, whereas prebiotics stimulate and support their growth.

In this article, we have compiled a list of prebiotic and probiotic products with a comprehensive overview of their benefits and features.

The best prebiotic and probiotic combination: a shortlist

  1. Unbloat — overall best prebiotics and probiotics supplements
  2. Ritual — best prebiotic, probiotic, and postbiotic blend
  3. Bioma Health — best pre and probiotics with delayed-release capsules
  4. YourBiology — best synbiotic with digestive enzymes
  5. Bulletproof — best synbiotic supplement with a large CFU count

How did we choose the best prebiotic and probiotic combination?

We looked at brands and products that offer the best combination of prebiotics and probiotics.

The recommended products in this list adhere to specific standards such as quality, safe ingredients, and adequate dosage-price ratio. Additionally, we considered the brand's reputation to ensure the authenticity of the products.

Quality ingredients Evidence-based
Synbiotic formulationContains prebiotics and probiotics
Adequate dosage and pricePrice vs. quantity
Provider reputationCustomer feedback and ratings
  • Quality ingredients. Our chosen supplements feature evidence-based ingredients. Many products on the market lack robust evidence, which makes it essential to choose supplements with proven effectiveness.
  • Synbiotic formulation. We focused on products that work synergistically to support optimal gut health containing both prebiotics and probiotics in their formulation.
  • Adequate dosage and price. We assessed the dosage and cost of each product featured on our list.
  • Provider reputation. We highlighted brands with a track record of producing high-quality products. Additionally, we recognized the value of customer reviews and ratings in gauging the experiences and contentment of previous consumers.

Synbiotics: understanding this prebiotic and probiotic combination

Prebiotics are non-digestible fibers that may selectively support the growth of beneficial gut bacteria, known as probiotics.

Together, they establish a synbiotic relationship: prebiotics may feed and enhance probiotics, optimizing their role in supporting gut health and nourishing a healthy microbiome.

Choosing the best prebiotic and probiotic supplement: a buyer's guide

When selecting a prebiotic and probiotic supplement, it's essential to consider several key factors to ensure optimal benefits and safety.

  • Strain diversity. Look for supplements with a variety of probiotic strains, as different strains may provide different health benefits.
  • Quality. Make sure the ingredients are tested for quality and suitable for your personal health needs.
  • Food intake. Consider how the supplement interacts with your diet and if certain foods should be consumed or avoided for optimal results.
  • Additional ingredients. Review the label for additional ingredients in the supplement to avoid unnecessary additives or side effects.

The best prebiotic and probiotic combination: an overview

It is crucial to identify high-quality products designed for individual needs. While numerous prebiotic and probiotic products might have similar ingredients, their individual formulations can bring varied results. Considering this is key when aiming for specific health goals.

The products in this list are organized using a classification highlighting their particular benefits, ingredients, and additional attributes. Moreover, the list offers a deeper insight into the pros and cons of each product.

1. Unbloat — overall best prebiotics and probiotics supplements

Unbloat Daily Capsules

Amazon rating - 3.6 ⭐⭐⭐⭐

Unbloat Daily Capsules are formulated to address persistent bloating using a combination of 40 unique anti-bloating ingredients, including prebiotics and probiotics. The official website indicates that users could potentially get relief from bloating-related discomfort within 6 hours post-ingestion.

This supplement boasts probiotic strains such as Lactobacillus and Bifidobacterium and prebiotic fiber, renowned for their positive effects on gut health. The product also includes 25 billion CFUs of probiotics in every serving, potentially making it an effective support for bloating and assisting users in feeling more harmonized with their physical state. Furthermore, this product might enhance digestion and support the immune system.

Produced in the USA, Unbloat Capsules cater to vegetarians, lack gluten, and steer clear of genetically modified ingredients. However, the website doesn't provide an in-depth overview of its quality checks and certifications.

A single package holds 60 capsules, and the provider’s suggested dosage is 2 capsules daily.

Key ingredients

  • 7 live bacterial strains: L. casei, B. lactis, L. plantarum, L. acidophilus, L. rhamnosus, B. longum, and B. bifidum.
  • 2 prebiotic fibers for gut bacteria health and bowel function.
  • 21 digestive enzymes to help improve the digestion of food.
  • 6 herbal remedies to help support gut health.

Who is this product for?

Unbloat is designed for individuals who struggle with bloating and digestive discomfort and are looking for a comprehensive solution to help address these symptoms.

What users like about the product

  • Immediate relief. Many users report significant and quick relief from bloating right from the first day of using the pills.
  • Specialized ingredients. Customers appreciate the combination of digestive enzymes, herbs like ginger and fennel, and probiotics, which they find effective in managing digestive discomfort.
  • Overall gut health improvement. Users have mentioned improvements in better digestion and less discomfort during the day.

What users don’t like about the product

  • Side effects. Some users experienced negative side effects such as stomach pain and constipation, which they attribute directly to the product.
  • Price concerns. The price point has been mentioned as a barrier, with some users feeling that it is too high for the value offered, especially for long-term use.

Company review

Unbloat, founded by Dr. Shilpa Mehra, a board-certified gastroenterologist, focuses on creating solutions for common and often overlooked digestive issues like bloating.

The company emphasizes natural and comprehensive approaches to gut health, promising a formula that can help address common causes of bloating.

Additionally, the brand offers a satisfaction guarantee, reflecting its confidence in the product's effectiveness.

Our verdict about the product

Based on the reviews on Amazon, the reception for Unbloat's Anti-Bloat Pills is mixed.

Quite a few people have found quick relief from bloating and really like the blend of digestive enzymes, herbs, and probiotics. But there’s another side to it: some users have run into issues like stomach pain or found that the results can vary, especially if they buy the product from different stores.

Even though many praise the product for improving gut health, the price and some negative experiences mean it's not a slam dunk for everyone.

So, if you're thinking about giving Unbloat a try, especially if you have a sensitive stomach or you're conscious of your budget, it might be worth considering these points.


The product is available at $53 for standalone orders, but discounts are available for those selecting the periodic subscription options.

2. Ritual — best prebiotic, probiotic, and postbiotic blend


Amazon rating - 4.1 ⭐⭐⭐⭐

Ritual is known for its Synbiotic+ supplement, which combines prebiotics, probiotics, and postbiotics in a single blend. This special mix is designed to bolster gut health and support overall well-being. A notable characteristic is its delayed-release design, ensuring the capsule bypasses stomach acid and only breaks down in the small intestine. This feature allows users to consume the supplement without aligning it with meal time.

Ritual Synbiotic+ is third-party tested by independent labs and does not contain genetically modified ingredients. The product incorporates the Made Traceable® feature, granting users clarity regarding the supplement's composition, sources, and purpose.

Potential benefits of Ritual Synbiotic+ include enhanced digestion and relief from bloating and gas.

Each Ritual Synbiotic+ bottle contains 30 capsules. The manufacturer suggests a daily intake of 1 capsule.

Key ingredients

  • LH01 - Myoviridae
  • LL5 - Siphoviridae
  • T4D - Myoviridae
  • LL12 - Myoviridae
  • Bifidobacterium animalis ssp. lactis
  • Lactobacillus rhamnosus
  • Tributyrin

Who is this product for?

Ritual Synbiotic+ is designed for people seeking digestive support, including those looking to improve gut health, enhance immune function, and maintain a healthy gut barrier.

It might be particularly suited for individuals interested in an all-in-one supplement that offers prebiotics, probiotics, and postbiotics.

What users like about the product

  • Comprehensive formula. Users appreciate the combination of prebiotics, probiotics, and postbiotics in one capsule for more advanced health benefits.
  • Convenience. Users enjoy the convenience of a single capsule that is easy to remember to take and doesn't need to be refrigerated.

What users don’t like about the product

  • Price. Some users find the product expensive compared to other probiotic supplements.
  • Mint flavor. While some enjoy the minty capsule, others do not prefer the flavor.

Company review

Ritual is a health brand known for its transparency and science-backed approach to supplements.

Their products are designed with traceable ingredients, and they emphasize sustainability in their packaging and operations.

Additionally, the company is committed to continuous innovation and offers products that are vegan, non-GMO, and free of major allergens.

Our verdict about the product

Ritual Synbiotic+ stands out for its holistic approach to gut health, combining probiotics, prebiotics, and postbiotics in a single, delayed-release capsule.

Although it may be priced higher than some alternatives, the quality and comprehensive nature of the formulation make it a potentially valuable option for those serious about improving their digestive health.

The positive reviews highlight the product’s effectiveness in enhancing gut function and overall well-being. It’s a recommended choice for those looking to invest in a top-tier gut health supplement.


A one-month supply of Ritual Synbiotic+ is available at $54. The product is accessible via a subscription model and includes free shipping.

📢 Memorial Day offer:

3. Bioma Health — best pre and probiotics with delayed-release capsules

Bioma Health probiotics

Amazon rating - 3.7 ⭐⭐⭐⭐

Bioma Health offers a scientifically formulated product designed to provide relief from common digestive issues such as diarrhea, gas, bloating, and constipation. According to the website, the supplement may support metabolism and digestion while restoring and strengthening the gut balance.

The product contains key ingredients like dietary fibers that feed natural gut bacteria, probiotics comprised of Bifidobacterium genus to increase the count of beneficial bacteria in the gut, and tributyrin to protect the gut lining and reduce inflammation.

Based on the brand’s claims, Bioma Health products are non-GMO, stimulant-free, and vegan-friendly. However, there is no available information on the testing methods.

The recommended dosage is 2 capsules before breakfast, with each bottle containing 30 servings (60 capsules) meant for a 30-day supply.

Key ingredients

  • Bifidobacterium lactis
  • Bifidobacterium longum
  • Bifidobacterium breve
  • Tributyrin
  • Xylooligosacharides

Who is this product for?

Bioma Probiotics is designed for individuals looking to improve their gut health, particularly those suffering from gastrointestinal issues such as bloating, gas, and irregular bowel movements.

What users like about the product

  • Digestive support. Many users report that the product significantly helps with digestive issues such as bloating and irregular bowel movements.
  • Overall health benefits. Users experience improvements in overall health, including better energy levels and well-being.
  • High-quality ingredients. The use of a blend of probiotics, prebiotics, and postbiotics is appreciated for its comprehensive approach to gut health.

What users don’t like about the product

  • Side effects. Some users have pointed out negative side effects such as increased bloating and constipation, particularly when starting the supplement.
  • No results. There were user reports of no health changes after taking the supplement.

Company review

Bioma takes an integrated approach to gut health, blending probiotics, prebiotics, and postbiotics in their products.

The company prioritizes scientific research to create supplements that not only enhance digestive health but also support weight management and promote general well-being.

Our verdict about the product

Bioma Probiotics offers an all-around approach to gut health which may be appealing to users looking for digestive relief and general health benefits.

Some users have mentioned side effects that may occur during the initial phase of use while other have highlighted the effectiveness of the supplement for improving gut health and regularity.

Regardless of some reports about mixed results, the product receives positive feedback for its benefits in supporting digestive and general wellness.


As for the pricing model, a 1-month supply costs $47.99 per bottle. There are also options for 3-month and 6-month supplies, with prices decreasing per bottle for bulk purchases.

4. YourBiology — best synbiotic with digestive enzymes


Trustpilot - 3.6 ⭐⭐⭐⭐

YourBiology is a probiotic supplement, featuring a combination of 4 bacterial strains: Lactobacillus acidophilus, Lactobacillus paracasei, Lactobacillus plantarum, and Bifidobacterium lactis, known to support the digestive system and equilibrium in the gut. It also includes natural prebiotic fibers fructo-oligosaccharides that may nourish good bacteria.

The brand creates custom probiotic blends after performing thorough gut microbiome analyses. Based on the gut bacteria assessment, YourBiology presents a probiotic mixture with 40 billion CFUs designed to address microbial imbalances.

Each bottle contains 90 capsules, with the brand’s suggested dosage of 3 capsules daily.

Produced in the USA, YourBiology undergoes third-party testing and has a GMP certification, showcasing its compliance with the standards set by the Food & Drug Administration (FDA).

Key ingredients

  • Lactobacillus acidophilus
  • Bifidobacterium breve
  • Lactobacillus plantarum
  • Lactobacillus paracasei
  • Lactobacillus fermentum
  • Saccharomyces boulardii
  • Digestive enzyme blend (amylase, lipase, protease)
  • Prebiotic bend (inulin, FOS)

Who is this product for?

YourBiology is targeted toward both men and women who are seeking to improve their digestive health, immune system function, and overall well-being.

It may be particularly beneficial for those dealing with gastrointestinal issues like bloating, gas, and irregular bowel movements.

What users like about the product

  • Improved digestive health. Users report significant improvements in digestion and a reduction in symptoms such as bloating and gas.
  • Improved mental health. Customers appreciate the positive effects on mental health and clarity, attributing it to better gut health.
  • Immune support. The probiotics in the supplement are praised for their role in strengthening the immune system.

What users don’t like about the product

  • Slow results. Some users have noted that it takes a while to see any noticeable improvements in health.
  • Customer service. A few customers expressed their frustration with the company's inability to respond on time and lack of clear information on pricing.

Company review

YourBiology offers a premium probiotic emphasizing scientific backing for its ingredient choice and manufacturing its products in GMP-certified facilities in the USA to ensure high quality and safety standards.

Additionally, YourBIology offers a 60-day money-back guarantee, highlighting its confidence in the effectiveness of its products.

Our verdict about the product

YourBiology probiotic supplement appears to be a well-rounded product for supporting digestive health, enhancing immune function, and improving mental well-being.

Despite some of the concerns, the overall user feedback for the supplement is positive, indicating that it may be a reliable choice for those looking to improve their gut health.

The combination of probiotics, prebiotics, and digestive enzymes in one formula makes it stand out in the crowded probiotic market.


A one-month supply of YourBiology supplements costs $64.99. A three-month bundle (including an additional month) is available for $129.99, while a five-month package (with two bonus months) is offered for $194.99.

5. Bulletproof — best synbiotic supplement with a large CFU count

Bulletproof Express 3-in-1 Probiotic

Amazon rating - 4.1 ⭐⭐⭐⭐⭐

Express 3-in-1 Probiotic by Bulletproof is a holistic supplement designed for those aiming to achieve optimal gut health. According to the brand, this unique blend is formulated to provide rapid and sustained support to the gut, combining the benefits of postbiotics, probiotics, and prebiotics.

The product boasts 1 billion CFUs of probiotics with other ingredients containing the postbiotic Tributyrin, which may increase short-chain fatty acid production in the gut, a prebiotic blend that may nourish good bacteria, and the probiotic strain Bifidobacterium lactis, known for its extensive clinical research and effectiveness in supporting a healthy gut microbiome.

According to the website, Bulletproof products undergo rigorous quality checks, although specific details about their testing and certifications are not explicitly mentioned on the site.

A single bottle contains 90 capsules (30 servings) with a manufacturer’s recommended dosage of 3 capsules daily.

Key ingredients

  • Postbiotic tributyrin (CoreBiome®)
  • Prebiotic bacteriophage blend (PreforPro®)
  • Probiotic Bifidobacterium lactis (Bl-04)

Who is this product for?

Bulletproof Express 3-in-1 Probiotic is designed for individuals who are interested in enhancing their gut health.

It may be particularly suitable for those looking for an all-in-one gut health solution that combines probiotics, prebiotics, and postbiotics.

What users like about the product

  • Quality ingredients. Users recognize science-backed ingredients and the combination of prebiotics, probiotics, and postbiotics aimed at providing health benefits.

What users don’t like about the product

  • Lack of effectiveness. Some users have noted no significant effects or benefits after taking the supplement.

Company review

Bulletproof is a well-known brand focused on providing high-performance food, drinks, and supplements designed to enhance physical and cognitive performance.

The company is recognized for its commitment to high-quality ingredients and innovative products that support overall wellness and are suitable for biohacking.

Additionally, Bulletproof emphasizes clean and sustainable practices in sourcing and producing its products.

Our verdict about the product

Bulletproof Express 3-in-1 Probiotic is an innovative supplement designed to offer comprehensive gut health support.

It combines prebiotics, probiotics, and postbiotics, aiming to provide immediate and sustained benefits to the digestive system.

Although there were some complaints regarding its effectiveness, the overall positive feedback suggests that this product is a strong contender for those looking to invest in their gut health with a reputable and scientifically backed supplement.


The product is priced at $47.95 for a one-time purchase. However, customers can also opt for a subscription to save 20% on their orders.

Comparing the best prebiotic and probiotic combinations

BrandPricePrice per servingDaily doseCapsules in a bottleReview
Unbloat$53.00$1.77 2 capsules60Unbloat review
Ritual$54.00$1.801 capsule30Ritual Synbiotic+ review
Bioma Health$47.99$1.59 2 capsules60Bioma Review
YourBiology$64.99$0.723 capsules 90YourBiology review
Bulletproof$47.95 $1.603 capsules90N/A

Summarizing the best prebiotic and probiotic products according to us

When it comes to these reviewed products, each has its unique strengths tailored for specific needs.

  1. Unbloat stands out as the best overall prebiotics and probiotics supplement, especially for those battling bloating and digestive discomfort. It combines digestive enzymes, herbal remedies, and a robust blend of bacterial strains, offering noticeable relief for many users.
  2. Ritual Synbiotic+ excels with its all-in-one approach, making it ideal for individuals looking for a comprehensive solution that includes prebiotics, probiotics, and postbiotics in a single formula. Its clinically studied ingredients and delayed-release capsules may enhance gut health, making it a premium choice for gut barrier and immune support.
  3. Bioma Health may be the right choice for those looking for a slow-release supplement that can provide extended support throughout the day. Its blend of bifidobacteria and prebiotic fibers may target persistent issues like irregular bowel movements and bloating.
  4. YourBiology offers a personalized blend of probiotics and prebiotics tailored to improve digestive health, immune function, and mental well-being. It's a solid choice for those seeking a holistic approach to gut health that also considers potential cognitive and immune system benefits.
  5. Bulletproof is a holistic supplement designed for optimal gut health, featuring a unique blend which may provide rapid and sustained support to the gut, combining the benefits of postbiotics, probiotics, and prebiotics.

Each product has its merits and can be the best fit depending on individual health goals and needs.

Whether seeking immediate relief from bloating, comprehensive digestive support, or a sustained boost to overall well-being — there is a tailored option available that meets these specific requirements.

Function of prebiotics in synbiotic formulas

Prebiotics are non-digestible food compounds that may feed gut microbes and stimulate the growth of healthy bacteria (probiotics). They may play a pivotal role in gut health by inducing shifts in microbial composition and directly affecting mucosal immunity, promoting regular bowel movements.

Role of probiotics in synbiotic combinations

Probiotics are live microorganisms that, when taken in adequate amounts, may offer various health benefits. Their effectiveness is rooted in their live nature and ability to positively influence the gut microbiome. Especially when combined with prebiotics to promote the growth of beneficial microorganisms.

Benefits of prebiotic and probiotic combination

Combining prebiotics and probiotics may provide significant support for gut health. The potential benefits of this synergy may include:

  • Balancing the intestinal ecosystem
  • Improved digestion
  • Immune system support
  • Reducing lactose intolerance

Side effects and risks to consider

While prebiotics and probiotics are generally considered safe, they may have some side effects.

Potential side effects, especially at the beginning of administration, can include gas, bloating, diarrhea, and constipation. Therefore, it is essential to ensure product quality and choose prebiotics and probiotics that suit your individual needs.

For a personalized plan, it is recommended to consult with a healthcare specialist.

Dosage and storage guidelines for synbiotics

Synbiotics, which combine probiotics and prebiotics, have the potential to deliver various gut health benefits. However, it is necessary to follow the recommended dosage and storage guidelines for their effectiveness.

  • Recommended dosage. Each product is different. Always check the label for the recommended dose to ensure effective results.
  • Proper storage. Make sure the probiotics are stored correctly, as they must be consumed alive for health benefits.

The best prebiotic and probiotic combination: conclusion

The combination of probiotics and prebiotics may provide supporting benefits for gut health. Certain bacterial strains, such as Lactobacillus and Bifidobacterium, may play a significant role in maintaining a healthy microbiome, while prebiotic fibers may nourish these good bacteria.

However, it's crucial to recognize that individual needs may differ. While these supplements present numerous potential benefits, they should never be used as a substitute for medical treatments. Always consult with a healthcare professional before making any dietary changes.

Explore other health benefits of probiotics

Best probiotics for constipation may increase bowel movements.

Best probiotics for IBS can help restore the balance of bacteria in the gut.

Best probiotics for women may support digestive and vaginal health.

Best probiotics for weight loss can help support weight management.

Best probiotics for kids may reduce the symptoms of eczema in children.

Best probiotics for oral health may also protect your gums and teeth.

Best prebiotics might help promote growth of good bacteria in your gut.


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