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Best Supplements for Arthritis: Top Recommendations & Reviews

Arthritis, a commonly encountered and highly incapacitating health issue, afflicts millions worldwide, resulting in painful joints and inflammation. Although analgesics and NSAIDs are the most frequently prescribed remedies for arthritis, these medications come with significant risks of adverse effects on the gastrointestinal and cardiovascular systems.

As a result, ingredients commonly found in certain joint pain supplements have been investigated as both primary and supplementary therapies for arthritis symptoms.

Given the rising interest in the best supplements for arthritis, we have put together a list of the top 5 brands that incorporate these offerings into their product portfolios.

Best supplements for arthritis: shortlist

  1. Utzy Naturals — best herbal blend for inflammation support in arthritis
  2. Natural Stacks — best supplement with clinically tested bioavailability for inflammation
  3. GenF20® — best joint pain supplement for bone mineral density
  4. VitaPost — best arthritis supplement with evidence-backed ingredients for joint health
  5. Pure Essence Labs — best supplement for joint support

How we compiled our list of best supplements for arthritis

Finding the best supplements for arthritis requires careful consideration of several important factors in order to make informed and sound choices. Here is what should be on your radar:

Ingredient qualityNatural and science-backed
FormulationFormulated for arthritis support
Brand reputationReputable and trustworthy
  • Ingredient quality. We prioritized joint pain supplements that contain high-quality ingredients derived from natural sources and backed by scientific research. We prioritized joint pain supplements that contain high-quality ingredients derived from natural sources, backed by scientific research, and formulated with increased bioavailability. On the contrary, we avoided those containing GMOs or unnecessary additives and fillers.
  • Formulation. When compiling our list of the best supplements for arthritis, we considered the supplement's formulation, as some ingredients may be more easily absorbed by the body than others. For instance, curcumin, a common active ingredient in the best arthritis supplements, may be better absorbed when combined with piperine.
  • Brand reputation. As reputable brands are more likely to be transparent about their sourcing and manufacturing processes, we have made an effort to choose those that provide information about the origins of their ingredients, their processing methods, and the measures taken to ensure product safety.
  • Price. Given that different brands offer similar supplements for arthritis pain support, among offerings on our list, you will find products at varying price points. This way, you can not only search for discounts and promotions but also select one that aligns with your budget, allowing you to save money without compromising on quality.

Best supplements for arthritis: an overview

While the best supplements for arthritis may not cure the condition or magically restore your joints to perfect health, recent studies indicate that some ingredients commonly found in joint supplements have the potential to support bone and joint health. Consider incorporating one of the following supplements into your routine to reap these benefits.

1. Utzy Naturals — best herbal blend for inflammation support in arthritis

Utzy Inflavinol

Utzy Naturals presents Inflavino, a dietary supplement designed to tackle joint pain at its source and enhance joint health. It is intended for those who experience discomfort that encroaches on daily activity.

By combining herbal extracts with flavonoids, Inflavinol works to balance the body's inflammatory response without interfering with the natural healing process. This, potentially, can result in a gradual sense of relief.

In line with its stance on quality, Utzy Naturals manufactures its products in the United States, operating within an FDA-audited facility.

The manufacturer also assures that they test their products not only via their in-house lab but also by verified third-party laboratories. You can check the results for yourself by visiting their official website and accessing the Certificate of Analysis (COA).

Inflavinol, priced at $41.50 for a single purchase, can be found on Utzy Naturals official website.

2. Natural Stacks — best supplement with clinically tested bioavailability for inflammation

Natural Stacks Turmeric

Natural Stacks Turmeric Curcumin is a liquid-form dietary supplement that is marketed to have 185 times greater bioavailability compared to regular powdered curcumin, all due to its concentrated nature.

With the patented NovaSOL technology, curcumin — the active ingredient in turmeric — is formulated into liquid micelles that can be rapidly absorbed, allowing you to experience curcumin's effects more quickly.

With its "Open Source" transparency initiative, Natural Stacks delivers ingredient traceability and third-party lab test results for each and every product batch.

Natural Stacks Curcumin comes in bottles containing 30 servings, and the manufacturer advises taking 2 softgels each day. This daily intake of 2 Turmeric Curcumin softgels is suggested to give you the equivalent of over 150 standard curcumin extract capsules, as per the provider.

This supplement by Natural Stacks is currently priced at $29.95 for a one-time purchase. To get yours, you can simply visit the official provider's website.

3. GenF20® — best supplement for bone mineral density

GenF20® Icelandic Red Algae Calcium

Icelandic Red Algae Calcium by GenF20® is a dietary supplement designed to support bone and joint health. It is formulated with a complex of bone-building and joint-strengthening ingredients, per its creators.

Loaded with clinically studied plant-based magnesium, vitamin D3, and a patented form of vitamin K called MK7, this GenF20® supplement also includes plant-based calcium to enhance bone strength and density. Studies have indicated that this form of calcium exhibits superior bioavailability compared to other products available on the market.

Among the best supplements for arthritis and joint pain, the GenF20® formula is quite convenient to incorporate into your daily routine. The manufacturer recommends simply taking 3 capsules with a meal.

The one-time purchase of Icelandic Icelandic Red Algae Calcium is currently priced at $59.95. You can claim yours by visiting the official website of the provider. Keep in mind that ordering bundles will grant you additional discounts.

4. VitaPost — best supplement with evidence-backed ingredients for joint health

vitapost ProJoint Plus

As we conclude our list of the best supplements for arthritis, ProJoint Plus emerges as a promising option to support joint health, featuring an ingredient profile that has received scientific backing.

Containing glucosamine sulfate and chondroitin, commonly used supplements for arthritis pain, VitaPost ProJoint Plus is an expertly crafted blend of herbal extracts designed to promote joint and cartilage health, as well as natural joint mobility.

Crafted in an FDA-registered facility within the United States, ProJoint Plus complies with GMP regulations, employing a mix of imported and locally sourced quality ingredients.

In line with the manufacturer's recommendations, it is advisable to take 3 capsules daily, ideally with food. For those in need of faster relief, the provider proposes a loading dose of 6 capsules per day for the first fourteen days.

A bottle containing 60 capsules, intended to last 20 days, is currently priced at $29.95 for a one-time purchase. We would like to highlight that ordering in bundles can result in additional savings, making this supplement even more cost-effective, despite its already affordable price.

5. Pure Essence Labs — best supplement for joint support

Pure Essence Labs JointEssence™

The standout feature of JointEssence by Pure Essence Labs is its fine group of main ingredients. The joint pain supplement combines Natural Eggshell Membrane (NEM), boron, and AprèsFLEX — a patented Boswellia serrata extract formulated to promote improved bioavailability. As per its creators, these ingredients are included in the exact amounts used in the studies that found them effective.

Within the supplement, you will also find cordyceps, a mushroom extract the provider claims is used to support the entire skeletal structure, most notably the lower back, knees, and ankles.

Triple-tested for identity, heavy metals, and toxins, each batch of this Pure Essence Labs supplement reflects the brand’s steadfast commitment to quality.

For the best results, it is advised by the manufacturer to consume 2 capsules daily.

JointEssence comes in a single bottle containing 60 capsules and is priced at $56.69 for a one-time purchase. To get your hands on it, visit the official provider's website.

Comparison of the best supplements for arthritis

BrandPrice per containerServing sizeServings per containerPrice per servingActive ingredients
Utzy Naturals$41.502 capsules30$1.387
Natural Stacks$29.952 softgels30$0.992
GenF20®$59.953 capsules30$1.9915
VitaPost$29.953 capsules20$1.498
Pure Essence Labs$56.692 capsules30$1.888

Please be aware that the FDA is not authorized to approve dietary supplements for safety and effectiveness. Therefore, always consult with your doctor before deciding to purchase or use dietary supplements, especially together with prescription medications.

What is arthritis?

Arthritis, in essence, is a common medical condition marked by inflammation in the joints. While its causes can vary, this condition can be attributed to a range of factors, including aging, injuries, infections, genetics, or faults in the immune system. The most common symptoms of arthritis comprise inflammation, pain, stiffness, and often swelling, all of which can significantly reduce mobility and even make simple tasks like gripping objects a real challenge.

Arthritis encompasses an abundance of different joint disorders, with the three common types being osteoarthritis (OA), rheumatoid arthritis (RA), and gout. We cover these disorders below:


Osteoarthritis, often dubbed the "wear and tear" disease, stands as the most widespread form of arthritis. Statistics from the Centers for Disease Control and Prevention reveal that over 32.5 million adults in the United States are affected by this condition. This type of arthritis primarily affects the back, hips, knees, and sometimes even the toes and fingers. It occurs when the protective cartilage that cushions the ends of bones in a joint gradually breaks down and deteriorates.

Commonly associated with aging, osteoarthritis can also result from joint injuries, genetic factors, obesity, and joint abnormalities. Its hallmark symptoms include joint pain, stiffness, and reduced flexibility, often leading to diminished mobility and discomfort.

Rheumatoid arthritis

Rheumatoid arthritis is a chronic and inflammatory condition. It is characterized by the immune system, which normally protects the body from infections, mistakenly attacking the synovium — the lining of the membranes that surround the joints. While the exact cause of rheumatoid arthritis is not fully understood, it is believed to result from a combination of genetic, environmental, and hormonal factors.

Rheumatoid arthritis commonly manifests in the hands, wrists, knees, and feet, potentially causing deformities in the joints. It also has the capacity to affect organs within the body, including the liver, heart, lungs, and eyes.


Gout is an inflammatory form of arthritis caused by the buildup of uric acid crystals within joints. This condition manifests with sudden and severe onset of pain, along with swelling, redness, and tenderness in one or multiple joints. The root cause of this condition is hyperuricemia, which refers to high levels of uric acid in the blood.

While gout can flare up in multiple joint locations like the foot, ankle, knee, and elbow, the metatarsophalangeal (MTP) joint of the first toe remains the most frequent target.

Role of supplements in arthritis management

Although the best arthritis supplements can certainly offer support in managing the condition, it is imperative to note that they usually do not serve as primary or independent treatment options. Instead, rather than being integrated in isolation, they are commonly incorporated into a broader strategy aimed at alleviating arthritis symptoms and improving joint health.

That being said, a number of joint pain supplements have promise in easing the pain, stiffness, and other manifestations of arthritis. Among them, glucosamine, chondroitin, and curcumin have been subjects of research for their potential to alleviate symptoms of both osteoarthritis and rheumatoid arthritis.

Ingredients to look for when choosing the best supplement for arthritis

If you fall under the category of those who want to find out what are the best natural supplements for arthritis, it is imperative to begin by examining the ingredient profile. This means you should search for specific ingredients that have been studied and shown to offer potential benefits for joint health and arthritis symptoms. Below, we present some of the most prominent ingredients:

  • Glucosamine. Derived from shellfish, this ingredient has been demonstrated in research studies to support joint health and reduce joint tissue degradation.
  • Chondroitin. Several studies suggest that chondroitin, alone or in combination with glucosamine, can provide better pain relief than a placebo for individuals with osteoarthritis in short-term trials, although the observed benefit was small to moderate.
  • Turmeric. Recent human clinical trials have provided evidence that supplementation with standardized turmeric extract can have a positive effect on reducing arthritis, specifically osteoarthritis symptoms — mostly inflammation and pain.

Other ways to manage arthritis symptoms

Managing arthritis symptoms often calls for a multifaceted strategy that extends beyond supplements and medications. Ways to manage arthritis symptoms include options like strength training and maintaining a balanced diet. While physical activity can improve muscle strength and joint support, thus reducing pain and enhancing function, a balanced, anti-inflammatory diet can also provide relief for those with arthritis. Such a diet includes foods rich in nutrients such as fruits, vegetables, whole grains, and fatty fish containing omega-3 fatty acids, with the latter boasting anti-inflammatory properties.

Best supplements for arthritis — conclusion

When it comes to finding the best supplements for arthritis management, it is essential to approach the topic with a mix of caution and informed decision-making. Although the best supplements for arthritis have the potential to provide some relief, containing ingredients like glucosamine, chondroitin, and curcumin — all of which hold promise for arthritis management — their impact can differ greatly from person to person. The scientific consensus regarding the effectiveness of arthritis supplements remains rather inconclusive.

With arthritis being a complex condition, and an effective treatment plan often involving a combination of medications, physical activity, and diet changes, it should be noted that while joint pain supplements may offer some relief for arthritis symptoms, they should not be considered a replacement for medical treatment or prescription medications prescribed by a healthcare professional.

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