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5 Best Anti Inflammatory Supplements in the Market in 2024

Inflammation, a natural part of the body's healing process, may serve as a defense mechanism against infections and contribute to injury healing. It may physically manifest through pain, fever and swelling, indicating the body's response to distress.

Acute or chronic inflammation persisting for a long time can potentially lead to a range of different health problems. Thus, adopting a healthy diet, lifestyle choices, and introducing daily exercise might be beneficial in managing systemic inflammation.

Certain food supplements may also be a valuable assistance to support a healthier lifestyle.

In this article, we are going to review our top 5 picks of the best supplements for inflammation.

Best supplement for inflammation: shortlist

  1. Natural Stacks — overall best turmeric curcumin anti-inflammatory supplement
  2. Performance Lab® — best omega-3 booster to fight inflammation
  3. Purovitalis Resveratrol— best plant-based supplement with anti-inflammatory properties
  4. Purovitalis Quercetin — best potent antioxidant supplement for reducing inflammation
  5. NuLeaf Naturals — best CBD oil for inflammation

How we chose the best supplements for inflammation

Third-party testingVerify that ingredients match the label
Price and value$34.95 – $45.00
Ingredient dosage Ingredient verification for safe dosages
Clinical studiesIngredients backed by scientific research
  • Third-party testing. It is important to ensure that the supplements are third-party tested for the quality of the product using an independent laboratory.
  • Price and value. Ensuring the supplement provides a reasonable price per serving, guaranteeing you’ll receive a cost-effective product.
  • Ingredient dosage. We checked that included ingredients are in safe dosages.
  • Clinical studies. Incorporating scientifically validated ingredients is vital to guarantee the use of only premium-quality components in each supplement.

Best anti-inflammatory supplements: overview of top products

Our selection of anti-inflammatory supplements offers a diverse range of options to support your well-being. These products come in various forms and combinations, catering to different health needs. We'll explore third-party testing, and scientific research on additional ingredients to help you make informed choices.

1. Natural Stacks — overall best turmeric curcumin anti-inflammatory supplement

Natural Stacks Turmeric

Natural Stacks Curcumin takes the first place in our list for the best inflammation supplement due to its advanced bioavailability, a key factor in delivering the active ingredients to inflamed tissues.

According to the brand, with a bioavailability 185 times higher than standard powdered curcumin, it ensures the body can readily absorb and utilize the potent compound from turmeric. Natural Stacks believes that the application of NovaSOL technology enhances bioavailability by transforming curcumin into liquid micelles for rapid absorption, complemented by organic coconut oil.

The brand reports that turmeric curcumin supplement may also aid in maintaining healthy cellular function, cognitive health, and metabolic function.

Priced at $34.95, each bottle offers 30 servings, making it a cost-effective choice. Furthermore, Natural Stacks unwavering commitment to ingredient transparency, rigorous third-party lab testing, and full-label disclosure make it a trustworthy option for the health-conscious.

Warning: If you are pregnant, nursing, or taking medications, consult a healthcare practitioner before use.

2. Performance Lab® — best omega-3 booster to fight inflammation

Performance Labs Omega3

The Omega-3 booster from Performance Lab® provides fatty acids that have been linked to reducing inflammation in the body, making this booster an appealing option for those aiming to enhance overall well-being.

Performance Lab® supplement is made from algal oil; it offers a full spectrum of Omega-3 fatty acids, including EPA and DHA, without the fishy aftertaste.

According to Performance Lab®, a formula encapsulated in carrageenan-free NutriGels® has maximum absorption and may benefit your brain, eyes, and heart health. It is also ideal for those seeking to balance their Omega-6 to Omega-3 ratio, support well-being, and potentially reduce inflammation.

Performance Lab® ensures safety and quality standards, with their product being eco-friendly and tested by third parties.

Priced at $49, this booster is a valuable addition for individuals seeking essential fatty acid supplementation with anti-inflammatory benefits.

Warning: To maintain optimal quality, it is advisable to refrigerate this product.

3. Purovitalis Resveratrol — best plant-based supplement with anti-inflammatory properties


Purovitalis introduces Liposomal Resveratrol, a supplement harnessing the anti-inflammatory properties of resveratrol, a potent polyphenol found in grapes and berries.

What sets Purovitalis apart is its innovative formulation — Liposomal Resveratrol features micronized resveratrol encapsulated within liposomes. This delivery method, according to the brand, enhances absorption and maximizes its anti-inflammatory effectiveness.

Purovitalis takes product quality seriously, subjecting Liposomal Resveratrol to third-party testing and obtaining essential certifications such as a Certificate of Analysis (COA). The supplement is also non-GMO, gluten-free, and convenient to incorporate into your daily routine.

Priced at just $45, Liposomal Resveratrol offers an attractive option for individuals seeking the potential health benefits of resveratrol, particularly in the context of inflammation management.

Warning: Prior to incorporating any supplement into your routine, it is advisable to consult a healthcare professional.

4. Purovitalis Quercetin — best potent antioxidant supplement for reducing inflammation

Purovitalis Quercetin

Purovitalis introduces Liposomal Quercetin, which has potent antioxidant and anti-inflammatory properties. Quercetin is a flavonoid found in nature's superfoods like citrus fruits, broccoli, and asparagus, and is beneficial for our well-being.

According to the brand, this supplement provides an optimal amount of quercetin in liposomes. The liposomal formula enhances absorption, ensuring you get the most out of every capsule.

Quercetin is also observed to combat free radicals, reduce inflammation, and support the immune system, thus potentially playing a role in maintaining good health.

Each package contains a 60-day supply. As advised you should consume one capsule a day, preferably with breakfast, to get the most benefits of quercetin.

Priced at $35, Purovitalis offers a subscription of 10%, fast shipping, and easy returns.

5. NuLeaf Naturals — best pure CBD oil for inflammation

NuLeaf CBD Oil

NuLeaf Naturals offers full-spectrum CBD oil with 900 mg of CBD at a concentration of 60 mg/ml. This product is derived from organically grown hemp in Colorado and undergoes advanced CO2 extraction, making it the best chemical-free and pure CBD extract.

This full-spectrum CBD oil contains additional cannabinoids like CBC, CBG, and CBN, along with terpenes and phytonutrients, potentially enhancing its effectiveness through the "entourage effect."

NuLeaf Naturals CBD can potentially help manage inflammation. It achieves this by interacting with the body's endocannabinoid system, a pivotal regulator of numerous physiological processes.

The brand prioritizes transparency and quality, subjecting its products to third-party lab testing for potency and purity. They hold a current Good Manufacturing Practice (cGMP) certification, setting high industry standards for hemp oil quality.

Priced at $39.20, with the subscribe and save option, it offers an affordable option for those seeking the potential benefits of CBD.

Comparison of the best supplements for inflammation

ProductPrice per bottle Serving sizeCost per servingServing per bottleIngredients
Natural Stacks$34.952 softgels per day$1.1630NovaSOL curcumin, liquid extract 50 mg, organic coconut oil 100 mg
Performance Lab®$49.003 capsules per day$1.6330Algal oil 1800 mg, Omega-3 fatty acids 990 mg, DHA 540 mg, EPA 270 mg
Purovitalis Resveratrol$45.001 capsule per day$0.7560Micronized Trans-Resveratrol 240 mg
Purovitalis Quercetin$35.001 capsule per day$0.5860Quercetin 125 mg
NuLeaf Naturals$39.2010 drops per day$1.3030Full spectrum hemp extract 30 mg, organic virgin hemp seed oil 436 mg, secondary cannabinoids 4 mg

What is inflammation?

Inflammation is a fundamental biological response that occurs within our body as a defense mechanism against a wide range of potential threats. It is important to understand that inflammation is not solely confined to infections; rather, it can be triggered by various factors, including lifestyle habits, trauma, autoimmune disorders, and even cancer.

When our body's innate immune system senses an injury or an invader, it initiates the inflammatory process as a means of protection. This intricate response involves a cascade of cellular and molecular events aimed at neutralizing the threat, repairing damaged tissue, and restoring balance.

The essential hallmark of inflammation consists of five cardinal signs: redness, swelling, heat, pain, and in some cases, loss of function. These indicators may serve as an alert system, allowing us to recognize when inflammation is occurring.

Redness and warmth arise due to increased blood flow to the affected area, while swelling results from an accumulation of immune cells and fluid. Pain and loss of function are often attributed to the pressure caused by swelling and tissue damage. In essence, inflammation is a complex, yet indispensable, component of our body's defense and repair mechanisms that play a pivotal role in maintaining overall health.

Chronic inflammation

Chronic inflammation is a persistent immune response that lasts for an extended period, often without resolution. Unlike acute inflammation, which is a short-term defense mechanism, chronic inflammation lingers longer than three months, and potentially can lead to additional health issues.

Acute inflammation

Acute inflammation is a short-term, immediate response by the body's immune system to injury, infection, or tissue damage. It may involve redness, swelling, heat, pain at the affected site and typically serves as a protective mechanism which contributes to healing initiation.

A break-down of natural supplements for inflammation and their benefits

Let's take a research-based look at key ingredients like curcumin, omega-3, Quercetin, resveratrol, and CBD. We'll uncover their benefits and limitations for better understanding of their anti-inflammatory potential.

1. Curcumin

Curcumin, the primary bioactive compound in turmeric, is proposed to have anti-inflammatory and antioxidant properties.

Recent clinical findings suggest that curcumin may interact with multiple pro-inflammatory proteins and therefore may reduce inflammation.

However, it is important to note that curcumin is not a drug, and currently, it is not approved to prevent or cure inflammation. There is still limited evidence as most of the clinical trials were small-scale.

2. Omega 3

Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oil may help modulate inflammation via multifaceted interactions on inflammatory processes.

Certain omega 3 metabolites — resolvins, have been reported to potentially play a role in inflammation control in multiple inflammatory skin conditions.

Omega-3 fatty acid supplementation efficacy varies among inflammatory conditions, lacking consistent evidence across most pathologies.

Individual responses to omega-3 supplementation may vary, and caution should be exercised when addressing specific health concerns.

3. Resveratrol

Resveratrol, a natural compound found in various foods, such as berries, is proposed to exhibit notable anti-inflammatory properties. Resveratrol's multifaceted mechanisms of action, including its antioxidant effects and modulation of pro-inflammatory signaling pathways, make it a promising candidate for therapeutic interventions.

However, it's low bioavailability and limited research in clinical trials pose significant challenges for effective clinical application. Further clinical trials are essential to address these limitations and establish the true clinical potential of resveratrol for individuals with systemic inflammation.

4. Quercetin

Quercetin, a natural compound found in fruits and vegetables, demonstrates anti-inflammatory and antioxidant-properties, highlighted in multiple research studies. It also is proposed to aid in reducing lipid peroxidation and may support immune function.

Unfortunately, the bioavailability of quercetin after oral administration can be low, hence higher doses may be recommended, increasing the chance of potential side effects and individual responses may vary.

Further research is needed to fully understand quercetin’s optimal usage and its potential drawbacks.

5. Boswellia

Boswellia serrata is one of the ancient and most valued herbs used for inflammation in Ayurvedic medicine.

Boswellia extracts are typically rich in numerous terpenes and multiple acids, which are proposed to prevent the activity of pro-inflammatory enzymes and, hence, play an anti-inflammatory role in systemic inflammation.

However, currently, there are limited clinical studies investigating the activity and effects of Boswellia, and future research is needed.

Are there side effects when taking anti-inflammatory supplements?

Taking anti-inflammatory supplements can have side effects, and it's essential to approach them with caution. While supplements like turmeric, fish oil, or ginger can help reduce inflammation, they may interact with other medications you're taking. For example, they can potentiate the effects of blood-thinning drugs, potentially leading to bleeding issues.

Additionally, excessive use of supplements can result in adverse effects. For instance, high doses of fish oil may cause digestive problems. It's advisable to consult a healthcare professional before starting any supplement regimen, especially if you're already on prescription medication.

They can evaluate potential interactions and determine whether a supplement is suitable for your specific needs. In some cases, a blood test might be necessary to identify deficiencies, ensuring a more targeted and safe approach to supplementation.

Before buying supplements to reduce inflammation: what to consider

Supplements should be viewed as complementary additions to a holistic approach that includes maintaining a healthy diet and engaging in regular exercise. When combined, supplements, diet, and exercise collectively might potentially contribute to alleviating mild inflammation or its associated symptoms.

  • Reviews. Check customer reviews and testimonials to gauge the supplement's effectiveness and any potential side effects. Real experiences can provide valuable insights.
  • Form. Look for supplements in forms suitable for your preferences, such as capsules, powders, or liquids. Consider factors like ease of consumption and absorption.
  • Price. Compare prices among different brands and products. Ensure you're getting a reasonable price per serving.
  • Research ingredients. Prioritize supplements containing scientifically backed ingredients known for their anti-inflammatory properties. Consult a healthcare professional to understand which ingredients are suitable for your specific needs. Remember, supplements should complement a healthy lifestyle, including diet and exercise, which all together may make a contribution in managing inflammation.

Warning: It's critical to emphasize that these supplements can’t cure inflammation alone.

Other ways to naturally reduce inflammation

Reducing inflammation naturally requires a nuanced approach, as inflammation is a complex and often necessary bodily process. While the body's inflammatory response can be beneficial, aiding in infection control and tissue repair, chronic inflammation may be harmful and debilitating.

To help mitigate excessive inflammation, lifestyle choices play a pivotal role. Maintaining a balanced diet rich in anti-inflammatory foods like fruits, vegetables, and fatty fish can help.

Regular exercise, sufficient sleep, and stress management techniques like meditation can also contribute to inflammation control. However, for severe or chronic cases, medication remains the most effective option.

Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are commonly prescribed to manage inflammation, but their use should be supervised by a healthcare professional due to potential adverse effects.

Best supplement for inflammation — conclusion

In conclusion, when seeking the best supplement for inflammation, it's important to prioritize products that have quality ingredients, undergo third-party testing, and are backed by scientific research.

Look for supplements that demonstrate anti-inflammatory properties. It's crucial to approach them cautiously, seek advice from healthcare professionals, and be aware of potential limitations and interactions.

Supplements should be viewed as complementary rather than as medications that can cure inflammation alone. A holistic lifestyle encompassing a balanced diet, exercise, and stress management can all potentially contribute to inflammation control.

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