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Best Supplements for Pain and Inflammation 2024

Inflammation, a natural part of the body's healing process, may serve as a defense mechanism against infections and contribute to injury healing. It may physically manifest through pain, fever and swelling, indicating the body's response to distress.

Acute or chronic inflammation persisting for a long time can potentially lead to a range of different health problems. Thus, adopting a healthy diet, lifestyle choices, and introducing daily exercise might be beneficial in managing systemic inflammation or its associated symptoms like pain.

Certain food supplements may also be a valuable assistance to support a healthier lifestyle.

In this article, we are going to review our top 5 picks of the best supplements for inflammation.

Best supplements for pain and inflammation: shortlist

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Best anti-inflammatory supplements: overview of top products

Our selection of anti-inflammatory supplements offers a diverse range of options to support your well-being. These products come in various forms and combinations, catering to different health needs. We'll explore third-party testing, and scientific research on additional ingredients to help you make informed choices.

1. ProHealth — overall best curcumin anti-inflammatory supplement

Prohealth curcumin

Optimized Curcumin Longvida® by ProHealth takes first place in our list of the best inflammation supplements due to its attempt to increase the compound's bioavailability, a key factor in increasing the chance of delivering the active ingredients to inflamed tissues.

According to the brand, Curcumin Longvida®'s bioavailability is 285 times higher than that of regular curcumin, ensuring the body can readily absorb and utilize the potent compound from Curcuma longa root.

The manufacturers state that the supplement may promote joint health and a healthy inflammatory response. The brand also claims Longvida® is supported by extensive research and clinical trials, demonstrating positive health benefits.

Third-party tested and certified, this product contains no harsh solvents, offering high quality at a low cost. Available in packs of 60 capsules, ProHealth is priced at $88.47 for a 3-pack, with options for subscription and free U.S. shipping on orders over $30. Additionally, you can purchase a single pack for just $31.49.

Warning: If you are pregnant, nursing, or taking medications, consult a healthcare practitioner before use.

2. Performance Lab® — best omega-3 booster to fight inflammation

Performance Labs Omega3

The Omega-3 booster from Performance Lab® provides fatty acids that have been linked to reducing inflammation in the body, making this booster an appealing option for those aiming to enhance overall well-being.

Performance Lab® supplement is made from algal oil; it offers a full spectrum of Omega-3 fatty acids, including EPA and DHA, without the fishy aftertaste.

According to Performance Lab®, a formula encapsulated in carrageenan-free NutriGels® has maximum absorption and may benefit your brain, eyes, and heart health. It is also ideal for those seeking to balance their Omega-6 to Omega-3 ratio, support well-being, and potentially reduce inflammation.

Performance Lab® ensures safety and quality standards, with their product being eco-friendly and tested by third parties.

Priced at $49, this booster is a valuable addition for individuals seeking essential fatty acid supplementation with anti-inflammatory benefits.

Warning: To maintain optimal quality, it is advisable to refrigerate this product.

3. Purovitalis Resveratrol — best plant-based supplement with anti-inflammatory properties

purovitalis-liposomal-resveratrol-commerc

Purovitalis introduces Liposomal Resveratrol, a supplement harnessing the anti-inflammatory properties of resveratrol, a potent polyphenol found in grapes and berries.

What sets Purovitalis apart is its innovative formulation — Liposomal Resveratrol features micronized resveratrol encapsulated within liposomes. This delivery method, according to the brand, enhances absorption and maximizes its anti-inflammatory effectiveness.

Purovitalis takes product quality seriously, subjecting Liposomal Resveratrol to third-party testing and obtaining essential certifications such as a Certificate of Analysis (COA). The supplement is also non-GMO, gluten-free, and convenient to incorporate into your daily routine.

Priced at just $45, Liposomal Resveratrol offers an attractive option for individuals seeking the potential health benefits of resveratrol, particularly in the context of inflammation management.

Warning: Prior to incorporating any supplement into your routine, it is advisable to consult a healthcare professional.

4. Purovitalis Quercetin — best potent antioxidant supplement for reducing inflammation

Purovitalis Quercetin

Purovitalis introduces Liposomal Quercetin, which has potent antioxidant and anti-inflammatory properties. Quercetin is a flavonoid found in nature's superfoods like citrus fruits, broccoli, and asparagus, and is beneficial for our well-being.

According to the brand, this supplement provides an optimal amount of quercetin in liposomes. The liposomal formula enhances absorption, ensuring you get the most out of every capsule.

Quercetin is also observed to combat free radicals, reduce inflammation, and support the immune system, thus potentially playing a role in maintaining good health.

Each package contains a 60-day supply. As advised you should consume one capsule a day, preferably with breakfast, to get the most benefits of quercetin.

Priced at $35, Purovitalis offers a subscription of 10%, fast shipping, and easy returns.

5. NuLeaf Naturals — best pure CBD oil for inflammation

NuLeaf CBD Oil

NuLeaf Naturals offers full-spectrum CBD oil with 900 mg of CBD at a concentration of 60 mg/ml. This product is derived from organically grown hemp in Colorado and undergoes advanced CO2 extraction, making it the best chemical-free and pure CBD extract.

This full-spectrum CBD oil contains additional cannabinoids like CBC, CBG, and CBN, along with terpenes and phytonutrients, potentially enhancing its effectiveness through the "entourage effect."

NuLeaf Naturals CBD can potentially help manage inflammation. It achieves this by interacting with the body's endocannabinoid system, a pivotal regulator of numerous physiological processes.

The brand prioritizes transparency and quality, subjecting its products to third-party lab testing for potency and purity. They hold a current Good Manufacturing Practice (cGMP) certification, setting high industry standards for hemp oil quality.

Priced at $39.20, with the subscribe and save option, it offers an affordable option for those seeking the potential benefits of CBD.

How we chose the best supplements for pain and inflammation?

Check the criteria below to see how we evaluated supplements for pain and inflammation.

Third-party testingPrice and valueIngredient dosage Clinical studies
Verify that ingredients match the label$34.95 – $45.00Ingredient verification for safe dosagesIngredients backed by scientific research
  • Third-party testing. It is important to ensure that the supplements are third-party tested for the quality of the product using an independent laboratory.
  • Price and value. Ensuring the supplement provides a reasonable price per serving, guaranteeing you’ll receive a cost-effective product.
  • Ingredient dosage. We checked that included ingredients are in safe dosages.
  • Clinical studies. Incorporating scientifically validated ingredients is vital to guarantee the use of only premium-quality components in each supplement.

Comparison of the best supplements for inflammation

ProductPrice per bottle Serving sizeCost per servingServing per bottleIngredients
Prohealth$31.492 capsules per day$1.0530LONGVIDA® optimized curcumin extract (from Curcuma longa root) 1000 mg
Performance Lab®$49.003 capsules per day$1.6330Algal oil 1800 mg, Omega-3 fatty acids 990 mg, DHA 540 mg, EPA 270 mg
Purovitalis Resveratrol$45.001 capsule per day$0.7560Micronized Trans-Resveratrol 240 mg
Purovitalis Quercetin$35.001 capsule per day$0.5860Quercetin 125 mg
NuLeaf Naturals$39.2010 drops per day$1.3030Full spectrum hemp extract 30 mg, organic virgin hemp seed oil 436 mg, secondary cannabinoids 4 mg

Best supplements for pain and inflammation: conclusion

In conclusion, when seeking the best supplement aimed at helping with mild inflammation or its associated symptoms like pain, it's important to prioritize products that have quality ingredients, undergo third-party testing, and are backed by scientific research.

Look for supplements that demonstrate anti-inflammatory properties. It's crucial to approach them cautiously, seek advice from healthcare professionals, and be aware of potential limitations and interactions.

Lastly, supplements should be viewed as complementary rather than as medications that can cure inflammation alone. A holistic lifestyle encompassing a balanced diet, exercise, and stress management can all potentially contribute to inflammation control.


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