If you purchase via links on our site, we may receive commissions. However, our experts carefully research and evaluate each product or service, ensuring it meets our quality standards.

Best Supplements for Nerve Pain in 2024: Top 5 Brands Reviewed

Nerve pain, often described as a burning or tingling sensation, can be debilitating and disrupt daily life. While various underlying causes, from diabetes to injuries, can contribute to neuropathy, finding effective remedies remains a priority for many sufferers. Among the myriad of strategies available, certain supplements have emerged as potential aids in managing nerve pain.

Diving into the world of supplements for nerve pain, this article will explore the most researched and recommended options, shedding light on their efficacy and mechanisms of action. Let's explore some of the best supplements for nerve pain and how they might help.

Best supplements for nerve pain: shortlist

  1. Performance Lab — best omega 3 supplement for nerve pain
  2. NuLeaf Naturals — best CBD supplement for nerve pain
  3. Future Kind + — best turmeric supplement for nerve pain
  4. Natural Stacks — best supplement for nerve pain with a patented formula
  5. Thrivous — best supplement for nerve pain with ginkgo biloba

How we compiled our list of the best supplements for nerve pain

When selecting supplements for nerve pain, it's crucial to consider various factors to identify the best supplements for nerve pain. Below is a quick reference table outlining key criteria.

CriteriaScientific evidencePriceReviewsQuality of ingredients
ExplanationBacked by research and studies $0.50–3.00 per servingPositive user feedbackPure, natural, and third-party tested
  • Scientific evidence. Supplements for nerve health or those claiming to help with nerve damage should be supported by scientific research. Evidence-based options may enhance the likelihood of positive outcomes.
  • Price. The cost of supplements for nerve inflammation or other nerve-related issues can vary. Always ensure that you're getting a good balance between price and quality.
  • Reviews. Looking at what other users say about supplements for nerve pain in feet or supplements for peripheral nerve pain can offer insights. Positive reviews may indicate effectiveness, but it's essential to look for genuine feedback.
  • Quality of ingredients. When searching for herbal supplements for nerve pain or other natural supplements for nerve pain, the purity and source of the ingredients are paramount. Quality supplements for nerve function typically avoid fillers and questionable additives, and are third-party tested for conformity and consistency.

Supplements for nerve pain: an overview

Nerve pain can be an intrusive ailment, prompting many to seek effective alleviation. In the burgeoning world of supplements for nerve pain, discerning the best options hinges on several criteria, such as scientific evidence, reviews, price, and quality.

This overview will delve into five noteworthy brands, examining them against these standards. As you navigate the world of supplements for nerve health, let this guide offer clarity and direction.

1. Performance Lab — best omega-3 supplement for nerve pain

Performance Labs Omega3

Among the best supplements for nerve pain, the Performance Lab Omega 3 stands out. Enriched with omega-3 fatty acids including DHA and EPA, this supplement claims to be a game-changer. Omega-3 fatty acids have garnered attention for their potential in addressing nerve damage and inflammation.

What sets this product apart is its source — omega-3s are derived directly from algae, ensuring high purity and potency. By circumventing the common issues of heavy metals and contaminants found in fish oils, it offers a clean and sustainable product. Furthermore, no fishy aftertaste is a bonus.

For those exploring supplements for nerve health, this product, backed by good customer reviews and third-party testing, may be a promising addition to their regimen.

A month’s supply of softgel capsules costs $49.00 ($1.63 per serving).

2. NuLeaf Naturals — best CBD supplements for nerve pain

NuLeaf CBD Softgels

Exploring supplements for nerve pain often leads individuals to consider CBD, and Nuleaf CBD capsules make a notable impression. Incorporating full-spectrum hemp extract, these capsules are positioned to leverage the entourage effect, which is believed to enhance the therapeutic benefits of CBD.

Research indicates that CBD may help address nerve pain and neuropathy by reducing inflammation and interacting with neurotransmitters. By being a full-spectrum product, Nuleaf ensures a comprehensive range of cannabinoids that work synergistically.

For those seeking supplements for neuropathic pain, these capsules, with their positive customer reviews and third-party testing, appear promising.

30-day supply costs $19.00 ($0.63 per serving).

3. Future Kind + — best curcumin supplements for nerve pain

Future Kind Turmeric

Vegan Turmeric Curcumin With Black Pepper Inflammation Supplement by Future Kind + is designed to support anti-inflammatory functions with a 100% clean vegan formula.

This supplement harnesses the power of potent antioxidants combined with naturally-derived curcumin that may have anti-inflammatory benefits for nerve pain.

Each serving contains organic turmeric powder and organic black pepper, with the former offering 700 mg of antioxidant power to support the inflammatory response and the latter enhancing the absorption of turmeric's benefits.

The product is third-party tested and manufactured in an FDA-regulated and GMP-certified facility in the USA, providing transparency in its ingredients and manufacturing process.

30-day supply costs $19.99 ($0.67 per serving).

4. Natural Stacks — best supplement for nerve pain with a patented formula

Natural Stacks NEUROFUEL™

For those seeking supplements for nerve pain, the quest often leads to products that bolster nerve health and function. Enter Natural Stacks Neurofuel — a blend that harnesses the synergy of five natural ingredients, including artichoke extract and acetyl-L-carnitine.

Its claims center around enhancing long-term potentiation (LTP), a pivotal function in memory formation and synaptic strength — both crucial for optimal nerve health. Particularly, acetyl-L-carnitine may help nerve cells produce energy and repair damaged nerves. Several studies suggest it might be beneficial in diabetic neuropathy. The combination of the ingredients in Natural Stacks Neurofuel may also benefit those looking for supplements with neuroprotective properties.

With third-party testing, excellent customer reviews, and a patented formula, this product resonates reliability and innovation.

20-day supply costs $29.95 ($1.50 per serving).

5. Thrivous — best supplement for nerve pain with ginkgo biloba

Thrivous Alpha Neuroprotector

For individuals searching for supplements for nerve pain, Thrivous Alpha Neuroprotector stands out with its unique blend specifically crafted to support the overall nerve health.

Acetyl-L-carnitine is recognized for its potential in aiding nerve energy production and repair. R-alpha-lipoic acid is an antioxidant that may help in reducing oxidative stress often associated with nerve damage. Ginkgo biloba, celebrated for promoting circulation, might enhance blood flow to nerves, potentially aiding nerve health.

With the claims of enhancing brain and nerve function for better aging, this product seems to align with those seeking supplements for nerve health. The regime of 4 capsules per serving ensures a potent dose, and the third-party testing amplifies its credibility.

30-day supply costs $51.90 ($1.73 per serving).

Comparison of the best supplements for nerve pain

BrandPrice per bottlePrice per servingNumber of servingsServing sizeNumber of ingredients
Performance Lab$49.00$1.63303 capsules1
NuLeaf Naturals$19.00$0.63302 capsules1
Future Kind +$19.99
302 capsules2
Natural Stacks$29.95$1.50203 capsules5
Thrivous$51.90$1.73304 capsules5

Criteria to have in mind when looking for supplements for neuropathy

When seeking the best supplements for nerve pain, several considerations can guide your choice. Here are key criteria to keep in mind:

  • Diet. Ensure the supplement complements your dietary needs and doesn't interfere with any foods or other supplements you consume.
  • Scientific evidence. Opt for supplements for nerve health that are backed by credible research and studies, ensuring their potential efficacy.
  • Reviews. Real user feedback on supplements for nerve damage or pain can provide valuable insights into their effectiveness and side effects.
  • Nutrient deficiencies. If you have specific deficiencies — like vitamin B12, often linked to nerve health — choose supplements that may help fill those gaps.

What is nerve pain?

Nerve pain, also known as neuropathy, refers to a condition where the nerves are damaged or affected, leading to pain, tingling, and numbness. Neuropathy can be categorized based on its duration and causes:

  • Acute neuropathy. This type of nerve pain appears suddenly and is often triggered by specific events or injuries. It can be severe but usually resolves in a short period.
  • Chronic neuropathy. Chronic nerve pain persists for longer durations, often months or even years. It may be due to long-term health conditions, injuries, or unknown causes.
  • Peripheral neuropathy. This affects the peripheral nerves — those outside the brain and spinal cord, leading to symptoms in the extremities.
  • Central neuropathy. This involves the central nervous system, impacting the brain and spinal cord.

Research on supplements for neuropathy pain

Neuropathic pain, or nerve pain, affects numerous individuals globally. Over the years, the quest for relief has led to increased interest in supplements that may help alleviate symptoms. While research is ongoing, several supplements have gained attention due to their potential beneficial effects.


Acetyl-L-carnitine (ALC) is an amino acid derivative that plays a pivotal role in cellular energy production, particularly in nerve cells. It aids in the transport of fatty acids into the mitochondria — the energy-producing units of cells — thus facilitating energy generation. This is crucial for nerve cells, which require a significant amount of energy to maintain function and repair.

Additionally, ALC has demonstrated potential neuroprotective properties. Research suggests it can support nerve cell health by reducing oxidative stress and promoting nerve regeneration. In conditions like diabetic neuropathy, studies have indicated that ALC supplementation may help reduce pain and improve nerve fiber regeneration.

Alpha-lipoic acid

Alpha-lipoic acid (ALA) is a potent antioxidant that offers multiple benefits for nerve health. Its primary mechanism revolves around its ability to neutralize harmful free radicals, thereby reducing oxidative stress that can damage nerve cells. This protective quality is particularly valuable in conditions like diabetic neuropathy, where oxidative stress is a contributing factor.

ALA has also been shown to improve nerve blood flow and promote better nerve conduction, supporting overall nerve function. Clinical studies have found that ALA supplements can help alleviate the pain, burning, tingling, and numbness associated with neuropathic conditions, making it a frequently recommended supplement for nerve pain management.

Ginkgo biloba

Ginkgo biloba, a longstanding medicinal herb, has properties that may potentially benefit nerve health. The primary mechanism is its ability to improve blood circulation, which is vital for delivering nutrients and oxygen to nerve cells. Enhanced circulation can aid in the health and repair of damaged nerves.

Furthermore, ginkgo biloba contains powerful antioxidants that combat oxidative stress, a contributor to nerve damage. This dual action of promoting circulation and reducing oxidative damage means that ginkgo may support overall nerve function and health. Some studies have indicated its potential in managing conditions related to poor circulation, which may benefit nerves affected by reduced blood flow.


Phosphatidylserine is a phospholipid molecule essential for the health and function of cell membranes, especially in neurons. It plays a pivotal role in supporting neuronal membranes, ensuring fluidity, and facilitating cell-to-cell communication. Proper nerve signaling is critical for overall nerve function, and phosphatidylserine aids in optimizing this process.

Additionally, this lipid has been shown to have neuroprotective properties, potentially guarding neurons against oxidative stress and other damaging factors. By maintaining the integrity of neuronal membranes and supporting cell signaling, phosphatidylserine can contribute to overall nerve health, potentially aiding in cognitive function and slowing neurodegenerative processes.

Omega-3 fatty acids

Omega-3 fatty acids, notably EPA and DHA, are fundamental components of cell membranes, ensuring fluidity and proper nerve signaling. By integrating into the neuronal cell membranes, they enhance neurotransmission, crucial for nerve communication. Additionally, omega-3s possess potent anti-inflammatory properties. Chronic inflammation can adversely affect nerve function and contribute to neuropathic pain. By modulating inflammation, omega-3s can potentially alleviate nerve pain and promote nerve regeneration.

Moreover, these fatty acids support myelin, the protective sheath surrounding nerve fibers, essential for rapid and efficient nerve signal conduction. Regular intake of omega-3s may thus bolster nerve function, reduce inflammation, and support overall nerve health.

Can supplements prevent nerve damage?

The potential of supplements to prevent nerve damage remains a topic of interest and research. While certain supplements may help in restoring nerve function to some extent, their primary role often revolves around halting the progression of worsening symptoms or supporting overall nerve health. Taking supplements can be beneficial if there's an identified deficiency, as some deficiencies can lead to or exacerbate neuropathy. However, taking supplements without a diagnosed deficiency or pain might not guarantee prevention.

Moreover, it's essential to note that while some supplements might support nerve health, they shouldn't be seen as a definitive shield against nerve damage. Always consult with a healthcare professional before starting any supplementation, especially for prevention purposes.

Side effects of supplement for nerve pain

Utilizing supplements for nerve pain requires caution, especially when combined with specific prescription or over-the-counter medications due to potential interactions:

  • Digestive issues. Some supplements can lead to stomach upset, diarrhea, or constipation.
  • Allergic reactions. Individuals might experience symptoms from rashes to severe reactions.
  • Interaction with anticoagulants. Omega-3 fatty acids, for instance, can enhance the blood-thinning effects of medications like warfarin, increasing the risk of bleeding.
  • Effect on diabetes medication. Alpha-lipoic acid might lower blood sugar, which could amplify the effects of insulin or oral hypoglycemic agents.
  • Antidepressant interaction. St. John's wort, sometimes used for nerve pain, can interact with SSRIs and MAOIs, possibly leading to serotonin syndrome.
  • Blood pressure fluctuation. Some supplements might interact with blood pressure medications, either elevating or reducing their effectiveness.

It’s important to consult with a healthcare provider before starting any supplements, especially when taking medications to ensure safety.

Supplements for nerve pain - conclusion

Navigating the realm of supplements for nerve pain reveals a myriad of options, each with its distinct benefits. From omega-3 fatty acids' anti-inflammatory properties to the neuroprotective qualities of alpha-lipoic acid and ginkgo biloba, numerous supplements may offer potential relief. While research underscores the efficacy of certain active ingredients in supporting nerve health, it's crucial to approach supplementation with caution, considering individual needs and consulting a healthcare professional before embarking on any regimen.

Explore more nerve and brain supplements

Best CBD for fibromyalgia may help alleviate pain and inflammation in muscles as well as nerves.

Best CBD oil for pain and pain relief may reduce pain symptoms and alleviate stress contributing to pain management efforts.

Best nootropics to optimize brain health may support healthy nerve and brain function.


Leave a reply

Your email will not be published. All fields are required.