Driven by the pursuit of a longer life, many people are discovering the benefits of trimethylglycine (TMG). It’s a form of amino acid known to play a role in methylation processes, critical for maintaining energy metabolism and overall cellular function.
TMG supplements may help support cardiovascular health by reducing elevated homocysteine levels, which have been linked to an increased risk of heart disease and stroke. However, with many options available, choosing the best trimethylglycine supplement can be a challenge.
We have compiled a list of the best TMG supplements on the market to help you choose the most suitable product for your personal needs, as well as consulted our in-house experts for their insights on the matter.
Best TMG supplement: shortlist
- Best overall TMG supplement: partiQlar
- Top-rated TMG supplement in tablet form: ProHealth Longevity
- Best TMG supplement with many servings: Vitality Pro
- Best TMG supplement in capsule form: BrainMD
- Best TMG powder supplement: BulkSupplements.com
Your well-being is our top priority. Our in-house Research team and expert fact-checkers diligently review every content piece, ensuring you receive accurate, safe, and up-to-date health information to support your health decisions. Get an inside look at our thorough testing framework.
Why do we think partiQlar TMG is the best?
We picked partiQlar as the best overall TMG supplement for its quality, purity, and affordability.
According to the provider, the supplement may help support cardiovascular health and may work well alongside NMN for healthy aging.
Furthermore, the partiQlar TMG is made in GMP-certified, FDA-registered facilities, and every batch is third-party tested, so you know you're getting a good quality product. This level of quality control isn’t always guaranteed with other brands, even if their labels look similar.
partiQlar places a strong emphasis on sourcing its ingredients from ethical, sustainable suppliers. This attention to detail and commitment to eco-friendly practices set it apart from many competitors who may not prioritize such factors.
Best TMG supplement: overview
We selected the best TMG supplements based on specific nominations and criteria, highlighting their features, benefits, and certifications.
Our team has examined more than 100 research articles related to longevity and TMG in particular. This helped us better understand the quality of our chosen products.
1. partiQlar — best overall TMG supplement
Designed to support your body's methylation processes and general health, partiQlar enters our list as the best overall TMG supplement.
One key potential benefit of the supplement is lowering homocysteine levels to support cardiovascular health. The brand also suggests that it is particularly beneficial for users who take NMN, which may play an important role in healthy aging.
Each capsule of the product contains 500 mg of TMG, without any additives.
partiQlar Pure TMG is manufactured in GMP-certified and FDA-registered facilities. Each batch undergoes third-party testing for quality assurance. The product is free from unnecessary binders, fillers, and preservatives.
A single container of the product includes 60 capsules with a serving size of 1 capsule.
Who might benefit the most from this product?
partiQlar Pure TMG may be suitable for individuals seeking to support their cardiovascular health and overall well-being.
Company review
partiQlar is a company focused on producing high-quality longevity supplements like NMN, resveratrol, TMG, and more.
The emphasizes transparency and quality, ensuring that all products are made in GMP-certified company and FDA-registered facilities.
Each product undergoes third-party testing, with certificates of analysis available on their website for consumers to verify.
Our verdict about the product
In our view, partiQlar Pure TMG could be a solid choice for individuals who care about longevity and cardiovascular health.
The supplement contains no additives and offers peace of mind with third-party testing and transparent ingredient sourcing.
However, it’s worth considering that the product’s effectiveness may vary from person to person, and there have been reports of occasional shipping delays.
Price
partiQlar Pure TMG is priced at $13.99 for a two-month supply, which is one of the most affordable options on our list. The brand also offers a 60-day money-back guarantee, ensuring customer satisfaction at a competitive price point.
2. ProHealth Longevity — top-rated TMG supplement in tablet form
If you're looking for enhanced cellular health and cardiovascular support, TMG Pro Tablets by ProHealth Longevity may be your key to unlocking these benefits.
Each tablet contains 1,000 mg of TMG, an amino acid derivative involved in the body's methylation processes. It is also proposed to contribute to anti-aging, energy production, and combating oxidative stress.
Furthermore, the supplement may also help reduce elevated homocysteine levels, promoting support for cardiovascular health.
Each container comes with 120 tablets and a recommended serving size of 1 tablet.
Last but not least, the product undergoes rigorous third-party lab testing and is produced in a GMP-certified, FDA-registered facility, reflecting a commitment to quality and production safety.
Who might benefit the most from this product?
ProHealth Longevity TMG Pro Tablets are designed for individuals looking to support cardiovascular health, promote healthy aging, and improve overall well-being.
Company review
ProHealth Longevity, founded by Rich Carson in 1988, has established itself as a leader in the supplement industry.
The company’s products are made in GMP-certified and FDA-registered facilities and undergo third-party testing, aiming to ensure the highest standards of quality and safety from contaminants.
According to the brand website, with an A+ rating from the Better Business Bureau for 35 consecutive years, ProHealth Longevity is a reliable choice for customers seeking research-backed supplements.
Our verdict about the product
TMG Pro Tablets by ProHealth Longevity offer high-quality TMG supplements at an affordable price.
Manufactured in GMP-certified facilities with third-party testing, the brand offers you reassurance about product quality.
The product remains a solid option for individuals looking for potential cardiovascular and cellular health support.
Price
TMG Pro Tablets are priced at $16.57, offering great value for maintaining overall health. The product also includes a 100-day money-back guarantee.
3. Vitality Pro — best TMG supplement with many servings
Elevate your health with Vitality Pro TMG designed for your cellular health and general well-being.
Each bottle contains 120 capsules, with 500 mg of TMG per capsule — a serving size amount.
The supplement is GMP-certified and third-party tested by independent laboratories, boasting high levels of purity.
It is also free from GMOs, artificial colors, preservatives, flavors, or major allergens and is suitable for vegans, ensuring it meets a wide range of dietary needs.
Additionally, the packaging is 100% biodegradable, reflecting a commitment to environmental sustainability.
Who might benefit the most from this product?
Vitality Pro TMG supplement is tailored to individuals who are looking to support their cardiovascular health, promote healthy methylation, and improve overall cellular function.
Company review
Vitality Pro is known for providing high-quality supplements backed by third-party testing and transparent manufacturing processes.
The company’s products are made in GMP-certified facilities with ingredients that are free of GMOs, artificial colors, preservatives, and major allergens. Additionally, Vitality Pro prioritizes sustainability, with 100% biodegradable packaging for its supplements.
Our verdict about the product
We believe Vitality Pro TMG may be a suitable option for those who are looking for a supplement with a focus on purity, eco-friendly packaging, and third-party testing.
Additionally, this product offers great value for individuals seeking a vegan-friendly and potentially effective TMG supplement.
Price
Vitality Pro TMG is available for $22.00, offering a relatively cost-effective way to enhance your health regimen with a high-quality product.
4. BrainMD — best TMG supplement in capsule form
Seeking to boost your mood and optimize your body's methylation? Look no further than Betaine TMG by BrainMD.
This unique supplement may support energy production, including the functioning of your cardiovascular, nervous, and endocrine systems.
According to the brand, Betaine TMG may be helpful for individuals with folate or vitamin B12 deficiencies, indicating poor methylation.
Each serving contains 1,000 mg of betaine (TMG). A single bottle of Betaine TMG includes 60 capsules with a serving size of 2 capsules.
BrainMD ensures the highest quality by conducting third-party testing and manufacturing its products in GMP-certified facilities.
Who might benefit the most from this product?
BrainMD’s Betaine TMG is presented for individuals seeking to support their body's methylation process, particularly those with folate or vitamin B12 deficiencies.
It may also be suitable for people who want to improve cardiovascular, nervous, and endocrine health or those interested in enhancing mood and energy levels.
Company review
BrainMD is a well-known brand founded by Dr. Daniel Amen, who is dedicated to developing science-backed supplements for brain health and overall wellness.
The company operates under strict quality controls. All products are manufactured in GMP-certified facilities and undergo third-party testing.
BrainMD’s product lines focus on mental clarity, mood, and cognitive support. The brand also has a strong reputation for delivering reliable, high-quality supplements.
Our verdict about the product
We find that BrainMD’s Betaine TMG could be a solid choice for supporting the body’s methylation process. This product may also benefit individuals with mood imbalances, low energy, or cardiovascular concerns.
Also, its potential ability to improve methylation makes it a valuable addition to any wellness routine.
Price
Betaine TMG is available at $15.50 and comes with free shipping on subscriptions and a 100% money-back guarantee.
5. BulkSupplements.com — best TMG powder supplement
Support your fitness journey with Betaine Anhydrous (TMG) by BulkSupplements.com — a natural compound suggested to be beneficial for muscle strength, endurance, liver, and heart health.
Available in various package sizes from 100 grams to 25 kilograms, this vegan, gluten-free, and additive-free supplement is designed to meet your specific needs and fitness goals.
A 100-gram package of Betaine Anhydrous (TMG) contains 67 servings with 1,500 mg of TMG powder per serving.
The product is produced in an NSF-certified and FDA-registered cGMP manufacturing facility. It is also third-party tested by US-based independent laboratories.
Who might benefit the most from this product?
Betaine Anhydrous (TMG) is designed for fitness enthusiasts, bodybuilders, and individuals seeking cardiovascular, liver, and heart health support.
This product may be especially great for those who want to enhance physical endurance and muscle strength.
Company review
BulkSupplements.com is a well-established company based in Henderson, Nevada, known for providing high-quality, pure supplements to consumers and manufacturers.
Staying committed to transparency and quality, BulkSupplements.com operates an NSF-certified and FDA-registered cGMP manufacturing facility. Each product undergoes third-party testing in U.S.-based labs, ensuring customers receive high-quality supplements.
Our verdict about the product
We believe BulkSupplements.com may offer decent value for those looking to boost their endurance, muscle strength, and overall cardiovascular health.
The affordable pricing and minimalistic composition make it an attractive option for athletes and fitness enthusiasts.
Although the taste and texture may be an issue for some, the product's potential to support energy and recovery may outweigh the minor inconveniences.
Price
Priced competitively at $9.96 for 100 grams, BulkSupplements.com offers an affordable way to incorporate a high-quality supplement into your routine.
Comparison of the best TMG supplement
| Brand | Price | Price per serving | TMG per serving | Servings per container |
| partiQlar | $13.99 | $0.23 | 500 mg | 60 |
| ProHealth Longevity | $16.57 | $0.14 | 1,000 mg | 120 |
| Vitality Pro | $22.00 | $0.18 | 500 mg | 120 |
| BrainMD | $15.50 | $0.52 | 1,000 mg | 30 |
| BulkSupplements.com | $9.96 | $0.15 | 1,500 mg | 67 |
How did we evaluate the best TMG supplements?
We reviewed the best trimethylglycine supplement products according to specific criteria, such as ingredient transparency, quality, and price.
| Ingredients | Quality | Price |
| No additional active ingredients | GMP-certified, third-party tested | Balance of quality and cost |
- Ingredients. We picked TMG supplements without any additional active ingredients.
- Quality. We chose products that adhere to good manufacturing practices (GMP) and conduct third-party testing by independent laboratories.
- Price. We looked for TMG supplements that offer a balance between quality and cost.
Expert opinion
Gabija Dimšaitė, BSc in Pharmacology and Innovative Therapeutics, shared her insights on betaine, known as trimethylglycine (TMG), and its uses in supplements and medicine. “Betaine is a naturally occurring compound found in foods like beets, spinach, quinoa, and shellfish, but it’s also produced in the human body from choline, an essential nutrient,” she explained. Betaine is becoming increasingly popular for both pharmaceutical and dietary supplement products.
Dimšaitė highlighted its established medical use. “In the pharmaceutical field, betaine is used to treat homocystinuria, a genetic condition linked to high homocysteine levels. Medications like Cystadane provide purified and standardized doses specifically for this purpose.” However, she pointed out that the benefits marketed for betaine supplements — such as improving liver function, heart health, and athletic performance — are less certain. “The research on these claims is still in its early stages and not yet conclusive,” she noted.
One key difference between betaine sources is their purity and concentration. The researcher explained:
Betaine in foods is naturally present in small, variable amounts along with other nutrients. Supplements, on the other hand, provide controlled doses that align with those used in clinical studies. Pharmaceutical-grade formulations, however, are quality-tested and proven safe and effective for specific medical conditions.
Dimšaitė emphasized the importance of choosing TMG sources carefully. She recommends consulting a healthcare provider to determine the right source and dosage for your needs. For general health, a doctor can assess whether your diet provides enough betaine or if supplementation is necessary. “For individuals with homocystinuria, doctors will prescribe betaine in precise doses tailored to their condition,” she added.
As a final note, Dimšaitė urged users to be mindful when considering TMG supplements.
While betaine has potential, it’s essential to approach supplementation cautiously and prioritize medical guidance to ensure safety and effectiveness.
Gabija Dimšaitė
Diving into TMG supplements: what are they?
TMG supplements contain trimethylglycine or betaine — a natural compound that can be derived from beets and other sources.
TMG may play an important role in methylation, a process essential for organ function, cell repair, and regulating homocysteine levels, which, when elevated, can directly impact cardiovascular health.
Here’s why methylation is important:
- Gene regulation. Methylation is a key epigenetic mechanism that affects gene expression without altering the DNA sequence itself. It can turn genes ‘on’ or ‘off’ as needed, influencing cell differentiation, development, and responses to environmental stimuli. Abnormal methylation can lead to inappropriate gene activation or silencing, which can lead to various health issues.
- Cellular function and repair. Methylation is critical for maintaining cellular homeostasis, regulating how cells respond to stress, communicate with each other, and facilitate repair mechanisms throughout the body. Disrupted methylation patterns can impair these essential functions, leading to errors in cell signaling, impaired DNA repair, or uncontrolled cell division, all of which can contribute to the development of diseases like cancer and premature aging.
- Epigenetic changes in disease progression. Since methylation influences gene expression in a dynamic and reversible way, it can play an important role in disease prevention or progression. Changes in methylation patterns can build up over time, leading to an increased risk of diseases like cardiovascular disease, metabolic disorders, and neurodegenerative conditions.
As a methyl group donor, TMG is proposed to help maintain normal physiological balance, contributing to overall well-being. It is also suggested to complement the effects of other nutrients and supplements when part of a balanced diet and lifestyle.
Is TMG worth taking? Potential health benefits
According to currently available research studies, TMG may provide various health benefits:
| Potential benefit | Description | Supporting research |
| Blood pressure regulation | While there is limited evidence on the effects of TMG supplementation on blood pressure, one prospective cohort study has reported that higher concentrations of TMG in serum were related to favorable blood pressure in middle-aged and older adults. | Research article from Food & Function, Huang et al. (2023) |
| Cardiovascular health support | TMG is reported to help reduce elevated homocysteine levels, potentially lowering the risk of cardiovascular issues. | Meta-analysis from Journal of Chiropractic Medicine, McRae M. P. (2013) |
| Enhanced athletic performance | TMG is reported to improve endurance, strength, and post-exercise recovery. | Studies published in Biology, Yang et al. (2022), Journal of the International Society of Sports Nutrition, Hoffman et al. (2009) |
| Liver function support | Currently, there is limited evidence on whether TMG supplementation can support liver health. While studies in animal models demonstrated positive results, results in humans are conflicting. | Review article published in World Journal of Gastroenterology, Mukherjee (2020) |
Blood pressure regulation
According to one cohort study, TMG may provide potential benefits for blood pressure regulation. It revealed that higher betaine serum levels were associated with more favorable blood pressure in middle-aged and older adults.
However, a meta-analysis evaluating the effects of betaine supplementation on various cardiovascular disease markers reported that TMG does not significantly affect blood pressure.
These varied results show that research on blood pressure regulating effects is still limited and inconclusive, and more human studies are needed.
Cardiovascular health support
TMG is recognized for helping maintain normal homocysteine levels, an amino acid that, when elevated, may increase the risk of heart disease.
By donating a methyl group, TMG may help convert homocysteine into a non-harmful substance, thus potentially reducing the risk of heart-related issues. This effect has been observed in multiple research studies.
However, maintaining cardiovascular health is multifactorial, and some researchers hypothesize that increased dietary intake of TMG may also have negative effects on cardiovascular health. Therefore, more large-scale clinical research is necessary to understand TMG’s full impact.
Enhanced athletic performance
Some preliminary research studies have shown that TMG supplementation may enhance athletic performance by improving endurance and strength, potentially making you feel less tired during prolonged exercise.
It is also believed to increase maximal oxygen uptake and power output, which are crucial for high-intensity exercises. Athletes and fitness enthusiasts might find TMG beneficial for improving their exercise performance and recovery. However, more research on TMG use for athletic performance is necessary.
Liver function support
Animal studies have reported that TMG supplementation may show some benefits in supporting liver health. The compound may help in the process called lipotropic effect, where it participates in the breakdown and distribution of fats, preventing their accumulation in the liver.
However, a limited number of studies on human liver health support have reported conflicting results. More research is needed on the potential benefits of TMG for liver health in humans.
Possible TMG supplement side effects
While TMG supplements are generally considered safe for most people, some individuals may experience mild side effects.
Commonly reported side effects may include gastrointestinal issues, such as:
- Diarrhea
- Stomach upset
- Nausea
In some cases, TMG has been observed to raise total cholesterol levels, which may be a concern for individuals with or at risk for cardiovascular disease.
Other less common side effects noted in research include:
- Agitation
- Irritability
- Sleep disturbances
- Vomiting
- Hair loss
How to minimize the risk of side effects from TMG supplements
- Start with a lower dose. You should begin with a lower dose of TMG and gradually increase it. This may allow your body to adjust and may help reduce gastrointestinal discomfort, such as nausea or diarrhea, which are common with higher doses.
- Take it with food. Consuming TMG supplements with a meal may help minimize stomach upset and other digestive side effects, as it eases the digestion of the supplement.
- Stay hydrated. Drinking plenty of water while taking TMG may help reduce gastrointestinal discomfort, such as stomach cramps.
- Monitor cholesterol levels. Since TMG has been reported to raise total cholesterol in some individuals, regular cholesterol monitoring is advised, especially if you have pre-existing cholesterol concerns.
As with any supplement, it's crucial to monitor your body's response and consult with a healthcare professional. This is particularly important if you have a medical condition or are taking medication.
When is the best time to take TMG supplements?
The best time to take TMG supplements largely depends on your individual health goals and daily routine. Generally, TMG can be taken with meals to support its absorption and minimize any potential gastrointestinal discomfort.
For those using it to enhance their physical performance, taking TMG before a workout may be a good way to extract more potential benefits. As for duration, manufacturers typically recommend taking the supplements on a long-term basis, claiming that consistency is key to experiencing their full benefits.
There are no defined dosage guidelines for betaine (TMG) in the U.S. While multiple research papers suggest that betaine is safe at a daily intake of 9–15 g, according to the safety evaluation of EFSA (2019), the maximum level of 400 mg/day (in addition to intake from diet) of betaine is deemed to be safe.
What are the best sources of TMG?
Aside from taking supplements, you can increase your TMG levels by consuming foods that contain this compound naturally. Such foods encompass grains, meats, fruits, and vegetables.
| Meats | Fruits and vegetables | Grains |
| Chicken | Beets | Pasta |
| Beef | Asparagus | Bread |
| Shrimp | Avocados | Cereal |
| Fish | Spinach | Quinoa |
Supplements tend to provide higher amounts of TMG compared to natural food sources. However, a higher intake of TMG supplements may cause gastrointestinal discomfort or cholesterol problems. If you’re looking for a safer alternative, consuming TMG-rich foods might be a better option.
Also, keep in mind that several elements can influence the TMG content of foods. Certain cooking techniques, particularly boiling vegetables, can significantly diminish the TMG levels. The best way to preserve TMG levels in your plant-based foods is to eat raw when possible and minimize the cooking time.
Best TMG supplement: conclusion
TMG supplements may offer promising health benefits, particularly for supporting methylation processes and supporting overall health.
While the early research is encouraging, it's important to remember that TMG is still a relatively new supplement, and more studies are needed to fully understand its long-term effects and overall effectiveness.
As with any supplement, it's best to consult a healthcare provider before you decide to include TMG in your wellness routine.
FAQ
Is TMG necessary with NMN?
No. At the moment, there is no research evidence supporting the need to combine TMG with NMN for better effectiveness.
How does TMG affect the liver?
Animal studies suggest that TMG may support liver health by reducing fatty deposits and oxidative stress, particularly in cases of alcohol-induced liver damage. However, there are limited studies on TMG supplementation for liver health in humans. While studies in animal models demonstrated positive results, results in humans are conflicting.
Is TMG the same as choline?
No. TMG and choline are related but not the same. Choline is a precursor to TMG, which means the body converts choline into TMG. Both compounds may support methylation and help lower homocysteine levels, but they perform distinct functions in the body.
8 resources
- PLOS Medicine. Effect of Homocysteine-Lowering Nutrients on Blood Lipids: Results from Four Randomised, Placebo-Controlled Studies in Healthy Humans.
- ARYA Atherosclerosis. Dietary Choline and Betaine Intakes and Risk of Cardiovascular Diseases: Review of Epidemiological Evidence.
- Journal of the International Society of Sports Nutrition. Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial.
- American Journal of Physiology-Gastrointestinal and Liver Physiology. Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine.
- Journal of Multidisciplinary Healthcare. Role of betaine in improving the antidepressant effect of S-adenosyl-methionine in patients with mild-to-moderate depression.
- Journal of Chiropractic Medicine. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis.
- Food & Function. Associations of serum betaine with blood pressure and hypertension incidence in middle-aged and older adults: a prospective cohort study.
- Critical Reviews in Food Science and Nutrition. Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis.
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