Driven by the pursuit of a longer life, many are uncovering the benefits of trimethylglycine (TMG) — a form of the amino acid known to potentially maintain sufficient energy levels and enhance athletic performance.
TMG supplements, becoming increasingly recognized for their general health support, may bolster cardiovascular health by reducing homocysteine levels, which have been linked to an increased risk of heart disease and stroke. However, with many options available, choosing the best TMG supplement can be daunting.
This article will guide you through our top selection of TMG supplements, reviewing their features and benefits to help you make an informed decision.
Best TMG supplement: shortlist
- partiQlar — best overall TMG supplement
- ProHealth Longevity — best supplement in tablet form
- Vitality Pro — best TMG supplement with many servings
- BrainMD — best TMG supplement in capsule form
- BulkSupplements.com — best TMG powder supplement
How did we rank the best TMG supplement?
We reviewed the best TMG supplement products according to specific criteria, such as customer feedback, ingredient transparency, quality, and price.
|No additional active ingredients
|GMP-certified, third-party tested
|Balance of quality and cost
- Customer feedback. We selected products with positive customer feedback and ratings, offering good experience and satisfaction.
- Ingredients. We chose TMG supplements that contain no additional active ingredients for a valid comparison.
- Quality. Choosing high-quality supplements is a crucial factor. We made sure to pick products produced by brands adhering to good manufacturing practices (GMP) and conducting third-party testing by independent laboratories.
- Price. With a large variety of TMG supplements available, we selected the ones with a good balance between quality and cost.
Best TMG supplements: an overview
Those who are looking for extensive TMG supplement reviews to enhance their health may benefit from our thoroughly selected list of products.
The supplements are classified according to specific nominations and criteria, highlighting their features, benefits, certifications, and serving size. Additionally, the overview also dives into dissecting the pros and cons of each product.
1. partiQlar — best overall TMG supplement
Designed to enhance your body's methylation processes and general health, partiQlar Pure TMG enters our list as the best overall TMG supplement.
One of the key potential benefits of the supplement is lowering homocysteine levels to support cardiovascular health. It may also be particularly beneficial for users who take NMN, which may play an important role in healthy aging.
Each capsule of the product contains 500 mg of TMG, offering a range of potential benefits without any additives.
partiQlar Pure TMG is manufactured in GMP-certified and FDA-registered facilities. Each batch undergoes third-party testing for quality assurance. The product is free from unnecessary binders, fillers, and preservatives.
A single container of the product includes 60 capsules with a serving size of 1 capsule.
The pricing starts at $13.99 for a 2-month supply. The brand also offers a 60-day money-back guarantee, ensuring customer satisfaction, all at a competitive price point.
2. ProHealth Longevity — best TMG supplement in tablet form
If you're looking for enhanced cellular health and cardiovascular support, TMG Pro Tablets by ProHealth Longevity may be your key to unlocking these benefits.
Each tablet is packed with 1000 mg of TMG — an amino acid derivative vital for the body's methylation processes, potentially contributing to anti-aging, energy production, and combating oxidative stress.
The supplement may also reduce harmful homocysteine levels, promoting support for cardiovascular health.
TMG Pro Tablets comes with 120 tablets in a container and a serving size of 1 tablet.
The product undergoes rigorous third-party lab testing and is produced in a GMP-certified, FDA-registered facility, reflecting a commitment to quality and safety.
TMG Pro Tablets by ProHealth Longevity is priced at $16.57, offering great value for maintaining your overall health.
3. Vitality Pro — best TMG supplement with many servings
Elevate your health with Vitality Pro TMG supplement designed for your cellular health and general well-being.
Each bottle contains 120 capsules, with 500 mg of TMG per capsule — a serving size amount.
The supplement is GMP-certified and third-party tested by independent laboratories, boasting high levels of purity.
It is also free from GMOs, artificial colors, preservatives, flavors, or major allergens and is suitable for vegans, ensuring it meets a wide range of dietary needs.
Additionally, the packaging is 100% biodegradable, reflecting a commitment to environmental sustainability.
Vitality Pro TMG is available for $22.00, offering a cost-effective way to enhance your health regimen with a high-quality product.
4. BrainMD — best TMG supplement in capsule form
Seeking to boost your mood and optimize your body's methylation? Look no further than Betaine TMG by BrainMD.
This unique supplement may support energy production while also enhancing the functioning of your cardiovascular, nervous, and endocrine systems.
According to the brand, Betaine TMG may be helpful for individuals with folate or vitamin B12 deficiencies, indicating poor methylation.
Each serving contains 1000 mg of betaine (TMG). A single bottle of Betaine TMG includes 60 capsules with a serving size of 2 capsules.
BrainMD ensures the highest quality by conducting third-party testing and manufacturing its products in GMP-certified facilities.
Betaine TMG is available at $15.50 and comes with free shipping on subscriptions and a 100% money-back guarantee.
5. BulkSupplements.com — best TMG powder supplement
Support your fitness journey with Betaine Anhydrous (TMG) by Bulk Supplements — a natural compound beneficial for muscle strength, endurance, liver, and heart health.
Available in various package sizes from 100 grams to 25 kilograms, this vegan, gluten-free, and additive-free supplement is designed to meet your specific needs and fitness goals.
A 100-gram package of Betaine Anhydrous (TMG) contains 67 servings with 1500 mg of TMG powder per serving.
The product is produced in an NSF-certified and FDA-registered cGMP manufacturing facility. It is also third-party tested by US-based independent laboratories.
Priced competitively at $9.96 for 100 grams, Bulk Supplements offers an affordable way to incorporate a high-quality supplement into your routine.
Comparison of the best TMG supplement
|Price per serving
|Servings per container
What exactly are TMG supplements?
TMG supplements, known as trimethylglycine — consist of natural compounds derived from beets and other sources. They may play an important role in methylation, a process in the body that's essential for organ function, cell repair, and controlling homocysteine levels, which can directly impact cardiovascular health.
TMG is able to donate methyl groups, which help create vital body substances such as neurotransmitters, DNA, and other critical molecules. This donation may support bodily functions, enhance cellular health, and increase energy.
By improving methylation, TMG may help maintain a healthy balance within the body, contributing to overall well-being and potentially enhancing the effects of other nutrients and supplements.
TMG proposed benefits
Trimethylglycine (TMG), also known as betaine, is a compound naturally found in the body and certain foods. It's recognized for its potential health benefits, particularly in supporting methylation processes. Here are some of the key proposed benefits of TMG based on research studies.
TMG is recognized for its role in reducing homocysteine levels, an amino acid associated with an increased risk of heart disease. By donating a methyl group, TMG may help convert homocysteine into a non-harmful substance, thus potentially reducing the risk of heart-related issues. This effect has been observed in research studies, indicating its position in supporting cardiovascular health.
Enhanced athletic performance
Research has shown that TMG supplementation may enhance athletic performance by improving endurance and strength, making you feel less tired. It's believed to increase maximal oxygen uptake and power output, which are crucial for high-intensity exercises. Athletes and fitness enthusiasts might find TMG beneficial for improving their physical performance and recovery.
Liver function support
TMG has been found to show some benefits in supporting liver health. The compound may help in the process called lipotropic effect, where it participates in the breakdown and distribution of fats, preventing their accumulation in the liver. This could make TMG a potential option for individuals with liver-related issues.
The role of TMG in the methylation process is essential for the production and regulation of neurotransmitters, which serve as chemical messengers in the brain responsible for influencing mood and behavior.
Some studies suggest that TMG supplementation might help reduce the issues associated with depression and improve mental well-being. This is likely due to its impact on neurotransmitter pathways.
When is the best time to take TMG supplements?
The best time to take TMG supplements largely depends on your individual health goals and daily routine. Generally, TMG can be taken with meals to support its absorption and minimize any potential gastrointestinal discomfort.
For those using it to enhance their physical performance, taking TMG before a workout may be a good way to extract more potential benefits. As for duration, the supplements should typically be taken on a long-term basis because consistency is key to experiencing their full benefits.
However, it's highly advised to follow the specific dosage and timing recommendations provided by your healthcare provider or the supplement manufacturer’s instructions, as individual needs can vary.
Optimal TMG dosage
The optimal dosage of TMG varies based on individual needs and health goals. According to research studies, the impact of reducing homocysteine levels is typically assessed using a daily dosage of 0.5–6 grams. However, a lower daily intake might be just as beneficial for healthy individuals as higher quantities.
Always consult a healthcare specialist to determine the best dosage for your specific circumstances.
Possible TMG supplement side effects
While TMG supplements are generally considered safe for most people, some individuals may experience mild side effects.
Commonly reported side effects may include gastrointestinal issues, such as:
- Stomach upset
In some cases, TMG can raise total cholesterol levels, which may be a concern for individuals with or at risk for cardiovascular disease.
Other less common side effects noted in research include agitation, irritability, sleep disturbances, vomiting, and hair loss.
As with any supplement, it's crucial to monitor your body's response and consult with a healthcare professional, especially if you have pre-existing health conditions or are taking medication.
Sources of TMG
TMG is a natural compound produced in the body and found in various foods. It's a valuable provider of methyl groups, essential for numerous metabolic processes in the body that maintain good health.
Aside from taking supplements, you can increase your TMG levels by consuming foods that contain this compound naturally. Such foods encompass grains, meats, fruits, and vegetables.
|Fruits and vegetables
Keep in mind that several elements can influence the TMG content in foods. Certain cooking techniques, particularly boiling, can significantly diminish the TMG levels.
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Can you take TMG with other supplements?
It depends. TMG may interact with certain enzymes and cellular transporters, which may affect the metabolism and absorption of other supplements and drugs, thus increasing or decreasing their bioavailability. Therefore, it is important to consult with a healthcare professional to ensure compatibility and optimal dosing.
Are TMG supplements worth taking?
Yes. TMG supplements may be worth considering for their potential benefits, including heart health support, athletic performance enhancement, and homocysteine regulation. However, it's recommended to consult a healthcare specialist before starting any new supplement to ensure it matches your individual needs.
Can TMG lower cortisol?
It depends. TMG may play a role in lowering cortisol levels. Studies suggest that it can enhance the testosterone-to-cortisol ratio, reduce systemic inflammation, and potentially maintain lower resting cortisol concentrations. However, more research is needed to determine its full effects.
- PLOS Medicine. Effect of Homocysteine-Lowering Nutrients on Blood Lipids: Results from Four Randomised, Placebo-Controlled Studies in Healthy Humans.
- ARYA Atherosclerosis. Dietary Choline and Betaine Intakes and Risk of Cardiovascular Diseases: Review of Epidemiological Evidence.
- Journal of the International Society of Sports Nutrition. Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season: a double blind, randomized, placebo-controlled trial.
- American Journal of Physiology-Gastrointestinal and Liver Physiology. Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine.
- Journal of Multidisciplinary Healthcare. Role of betaine in improving the antidepressant effect of S-adenosyl-methionine in patients with mild-to-moderate depression.
- Journal of Chiropractic Medicine. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis.