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Best Urolithin A Supplement for Optimal Health in 2024

When searching for supplements that may aid in muscle function, Urolithin A will often be identified. But, many wonder what the Urolithin A compound is. Urolithin A is a metabolic product of bacteria present in the human gut. It is produced as the bacteria break down ellagitannins, which are polyphenolic compounds seen in foods such as pomegranates, berries, and walnuts.

However, the supply of Urolithin A can vary significantly. Thus, many products have been introduced to the market to help provide a consistent amount of this compound. With the multitude of choices, it can be difficult to select the best Urothilin A supplement for you. Therefore, we developed a list to aid in the decision process.

Best Urolithin A supplement: shortlist

  1. Aeternum — best overall Urolithin A supplement powder option
  2. Aeternum — best overall Urolithin A supplement capsule option
  3. Timeline — best specialized Urolithin A supplement
  4. The Supermom Company — best vegan Urolithin A supplement
  5. Pepeior — best precursor-containing Urolithin A supplement
  6. Codeage — best multi-ingredient Urolithin A supplement

How did we compile the list of the best urolithin A supplements?

Evaluating individual supplements can be difficult as the FDA doesn't regulate them. That is why we are transparent with the reasons for our recommendations. We aim to select high-quality products based on the below criteria.

Price-to-Value RatioThird-party testingEvidence-based ingredientsReputable manufacturer
$34.95–185Ensures products are free of contaminants and contain listed dosesUses ingredients that have scientific evidence supportManufactured in facilities compliant with good manufacturing practices
  • Value-to-price ratio. Products with varying price points that offer significant value per serving size.
  • Third-party testing. We prioritize supplements subjected to independent lab testing to ensure the product is free of harmful substances and contains the correct doses of its components.
  • Evidence-based ingredients. Selecting products with ingredients backed by scientific evidence is important to potentially provide health benefits to users.
  • Reputable manufacturer. Items manufactured at facilities compliant with current good manufacturing practices (cGMP) and with certifications such as NSP and USP ensure they have been formulated to the highest quality.

Best Urolithin A supplements 2024: overview

Urolithin A is a by-product of ellagitannin metabolism that has been increasingly used for potential health benefits. Given the inconsistent production by the bacteria and absorption within the intestines, many health and wellness companies offer Urolithin A supplements.

These products are available in a variety of different forms, and using the above criteria, we were able to identify the top 6 supplements on the market. However, it is advised that you talk to your doctor before starting any new supplement to ensure it is appropriate, given your medical history and current medications.

1. Aeternum — best overall Urolithin A supplement powder option

Aeternum Pure Urolithin A Powder

Aeternum manufactures its Urolithin A supplement in powder form, providing additional ease of use for those who have difficulty swallowing pills. This powder offers a product free from fillers, preservatives, trans-fats, and hydrogenated oils. This Urolithin A supplement is GMO- and gluten-free.

To ensure the highest quality of ingredients, Aeternum utilizes a third-party laboratory to evaluate its product and provides a certificate of analysis on its website. The manufacturer's recommended dosage is one to two scoops (500 to 1,000 mg) per day, taken sublingually with or without food.

The company offers its Urolithin A powder in a variety of different sizes, including 15, 30, and 100-gram bags, each containing 500 mg of Urolithin A per scoop and costing $39, $69, and $185, respectively.

2. Aeternum — best overall Urolithin A supplement capsule option

Urolithin A – UA – Capsules

If you have no trouble swallowing capsules and find them more convenient but still prefer Aeternum as your choice for Urolithin A supplementation, the company offers just that — an alternative to its powder option.

Like its powdered version, this product contains no fillers, preservatives, trans fats, or hydrogenated oils and is non-GMO and gluten-free.

Aeternum sends its Urolithin A capsules to a third-party laboratory for testing. They openly share the results on their website in a form of a certificate of analysis.

As per the makers, the recommended intake is one to two capsules daily. Each capsule contains 500 mg of Urolithin A.

The Urolithin A capsules are available in a 60-count bottle priced at $99. Depending on which route you choose to take when it comes to dosage, it can last you either a month or two.

3. Timeline — best specialized Urolithin A supplement

Mitopure Urolithin A Supplement

Timeline has developed a propriety product, Mitopure®, that delivers a higher dose of Urolithin A than obtained from a typical diet. A single capsule has been shown to provide 6x the amount of Urolithin A compared to a glass of pomegranate juice and is a sugar-free alternative to juice.

This product has been clinically tested and is gluten and GMO-free. Mitopure® softgels are free from the big eight food allergens and may be suitable for a wide range of diets.

Timeline offers its product through Amazon to provide fast, free two-day shipping for Prime membership consumers. Mitopure® softgels are available in 28 and 60-count bottles that can be purchased for $62.50 and $125, respectively. Given the recommended dosage of two softgel capsules per day, these products can last 14 to 30 days, based on the bottle size.

4. The Supermom Company — best vegan-friendly Urolithin A supplement

The Supermom Company Urolithin A Plus

The Supermom Company manufactures Urolithin A Plus with Bioperine to provide a vegan-friendly option for those adhering to vegan and vegetarian diets. This product is formulated with 5 mg of Bioperine, derived from black pepper, to aid in the absorption of Urolithin A.

The brand ensures the product is free of major allergens like soy and gluten to further accommodate those with dietary restrictions.

This product is manufactured in a facility certified to be in accordance with current cGMP.

The recommended dosage of Urolithin A Plus with Bioperine is two capsules daily, which supplies 1000 mg of Urolithin A. This product is available on Amazon in 60-count bottles for a 30-day supply for $34.95, which includes free, 2-day shipping for Prime members.

5. Pepeior — best precursor-containing Urolithin A supplement

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Pepeior manufactures its Urolithin A product to contain a proprietary blend of pomegranate, strawberry, and walnut shell extract to provide 1,000 mg of ellagitannin-rich compounds to enhance the natural intestinal production of Urolithin A. While this product is manufactured using non-GMO and gluten-free ingredients, it does contain a warning for those allergic to walnuts.

Despite the risk of nut allergies, this product is free of soy and dairy to cater to consumers with those dietary restrictions.

This product is available on Amazon and does qualify for free shipping for those members with a Prime membership. The recommended daily dosage is two easy-to-swallow capsules providing 1,000 mg of Urolithin A and 1,000 mg of its 3-in-1 proprietary blend. Following this dosage schedule, each bottle provides a 60-day supply.

With two options available, consumers can purchase a 120-count bottle for $40.49 or a two-pack of 120-count bottles for $71.99.

6. Codeage — best multi-ingredient Urolithin A supplement

Liposomal Urolithin A Eternal features a liposomal delivery system using non-GMO sunflower oil to help enhance the absorption of the ingredients. In addition to Urolithin A, this product contains resveratrol, betaine anhydrous, and CoQ10 to help support healthy aging.

This vegan-friendly product is manufactured using non-GMO ingredients and is gluten-, soy-, and dairy-free to provide a convenient supplement for those with dietary restrictions. Codeage uses cGMP-certified facilities located in the U.S. to manufacture high-quality products.

The recommended dosage for Liposomal Urolithin A is two capsules daily, taken with 8 ounces of water. This supplement can be taken with or without food and is provided in bottles containing 60 capsules. Therefore, each bottle provides a 30-day supply for $99, which includes free shipping within the continental United States.

Best Urolithin A supplements 2024: comparison

BrandPricePrice per servingServing sizeUrolithin A per serving
Aeternum Powder$39-$185 (depending on packet size)$0.93–$2.60 (based on package size)1-2 scoops500 mg–1000mg
Aeternum Capsules$99.00$1.651-2 capsules500 mg–1000mg
Timeline$62.50 (28-count) to $125 (60-count)$4.17–$4.462 capsules500 mg
The Supermom Company$34.95$1.172 capsules1000 mg
Pepeior$40.49$0.672 capsules1000 mg
Codeage$99.00$3.302 capsules500 mg

What are the benefits of Urolithin A supplement?

Mitochondrial aging has been linked to the aging process and age-related deterioration of skeletal muscle. Studies demonstrated that Urolithin A may enhance the removal of damaged mitochondria and support mitochondrial function. Urolithin A was shown to induce mitochondrial gene expression in skeletal muscle, resulting in molecular patterns associated with cellular health, and it also has a positive impact on muscle endurance.

While the results on muscle endurance and improved strength have been observed in human clinical trials, long-term and more extensive studies still need to be conducted to validate these observed results. Overall Urolithin A supplement benefits include:

  • Support of mitochondrial function and removal of damaged mitochondria.
  • Improved muscle endurance.
  • Improved walking distance and gait speed.
  • Improvements in the 6-minute walk test.

In addition, Urolithin A indicates to have many additional properties that contribute to enhancing longevity, reducing inflammation, providing neuroprotection, and reducing cartilage destruction. However, these findings have only been observed in animal studies and cell culture experiments. Human studies are needed to confirm these effects on the body.

How to choose the best Urolithin A supplement?

The FDA does not regulate supplements, resulting in some products not meeting the purity standards seen with prescription drugs. However, selecting products that have undergone third-party testing and are either USP or NSF-certified can help identify high-quality products. Independent laboratory evaluation is essential to test the contents of the supplement. This helps to reduce the risks associated with contaminants and provides an added assurance customers are getting what they paid for. In addition, USP- or NSF-certified products undergo strict testing and evaluation before reaching the shelves.

Carefully reading the labeling to identify additional ingredients is important to determine exactly what you put into your body. Finally, the price point is also an important determinant in picking a supplement. Finding a good value for the price makes it easier to afford prolonged usage while achieving expected results.

Tips for choosing a Urolithin A supplement:

  • Look for third-party testing certifications.
  • Choose a product with USP or NSF-certifications.
  • Read the label to identify any added ingredients.
  • Identify products with a good price-to-value ratio.

Safety considerations and precautions for using Urolithin A supplements

While long-term studies evaluating Urolithin A's effects on the body still need to be conducted, Urolithin A has been shown to be well-tolerated when used at a dose of 500–1000 mg daily.

In a study conducted on middle-aged adults taking a Urolithin A supplement for 4 months, the main side effects included headache, bloating, nausea, and diarrhea. A slightly higher occurrence of side effects was noted in participants using a Urolithin A dosage of 1000 mg compared to 500 mg.

Before considering a Urolithin A supplement, it is important to discuss with your doctor to determine if it is safe to do so, given your current medications and health conditions. Additionally, it is important to follow the manufacturer's recommended dosages as indicated on the product label.

Best Urolithin A supplement 2024: conclusion

Urolithin A supplements have increased in popularity, with numerous products available on the market. However, many still wonder, "What is Urolithin A good for"? While more comprehensive research is needed, supplementation with Urolithin A has been shown to support mitochondrial function and improve muscle endurance.

Furthermore, ongoing research aims to reveal additional potential applications for Urolithin A and its utility in various health contexts, including aging and disease prevention. As the interest in the supplement grows, consider products available in optimal dosages and convenient forms backed by a reputable brand known for quality and reliability.


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