You might not have heard of urolithin A, but it’s a compound worth knowing about. This substance may support your health in several ways, including promoting longevity and supporting muscle as well as cellular function.
So, how do we get urolithin A? It’s produced in our guts when various bacteria break down polyphenols called ellagitannins, compounds found in foods like pomegranates, berries, and walnuts. As these foods are digested, our gut bacteria turn ellagitannins into urolithin A.
Although you can obtain urolithin A from certain foods, research indicates that not everyone has the gut bacteria to produce it. In fact, some people have gut microbiomes that are simply more efficient at converting polyphenols into urolithin A than others.
This is where supplementation might come into play, providing a means to ensure more precise delivery of urolithin A than dietary sources alone.
With the help of our Healthnews Research team, we have done the legwork to find the best urolithin A supplements available. We’ve narrowed it down to the top five brands you should consider. Keep reading to discover which option might be the right fit for you.
Best urolithin A supplement: shortlist
- Best overall urolithin A powder: Aeternum
- Best pure urolithin A capsules: Aeternum
- Best vegan-friendly urolithin A softgels: Timeline
- Best urolithin A supplement with enhanced absorption: Codeage
- Best urolithin A supplement with bioperine: The Supermom Company
Why do we think the Aeternum urolithin A supplement is the best?
After careful assessment, we consider the Aeternum urolithin A supplement as the best overall option on this list. This supplement comes in a user-friendly powder form, making it an excellent choice for those with difficulty swallowing pills.
Crafted without fillers, preservatives, trans fats, or hydrogenated oils, Aeternum’s formula is both GMO- and gluten-free, ensuring an additive-free product.
To guarantee the highest quality, Aeternum utilizes third-party testing and provides a certificate of analysis on its website, giving customers confidence in their purchase.
The brand-recommended dose is easy to follow: 1–2 scoops per day can be taken sublingually with or without food. Aeternum offers flexible packaging options to cater to different needs and budgets.
With a subscription option that saves you on your order, Aeternum offers excellent value.
Best urolithin A supplements: overview
Explore our list of the top five Urolithin A supplements, each potentially supporting cellular health and energy levels with unique blends and quality ingredients.
Urolithin A may assist mitochondrial function and encourage cellular renewal, possibly enhancing energy and vitality. Our selection considers ingredient transparency, pricing, and manufacturing quality, helping you choose a product that might align with your wellness goals.
1. Aeternum — best overall urolithin A powder
Amazon rating — 5.0 ⭐⭐⭐⭐⭐
Our top choice is Pure Urolithin A Powder by Aeternum. This supplement stands out because it's in powder form, making it a versatile option for anyone, especially those who have trouble swallowing capsules or pills.
The manufacturer suggests using the included 500 mg scoop to take approximately 0.5–1 g of urolithin A each day. This supplement can be taken by placing it under the tongue and can be consumed with or without food, depending on your preference.
Why we recommend this brand
We recommend Aeternum for its commitment to high-quality standards and transparency. The brand uses third-party lab testing to verify product quality and label accuracy, with certificates of analysis available on its website.
Additionally, the product is free from fillers, preservatives, flavorings, colorings, trans fats, hydrogenated oils, GMOs, and gluten.
Customer feedback
- Many customers have mentioned that the product is easy to measure and take.
- Some users reported experiencing noticeable results shortly after they began using it.
- Only a few customers have expressed that they did not enjoy the taste of the product.
The price of Pure Urolithin A Powder by Aeternum varies based on the size you choose. The options are priced at $35 for a 15-gram bag, $59 for a 30-gram bag, and $165 for a 100-gram bag.
2. Aeternum — best overall urolithin A capsules
Next up on our list is Aeternum’s urolithin A capsules — perfect if you find capsules more convenient or if swallowing them is easier than taking powder. This option provides the same quality urolithin A as Aeternum’s powder form but in a simple-to-use capsule format.
The manufacturer recommends taking one to two capsules daily, with each capsule providing 500 mg of urolithin A. It’s advised to take these capsules at your convenience, whether with or without food.
Why we recommend this brand
Aeternum is committed to quality, ensuring that its products undergo rigorous third-party lab testing for label adherence. Additionally, the brand provides transparency by offering certificates of analysis on its website so consumers can verify the composition of what they're taking.
With its focus on natural ingredients, Aeternum capsules are free from fillers, preservatives, and GMOs, making it a trustworthy company for those seeking to support their health and wellness.
Customer feedback
I checked several popular review platforms for customer feedback on this product but found no reviews specifically for the capsule form of Aeternum’s urolithin A. Currently, only feedback for the powdered version is available.
The urolithin A capsules come in a 60-count bottle for $99. Depending on dose, this supply could last either one or two months.
3. Timeline — best vegan-friendly urolithin A softgels
Trustpilot rating — 3.2 ⭐⭐⭐
Amazon rating — 4.0 ⭐⭐⭐⭐
Another one of our top picks is the vegan Mitopure Softgels by Timeline. These easy-to-take vegan softgels may be ideal for those with dietary restrictions. Notably, according to the brand, Mitopure Softgels may offer six times more urolithin A than dietary sources like a glass of pomegranate juice.
To get the most out of Mitopure, the brand suggests taking two softgels each day for a total of 500 mg of urolithin A. Each pack contains 60 softgels, giving you a one-month supply.
Why we recommend this brand
We recommend Timeline because they are a science-backed company that participates in randomized, double-blind, placebo-controlled studies to evaluate its Mitopure urolithin A formula. The brand prioritizes safety and suitability for people from various walks of life, holding Clean Label certification and being NSF Certified for Sport®.
Customer feedback
- Some users reported noticeable increases in energy and vitality.
- Many customers mentioned improvements in workout endurance and faster muscle recovery.
- A few individuals mentioned that the price is on the higher side.
The price for Mitopure Softgels by Timeline is $112.50 for a one-month supply, and there are subscription options if you want to save a little over time.
4. Codeage — best urolithin A supplement with enhanced absorption
Trustpilot rating — 4.5 ⭐⭐⭐⭐⭐
iHerb — 4.6 ⭐⭐⭐⭐⭐
Amazon rating — 4.1 ⭐⭐⭐⭐
Liposomal Urolithin A Eternal by Codeage is another option that is worth your consideration. This product features a liposomal delivery system derived from non-GMO sunflower oil to potentially help enhance the absorption of the ingredients. In addition to 500 mg of urolithin A, this product also contains resveratrol, betaine anhydrous, and CoQ10 to help support healthy aging.
The brand recommends taking two capsules daily with 8 ounces of water. This supplement can be consumed with or without food and is available in bottles containing 60 capsules.
Why we recommend this brand
We recommend considering Codeage because the brand uses non-GMO ingredients and ensures that its products are gluten-free, soy-free, and dairy-free, making them suitable for individuals with dietary restrictions. Additionally, Codeage operates in cGMP-certified facilities in the U.S., which ensures that its products are manufactured following current Good Manufacturing Practices for quality.
Customer feedback
- The capsules were also described as easy to swallow, making the supplement convenient to incorporate into daily routines.
- Several reviews indicated that the supplement helped with focus and energy levels, contributing to an overall sense of well-being.
- A few customers mentioned that the capsules were sticky, making them difficult to handle or swallow.
Cordeage Liposomal Urolithin A Eternal is priced at $99.99 and includes free shipping within the continental United States.
5. The Supermom Company — best urolithin A supplement with Bioperine
Amazon rating — 4.6 ⭐⭐⭐⭐⭐
Lastly, we have Urolithin A Plus with Bioperine from the Supermom Company, a vegan-friendly choice for those following vegetarian and vegan diets. This product features 1,000 mg of urolithin A and 5 mg of black pepper extract Bioperine that may enhance the absorption of urolithin A.
The brand claims the product is free of major allergens like soy and gluten to further accommodate those with dietary restrictions.
The recommended dosage of Urolithin A Plus with Bioperine is two capsules daily, which supplies 1,000 mg of urolithin A.
Why we recommend this brand
We believe this brand is worth considering because the products are made free of major allergens like soy and gluten. Additionally, this product contains urolithin A and black pepper extract for potentially enhanced absorption.
Customer feedback
- Many customers reported a noticeable boost in their energy levels and overall vitality after taking the supplement.
- Several users praised the antioxidant effects of urolithin A, noting improvements in skin texture and a natural glow.
- One customer expressed skepticism regarding the company's marketing.
Urolithin A Plus with black pepper extract from the Supermom Company is available on Amazon in 60-count bottles for a 30-day supply for $34.95, which includes free 2-day shipping for Prime members.
Best Urolithin A supplements 2024: Comparison
Brand | Price* | Serving size | Urolithin A per serving | Third-party tested | Additional certifications | Made in cGMP-certified facilities |
Aeternum Powder | $35, $59, or $165 | 1–2 scoops | 500–1,000mg | Yes | N/A | N/A |
Aeternum Capsules | $99.00 | 1–2 capsules | 500–1,000mg | Yes | N/A | N/A |
Timeline | $112.50 | 2 softgels | 500 mg | No | Clean Label certified and NSF Certified for Sport® | Yes |
Codeage | $99.99 | 2 capsules | 500 mg | No | N/A | Yes |
The Supermom Company | $34.95 | 2 capsules | 1,000 mg | No | N/A | N/A |
*Price may vary depending on the size you select
How we evaluated the best urolithin A supplement
With the help of the Healthnews Research team, we reviewed multiple urolithin A supplements to compile this list. Our team dedicated over 100 hours to reviewing currently available scientific studies on urolithin A and its relation to human health.
I also spent approximately 20 hours not only researching customer feedback but also analyzing brand transparency and examining each product’s manufacturing processes.
Our evaluation was based on evaluating product formulation, as well as the scientific backing behind them. Additionally, we compared each product's ingredients, features, pricing, and brand transparency to ensure all options on this list meet high standards of quality.
What is urolithin A?
Urolithin A is a compound produced in the gut when specific bacteria break down polyphenols found in foods like pomegranates, berries, and nuts. Its formation depends on an individual’s unique gut microbiome, as not everyone has the bacteria required to produce urolithin A naturally.
This compound has drawn attention for its role in cellular health, particularly for its effects on mitochondria — the energy-producing components of cells — by promoting a process called mitophagy, where old or damaged mitochondria are cleared out, potentially supporting overall cell vitality.
What are the benefits of urolithin A supplements?
Urolithin A (UA) supplements may provide a multifaceted approach to health, particularly for those concerned about the effects of aging and seeking to support their well-being.
A recent 2024 systematic review published in Ageing Research Reviews screened 2,700 articles on urolithin A, narrowing them down to four studies in humans that met the inclusion criteria. Here are some key benefits of urolithin A (UA) according to the review:
Anti-inflammatory effects
Some studies suggest that UA might have anti-inflammatory effects, which is currently being explored as a potential beneficial compound in inflammation-related chronic diseases.
The review concluded that UA may help reduce inflammation in the body by lowering certain inflammatory marker levels associated with systemic inflammation. These findings suggest that urolithin A may be a promising compound for addressing inflammation and inflammatory conditions.
Longevity and overall vitality
Urolithin A has gained attention for its potential to support healthy aging and improve mitochondrial function.
Research indicates that UA may enhance the cell’s ability to clear damaged mitochondria through a process called mitophagy, which is crucial for maintaining cellular function.
The accumulation of damaged mitochondria is believed to be linked to the development of age-related diseases. Because of this, researchers are now exploring how urolithin A’s effects on mitophagy may impact human health and aging.
Improved muscle strength and endurance
Urolithin A has been explored in boosting muscle strength and endurance. The review suggested that UA supplementation may lead to improvements in muscle performance during physical activities. For example, urolithin A supplementation was associated with increased grip strength in animal studies and showed positive effects on muscle strength tests in humans.
Additionally, another 2020 double-blind, placebo-controlled randomized clinical trial demonstrated that elderly participants who received supplementation with 1,000 mg of urolithin A daily for four months had a significant improvement in muscle endurance compared to the placebo group.
The observations from initial urolithin A research suggest that urolithin A may be a promising supplement for promoting muscle health, reducing inflammation, and supporting energy production, although more research is needed to fully understand its effects in humans.
How to choose the best urolithin A supplement
- Select a supplement with a generally safe urolithin A dose. GRAS approval for urolithin A use in food includes common doses ranging from 250 to 500 mg per serving, with a likely safe intake of up to 1,000 mg daily in various products like protein shakes and nutrition bars. The GRAS approval information may help you consider which supplement doses are revered as generally safe, but you should always consult with your healthcare provider about the safety in your particular case.
- Choose a product that is properly manufactured and tested. Certification such as USP or NSF verifies that the supplement meets strict standards for quality. Additionally, third-party testing confirms that the ingredients listed on the label are accurate, providing further assurance of what you're actually consuming.
- Consider brand reputation. Go with brands that are transparent about their sourcing and manufacturing process, ideally, companies that specialize in supplements and have a good track record for quality and customer satisfaction.
Safety considerations and precautions for using urolithin A supplements
Although long-term studies on urolithin A’s effects are still needed, it has been reported to be well-tolerated at doses of 500–1,000 mg per day. In a study involving middle-aged adults who took a urolithin A supplement over a 4-month period, side effects included headache, bloating, nausea, and diarrhea. Those taking the higher 1,000 mg dose experienced slightly more side effects than those taking 500 mg.
It’s essential to consult your doctor before starting a urolithin A supplement to ensure it is safe based on your current medication and health status. Be sure to follow the dose instructions provided by your healthcare professional or the manufacturer.
Last words
In conclusion, urolithin A is a promising compound with potential benefits on mitochondrial function and healthy aging support, and urolithin A supplements may be a considerable option for those interested in supplements for longevity.
However, while urolithin A shows potential in the field of healthy aging, it is not a guaranteed solution for all your problems and should be carefully considered prior to adding it to your regimen. In addition, it is important to avoid relying solely on supplements and practice a comprehensive approach to health, which includes a balanced diet and physical exercise, as well as stress management techniques. The effects of urolithin A may vary based on individual health, dose, and product quality, so consulting a healthcare provider is recommended for safe use.
Discover additional health and wellness supplements
Read more about the best NMN supplements for healthy aging.
Find out more about the best quercetin supplement to boost your overall health.
Consider the best lion's mane supplements for potential cognitive support.
Check out the best NR (nicotinamide riboside) supplement that can help you boost NAD+ levels in the body.
FAQ
What is the best urolithin A supplement?
The best urolithin A supplements are third-party tested for quality and produced according to best manufacturing practices. Look for supplements with transparent ingredient sourcing, clear labeling, and certifications, such as USP or NSF, to ensure quality.
What are the best sources of urolithin A?
Urolithin A is not directly found in foods but is produced when gut bacteria break down ellagitannins in foods like pomegranates, berries, and walnuts. Supplements offer a direct source of urolithin A, especially for individuals whose gut bacteria may not efficiently produce urolithin A.
How much urolithin A should I take daily?
Daily doses of urolithin A used in clinical trials vary from 250 mg to 1,000 mg daily. Some research has suggested that higher intake doses may have a higher occurrence of side effects. It's best to consult a healthcare provider for advice on daily intake of urolithin A.
Is CoQ10 better than urolithin A?
No. CoQ10 and urolithin A may support cellular energy production differently. CoQ10 directly participates in mitochondrial energy production, while urolithin A is thought to promote mitochondrial renewal. Urolithin A may provide additional anti-aging benefits, though both supplements have unique properties. Consider your health needs or consult a professional for tailored guidance.
9 resources
- Cell Reports Medicine. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.
- Nature metabolism. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans.
- JAMA Network Open. Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults.
- Ageing Research Reviews. Targeting aging with urolithin A in humans: a systematic review.
- NIH. Urolithin A supplement.
- JAMA Network Open. Effect of urolithin A supplementation on muscle endurance and mitochondrial health in older adults a randomized clinical trial.
- FDA. GRN No. 791 Urolithin A.
- Trends in Molecular Medicine. Impact of the natural compound urolithin A on health, disease, and aging.
- Nutrients. The therapeutic relevance of urolithins, intestinal metabolites of ellagitannin-rich food: a systematic review of in vivo studies.
Your email will not be published. All fields are required.