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A Review of Mushrooms for Brain Health: 5 Products in 2023

Medicinal mushrooms have been used for centuries for their perceived benefits. As of now, we are learning more about them because emerging scientific research is shedding light on their potential therapeutic properties and mechanisms of action.

Some data suggest that mushrooms could be beneficial for one’s brain. In this article, we will explore this notion in more detail and look over a few mushrooms for brain health products that are, in our view, worth considering.

Best mushrooms for brain health: a shortlist

  • Nooceptin — overall best mushrooms for brain health
  • Mind Lab Pro — best mushrooms for memory and focus
  • Real Mushrooms — best affordable mushrooms for brain health
  • Focl — best mushrooms for cognitive function support
  • Oweli — best brain health supplement with a wide range of mushrooms

Criteria we follow for choosing the best mushrooms for brain health

Mushroom typeIncludes science-backed mushrooms
Additional ingredientsMay also support brain health
Manufacturing GMP-compliant or/and FDA-registered
Price$0.50-$2.57 per serving
  • Mushroom type. We picked products that include mushrooms that have been evaluated by scientific research and showed possible benefits for brain health. However, it is important to understand that, although promising, the data on medicinal mushrooms is currently scarce.
  • Additional ingredients. We analyzed the product’s label carefully to understand what benefits it may potentially deliver. Our preference leaned towards products that include a variety of additional ingredients that promote brain health.
  • Manufacturing. We looked for products that adhere to strict manufacturing standards. Manufacturing in FDA-registered and GMP-compliant facilities could indicate that the company produces products containing no industrial contaminants such as heavy metals.
  • Price. We calculated the price per serving to roughly estimate how much these products would cost you daily.

Best mushrooms for brain health: an overview

After analyzing several products on the market, we picked a few mushroom supplements that may be good for brain health.

1. Nooceptin — best mushrooms for brain health overall


Nooceptin is a popular brain supplement that contains a diverse range of ingredients, including lion’s mane — one of the most renowned mushrooms for brain health.

The emerging studies suggest that several compounds in lion’s mane may have neuroprotective properties, enhance cognitive function, and improve mood and sleep. As of now, lion’s mane is one of the most researched mushrooms for brain health.

One serving of this product delivers 400 mg of lion’s mane extract from the fruiting body. Supplements made from fruiting bodies are seen as more potent compared to mycelium-derived products.

The remaining six active ingredients in Nooceptin are additional compounds potentially advantageous for brain function, e.g., citoline, l-theanine, and Panax ginseng extract.

As of now, one bottle of 60 capsules of Nooceptin is priced at $77.00. As one serving is 2 capsules per day, a daily dose of Nooceptin is $2.57. You can opt for a bundle purchase and save in the long run.

2. Mind Lab Pro — top mushrooms for memory and focus

Mind Lab Pro comm

If you are seeking mushrooms for memory and focus, this Mind Lab Pro supplement is worth considering.

In addition to other ingredients that may be associated with brain health, including citicoline, l-theanine, and vitamins B6, B9, and B12, Mind Lab Pro features 500 mg of organic lion’s mane extract per serving.

Lion’s mane is seen as the first choice among people exploring medicinal mushrooms for memory and focus. A few clinical trials on supplementation with lion’s mane extract have suggested that this mushroom could be beneficial for cognitive function. Although presently there is a limited amount of studies, and most of them were conducted on animals only, the lion’s mane takes the prize as being the most researched mushroom for brain health.

One bottle of this product is priced at $69.00. Each bottle contains a monthly supply of 60 capsules. By following the recommended dosage of 2 capsules per day, you would spend $2.30 on this supplement per day.

3. Real Mushrooms — the best affordable mushrooms for the brain

Real Mushrooms lions mane supplement bottle

Real Mushrooms is a renowned medicinal mushroom company that offers comparably lower-priced but high-quality products. This supplement features organic lion’s mane mushroom extract and delivers 1000 mg per serving.

Although this Real Mushrooms product does not contain any other active ingredients, it is worth considering if you are seeking to introduce mushrooms into your routine because lion’s mane is one of the most studied medicinal mushrooms out there.

In addition, Real Mushrooms products are made from fruiting bodies rather than mycelium. As a result, this particular Real Mushrooms product is expected to boast a higher concentration of active beneficial compounds compared to mycelium-based counterparts.

A bottle containing 120 capsules is currently priced at $29.95. The recommended serving of this product is 2 capsules per day, which amounts to $0.50 per day.

4. Focl — best mushroom supplement for cognitive function support


If you are seeking a product that may provide cognitive function support, consider the Focl product as an excellent choice. It contains a significant 1000 mg of lion's mane mushroom, which is one of the most extensively researched medicinal mushrooms for promoting brain health.

Moreover, it includes a wide range of ingredients that are often promoted to be useful for brain health support: vitamin B6, Bacopa monnieri, Rhodiola rosea, and l-theanine.

This supplement is produced in a GMP-certified facility within the United States, guaranteeing rigorous manufacturing standards.

One bottle of this Focl supplement is priced at $49.00 and contains 60 capsules. As the manufacturer recommends taking 2 capsules per day, this product would cost you $1.63 per day.

5. Oweli — best brain supplement with a wide range of mushrooms


10 SHROOMS by Oweli provides a combination of ten different types of mushrooms in one supplement.

The main mushroom extracts in this supplement complex are lion’s mane, cordyceps, shiitake, and reishi. Emerging evidence from preclinical studies suggests that lion’s mane, cordyceps, and reishi may have neuroprotective properties.

Moreover, the proprietary blend includes other mushrooms such as turkey tail and maitake extracts which may be beneficial for immune system support.

Besides mushrooms, this Oweli product does not include any other active ingredient.

The official Oweli website asserts that their product undergoes third-party testing. Moreover, it's worth noting that 10 SHROOMS are produced in FDA-registered and cGMP-compliant facilities, suggesting the supplement's adherence to stringent manufacturing quality criteria.

One bottle (60 capsules) of this Oweli product is priced at $49.99. As one serving is 2 capsules, this supplement comes to $1.67 per day.

Comparing the best mushrooms for brain health

BrandMushroom typeAdditional beneficial ingredients ManufacturingPrice per bottlePrice per serving
NooceptinLion’s maneCiticoline, Rhodiola Rosea, Bacopa monnieri, L-theanine, Ginkgo biloba, Panax ginseng FDA-registred facilities$77.00$2.57
Mind Lab ProLion’s maneCiticoline, Bacopa monnieri, Rhodiola rosea, N-Acetyl-L-tyrosine, Maritime pine bark extract, L-theanine, vitamins B6, B9, and B12FDA-registered, GMP-compliant facilities$69.00$2.30
Real MushroomsLion’s mane NoneNSF-certified facility$29.95$0.50
Lion’s maneVitamin B6, Bacopa monnieri, Rhodiola rosea, and l-theanineGMP-compliant facilities$49.00$1.63
OweliLion's mane, cordyceps, shiitake, and reishi, and othersNoneFDA-registered, cGMP-compliant facilities $49.99$1.67

* — If purchasing one bottle or without a subscription.

While some individual active ingredients in dietary supplements may have been studied for their potential benefits discussed in this article, their interactive effects, as well as the safety and effectiveness of the overall formulation has not been fully established.

Can mushrooms help brain health?

As the practice of using mushroom-based supplements, also known as mushroom stacking, is rising in popularity, many are left wondering whether medicinal mushrooms can help brain function.

As of now, certain types of mushrooms are associated with improvement in brain health — although scientific research on them is in its infancy. For example, the majority of evidence supporting the positive effects of mushrooms on brain health is derived from studies conducted on cells or animals only.

Below we will go into more detail about the proposed medicinal mushroom benefits for brain health.

Cognitive function

Cognitive function is a broad term and includes various abilities such as memory, attention, problem-solving, and decision-making. Some medicinal mushrooms could potentially support some of these abilities.

Mushrooms that have been studied and showed promising results for cognitive function include lion’s mane, chaga, and cordyceps, although only lion’s mane was studied on humans. More research is needed to establish the full extent of their cognitive benefits.


It has been postulated that some medicinal fungi may carry neuroprotective properties. This could be possible because of certain bioactive compounds found in medicinal mushrooms such as erinacines and hericenones found in lion’s mane.

Other mushrooms are also linked to neuroprotective properties. Although the research is very limited, and scientists are not ready to draw conclusions, early mouse models show that supplementation with Reishi could reduce cognitive decline. This is seen, for example, in a study that analyzed reishi's effects on mice with Alzheimer’s disease.

Mental health support

Some limited data suggests that medicinal mushrooms could be useful in supporting mental health. Just like with other indications, there is little scientific data on mushroom usage and mental health, but what is available suggests that they may be introduced as adjunctive interventions.

For instance, the lion's mane mushroom was used in a clinical trial to assess its impact on sleep and mood while on a caloric-restrictive diet. The study included 77 overweight or obese participants and showed better outcomes for people taking lion’s mane compared to placebo, meaning they self-reported improvement in symptoms of anxiety, depression, and sleep disturbances.

Although mushrooms for anxiety and depression have been attracting people’s attention not without a reason, more scientific data is needed to fully grasp their benefits. It is best to consult your primary healthcare provider if you are planning to use mushrooms for mental health support or any other indication.

Other health benefits of medicinal mushrooms

Mushrooms for the brain may offer other benefits. Below we outlined a few of the most eminent ones.

Improve immune function

According to early studies, some medicinal mushrooms could have positive effects on the immune system.

For example, reishi mushroom is rich in several active compounds, such as ganoderic acid, that may stimulate immune system defense responses. Turkey tail is also popular for this indication as they are both believed to potentially boost the production of anti-inflammatory cytokines and support the activity of cells responsible for eliminating infections.

Improve energy and endurance levels

Medicinal mushrooms are often included in nootropic supplements as they are believed to help increase energy levels. Although scientific research is still lacking, certain studies suggest some mushrooms may possess this property.

For instance, cordyceps is linked to improved endurance. Some scientific research suggests that it may improve oxygen uptake, fatigue resistance, and tolerance to high-intensity exercises.

Support digestion

Medicinal mushrooms are also finding application in the realm of digestive health.

Chaga is the most popular one when it comes to this indication, although further research is needed to fully understand its effectiveness and potential benefits in this area.

Contraindications and side effects to consider

Mushrooms for brain health are usually considered to be safe. However, they may also cause side effects, especially if taken in larger doses. Keep in mind that we still lack human trials to fully understand the possible side effects of medicinal mushrooms.

Here are some of the most commonly mentioned side effects that some individuals may have from mushrooms for brain health:

  • Digestive stress
  • Nausea
  • Dry mouth
  • Dizziness

Also, keep in mind that the side effects will highly depend on the mushroom type.

It is best to avoid medicinal mushrooms if you are pregnant, have any underlying conditions or allergies to mushrooms. Moreover, it is always worth consulting with your doctor before starting any supplement, including mushroom-based ones.

What to consider before buying mushrooms for the brain?

Presently, scientists are still trying to answer: are mushrooms good for your brain? Certain mushrooms have been studied by scientists and shown positive effects. However, there is still too little data to conclude their effectiveness for brain health as most studies were not actually conducted on humans but on animals or cells.

If you decide to try mushrooms for brain, you should consider the factors mentioned below to find the most suitable products for you.

  • Mushroom type. Certain mushrooms have been studied for brain health. For example, lion’s mane is the most widely studied mushroom for this indication and has undergone human clinical trials. Other mushrooms may be promoted using data from animal and cell studies.
  • Mushroom part. Mushroom supplements are made from either the fruiting body (the part that grows above ground) or mycelium (the underground root system of the fungus). While mycelium-derived products may be cheaper (as they are easier to produce), extracts from fruiting bodies will be more potent as they contain more active ingredients.
  • Other ingredients. There are plenty of brain supplements to choose from on the market. They oftentimes feature a wide range of active ingredients and thus can deliver various benefits depending on their formula. However, products that contain a huge range of ingredients may also be more expensive than their minimal ingredient counterparts.
  • Personal goals. Different mushrooms will deliver different benefits, thus it is important to understand your goals. For example, it could be said that one of the best mushrooms for memory is lion’s mane because right now it is the most studied one.

Best mushrooms for brain health — conclusion

The field of medicinal mushrooms and their potential benefits for brain health is both intriguing and constantly evolving. While centuries of traditional use have laid the foundation for their interest, emerging scientific research is shedding light on their possible benefits.

In this article, we have explored the potential mushrooms may have for brain health and highlighted five products that, in our opinion, stand out as worthy options for those seeking to explore mushroom-based products.

Find out other products that could be beneficial for your brain health and mental state

Best brain supplements that could potentially offer benefits for memory, sleep quality, and cognitive performance.

Best focus and concentration supplements reviewed by our team.

Best over-the-counter nootropics that may aid performance, increase focus and alertness.

Best anxiety supplements that may help to manage stress.


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