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Seed Probiotic Review 2024: Benefits for Gut Health & Beyond

Probiotic supplements are becoming increasingly popular due to growing interest in gut health. They contain live bacteria and yeasts in defined quantities designed to provide positive health benefits when consumed.

Disruptions in the microbial content have been linked to several diseases, such as inflammatory bowel disease, colon cancer, tooth decay, gingivitis, and more. Maintaining a healthy, beneficial microbial population in the gut may help strengthen immunity and support healthy gut function.

Seed DS-01® Daily Synbiotic provides a blend of probiotics and prebiotics to support a healthy digestive system. Seed probiotic utilizes ViaCap® delivery technology, a broad range of probiotic strains, and prebiotics to optimize its effectiveness.

Our Seed probiotic review focuses on assessing the overall effectiveness, value, and pros and cons of its various ingredients as well as potential health benefits.

How we evaluated Seed probiotic?

Our Seed probiotic review evaluated the current scientific literature regarding specific trials using the Seed DS-01® Daily Synbiotic product and studies investigating each microorganism contained within this supplement.

Comparing these results to Seed's advertising claims, we provide an honest review of the effectiveness and potential health benefits.

User reviews were evaluated, as they can provide first-hand experience concerning the benefits and tolerability of supplements.

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Seed DS-01® Daily Synbiotic comm block

What is Seed probiotic?

Seed Synbiotic is a supplement containing 24 strains of microorganisms in blends to target various health issues and non-fermenting prebiotics derived from an Indian pomegranate.

Using the counting method of tagging cells with fluorescent markers and counting them with a laser, Seed probiotic provides 56.3 billion active fluorescent units (AFUs).

To enhance the survival of probiotic strains, Seed uses ViaCap® delivery technology to improve delivery to the small intestine and colon. This two-in-one capsule contains an outer capsule that prevents the acidic environment of the stomach from killing the microorganisms in the supplement.

Seed is a vegan probiotic supplement that does not require refrigeration and has been tested for major allergens, including gluten, dairy, soy, nuts, and shellfish.

The science & ingredients

Seed probiotic ingredients and the science behind them are important considerations when selecting a probiotic. Seed groups the various strains into four categories based on the potential benefit of the strain.

  • Digestive health:
    • Bifidobacterium longum SD-BB536-JP
    • Bifidobacterium breve SD-BR3-IT
    • Lactiplantibacillus plantarum SD-LP1-IT
    • Lacticaseibacillus rhamnosus SD-LR6-IT
    • Lacticaseibacillus rhamnosus HRVD113-US
    • Bifidobacterium infantis SD-M63-JP
    • Bifidobacterium lactis SD-BS5-IT
    • Bifidobacterium lactis HRVD524-US
    • Lactobacillus crispatus SD-LCR01-IT
    • Lacticaseibacillus casei HRVD300-US
    • Bifidobacterium breve HRVD521-US
    • Bifidobacterium longum HRVD90b-US
    • Bifidobacterium lactis SD150-BE
    • Limosilactobacillus fermentum SD-LF8-IT
    • Lacticaseibacillus rhamnosus SD-GG-BE
    • Limosilactobacillus reuteri RD830-FR

In the digestive health blend, four strains have been shown in human clinical studies (as listed on the Seed website) to significantly improve constipation, defecation frequency, and fecal characteristics. While many of the other strains have shown potential benefits, the studies were conducted in the laboratory or animal models.

  • Dermatologic Health:
    • Bifidobacterium lactis SD-CECT8145-SP
    • Bifidobacterium longum SD-CECT7347-SP
    • Lacticaseibacillus casei SD-CECT9104-SP
    • Ligilactobacillus salivarius SD-LS1-IT

The strains included for dermatologic health have all demonstrated significant improvement in adults and children with inflammatory skin conditions, including eczema.

  • Cardiovascular health:
    • Lactiplantibacillus plantarum SD-LPLDL-UK
    • Bifidobacterium lactis SD-MB2409-IT

L. plantarum has been shown in two clinical trials to reduce levels of total cholesterol and "bad" cholesterol when used in supplements for at least 6 weeks.

  • Micronutrient support:
    • Bifidobacterium adolescentis SD-BA5-IT
    • Limosilactobacillus reuteri SD-LRE2-IT

While studies have shown both strains to increase the production of important micronutrients, only B. adolescentis has been studied in human subjects. This study showed this strain can produce folate within the human intestinal environment.

  • Prebiotics
    • Indian Pomegranate [whole fruit] (Punica granatum) (>40% Polyphenolic + Phenolic Bioactives)

Prebiotics are nutrients that can aid in the growth and health of beneficial bacteria within the intestinal tract. While Seed claims these non-fermenting prebiotics can reduce bloating and gas, user reviews have still noted them to occur upon initial use, but to resolve within a couple of weeks.

Potential benefits of Seed probiotic

Whether Seed is a good probiotic for you depends on the specific reasons you decide to take it. Some of the potential benefits include:

  • Digestion and gut health. Seed Probiotics can aid in the digestion and absorption of various amino acids, help maintain regularity, and reduce symptoms such as constipation, diarrhea, and gas. The probiotics in Seed show some promise in reducing gastrointestinal discomfort and other symptoms however, the evidence is from small studies.
  • Immune system regulation. Probiotics can improve the integrity of the gastrointestinal (GI) tract's cell lining, which can prevent the absorption of potentially harmful compounds. In addition, this helps modulate the inflammatory response within the GI tract, which helps in conditions such as IBS and celiac disease.
  • Cardiovascular health. The probiotic strains in Seed have shown some evidence in small clinical trials that they can reduce "bad" cholesterol levels and increase "good" cholesterol, which could help reduce the risk of cardiovascular diseases.
  • Skin health. Regular use of the strains in Seed has been shown to reduce the symptoms of inflammatory skin concerns.

Who is Seed probiotic best for?

Seed DS-01® Daily Synbiotic is recommended for adults over the age of 18. However, Seed makes PDS-08® Pediatric Daily Synbiotic, formulated for children and adolescents between the ages of 3–17.

While there are no completed clinical studies directly assessing the effects of Seed probiotics on specific medical conditions, there are studies suggesting people with gastrointestinal conditions like IBD (inflammatory bowel disease), constipation, and IBS (irritable bowel syndrome) may benefit from taking a probiotic supplement. Additionally, research suggests that probiotics may provide benefits in conditions involving the skin (e.g., eczema).

The strains contained in Seed have been studied and shown to reduce "bad" cholesterol and stimulate the production of "good" cholesterol, which may be beneficial for those at risk of cardiovascular disease.

Overall, Seed probiotic is a well-rounded supplement that may be beneficial for those seeking wellness support, especially those with gastrointestinal concerns. However, it is important to talk to your doctor before starting any supplement.

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Seed PDS-08®PediatricDaily Synbiotic commercial

Important considerations

With so many different products on the market, it is important to develop criteria for the evaluation of each supplement. When considering this supplement, it is important to ask, "Is Seed probiotic worth it?"

One of the best predictors of effectiveness is the number of viable microorganisms, i.e., colony-forming units (CFUs or AFUs). The ViaCap® delivery technology has been shown to improve survival in simulated digestion models, but this has not been verified in human clinical studies.

Seed probiotic side effects can include gas and bloating despite claims for a reduction in these symptoms by including non-fermenting prebiotics. Luckily, these symptoms typically resolve after a week or so as the body becomes used to the supplement.

Each individual will respond differently to probiotics, which may be as quickly as 1–2 weeks or can take up to 3 months. Patients with few gastrointestinal symptoms may not notice any benefit of a probiotic, whereas those with frequent complaints of diarrhea and constipation may notice a better response.

At $49.99 for a month of Seed DS-01® Daily Synbiotic, it falls within the middle-to-upper price range of probiotic supplements. For users with frequent complaints, this price point may be acceptable.

User reviews

When reading through reviews, the most common question many want answered is, "Does seed probiotic work?" Although the answer may differ for everyone, the majority of reviews have been positive regarding the effects of Seed. These reviews have even included physician and dietician reviews.

Negative reviews have been particularly focused on customer service and subscription issues. Some feedback note a lack of effectiveness of this supplement. However, it is difficult to compare everyone's experience as there is no way to tell their initial symptoms and reasons for taking the supplement.

With the majority of reviews being positive, Seed DS-01® Daily Synbiotic is an option for those who have frequent gastrointestinal symptoms and are considering a probiotic supplement. However, talk with your doctor to determine if it is safe before starting.

Seed probiotic vs competitors

BrandCFUs or AFUsNumber of strainsPriceDosageCost per ServingAdditional active ingredients
Seed53.6 billion
24$49.992 capsules per day$1.67Punicalagins prebiotics
Now25 billion10$14.001 to 2 capsules per day$0.47–$0.93None
Nature's Bounty100 million1$7.521 capsule per day$0.06None
Ritual Symbiotic+11 billion2$601 capsule per day$2.00PreforPro prebiotic, Core Biome postbiotic

Conclusion: is Seed Probiotic worth it?

Overall, the reviews of Seed probiotic suggest it can be beneficial for those with certain digestive symptoms without causing significant side effects. While many of the claims presented on the website have yet to be scientifically proven, the probiotic does contain several strains supported by scientific studies.

The final verdict on this product is likely to be user-dependent, but it appears to be worthy of a trial for those with frequent digestive issues such as diarrhea and constipation.


  • It contains 24 strains with some scientific support for their use.
  • Utilizes ViaCap® delivery technology to deliver more viable microorganisms to the colon.
  • Each lot is tested for major allergens.
  • Well-tolerated with minor side effects that are typically short-lived.


  • Laboratory testing is unclear as to whether it is conducted in-house or by a third-party.
  • The exact content of each strain is not specified.
  • Expensive compared to some probiotic supplements.
  • A limited number of clinical studies have directly tested the effectiveness of this supplement.

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