Prebiotic and probiotic combination plays a crucial role in maintaining your gut health.
Probiotics are live bacteria that can help balance your gut, while prebiotics are plant fibers that feed those bacteria. In other words, probiotics bring in more good bacteria, and prebiotics make sure they have the food to thrive.
In this article, we have compiled a list of the best prebiotic and probiotic supplements, presenting their benefits and features.
The best prebiotic and probiotic combination: a shortlist
- Ritual — best prebiotic, probiotic, and postbiotic blend
- Bioma — best pre and probiotics with delayed-release capsules
- Unbloat — overall best prebiotics and probiotics supplements
- YourBiology — best synbiotic with digestive enzymes
- Routine — best prebiotic and probiotic blend for harmonizing vaginal microbiota
- Culturelle — best affordable prebiotic and probiotic supplement
Comparing the best prebiotic and probiotic combinations
| Brand | Price | Price per serving | Daily dose | Capsules in a bottle |
| Ritual | $54.00 | $1.80 | 1 capsule | 30 |
| Bioma | $47.99 | $1.59 | 2 capsules | 60 |
| Unbloat | $53.00 | $1.77 | 2 capsules | 60 |
| YourBiology | $64.99 | $0.72 | 3 capsules | 90 |
| Routine | $39.95 | $1.33 | 1 capsule | 30 |
| Culturelle | $24.99 | $0.83 | 1 capsule | 30 |
Summarizing the best prebiotic and probiotic products: our top pick
We believe Ritual Synbiotic+ is the best option on the list when it comes to combining both prebiotics and probiotics.
However, what sets it apart isn’t just prebiotics and probiotics — the product also includes postbiotics, all packed into one convenient, delayed-release capsule. This means you’re getting a potentially more effective supplement to support your gut health.
Plus, Ritual is all about transparency and sustainability, which we love. It might be a bit pricier, but with the quality and convenience the supplement offers, we think it’s totally worth it for anyone serious about their digestive health.
The best prebiotic and probiotic combination: an overview
When choosing a prebiotic and probiotic supplement, it's important to understand what suits your personal needs.
Even though most of these products have similar ingredients, slight differences in their formulation can determine the benefits you get from taking them. This is key to consider when aiming for specific health goals.
To help you find the right option, we have put together a list of the best prebiotic and probiotic supplements, highlighting their benefits, ingredients, and additional attributes. Moreover, the list offers a deeper insight into the pros and cons of each product.
Last but not least, we also checked customer reviews from Amazon, Trustpilot, Reddit, and other websites to better understand the sentiment toward the selected brands and products.
1. Ritual — best prebiotic, probiotic, and postbiotic blend
Amazon rating — 4.1 ⭐⭐⭐⭐
Ritual is known for its Synbiotic+ supplement, which combines prebiotics, probiotics, and postbiotics in a single blend. This special mix is designed to bolster gut health and support overall well-being. A notable characteristic is its delayed-release design, ensuring the capsule bypasses stomach acid and only breaks down in the small intestine. This feature allows users to consume the supplement without aligning it with meal time.
Ritual Synbiotic+ is third-party tested by independent labs and does not contain genetically modified ingredients. The product incorporates the Made Traceable® feature, granting users clarity regarding the supplement's composition, sources, and purpose.
Potential benefits of Ritual Synbiotic+ include enhanced digestion and relief from bloating and gas.
Each Ritual Synbiotic+ bottle contains 30 capsules. The manufacturer suggests a daily intake of 1 capsule.
Key ingredients
- LH01 - Myoviridae
- LL5 - Siphoviridae
- T4D - Myoviridae
- LL12 - Myoviridae
- Bifidobacterium animalis ssp. lactis
- Lactobacillus rhamnosus
- Tributyrin
Who is this product for?
Ritual Synbiotic+ is designed for people seeking digestive support, including those looking to improve gut health, enhance immune function, and maintain a healthy gut barrier.
It might be particularly suited for individuals interested in an all-in-one supplement that offers prebiotics, probiotics, and postbiotics.
What users like about the product
- Comprehensive formula. Users appreciate the combination of prebiotics, probiotics, and postbiotics in one capsule for more advanced health benefits.
- Convenience. Users enjoy the convenience of a single capsule that is easy to remember to take and doesn't need to be refrigerated.
What users don’t like about the product
- Price. Some users find the product expensive compared to other probiotic supplements.
- Mint flavor. While some enjoy the minty capsule, others do not prefer the flavor.
Company review
Ritual is a health brand known for its transparency and science-backed approach to supplements.
Their products are designed with traceable ingredients, and they emphasize sustainability in their packaging and operations.
Additionally, the company is committed to continuous innovation and offers products that are vegan, non-GMO, and free of major allergens.
Our verdict about the product
In our opinion, Ritual Synbiotic+ stands out for its holistic approach to gut health, combining probiotics, prebiotics, and postbiotics in a single, delayed-release capsule.
Although the product may be priced higher than some alternatives, its quality and comprehensive formulation make it a solid option for those who are serious about improving their digestive health.
The positive reviews highlight the product’s effectiveness in enhancing gut function and overall well-being. It’s a recommended choice for those looking to invest in a top-tier gut health supplement.
Price
A one-month supply of Ritual Synbiotic+ is available at $54. The product is accessible via a subscription model and includes free shipping.
2. Bioma — best pre and probiotics with delayed-release capsules
Amazon rating — 3.7 ⭐⭐⭐⭐
Bioma Health offers a scientifically formulated product designed to provide relief from common digestive issues such as diarrhea, gas, bloating, and constipation. According to the website, the supplement may support metabolism and digestion while restoring and strengthening the gut balance.
The product contains key ingredients like dietary fibers that feed natural gut bacteria, probiotics comprised of Bifidobacterium genus to increase the count of beneficial bacteria in the gut, and tributyrin to protect the gut lining and reduce inflammation.
The brand claims Bioma Health products are non-GMO, stimulant-free, and vegan-friendly. However, there is no available information on the website about the testing methods.
The recommended dosage is 2 capsules before breakfast, with each bottle containing 30 servings (60 capsules) meant for a 30-day supply.
Key ingredients
- Bifidobacterium lactis
- Bifidobacterium longum
- Bifidobacterium breve
- Tributyrin
- Xylooligosacharides
Who is this product for?
Bioma Probiotics is designed for individuals looking to improve their gut health, particularly those suffering from gastrointestinal issues such as bloating, gas, and irregular bowel movements.
What users like about the product
- Digestive support. Many users report that the product significantly helps with digestive issues such as bloating and irregular bowel movements.
- Overall health benefits. Users experience improvements in overall health, including better energy levels and well-being.
- High-quality ingredients. The use of a blend of probiotics, prebiotics, and postbiotics is appreciated for its comprehensive approach to gut health.
What users don’t like about the product
- Side effects. Some users have pointed out negative side effects such as increased bloating and constipation, particularly when starting the supplement.
- No results. There were user reports of no health changes after taking the supplement.
Company review
Bioma takes an integrated approach to gut health, blending probiotics, prebiotics, and postbiotics in their products.
The company prioritizes scientific research to create supplements that not only enhance digestive health but also support weight management and promote general well-being.
Our verdict about the product
We believe Bioma Probiotics offers an all-around approach to gut health that may appeal to users looking for digestive relief and general health benefits.
Some users have mentioned side effects that may occur during the initial phase of use while other have highlighted the effectiveness of the supplement for improving gut health and regularity.
Regardless of the mixed results, the product receives positive feedback for its benefits in supporting digestive and general wellness.
Price
As for the pricing model, a 1-month supply costs $47.99 per bottle. There are also options for 3-month and 6-month supplies, with prices decreasing per bottle for bulk purchases.
3. Unbloat — overall best prebiotics and probiotics supplements
Amazon rating — 3.6 ⭐⭐⭐⭐
Unbloat Daily Capsules are formulated to address persistent bloating using a combination of 40 unique anti-bloating ingredients, including prebiotics and probiotics. The official website indicates that users could potentially get relief from bloating-related discomfort within 6 hours post-ingestion.
This supplement boasts probiotic strains such as Lactobacillus and Bifidobacterium and prebiotic fiber, renowned for their positive effects on gut health. The product also includes 25 billion CFUs of probiotics in every serving, potentially making it an effective support for bloating and assisting users in feeling more harmonized with their physical state. Furthermore, this product might enhance digestion and support the immune system.
Produced in the USA, Unbloat Capsules cater to vegetarians without any gluten or genetically modified ingredients. However, the website doesn't provide an in-depth overview of its quality checks and certifications.
A single package holds 60 capsules, and the provider’s suggested dosage is 2 capsules daily.
Key ingredients
- 7 live bacterial strains: L. casei, B. lactis, L. plantarum, L. acidophilus, L. rhamnosus, B. longum, and B. bifidum.
- 2 prebiotic fibers for gut bacteria health and bowel function.
- 21 digestive enzymes to help improve the digestion of food.
- 6 herbal remedies to help support gut health.
Who is this product for?
Unbloat is designed for individuals who struggle with bloating and digestive discomfort and are looking for a comprehensive solution to help address these symptoms.
What users like about the product
- Immediate relief. Many users report significant and quick relief from bloating right from the first day of using the pills.
- Specialized ingredients. Customers appreciate the combination of digestive enzymes, herbs like ginger and fennel, and probiotics, which they find effective in managing digestive discomfort.
- Overall gut health improvement. Users have mentioned improvements in better digestion and less discomfort during the day.
What users don’t like about the product
- Side effects. Some users experienced negative side effects such as stomach pain and constipation, which they attribute directly to the product.
- Price concerns. The price point has been mentioned as a barrier, with some users feeling that it is too high for the value offered, especially for long-term use.
Company review
Unbloat, founded by Dr. Shilpa Mehra, a board-certified gastroenterologist, focuses on creating solutions for common and often overlooked digestive issues like bloating.
The company emphasizes natural and comprehensive approaches to gut health, promising a formula that can help address common causes of bloating.
Additionally, the brand offers a satisfaction guarantee, reflecting its confidence in the product's effectiveness.
Our verdict about the product
Based on the reviews on Amazon, the reception for Unbloat's Anti-Bloat Pills is mixed.
Quite a few people have found quick relief from bloating and really like the blend of digestive enzymes, herbs, and probiotics. But there’s another side to it: some users have run into issues like stomach pain or found that the results can vary, especially if they buy the product from different stores.
Even though many praise the product for improving gut health, the price and some negative experiences mean it's not a slam dunk for everyone.
So, if you're thinking about giving Unbloat a try, especially if you have a sensitive stomach or you're conscious of your budget, it might be worth considering these points.
Price
The product is available at $53 for standalone orders, but discounts are available for those selecting the periodic subscription options.
4. YourBiology — best synbiotic with digestive enzymes
Trustpilot — 3.6 ⭐⭐⭐⭐
YourBiology is a probiotic supplement featuring a combination of 4 bacterial strains: Lactobacillus acidophilus, Lactobacillus paracasei, Lactobacillus plantarum, and Bifidobacterium lactis, known to support the digestive system and equilibrium in the gut. It also includes natural prebiotic fibers fructo-oligosaccharides that may nourish good bacteria.
The brand creates custom probiotic blends after performing thorough gut microbiome analyses. Based on the gut bacteria assessment, YourBiology presents a probiotic mixture with 40 billion CFUs designed to address microbial imbalances.
Each bottle contains 90 capsules, with the brand’s suggested dosage of 3 capsules daily.
Produced in the USA, YourBiology undergoes third-party testing and has a GMP certification, showcasing its compliance with the standards set by the Food & Drug Administration (FDA).
Key ingredients
- Lactobacillus acidophilus
- Bifidobacterium breve
- Lactobacillus plantarum
- Lactobacillus paracasei
- Lactobacillus fermentum
- Saccharomyces boulardii
- Digestive enzyme blend (amylase, lipase, protease)
- Prebiotic bend (inulin, FOS)
Who is this product for?
YourBiology is targeted toward both men and women who are seeking to improve their digestive health, immune system function, and overall well-being.
It may be particularly beneficial for those dealing with gastrointestinal issues like bloating, gas, and irregular bowel movements.
What users like about the product
- Improved digestive health. Users report significant improvements in digestion and a reduction in symptoms such as bloating and gas.
- Improved mental health. Customers appreciate the positive effects on mental health and clarity, attributing it to better gut health.
- Immune support. The probiotics in the supplement are praised for their role in strengthening the immune system.
What users don’t like about the product
- Slow results. Some users have noted that it takes a while to see any noticeable improvements in health.
- Customer service. A few customers expressed their frustration with the company's inability to respond on time and lack of clear information on pricing.
Company review
YourBiology offers a premium probiotic emphasizing scientific backing for its ingredient choice and manufacturing its products in GMP-certified facilities in the USA to ensure high quality and safety standards.
Additionally, YourBIology offers a 60-day money-back guarantee, highlighting its confidence in the effectiveness of its products.
Our verdict about the product
Based on our overview, YourBiology probiotic supplement appears to be a well-rounded product for supporting digestive health, enhancing immune function, and improving mental well-being.
Despite some of the concerns, the overall user feedback for the supplement is positive, indicating that it may be a reliable choice for those looking to improve their gut health.
The combination of probiotics, prebiotics, and digestive enzymes in one formula makes it stand out in the crowded probiotic market.
Price
A one-month supply of YourBiology supplements costs $64.99. A three-month bundle (including an additional month) is available for $129.99, while a five-month package (with two bonus months) is offered for $194.99.
5. Routine — best prebiotic and probiotic blend for harmonizing vaginal microbiota
Amazon rating — 4.2 ⭐⭐⭐⭐
Routine Prebiotic + Probiotic For Her is a comprehensive daily supplement designed to support gut, vaginal, and immune health with a blend of prebiotics and probiotics.
Each capsule contains 24 billion CFUs, formulated with five clinically-researched probiotic strains, including Bifidobacterium lactis HN019 for gut health and Lactobacillus rhamnosus HN001 for vaginal flora.
Additional ingredients include organic ashwagandha, chicory root (prebiotic), cellulose, vitamin C, and organic rice extract.
The product is non-GMO, vegan, gluten-free, allergen-free, and manufactured in a cGMP-certified facility.
One bottle of Routine probiotics contains 30 capsules, with a recommended dosage of 1 capsule daily.
Key ingredients
- Bifidobacterium lactis B-420
- Lactobacillus rhamnosus HN001
- Lactobacillus acidophilus LA-14
- Bifidobacterium lactis HN019
- Bifidobacterium lactis BL-04
- Organic ashwagandha
- Chicory root (prebiotic)
- Vitamin C
Who is this product for?
Routine Prebiotic + Probiotic For Her is designed for women seeking to improve their gut health and vaginal health and reduce gastrointestinal issues such as bloating, gas, and irregular bowel movements.
What users like about the product
- Digestive relief. Many users report significant improvements in managing gastrointestinal symptoms such as bloating, gas, and constipation.
- Vaginal health benefits. There were some users reporting improvement in yeast infections and bacterial vaginosis symptoms.
- Eco-friendly packaging. Users appreciate the recyclable and compostable packaging, along with the reusable glass jar.
What users don’t like about the product
- No results. Some users report receiving no significant benefits for their health after taking the supplement.
Company review
Routine provides high-quality, science-backed probiotics specifically designed for women.
The brand focuses heavily on transparency, traceability, and sustainability. Its products are made from clinically researched ingredients without GMOs, contaminants, or fillers.
Last but not least, the company is also dedicated to minimizing its environmental footprint by using recyclable, compostable, and reusable packaging.
Our verdict about the product
We think Routine Prebiotic + Probiotic For Her is a great option for women looking to support their digestive and vaginal health.
It's packed with high-quality, clinically proven ingredients and even includes ashwagandha to help with stress relief.
While some users haven't noticed benefits, the majority of feedback is positive, making it a solid pick for those seeking to improve their well-being with a top-notch probiotic supplement.
Price
Routine Prebiotic + Probiotic For Her starts at $39.95, with discounts available for monthly subscriptions.
6. Culturelle — best affordable prebiotic and probiotic supplement
Amazon rating — 4.6 ⭐⭐⭐⭐⭐
Culturelle Advanced Regularity Probiotic + Prebiotic Fiber offers an advanced triple-action formula for promoting regularity and reducing digestive issues such as gas and bloating.
The supplement features a blend of clinically-researched probiotic strains with 11 billion CFUs, including Lactobacillus rhamnosus GG and prebiotic fiber derived from cold-pressed kiwi fruit.
Each capsule contains a balanced mix of probiotics and prebiotics formulated to help restore digestive regularity.
The product is vegetarian, non-GMO, gluten-free, and free from dairy, soy, artificial dyes, and sugar, ensuring it caters to a variety of dietary needs.
Culturelle Advanced Regularity Probiotic + Prebiotic Fiber undergoes third-party testing, maintaining high-quality standards.
The recommended dosage is 1 capsule daily, with each bottle containing 30 capsules.
Key ingredients
- Lactobacillus rhamnosus GG (LGG)
- Bifidobacterium lactis HN019
- Bifidobacterium lactis BL-04
- Cold-pressed kiwi fruit blend (prebiotic fiber)
Who is this product for?
Culturelle Advanced Regularity Probiotic + Prebiotic Fiber Capsules are designed for adults seeking to improve their digestive health, particularly those experiencing occasional constipation, gas, and bloating.
What users like about the product
- Digestive support. Users report improvements in managing symptoms such as constipation, gas, and bloating.
- Quality ingredients. Users appreciate the prebiotic fiber from kiwi fruit, which may enhance the effectiveness of the probiotics.
What users don’t like about the product
- Effectiveness. Some users report that the product did not work as expected for them, mentioning either no change or increased digestive discomfort.
Company review
Culturelle is a highly reputable company providing high-quality, science-backed probiotic supplements.
As voted by pharmacists and pediatricians, it is recognized as the #1 most trusted probiotic brand in America.
What’s more, Culturelle products are based on clinical evidence and produced according to good manufacturing practices (GMP).
Our verdict about the product
In our opinion, Culturelle Advanced Regularity Probiotic + Prebiotic Fiber Capsules is a great pick for individuals looking to boost their digestive health and tackle issues like constipation, gas, and bloating.
With a combination of clinically proven probiotic strains and prebiotic fiber from kiwi fruit, it may provide comprehensive support for your gut.
According to customer feedback, not everyone has seen the same results. However, the product's potential effectiveness, convenience, and brand reputation make it a reliable choice for improving your digestive well-being.
Price
Culturelle Advanced Regularity Probiotic + Prebiotic Fiber costs $24.99 for 30 capsules or $47.49 for a 60-capsule option.
How did we choose the best prebiotic and probiotic combination?
We looked at brands and products that offer the best combination of prebiotics and probiotics.
The recommended products in this list adhere to specific standards such as quality, ingredient safety, and adequate dosage-price ratio. Additionally, we considered the brand's reputation to ensure the authenticity of the products.
- Quality ingredients. Our chosen supplements feature evidence-based ingredients. Many products on the market lack robust evidence, which makes it essential to choose supplements with proven effectiveness.
- Synbiotic formulation. We focused on products that work synergistically to support optimal gut health containing both prebiotics and probiotics in their formulation.
- Adequate dosage and price. We assessed the dosage and cost of each product featured on our list.
- Provider reputation. We highlighted brands with a track record of producing high-quality products. Additionally, we recognized the value of customer reviews and ratings in gauging the experiences and contentment of previous consumers.
Synbiotics: understanding this prebiotic and probiotic combination
Prebiotics are non-digestible fibers that may selectively support the growth of beneficial gut bacteria, known as probiotics.
Together, they establish a synbiotic relationship: prebiotics may feed and enhance probiotics, optimizing their role in supporting gut health and nourishing a healthy microbiome.
Choosing the best prebiotic and probiotic supplement: a buyer's guide
When selecting a prebiotic and probiotic supplement, it's essential to consider several key factors to ensure optimal benefits and safety.
- Strain diversity. Look for supplements with a variety of probiotic strains, as different strains may provide different health benefits.
- Quality. Make sure the ingredients are tested for quality and suitable for your personal health needs.
- Food intake. Consider how the supplement interacts with your diet and if certain foods should be consumed or avoided for optimal results.
- Additional ingredients. Review the label for additional ingredients in the supplement to avoid unnecessary additives or side effects.
Function of prebiotics in synbiotic formulas
Prebiotics are non-digestible food compounds that may feed gut microbes and stimulate the growth of healthy bacteria (probiotics). This is important for keeping your gut healthy, supporting your body’s defenses, and promoting regular bowel movements.
Role of probiotics in synbiotic combinations
Probiotics are live microorganisms that, when taken in adequate amounts, may offer various health benefits. Their effectiveness is rooted in their live nature and ability to positively influence the gut microbiome. They can be more effective when combined with prebiotics to support the growth of beneficial microorganisms.
Benefits of prebiotic and probiotic combination
The combination of prebiotics and probiotics may provide numerous health benefits. These can include:
- Intestinal ecosystem balance
- Digestive support
- Immune system support
- Reduced lactose intolerance
Side effects and risks to consider
While prebiotics and probiotics are generally considered safe, they may have some side effects.
Potential side effects, especially at the beginning of administration, can include gas, bloating, diarrhea, and constipation. Therefore, it is essential to ensure product quality and choose prebiotics and probiotics that suit your individual needs.
For a personalized plan, it is recommended to consult with a healthcare specialist.
Dosage and storage guidelines for synbiotics
Synbiotics, which combine probiotics and prebiotics, have the potential to deliver various gut health benefits. However, it is necessary to follow the recommended dosage and storage guidelines for their effectiveness.
- Recommended dosage. Each product is different. Always check the label for the recommended dose to ensure effective results.
- Proper storage. Make sure the probiotics are stored correctly, as they must be consumed alive for health benefits.
The best prebiotic and probiotic combination: conclusion
When it comes to gut health, the combination of probiotics and prebiotics may provide various supporting benefits. Certain bacterial strains, such as Lactobacillus and Bifidobacterium, may play a significant role in maintaining a healthy microbiome, while prebiotic fibers may nourish these good bacteria.
However, it's crucial to recognize that individual needs may differ. While these supplements have the potential to support your health, they should never be used as a substitute for medical treatments. Always consult with a healthcare professional before making any dietary changes.
Explore other health benefits of probiotics
Best probiotics for constipation may increase bowel movements.
Best probiotics for IBS can help restore the balance of bacteria in the gut.
Best probiotics for women may support digestive and vaginal health.
Best probiotics for weight loss can help support weight management.
Best probiotics for kids may reduce the symptoms of eczema in children.
Best probiotics for oral health may also protect your gums and teeth.
Best prebiotics might help promote the growth of good bacteria in your gut.
FAQ
What is the best prebiotic and probiotic combination?
Probiotics are typically combined with prebiotics as this synbiotic synergy has been demonstrated to contribute to an increased microbiota diversity. The most commonly used evidence-based prebiotics are fructo-oligosaccharides, such as inulin.
How long does it take for prebiotics and probiotics to start working?
The time it takes for prebiotics and probiotics to start working varies, but most people may notice benefits within a few days to several weeks. Factors like individual gut health, the specific strains used, and dietary habits can influence the onset of effects. It's essential to maintain consistent intake for optimal results.
What are the signs that probiotics are working?
Signs that probiotics are working may include improved digestion, reduced bloating, and enhanced gut health. Individuals may also experience better mood and improved lactose tolerance.
5 resources
- Foods. Prebiotics: Definition, types, sources, mechanisms, and clinical applications.
- Nutrients. Effects of probiotics, prebiotics, and synbiotics on human health.
- ISRN Nutrition. Health benefits of probiotics: a review.
- International Journal of Environmental Research and Public Health. Microorganisms with claimed probiotic properties: an overview of recent literature.
- Frontiers in Immunology. The role of probiotics and prebiotics in inducing gut immunity.
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